James Voss, PhD
Institute Investigator
Department of Immunology and Microbiology
Research Focus
Because HIV broadly neutralizing antibodies (bnAbs) can suppress viremia, kill infected cells, and enhance host immunity, we believe that durable elicitation of multi-specific bnAb responses from engineered B cells is a promising approach for an HIV functional cure. Working towards this end, our group is further characterizing the behavior of modified B cells in the mouse model, and we are working to elicit bi- or tri-specific bnab memory responses in NHPs, where their ability to protect against infection or maintain suppression of viremia can be evaluated. We are also exploring other applications for this promising technology in immunotherapy and even for treatment of genetic diseases like hemophilia.
Our team is currently made up of four graduate students, one postdoc and one research assistant. We are funded by The Bill and Melinda Gates foundation and two R01 awards from the NIAID. You can learn more about our group and the science we are doing on our lab website (link above).
Select Publications
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Huang, D.; Tran, J. T.; Olson, A.; Vollbrecht, T.; Tenuta, M.; Guryleva, M. V.; Fuller, R. P.; Schiffner, T.; Abadejos, J. R.; Couvrette, L.; Blane, T. R.; Saye, K.; Li, W.; Landais, E.; Gonzalez-Martin, A ..; Schief, W.; Murrell, B.; Burton, D. R.; Nemazee, D.; Voss, J. E. Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells. Nat Commun 2020, 11, 5850.
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Voss, J. E.; Gonzalez-Martin, A ..; Andrabi, R.; Fuller, R. P.; Murrell, B.; McCoy, L. E.; Porter, K.; Huang, D.; Li, W.; Sok, D.; Le, K.; Briney, B.; Chateau, M.; Rogers, G.; Hangartner, L.; Feeney, A. J.; Nemazee, D.; Cannon, P.; Burton, D. R. Reprogramming the antigen specificity of B cells using genome-editing technologies. Elife 2019, 8.
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Nahmad, Alessio D.; Lazzarotto, Cice R.; Zelikson, Natalie; Kustin, Talia; Tenuta, Mary; Huang, Deli; Reuveni, Inbal; Nataf, Daniel; Raviv, Yuval; Horovitz-Fried, Miriam; Dotan, Iris; Carmi, Yaron; Rosin-Arbesfeld, Rina; Nemazee, David; Voss, Jam E.; Stern, Adi; Tsai, Shengdar Q.; Barzel, Adi In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice. 2022, 40, 1241-1249.
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Burton, Dennis R.; Briney, Bryan; Andrabi, Raiees; Teijaro, John R.; Voss, James E.; Wilson, Ian A.; Nemazee, David; Smith, Davey M.; Zhao, Fangzhu; Yuan, Meng; Yang, Linlin; Wu, Nicholas C.; Woehl, Jordan L.; Song, Ge; Sok, Devin; Smith, Davey M.; Smith, Chloe; Rogers, Thomas F.; Ricketts, James; Ricciardi, Michael J.; Rawlings, Stephen A.; Ramirez, Sydney I.; Peng, Linghang; Parren, Mara; Limbo, Oliver; Landais, Elise; Jardine, Joseph G.; Hurtado, Jonathan; Huang, Deli; He, Wan-ting; Garcia, Elijah; Callaghan, Sean; Burns, Alison; Beutler, Nathan; Abbott, Robert K. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model.. Science (New York, N.Y.) 2020, 956-963.
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Wec, A. Z.; Wrapp, D.; Herbert, A. S.; Maurer, D. P.; Haslwanter, D.; Sakharkar, M.; Jangra, R. K.; Dieterle, M. E.; Lilov, A.; Huang, D.; Tse, L. V.; Johnson, N. V.; Hsieh, C. L.; Wang, N.; Nett, J. H.; Champney, E.; Burnina, I.; Brown, M.; Lin, S.; Sinclair, M.; Johnson, C.; Pudi, S.; Bortz, 3rd; Wirchnianski, A. S.; Laudermilch, E.; Florez, C.; Fels, J. M.; O'Brien, C. M.; Graham, B. S.; Nemazee, D.; Burton, D. R.; Baric, R. S.; Voss, J. E.; Chandran, K.; Dye, J. M.; McLellan, J. S.; Walker, L. M. Broad neutralization of SARS-related viruses by human monoclonal antibodies. Science 2020, 369, 731-736.
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Voss, J. E.; Andrabi, R.; McCoy, L. E.; Val, N.; Fuller, R. P.; Messmer, T.; Su, C. Y.; Sok, D.; Khan, S. N.; Garces, F.; Pritchard, L. K.; Wyatt, R. T.; Ward, A. B.; Crispin, M.; Wilson, I. A.; Burton, D. R. Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model. Cell Rep 2017, 21, 222-235.
