Donghyun Raphael Park, PhD
Assistant Professor
Department of Integrative Structural and Computational Biology
Research Focus
To achieve infection and survival, various pathogens use complex multiprotein nanomachines to inject bacterial substrates into target cells and the extracellular environment. These nanomachines play critical roles in host-pathogen interactions by modulating eukaryotic host cell functions. The Park lab laboratory aims to utilize cutting-edge cryo-electron tomography (cryo-ET) technologies to define how bacterial nanomachines assemble to orchestrate substrate secretion and, thus, pathogenicity in the native environment.
Select Publications
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Freeman, Krista G.; Mondal, Sudipta; Macale, Lourriel S.; Podgorski, Jennifer; White, Simon J.; Silva, Benjamin H.; Ortiz, Valery; Huet, Alexis; Perez, Ronelito J.; Narsico, Joemark T.; Ho, Meng-Chia C.; Jacobs-Sera, Deborah; Lowary, Todd L.; Conway, James F.; Park, Donghyun; Hatfull, Graham F. Structure and infection dynamics of mycobacteriophage Bxb1. 2025, 188, 2925-2942.e17.
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Scholl, Daniel; Boyd, Tumara; Latham, Andrew P.; Salazar, Alexandra; Khan, Asma M A M; Boeynaems, Steven; Holehouse, Alex S.; Lander, Gabriel C.; Sali, Andrej; Park, Donghyun; Deniz, Ashok A.; Lasker, Keren The filamentous ultrastructure of the PopZ condensate is required for its cellular function. 2026, 33, 420-432.
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Lian, Huan; Park, Donghyun; Chen, Meixin; Schueder, Florian; Lara-Tejero, Maria; Liu, Jun; Galán, Jorge E. Parkinson's disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella. 2023, 8, 1880-1895.
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Park, Donghyun; Lara-Tejero, Maria; Waxham, M N.; Li, Wenwei; Hu, Bo; Galán, Jorg E.; Liu, Jun Visualization of the type III secretion mediated -host cell interface using cryo-electron tomography. 2018, 7.
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Park, Donghyun; Chetrit, David; Hu, Bo; Roy, C R.; Liu, Jun Analysis of Dot/Icm Type IVB Secretion System Subassemblies by Cryoelectron Tomography Reveals Conformational Changes Induced by DotB Binding. 2020, 11.
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Dev, Jyoti; Park, Donghyun; Fu, Qingshan; Chen, Jia; Ha, Heather J.; Ghantous, Fadi; Herrmann, Tobias; Chang, Weiting; Liu, Zhijun; Frey, Gary; Seaman, Michael S.; Chen, Bing; Chou, James J J. Structural basis for membrane anchoring of HIV-1 envelope spike. 2016, 353, 172-175.
