William Schief, PhD

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Scripps Research Joint Appointments

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Other Joint Appointments

The Ragon Institute of MGH, MIT and Harvard (Associate Member)
IAVI Neutralizing Antibody Center, The Scripps Research Institute

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Education

Ph.D. (Physics), 1999
B.S. (Applied Mathematics), Yale University, 1989

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Professional Experience

2011-2014 Associate Professor of Immunology, Immunology and Microbial Science (IMS), Scripps Research

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Selected References

All Publications

Crooks, E. T., Grimley, S. L., Cully, M., Osawa, K., Dekkers, G., Saunders, K., Ramisch, S., Menis, S., Schief, W. R., Doria-Rose, N., Haynes, B., Murrell, B., et al. Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation. (2018). PLoS Pathogens, 14. PMCID: PMC5951585.

Abbott, R. K., Lee, J. H., Menis, S., Skog, P., Rossi, M., Ota, T., Kulp, D. W., Bhullar, D., Kalyuzhniy, O., Havenar-Daughton, C., Schief, W. R., Nemazee, D., et al. Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens. (2018). Immunity, 48(1), 133-+. PMCID:

PMC5773359

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Adolf-Bryfogle, J., Kalyuzhniy, O., Kubitz, M., Weitzner, B. D., Hu, X., Adachi, Y., Schief, W. R. & Dunbrack, R. L. RosettaAntibodyDesign (RAbD): A general framework for computational antibody design. (2018). PLoS Computational Biology, 14. PMCID: PMC5942852.

Crooks, E. T., Osawa, K., Tong, T., Grimley, S. L., Dai, Y. D., Whalen, R. G., Kulp, D. W., Menis, S., Schief, W. R. & Binley, J. M. Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction. (2017). Virology, 505, 193.

Pauthner, M., Havenar-Daughton, C., Sok, D., Nkolola, J. P., Bastidas, R., Boopathy, A. V., Carnathan, D. G., Chandrashekar, A., Cirelli, K. M., Cottrell, C. A., Eroshkin, A. M., Guenaga, J., et al. Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches. (2017). Immunity, 46(6), 1073-1088. PMCID: PMC5483234.

Virnik, K., Nesti, E., Dail, C., Hockenbury, M., Ni, Y. S., Felber, B. K., Schief, W. R. & Berkower, I. Expression of complete SIV p27 Gag and HIV gp120 engineered outer domains targeted by broadly neutralizing antibodies in live rubella vectors. (2017). Vaccine, 35(24), 3272-3278.

Cao, L., Diedrich, J. K., Kulp, D. W., Pauthner, M., He, L., Park, S. K. R., Sok, D., Su, C. Y., Delahunty, C. M., Menis, S., Andrabi, R., Guenaga, J., et al. Global site-specific N-glycosylation analysis of HIV envelope glycoprotein. (2017). Nature Communications, 8.

Irimia, A., Serra, A. M., Sarkar, A., Jacak, R., Kalyuzhniy, O., Sok, D., Saye-Francisco, K. L., Schiffner, T., Tingle, R., Kubitz, M., Adachi, Y., Stanfield, R. L., et al. Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design. (2017). PLoS Pathogens, 13. PMCID: PMC5338832.

Scally, S. W., McLeod, B., Bosch, A., Miura, K., Liang, Q., Carroll, S., Reponen, S., Nguyen, N., Giladi, E., Ramisch, S., Yusibov, V., Bradley, A., et al. Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25. (2017). Nature Communications, 8. PMCID: PMC5691035.

Labonte, J. W., Adolf-Bryfogle, J., Schief, W. R. & Gray, J. J. Residue-centric modeling and design of saccharide and glycoconjugate structures. (2017). Journal of Computational Chemistry, 38(5), 276-287. PMCID: PMC5182120.