William Schief, PhD

Department of Immunology and Microbiology
California Campus


Scripps Research Joint Appointments

Faculty, Graduate Program

Other Joint Appointments

The Ragon Institute of MGH, MIT and Harvard (Associate Member)
IAVI Neutralizing Antibody Center, The Scripps Research Institute


Ph.D. (Physics), University of Washington, 1999
B.S. (Applied Mathematics), Yale University, 1989

Professional Experience

2011-2014 Associate Professor of Immunology, Immunology and Microbial Science (IMS), Scripps Research

Selected References

All Publications

Steichen, J. M., Lin, Y. C., Havenar-Daughton, C., Pecetta, S., Ozorowski, G., Willis, J. R., Toy, L., Sok, D., Liguori, A., Kratochvil, S., Torres, J. L., Kalyuzhniy, O., et al. A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. (2019). Science, 366.

Frenz, B., Ramisch, S., Borst, A. J., Walls, A. C., Adolf-Bryfogle, J., Schief, W. R., Veesler, D. & DiMaio, F. Automatically fixing errors in glycoprotein structures with Rosetta. (2019). Structure, 27(1), 134-139.

Boopathy, A. V., Mandal, A., Kulp, D. W., Menis, S., Bennett, N. R., Watkins, H. C., Wang, W., Martin, J. T., Thai, N. T., He, Y., Schief, W. R., Hammond, P. T., et al. Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination. (2019). Proceedings of the National Academy of Sciences of the United States of America, 116(33), 16473-16478. PMCID: PMC6697788.

Melo, M., Porter, E., Zhang, Y., Silva, M., Li, N., Dobosh, B., Liguori, A., Skog, P., Landais, E., Menis, S., Sok, D., Nemazee, D., et al. Immunogenicity of RNA replicons encoding HIV Env immunogens designed for self-assembly into nanoparticles. (2019). Molecular Therapy, 27(12), 2080-2090. PMCID: PMC6904793.

Tokatlian, T., Read, B. J., Jones, C. A., Kulp, D. W., Menis, S., Chang, J. Y. H., Steichen, J. M., Kumari, S., Allen, J. D., Dane, E. L., Liguori, A., Sangesland, M., et al. Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers. (2019). Science, 363(6427), 649-654.

McLeod, B., Miura, K., Scally, S. W., Bosch, A., Nguyen, N., Shin, H. J., Kim, D., Volkmuth, W., Ramisch, S., Chichester, J. A., Streatfield, S., Woods, C., et al. Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25. (2019). Nature Communications, 10. PMCID: PMC6760140.

Umotoy, J., Bagaya, B. S., Joyce, C., Schiffner, T., Menis, S., Saye-Francisco, K. L., Biddle, T., Mohan, S., Vollbrecht, T., Kalyuzhniy, O., Madzorera, S., Kitchin, D., et al. Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan. (2019). Immunity, 51(1), 141-154. PMCID: PMC6642152.

Havenar-Daughton, C., Carnathan, D. G., Boopathy, A. V., Upadhyay, A. A., Murrell, B., Reiss, S. M., Enemuo, C. A., Gebru, E. H., Choe, Y., Dhadvai, P., Viviano, F., Kaushik, K., et al. Rapid germinal center and antibody responses in non-human primates after a single nanoparticle vaccine immunization. (2019). Cell Reports, 29(7), 1756-+.

Cirelli, K. M., Carnathan, D. G., Nogal, B., Martin, J. T., Rodriguez, O. L., Upadhyay, A. A., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Nakao, C., Pauthner, M. G., et al. Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance. (2019). Cell, 177(5), 1153-1171.

Pauthner, M. G., Nkolola, J. P., Havenar-Daughton, C., Murrell, B., Reiss, S. M., Bastidas, R., Prevost, J., Nedellec, R., von Bredow, B., Abbink, P., Cottrell, C. A., Kulp, D. W., et al. Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers. (2019). Immunity, 50(1), 241-252. PMCID: PMC6335502.