William Schief, PhD
Scripps Research Joint Appointments
Other Joint Appointments
The Ragon Institute of MGH, MIT and Harvard (Associate Member)IAVI Neutralizing Antibody Center, The Scripps Research Institute
Education
Ph.D. (Physics), University of Washington, 1999B.S. (Applied Mathematics), Yale University, 1989
Professional Experience
2011-2014 Associate Professor of Immunology, Immunology and Microbial Science (IMS), Scripps ResearchSelected References
Moyer, T. J., Kato, Y., Abraham, W., Chang, J. Y. H., Kulp, D. W., Watson, N., Turner, H. L., Menis, S., Abbott, R. K., Bhiman, J. N., Melo, M. B., Simon, H. A., et al. Engineered immunogen binding to alum adjuvant enhances humoral immunity. (2020). Nature Medicine, 26(3), 430-440. PMCID: PMC7069805.
Rantalainen, K., Berndsen, Z. T., Antanasijevic, A., Schiffner, T., Zhang, X., Lee, W. H., Torres, J. L., Zhang, L., Irimia, A., Copps, J., Zhou, K. H., Kwon, Y. D., et al. HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies. (2020). Cell Reports, 31. PMCID: PMC7196886.
Xu, Z. Y., Wise, M. C., Chokkalingam, N., Walker, S., Tello-Ruiz, E., Elliott, S. T. C., Perales-Puchalt, A., Xiao, P., Zhu, X. Z., Pumroy, R. A., Fisher, P. D., Schultheis, K., et al. In vivo assembly of nanoparticles achieved through synergy of structure-based protein engineering and synthetic DNA generates enhanced adaptive immunity. (2020). Advanced Science,
Steichen, J. M., Lin, Y. C., Havenar-Daughton, C., Pecetta, S., Ozorowski, G., Willis, J. R., Toy, L., Sok, D., Liguori, A., Kratochvil, S., Torres, J. L., Kalyuzhniy, O., et al. A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. (2019). Science, 366.
Frenz, B., Ramisch, S., Borst, A. J., Walls, A. C., Adolf-Bryfogle, J., Schief, W. R., Veesler, D. & DiMaio, F. Automatically fixing errors in glycoprotein structures with Rosetta. (2019). Structure, 27(1), 134-139.
Boopathy, A. V., Mandal, A., Kulp, D. W., Menis, S., Bennett, N. R., Watkins, H. C., Wang, W., Martin, J. T., Thai, N. T., He, Y., Schief, W. R., Hammond, P. T., et al. Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination. (2019). Proceedings of the National Academy of Sciences of the United States of America, 116(33), 16473-16478. PMCID: PMC6697788.
Melo, M., Porter, E., Zhang, Y., Silva, M., Li, N., Dobosh, B., Liguori, A., Skog, P., Landais, E., Menis, S., Sok, D., Nemazee, D., et al. Immunogenicity of RNA replicons encoding HIV Env immunogens designed for self-assembly into nanoparticles. (2019). Molecular Therapy, 27(12), 2080-2090. PMCID: PMC6904793.
Tokatlian, T., Read, B. J., Jones, C. A., Kulp, D. W., Menis, S., Chang, J. Y. H., Steichen, J. M., Kumari, S., Allen, J. D., Dane, E. L., Liguori, A., Sangesland, M., et al. Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers. (2019). Science, 363(6427), 649-654.
McLeod, B., Miura, K., Scally, S. W., Bosch, A., Nguyen, N., Shin, H. J., Kim, D., Volkmuth, W., Ramisch, S., Chichester, J. A., Streatfield, S., Woods, C., et al. Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25. (2019). Nature Communications, 10. PMCID: PMC6760140.
Umotoy, J., Bagaya, B. S., Joyce, C., Schiffner, T., Menis, S., Saye-Francisco, K. L., Biddle, T., Mohan, S., Vollbrecht, T., Kalyuzhniy, O., Madzorera, S., Kitchin, D., et al. Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan. (2019). Immunity, 51(1), 141-154. PMCID: PMC6642152.