Source: Interfolio F180
Robyn Stanfield
Research Focus
X-ray crystallographic studies of antibody-antigen complexes
My research is focused on x-ray crystallographic studies of antibody-antigen complexes, with an emphasis on antibodies that neutralize the HIV-1 virus. By studying the detailed structures of these complexes we can better understand how antibodies recognize their antigens, and how to design antigens to elicit an effective anti-viral response.
Education
B.S. (Chemistry), North Carolina State University, 1980Ph.D. (Chemistry), The University of Texas at Austin, 1986
Selected Publications
Stanfield, Robyn L.; Dooley, Helen; Flajnik, Martin F.; Wilson, I A. Crystal structure of a shark single-domain antibody V region in complex with lysozyme. 2004, 305, 1770-3.
Stanfield, Robyn L.; Gorny, Miroslaw K.; Williams, Constance; Zolla-Pazner, Susan; Wilson, I A. Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D. 2004, 12, 193-204.
Stanfield, R; Cabezas, E; Satterthwait, A; Stura, E; Profy, A; Wilson, I Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs. 1999, 7, 131-42.