William Schief, PhD
Scripps Research Joint Appointments
Other Joint Appointments
The Ragon Institute of MGH, MIT and Harvard (Associate Member)IAVI Neutralizing Antibody Center, The Scripps Research Institute
Education
Ph.D. (Physics), University of Washington, 1999B.S. (Applied Mathematics), Yale University, 1989
Professional Experience
2011-2014 Associate Professor of Immunology, Immunology and Microbial Science (IMS), Scripps ResearchSelected References
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Veneziano, R., Moyer, T. J., Stone, M. B., Wamhoff, E. C., Read, B. J., Mukherjee, S., Shepherd, T. R., Das, J., Schief, W. R., Irvine, D. J. & Bathe, M. Role of nanoscale antigen organization on B-cell activation probed using DNA origami. (2020). Nature Nanotechnology,
Rantalainen, K., Berndsen, Z. T., Antanasijevic, A., Schiffner, T., Zhang, X., Lee, W. H., Torres, J. L., Zhang, L., Irimia, A., Copps, J., Zhou, K. H., Kwon, Y. D., et al. HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies. (2020). Cell Reports, 31. PMCID: PMC7196886.
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Moyer, T. J., Kato, Y., Abraham, W., Chang, J. Y. H., Kulp, D. W., Watson, N., Turner, H. L., Menis, S., Abbott, R. K., Bhiman, J. N., Melo, M. B., Simon, H. A., et al. Engineered immunogen binding to alum adjuvant enhances humoral immunity. (2020). Nature Medicine, 26(3), 430-440. PMCID: PMC7069805.
Huang, D. L., Abbott, R. K., Havenar-Daughton, C., Skog, P. D., Al-Kolla, R., Groschel, B., Blane, T. R., Menis, S., Tran, J. T., Thinnes, T. C., Volpi, S. A., Liguori, A., et al. B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models. (2020). Proceedings of the National Academy of Sciences of the United States of America, 117(37), 22920-22931. PMCID: PMC7502816.
Kato, Y., Abbott, R. K., Freeman, B. L., Haupt, S., Groschel, B., Silva, M., Menis, S., Irvine, D. J., Schief, W. R. & Crotty, S. Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo. (2020). Immunity, 53(3), 548-563. PMCID: PMC7451196.
Steichen, J. M., Lin, Y. C., Havenar-Daughton, C., Pecetta, S., Ozorowski, G., Willis, J. R., Toy, L., Sok, D., Liguori, A., Kratochvil, S., Torres, J. L., Kalyuzhniy, O., et al. A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. (2019). Science, 366.
Melo, M., Porter, E., Zhang, Y., Silva, M., Li, N., Dobosh, B., Liguori, A., Skog, P., Landais, E., Menis, S., Sok, D., Nemazee, D., et al. Immunogenicity of RNA replicons encoding HIV Env immunogens designed for self-assembly into nanoparticles. (2019). Molecular Therapy, 27(12), 2080-2090. PMCID: PMC6904793.