Source: Interfolio F180

Hugh Rosen

Department of Molecular and Cellular Biology


Scripps Research Joint Appointments

Molecular Medicine
Skaggs Graduate School of Chemical and Biological Sciences


MB.ChB. (Cape Town), D.Phil. (Oxford)

Selected Publications

Guerrero, M.; Urbano, M.; Kim, E. K.; Gamo, A. M.; Riley, S.; Abgaryan, L.; Leaf, N.; Van Orden, L. J.; Brown, S. J.; Xie, J. Y.; Porreca, F.; Cameron, M. D.; Rosen, H.; Roberts, E. Design and synthesis of a novel and selective kappa opioid receptor (KOR) antagonist (BTRX-335140). Journal of Medicinal Chemistry 2019, 62, 1761-1780.

Teijaro, J. R.; Studer, S.; Leaf, N.; Kiosses, W. B.; Nguyen, N.; Matsuki, K.; Negishi, H.; Taniguchi, T.; Oldstone, M. B.; Rosen, H. S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-alpha autoamplification. Proceedings of the National Academy of Sciences of the United States of America 2016, 113, 1351-1356.

Rosen, H.; Rosen, H.; Stevens, R. C.; Roberts, E.; Roberts, E.; Oldstone, M. B.; Oldstone, M. B.; Hanson, M. A. Sphingosine-1-phosphate and its receptors: structure, signaling, and influence. Annual review of biochemistry 2013, 82, 637-62.

Hanson, M. A.; Roth, C. B.; Jo, E. J.; Griffith, M. T.; Scott, F. L.; Reinhart, G.; Desale, H.; Clemons, B.; Cahalan, S. M.; Schuerer, S. C.; Sanna, M. G.; Han, G. W.; Kuhn, P. A.; Rosen, H.; Stevens, R. C. Crystal structure of a lipid G protein-coupled receptor. Science 2012, 335, 851-855.

Cahalan, S. M.; Gonzalez-Cabrera, P. J.; Sarkisyan, G.; Nguyen, N.; Schaeffer, M. T.; Huang, L. M.; Yeager, A.; Clemons, B.; Scott, F.; Rosen, H. Actions of a picomolar short-acting S1P(1) agonist in S1P(1)-eGFP knock-in mice. Nature Chemical Biology 2011, 7, 254-256.

Mandala, S.; Hajdu, R.; Bergstrom, J.; Quackenbush, E.; Xie, J.; Milligan, J.; Thornton, R.; Shei, G. J.; Card, D.; Keohane, C.; Rosenbach, M.; Hale, J.; Lynch, C. L.; Rupprecht, K.; Parsons, W.; Rosen, H. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. 2002, 296, 346-9.