William Schief, PhD
Scripps Research Joint Appointments
Other Joint Appointments
The Ragon Institute of MGH, MIT and Harvard (Associate Member)IAVI Neutralizing Antibody Center, The Scripps Research Institute
Education
Ph.D. (Physics), University of Washington, 1999B.S. (Applied Mathematics), Yale University, 1989
Professional Experience
2011-2014 Associate Professor of Immunology, Immunology and Microbial Science (IMS), Scripps ResearchSelected References
Frenz, B., Ramisch, S., Borst, A. J., Walls, A. C., Adolf-Bryfogle, J., Schief, W. R., Veesler, D. & DiMaio, F. Automatically fixing errors in glycoprotein structures with Rosetta. (2019). Structure, 27(1), 134-139.
Tokatlian, T., Read, B. J., Jones, C. A., Kulp, D. W., Menis, S., Chang, J. Y. H., Steichen, J. M., Kumari, S., Allen, J. D., Dane, E. L., Liguori, A., Sangesland, M., et al. Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers. (2019). Science, 363(6427), 649-654.
Umotoy, J., Bagaya, B. S., Joyce, C., Schiffner, T., Menis, S., Saye-Francisco, K. L., Biddle, T., Mohan, S., Vollbrecht, T., Kalyuzhniy, O., Madzorera, S., Kitchin, D., et al. Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan. (2019). Immunity, 51(1), 141-154. PMCID: PMC6642152.
Cirelli, K. M., Carnathan, D. G., Nogal, B., Martin, J. T., Rodriguez, O. L., Upadhyay, A. A., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Nakao, C., Pauthner, M. G., et al. Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance. (2019). Cell, 177(5), 1153-1171.
Pauthner, M. G., Nkolola, J. P., Havenar-Daughton, C., Murrell, B., Reiss, S. M., Bastidas, R., Prevost, J., Nedellec, R., von Bredow, B., Abbink, P., Cottrell, C. A., Kulp, D. W., et al. Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers. (2019). Immunity, 50(1), 241-252. PMCID: PMC6335502.
Cao, L. W., Pauthner, M., Andrabi, R., Rantalainen, K., Berndsen, Z., Diedrich, J. K., Menis, S., Sok, D., Bastidas, R., Park, S. K. R., Delahunty, C. M., He, L., et al. Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer. (2018). Nature Communications, 9. PMCID: PMC6135743.
Tokatlian, T., Kulp, D. W., Mutafyan, A. A., Jones, C. A., Menis, B., Georgeson, E., Kubitz, M., Zhang, M. H., Melo, M. B., Silva, M., Yun, D. S., Schief, W. R., et al. Enhancing humoral responses against HIV Envelope trimers via nanoparticle delivery with stabilized synthetic liposomes. (2018). Scientific Reports, 8. PMCID: PMC6224390.
Duan, H., Chen, X., Boyington, J. C., Cheng, C., Zhang, Y., Jafari, A. J., Stephens, T., Tsybovsky, Y., Kalyuzhniy, O., Zhao, P., Menis, S., Nason, M. C., et al. Glycan masking focuses immune responses to the HIV-1 CD4-binding site and enhances elicitation of VRC01-class precursor antibodies. (2018). Immunity, 49(2), 301-311.
Crooks, E. T., Grimley, S. L., Cully, M., Osawa, K., Dekkers, G., Saunders, K., Ramisch, S., Menis, S., Schief, W. R., Doria-Rose, N., Haynes, B., Murrell, B., et al. Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation. (2018). PLoS Pathogens, 14. PMCID: PMC5951585.
Lin, Y. C., Pecetta, S., Steichen, J. M., Kratochvil, S., Melzi, E., Arnold, J., Dougan, S. K., Wu, L., Kirsch, K. H., Nair, U., Schief, W. R., Batista, F. D. One-step CRISPR/Cas9 method for the rapid generation of human antibody heavy chain knock-in mice. (2018). EMBO Journal, 37. PMCID: PMC6138433.