Source: Interfolio F180
Hugh Rosen
Scripps Research Joint Appointments
Education
MB.ChB. (Cape Town), D.Phil. (Oxford)Selected Publications
Guerrero, M.; Urbano, M.; Kim, E. K.; Gamo, A. M.; Riley, S.; Abgaryan, L.; Leaf, N.; Van Orden, L. J.; Brown, S. J.; Xie, J. Y.; Porreca, F.; Cameron, M. D.; Rosen, H.; Roberts, E. Design and synthesis of a novel and selective kappa opioid receptor (KOR) antagonist (BTRX-335140). Journal of Medicinal Chemistry 2019, 62, 1761-1780.
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Teijaro, J. R.; Studer, S.; Leaf, N.; Kiosses, W. B.; Nguyen, N.; Matsuki, K.; Negishi, H.; Taniguchi, T.; Oldstone, M. B.; Rosen, H. S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-alpha autoamplification. Proceedings of the National Academy of Sciences of the United States of America 2016, 113, 1351-1356.
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Rosen, H.; Rosen, H.; Stevens, R. C.; Roberts, E.; Roberts, E.; Oldstone, M. B.; Oldstone, M. B.; Hanson, M. A. Sphingosine-1-phosphate and its receptors: structure, signaling, and influence. Annual review of biochemistry 2013, 82, 637-62.
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Hanson, M. A.; Roth, C. B.; Jo, E. J.; Griffith, M. T.; Scott, F. L.; Reinhart, G.; Desale, H.; Clemons, B.; Cahalan, S. M.; Schuerer, S. C.; Sanna, M. G.; Han, G. W.; Kuhn, P. A.; Rosen, H.; Stevens, R. C. Crystal structure of a lipid G protein-coupled receptor. Science 2012, 335, 851-855.
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Cahalan, S. M.; Gonzalez-Cabrera, P. J.; Sarkisyan, G.; Nguyen, N.; Schaeffer, M. T.; Huang, L. M.; Yeager, A.; Clemons, B.; Scott, F.; Rosen, H. Actions of a picomolar short-acting S1P(1) agonist in S1P(1)-eGFP knock-in mice. Nature Chemical Biology 2011, 7, 254-256.
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Mandala, S.; Hajdu, R.; Bergstrom, J.; Quackenbush, E.; Xie, J.; Milligan, J.; Thornton, R.; Shei, G. J.; Card, D.; Keohane, C.; Rosenbach, M.; Hale, J.; Lynch, C. L.; Rupprecht, K.; Parsons, W.; Rosen, H. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. 2002, 296, 346-9.