William Schief

Department of Immunology and Microbiology
California Campus


Scripps Research Joint Appointments

Faculty, Graduate Program

Other Joint Appointments

The Ragon Institute of MGH, MIT and Harvard (Associate Member)
IAVI Neutralizing Antibody Center, The Scripps Research Institute


Ph.D. (Physics), University of Washington, 1999
B.S. (Applied Mathematics), Yale University, 1989

Professional Experience

2011-2014 Associate Professor of Immunology, Immunology and Microbial Science (IMS), Scripps Research

Selected References

All Publications

Lee, J. H., Toy, L., Kos, J. T., Safonova, Y., Schief, W. R., Havenar-Daughton, C., Watson, C. T. & Crotty, S. Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naive human B cells. (2021). NPJ Vaccines, 6. PMCID: PMC8421370.

Antanasijevic, A., Sewall, L. M., Cottrell, C. A., Carnathan, D. G., Jimenez, L. E., Ngo, J. T., Silverman, J. B., Groschel, B., Georgeson, E., Bhiman, J., Bastidas, R., LaBranche, C., et al. Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM. (2021). Nature Communications, 12. PMCID: PMC8355326.

Martin, J. T., Hartwell, B. L., Kumarapperuma, S. C., Melo, M. B., Carnathan, D. G., Cossette, B. J., Adams, J., Gong, S. Q., Zhang, W., Tokatlian, T., Menis, S., Schiffner, T., et al. Combined PET and whole-tissue imaging of lymphatic-targeting vaccines in non-human primates. (2021). Biomaterials, 275. PMCID: PMC8325633.

Schoeder, C. T., Schmitz, S., Adolf-Bryfogle, J., Sevy, A. M., Finn, J. A., Sauer, M. F., Bozhanova, N. G., Mueller, B. K., Sangha, A. K., Bonet, J., Sheehan, J. H., Kuenze, G., et al. Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design. (2021). Biochemistry, 60(11), 825-846. PMCID: PMC7992133.

Lee, J. H., Hu, J. K., Georgeson, E., Nakao, C., Groschel, B., Dileepan, T., Jenkins, M. K., Seumois, G., Vijayanand, P., Schief, W. R. & Crotty, S. Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers. (2021). Journal of Experimental Medicine, 218. PMCID: PMC7769167.

Baboo, S., Diedrich, J. K., Martinez-Bartolome, S., Wang, X. N., Schiffner, T., Groschel, B., Schief, W. R., Paulson, J. C. & Yates III, J. R. DeGlyPHER: An Ultrasensitive Method for the Analysis of Viral Spike N-Glycoforms. (2021). Analytical Chemistry, 93(40), 13651-13657.

Wang, X. S., Ray, R., Kratochvil, S., Melzi, E., Lin, Y. C., Giguere, S., Xu, L. L., Warner, J., Cheon, D., Liguori, A., Groschel, B., Phelps, N., et al. Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors. (2020). EMBO Journal, 40. PMCID: PMC7809789.

Huang, D. L., Abbott, R. K., Havenar-Daughton, C., Skog, P. D., Al-Kolla, R., Groschel, B., Blane, T. R., Menis, S., Tran, J. T., Thinnes, T. C., Volpi, S. A., Liguori, A., et al. B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models. (2020). Proceedings of the National Academy of Sciences of the United States of America, 117(37), 22920-22931. PMCID: PMC7502816.

Kato, Y., Abbott, R. K., Freeman, B. L., Haupt, S., Groschel, B., Silva, M., Menis, S., Irvine, D. J., Schief, W. R. & Crotty, S. Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo. (2020). Immunity, 53(3), 548-563. PMCID: PMC7451196.

Martin, J. T., Cottrell, C. A., Antanasijevic, A., Carnathan, D. G., Cossette, B. J., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Fischinger, S., Tokatlian, T., Cirelli, K. M., et al. Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations. (2020). NPJ Vaccines, 5. PMCID: PMC7406516.