William Schief, PhD
Scripps Research Joint Appointments
Other Joint Appointments
The Ragon Institute of MGH, MIT and Harvard (Associate Member)IAVI Neutralizing Antibody Center, The Scripps Research Institute
Education
Ph.D. (Physics), 1999B.S. (Applied Mathematics), Yale University, 1989
Professional Experience
2011-2014 Associate Professor of Immunology, Immunology and Microbial Science (IMS), Scripps ResearchSelected References
Cao, L. W., Pauthner, M., Andrabi, R., Rantalainen, K., Berndsen, Z., Diedrich, J. K., Menis, S., Sok, D., Bastidas, R., Park, S. K. R., Delahunty, C. M., He, L., et al. Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer. (2018). Nature Communications, 9. PMCID: PMC6135743.
Tokatlian, T., Kulp, D. W., Mutafyan, A. A., Jones, C. A., Menis, B., Georgeson, E., Kubitz, M., Zhang, M. H., Melo, M. B., Silva, M., Yun, D. S., Schief, W. R., et al. Enhancing humoral responses against HIV Envelope trimers via nanoparticle delivery with stabilized synthetic liposomes. (2018). Scientific Reports, 8. PMCID: PMC6224390.
Duan, H., Chen, X., Boyington, J. C., Cheng, C., Zhang, Y., Jafari, A. J., Stephens, T., Tsybovsky, Y., Kalyuzhniy, O., Zhao, P., Menis, S., Nason, M. C., et al. Glycan masking focuses immune responses to the HIV-1 CD4-binding site and enhances elicitation of VRC01-class precursor antibodies. (2018). Immunity, 49(2), 301-311.
Crooks, E. T., Grimley, S. L., Cully, M., Osawa, K., Dekkers, G., Saunders, K., Ramisch, S., Menis, S., Schief, W. R., Doria-Rose, N., Haynes, B., Murrell, B., et al. Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation. (2018). PLoS Pathogens, 14. PMCID: PMC5951585.
Lin, Y. C., Pecetta, S., Steichen, J. M., Kratochvil, S., Melzi, E., Arnold, J., Dougan, S. K., Wu, L., Kirsch, K. H., Nair, U., Schief, W. R., Batista, F. D. One-step CRISPR/Cas9 method for the rapid generation of human antibody heavy chain knock-in mice. (2018). EMBO Journal, 37. PMCID: PMC6138433.
Abbott, R. K., Lee, J. H., Menis, S., Skog, P., Rossi, M., Ota, T., Kulp, D. W., Bhullar, D., Kalyuzhniy, O., Havenar-Daughton, C., Schief, W. R., Nemazee, D., et al. Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens. (2018). Immunity, 48(1), 133-146. PMCID: PMC5773359.
Adolf-Bryfogle, J., Kalyuzhniy, O., Kubitz, M., Weitzner, B. D., Hu, X., Adachi, Y., Schief, W. R. & Dunbrack, R. L. RosettaAntibodyDesign (RAbD): A general framework for computational antibody design. (2018). PLoS Computational Biology, 14. PMCID: PMC5942852.
Havenar-Daughton, C., Sarkar, A., Kulp, D. W., Toy, L., Hu, X., Deresa, I., Kalyuzhniy, O., Kaushik, K., Upadhyay, A. A., Menis, S., Landais, E., Cao, L., et al. The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen. (2018). Science Translational Medicine, 10.
Havenar-Daughton, C., Abbott, R. K., Schief, W. R. & Crotty, S. When designing vaccines, consider the starting material: the human B cell repertoire. (2018). Current Opinion in Immunology, 53, 209. PMCID: PMC6148213.
Crooks, E. T., Osawa, K., Tong, T., Grimley, S. L., Dai, Y. D., Whalen, R. G., Kulp, D. W., Menis, S., Schief, W. R. & Binley, J. M. Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction. (2017). Virology, 505, 193.
