William Schief, PhD

Department of Immunology and Microbiology
California Campus


Scripps Research Joint Appointments

Faculty, Graduate Program

Other Joint Appointments

The Ragon Institute of MGH, MIT and Harvard (Associate Member)
IAVI Neutralizing Antibody Center, The Scripps Research Institute


Ph.D. (Physics), University of Washington, 1999
B.S. (Applied Mathematics), Yale University, 1989

Professional Experience

2011-2014 Associate Professor of Immunology, Immunology and Microbial Science (IMS), Scripps Research

Selected References

All Publications

Wang, X. S., Ray, R., Kratochvil, S., Melzi, E., Lin, Y. C., Giguere, S., Xu, L. L., Warner, J., Cheon, D., Liguori, A., Groschel, B., Phelps, N., et al. Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors. (2021). EMBO Journal, 40. PMCID: PMC7809789.

Martin, J. T., Cottrell, C. A., Antanasijevic, A., Carnathan, D. G., Cossette, B. J., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Fischinger, S., Tokatlian, T., Cirelli, K. M., et al. Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations. (2020). NPJ Vaccines, 5. PMCID: PMC7406516.

Veneziano, R., Moyer, T. J., Stone, M. B., Wamhoff, E. C., Read, B. J., Mukherjee, S., Shepherd, T. R., Das, J., Schief, W. R., Irvine, D. J. & Bathe, M. Role of nanoscale antigen organization on B-cell activation probed using DNA origami. (2020). Nature Nanotechnology,

Rantalainen, K., Berndsen, Z. T., Antanasijevic, A., Schiffner, T., Zhang, X., Lee, W. H., Torres, J. L., Zhang, L., Irimia, A., Copps, J., Zhou, K. H., Kwon, Y. D., et al. HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies. (2020). Cell Reports, 31. PMCID: PMC7196886.

Xu, Z. Y., Wise, M. C., Chokkalingam, N., Walker, S., Tello-Ruiz, E., Elliott, S. T. C., Perales-Puchalt, A., Xiao, P., Zhu, X. Z., Pumroy, R. A., Fisher, P. D., Schultheis, K., et al. In vivo assembly of nanoparticles achieved through synergy of structure-based protein engineering and synthetic DNA generates enhanced adaptive immunity. (2020). Advanced Science,

Moyer, T. J., Kato, Y., Abraham, W., Chang, J. Y. H., Kulp, D. W., Watson, N., Turner, H. L., Menis, S., Abbott, R. K., Bhiman, J. N., Melo, M. B., Simon, H. A., et al. Engineered immunogen binding to alum adjuvant enhances humoral immunity. (2020). Nature Medicine, 26(3), 430-440. PMCID: PMC7069805.

Huang, D. L., Abbott, R. K., Havenar-Daughton, C., Skog, P. D., Al-Kolla, R., Groschel, B., Blane, T. R., Menis, S., Tran, J. T., Thinnes, T. C., Volpi, S. A., Liguori, A., et al. B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models. (2020). Proceedings of the National Academy of Sciences of the United States of America, 117(37), 22920-22931. PMCID: PMC7502816.

Kato, Y., Abbott, R. K., Freeman, B. L., Haupt, S., Groschel, B., Silva, M., Menis, S., Irvine, D. J., Schief, W. R. & Crotty, S. Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo. (2020). Immunity, 53(3), 548-563. PMCID: PMC7451196.

Steichen, J. M., Lin, Y. C., Havenar-Daughton, C., Pecetta, S., Ozorowski, G., Willis, J. R., Toy, L., Sok, D., Liguori, A., Kratochvil, S., Torres, J. L., Kalyuzhniy, O., et al. A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. (2019). Science, 366.

Melo, M., Porter, E., Zhang, Y., Silva, M., Li, N., Dobosh, B., Liguori, A., Skog, P., Landais, E., Menis, S., Sok, D., Nemazee, D., et al. Immunogenicity of RNA replicons encoding HIV Env immunogens designed for self-assembly into nanoparticles. (2019). Molecular Therapy, 27(12), 2080-2090. PMCID: PMC6904793.