William Schief, PhD

Department of Immunology and Microbiology


Scripps Research Joint Appointments

Faculty, Graduate Program

Other Joint Appointments

The Ragon Institute of MGH, MIT and Harvard (Associate Member)
IAVI Neutralizing Antibody Center, The Scripps Research Institute


Ph.D. (Physics), University of Washington, 1999
B.S. (Applied Mathematics), Yale University, 1989

Professional Experience

2011-2014 Associate Professor of Immunology, Immunology and Microbial Science (IMS), Scripps Research

Selected References

All Publications

Antanasijevic, A., Bowman, C. A., Kirchdoerfer, R. N., Cottrell, C. A., Ozorowski, G., Upadhyay, A. A., Cirelli, K. M., Carnathan, D. G., Enemuo, C. A., Sewall, L. M., Nogal, B., Zhao, F., et al. From structure to sequence: Antibody discovery using cryoEM. (2022). Science Advances, 8. PMCID: PMC8769551.

Lee, J. H., Toy, L., Kos, J. T., Safonova, Y., Schief, W. R., Havenar-Daughton, C., Watson, C. T. & Crotty, S. Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naive human B cells. (2021). NPJ Vaccines, 6. PMCID: PMC8421370.

Antanasijevic, A., Sewall, L. M., Cottrell, C. A., Carnathan, D. G., Jimenez, L. E., Ngo, J. T., Silverman, J. B., Groschel, B., Georgeson, E., Bhiman, J., Bastidas, R., LaBranche, C., et al. Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM. (2021). Nature Communications, 12. PMCID: PMC8355326.

Martin, J. T., Hartwell, B. L., Kumarapperuma, S. C., Melo, M. B., Carnathan, D. G., Cossette, B. J., Adams, J., Gong, S. Q., Zhang, W., Tokatlian, T., Menis, S., Schiffner, T., et al. Combined PET and whole-tissue imaging of lymphatic-targeting vaccines in non-human primates. (2021). Biomaterials, 275. PMCID: PMC8325633.

Schoeder, C. T., Schmitz, S., Adolf-Bryfogle, J., Sevy, A. M., Finn, J. A., Sauer, M. F., Bozhanova, N. G., Mueller, B. K., Sangha, A. K., Bonet, J., Sheehan, J. H., Kuenze, G., et al. Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design. (2021). Biochemistry, 60(11), 825-846. PMCID: PMC7992133.

Lee, J. H., Hu, J. K., Georgeson, E., Nakao, C., Groschel, B., Dileepan, T., Jenkins, M. K., Seumois, G., Vijayanand, P., Schief, W. R. & Crotty, S. Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers. (2021). Journal of Experimental Medicine, 218. PMCID: PMC7769167.

Silva, M., Kato, Y., Melo, M. B., Phung, I., Freeman, B. L., Li, Z. M., Roh, K., Van Wijnbergen, J. W., Watkins, H., Enemuo, C. A., Hartwell, B. L., Chang, J. Y. H., et al. A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity. (2021). Science Immunology, 6. PMCID: PMC8763571.

Baboo, S., Diedrich, J. K., Martinez-Bartolome, S., Wang, X. N., Schiffner, T., Groschel, B., Schief, W. R., Paulson, J. C. & Yates III, J. R. DeGlyPHER: An Ultrasensitive Method for the Analysis of Viral Spike N-Glycoforms. (2021). Analytical Chemistry, 93(40), 13651-13657.

Leman, J. K., Lyskov, S., Lewis, S. M., Adolf-Bryfogle, J., Alford, R. F., Barlow, K., Ben-Aharon, Z., Farrell, D., Fell, J., Hansen, W. A., Harmalkar, A., Jeliazkov, J., et al. Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks. (2021). Nature Communications, 12. PMCID: PMC8630030.

Wang, X. S., Ray, R., Kratochvil, S., Melzi, E., Lin, Y. C., Giguere, S., Xu, L. L., Warner, J., Cheon, D., Liguori, A., Groschel, B., Phelps, N., et al. Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors. (2020). EMBO Journal, 40. PMCID: PMC7809789.