Robyn Stanfield, PhD
Institute Investigator
Department of Integrative Structural and Computational Biology
Research Focus
X-ray crystallographic studies of antibody-antigen complexes
My research is focused on x-ray crystallographic studies of antibody-antigen complexes, with an emphasis on antibodies that neutralize the HIV-1 virus. By studying the detailed structures of these complexes we can better understand how antibodies recognize their antigens, and how to design antigens to elicit an effective anti-viral response.
My research is focused on x-ray crystallographic studies of antibody-antigen complexes, with an emphasis on antibodies that neutralize the HIV-1 virus. By studying the detailed structures of these complexes we can better understand how antibodies recognize their antigens, and how to design antigens to elicit an effective anti-viral response.
Select Publications
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Stanfield, Robyn L.; Dooley, Helen; Flajnik, Martin F.; Wilson, I A. Crystal structure of a shark single-domain antibody V region in complex with lysozyme. 2004, 305, 1770-3.
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Stanfield, Robyn L.; Gorny, Miroslaw K.; Williams, Constance; Zolla-Pazner, Susan; Wilson, I A. Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D. 2004, 12, 193-204.
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Stanfield, R; Cabezas, E; Satterthwait, A; Stura, E; Profy, A; Wilson, I Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs. 1999, 7, 131-42.
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