Christopher Parker, PhD
Professor
Department of Chemistry
The Abide-Vividion Chair in Chemistry and Chemical Biology
Research Focus
Broadly speaking, the Parker Lab seeks to develop chemistry-enabled strategies to investigate human biology and disease pathology. Our research integrates organic synthesis with chemical proteomics and cell/molecular biology to (1) to study how small molecules might regulate, or be designed to regulate, complex biological processes such as immune responses and, (2) illuminate molecular mechanisms that contribute to disease. Our primary objectives are not only to better understand protein function and corresponding disease roles, but also to create chemical tools and technologies that might facilitate the development of new therapeutics. Check out our lab website for additional information on our research.
Select Publications
-
Li, Weichao; Wei, Qijia; Llanos, Manuel; Gathmann, Clara; Governa, Paolo; Chiu, Tzu-Yua Y.; Wozniak, Jacob M.; Jadhav, Appaso M.; Holcomb, Matthew; Cravatt, Jacob; Dongre, Ashok; Huang, Mia L.; Forli, Stefano; Parker, Christopher G. Posttranslational modifications remodel proteome-wide ligandability. 2026.
-
Forrest, Ines; Conway, Louis P.; Gathmann, Clara; Jadhav, Appaso M.; Chiu, Tzu-Yua Y.; Chaheine, Christian M.; Estrada, Michelle; Shrestha, Anurupa; Sarris, Kathy; Reitsma, Justin M.; Warder, Scott E.; Vasudevan, Anil; McLoughlin, Shaun M.; Parker, Christopher G. Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules. 2025, 11, 2240-2256.
-
Wozniak, J. M.; Li, W.; Governa, P.; Chen, L-Y.; Jadhav, A. M.; Dongre, A.; Forli, S.; Parker, C. G. Enhanced Mapping of Small-Molecule Binding Sites in Cells. Nature Chemical Biology 2024, 20, 823-834.
View -
Chemoproteomic Development of SLC15A4 Inhibitors with Anti-Inflammatory Activity. Nature Chemical Biology 2024, 20, 1000-1011.
View -
Tang, J.; Li, W.; Chiu, T-Y.; Martínez‐Peña, F.; Luo, Z.; Chong, C. K.; Wei, Q.; Gazaniga, N.; West, T. J.; See, Y. Y.; Lairson, L. L.; Parker, C. G.; Baran, P. S. Synthesis of Portimines Reveals the Basis of their Anti-cancer Activity. Nature 2023, 622, 507.
View -
Parker, Christopher G.; Wang, Wesley W.; Chen, Li-Yun; Wozniak, Jacob M.; Jadhav, Appaso M.; Anderson, Hayden; Malone, Taylor E. Targeted Protein Acetylation in Cells Using Heterobifunctional Molecules. Journal of the American Chemical Society 2021, 143, 16700-16708.
View
