William Schief, PhD

Professor
Department of Immunology and Microbiology
California Campus


 Email

Scripps Research Joint Appointments

Faculty, Graduate Program

Other Joint Appointments

The Ragon Institute of MGH, MIT and Harvard (Associate Member)
IAVI Neutralizing Antibody Center, The Scripps Research Institute

Education

Ph.D. (Physics), University of Washington, 1999
B.S. (Applied Mathematics), Yale University, 1989

Professional Experience

2011-2014 Associate Professor of Immunology, Immunology and Microbial Science (IMS), Scripps Research

Selected References

All Publications

Martin, J. T., Cottrell, C. A., Antanasijevic, A., Carnathan, D. G., Cossette, B. J., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Fischinger, S., Tokatlian, T., Cirelli, K. M., et al. Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations. (2020). NPJ Vaccines, 5. PMCID: PMC7406516.

Veneziano, R., Moyer, T. J., Stone, M. B., Wamhoff, E. C., Read, B. J., Mukherjee, S., Shepherd, T. R., Das, J., Schief, W. R., Irvine, D. J. & Bathe, M. Role of nanoscale antigen organization on B-cell activation probed using DNA origami. (2020). Nature Nanotechnology,

Rantalainen, K., Berndsen, Z. T., Antanasijevic, A., Schiffner, T., Zhang, X., Lee, W. H., Torres, J. L., Zhang, L., Irimia, A., Copps, J., Zhou, K. H., Kwon, Y. D., et al. HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies. (2020). Cell Reports, 31. PMCID: PMC7196886.

Xu, Z. Y., Wise, M. C., Chokkalingam, N., Walker, S., Tello-Ruiz, E., Elliott, S. T. C., Perales-Puchalt, A., Xiao, P., Zhu, X. Z., Pumroy, R. A., Fisher, P. D., Schultheis, K., et al. In vivo assembly of nanoparticles achieved through synergy of structure-based protein engineering and synthetic DNA generates enhanced adaptive immunity. (2020). Advanced Science,

Moyer, T. J., Kato, Y., Abraham, W., Chang, J. Y. H., Kulp, D. W., Watson, N., Turner, H. L., Menis, S., Abbott, R. K., Bhiman, J. N., Melo, M. B., Simon, H. A., et al. Engineered immunogen binding to alum adjuvant enhances humoral immunity. (2020). Nature Medicine, 26(3), 430-440. PMCID: PMC7069805.

Kato, Y., Abbott, R. K., Freeman, B. L., Haupt, S., Groschel, B., Silva, M., Menis, S., Irvine, D. J., Schief, W. R. & Crotty, S. Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo. (2020). Immunity, 53(3), 548-563. PMCID: PMC7451196.

Steichen, J. M., Lin, Y. C., Havenar-Daughton, C., Pecetta, S., Ozorowski, G., Willis, J. R., Toy, L., Sok, D., Liguori, A., Kratochvil, S., Torres, J. L., Kalyuzhniy, O., et al. A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. (2019). Science, 366.

Melo, M., Porter, E., Zhang, Y., Silva, M., Li, N., Dobosh, B., Liguori, A., Skog, P., Landais, E., Menis, S., Sok, D., Nemazee, D., et al. Immunogenicity of RNA replicons encoding HIV Env immunogens designed for self-assembly into nanoparticles. (2019). Molecular Therapy, 27(12), 2080-2090. PMCID: PMC6904793.

Havenar-Daughton, C., Carnathan, D. G., Boopathy, A. V., Upadhyay, A. A., Murrell, B., Reiss, S. M., Enemuo, C. A., Gebru, E. H., Choe, Y., Dhadvai, P., Viviano, F., Kaushik, K., et al. Rapid germinal center and antibody responses in non-human primates after a single nanoparticle vaccine immunization. (2019). Cell Reports, 29(7), 1756-+.

McLeod, B., Miura, K., Scally, S. W., Bosch, A., Nguyen, N., Shin, H. J., Kim, D., Volkmuth, W., Ramisch, S., Chichester, J. A., Streatfield, S., Woods, C., et al. Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25. (2019). Nature Communications, 10. PMCID: PMC6760140.