Source: Interfolio F180

William Schief

Professor of Subject
Department of Immunology and Microbiology



B.S. (Applied Mathematics), Yale University, 1989
Ph.D. (Physics), University of Washington, 1999
Sr. Fellow (Physiology & Biophysics), University of Washington, 2001
Sr. Fellow (Biochemistry), University of Washington, 2006

Awards & Professional Activities

1989 Cum Laude honors for B.S. degree, Yale University
1995 NIH Training Grant Fellowship in Molecular Biotechnology
1996 NIH Training Grant Fellowship in Molecular Biophysics
1999 Dahlstrom Prize for an outstanding experimental physics graduate student, Department of Physics, University of Washington
2002 NIH National Reserach Service Award Post-doctoral Fellowship

Selected Publications

Antanasijevic, A.; Bowman, C. A.; Kirchdoerfer, R. N.; Cottrell, C. A.; Ozorowski, G.; Upadhyay, A. A.; Cirelli, K. M.; Carnathan, D. G.; Enemuo, C. A.; Sewall, L. M.; Nogal, B.; Zhao, F.; Groschel, B.; Schief, W. R.; Sok, D.; Silvestri, G.; Crotty, S.; Bosinger, S. E.; Ward, A. B. From structure to sequence: Antibody discovery using cryoEM. Science advances 2022, 8, eabk2039.

Lee, J. H.; Toy, L.; Kos, J. T.; Safonova, Y.; Schief, W. R.; Havenar-Daughton, C.; Watson, C. T.; Crotty, S. Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells. 2021, 6, 113.

Antanasijevic, A.; Sewall, L. M.; Cottrell, C. A.; Carnathan, D. G.; Jimenez, L. E.; Ngo, J. T.; Silverman, J. B.; Groschel, B.; Georgeson, E.; Bhiman, J.; Bastidas, R.; LaBranche, C.; Allen, J. D.; Copps, J.; Perrett, H. R.; Rantalainen, K.; Cannac, F.; Yang, Y. R.; de la Peña, A. T.; Rocha, R. F.; Berndsen, Z. T.; Baker, D.; King, N. P.; Sanders, R. W.; Moore, J. P.; Crotty, S.; Crispin, M.; Montefiori, D. C.; Burton, D. R.; Schief, W. R.; Silvestri, G.; Ward, A. B. Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM. Nature communications 2021, 12, 4817.

Zhang, W.; Tokatlian, T.; Silvestri, G.; Schiffner, T.; Schief, W. R.; Ruprecht, R. M.; Menis, S.; Melo, M. B.; Martin, J. T.; Kumarapperuma, S. C.; Irvine, D. J.; Hartwell, B. L.; Gong, S.; Goins, B.; Franklin, C. G.; Fox, P. T.; Cossette, B. J.; Carnathan, D. G.; Adams, J. Combined PET and whole-tissue imaging of lymphatic-targeting vaccines in non-human primates.. Biomaterials 2021, 275, 120868.

Woods, H.; Smith, S. T.; Sheehan, J. H.; Sevy, A. M.; Schoeder, C. T.; Schmitz, S.; Schief, W. R.; Sauer, M. F.; Sangha, A. K.; Mueller, B. K.; Moretti, R.; Meiler, J.; Martina, C. E.; Marlow, B.; Kuenze, G.; Kodali, P.; Gulsevin, A.; Finn, J. A.; Crowe, J. E.; Correia, B. E.; Bozhanova, N. G.; Bonet, J.; Bender, B. J.; Alamo, D. D.; Adolf-bryfogle, J. Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design.. Biochemistry 2021, 60, 825-846.

Vijayanand, P.; Seumois, G.; Schief, W. R.; Nakao, C.; Lee, J. H.; Jenkins, M. K.; Hu, J. K.; Groschel, B.; Georgeson, E.; Dileepan, T.; Crotty, S. Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers.. The Journal of experimental medicine 2021, 218.