Laurent Mosnier, PhD

Associate Professor
Department of Molecular Medicine
California Campus



Ph.D. (Thrombosis and Hemostasis), Utrecht University, 2001
B.B.A. (Economics), Erasmus University, 1999
M.S. (Medical Biology), Utrecht University, 1997
B.S. (Medical Biology), Utrecht University, 1992

Professional Experience

2005-2017 Assistant Professor, Molecular and Experimental Medicine (MEM), Scripps Research

Selected References

All Publications

von Drygalski, A., Bhat, V., Gale, A. J., Averell, P. M., Cramer, T. J., Elias, D. J., Griffin, J. H. & Mosnier, L. O. An engineered factor Va prevents bleeding induced by direct-acting oral anticoagulants by different mechanisms. (2020). Blood Advances, 4(15), 3716-3727. PMCID: PMC7422119.

Mosnier, L. O. How much clotting is enough?. (2020). Blood, 136(6), 651-652. PMCID: PMC7414588.

Heeb, M. J., Fernandez, J. A., Yamashita, A., McDowell, O. R., Guo, Z. H., Mosnier, L. O., Deguchi, H. & Griffin, J. H. Activated protein C anticoagulant activity is enhanced by skeletal muscle myosin. (2020). Haematologica, 105(8), E424-E427. PMCID: PMC7395292.

Zhao, X. Y., Wilmen, A., Wang, D. L., Wang, X. Q., Bauzon, M., Kim, J. Y., Linden, L., Li, L., Egner, U., Marquardt, T., Moosmayer, D., Tebbe, J., et al. Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia. (2020). Nature Communications, 11. PMCID: PMC7293249.

Yamashita, A., Zhang, Y. Q., Sanner, M. F., Griffin, J. H. & Mosnier, L. O. C-terminal residues of activated protein C light chain contribute to its anticoagulant and cytoprotective activities. (2020). Journal of Thrombosis and Haemostasis, 18(5), 1027-1038.

Zilberman-Rudenko, J., Deguchi, H., Shukla, M., Oyama, Y., Orje, J. N., Guo, Z. H., Wyseure, T., Mosnier, L. O., McCarty, O. J. T., Ruggeri, Z. M., Eckle, T., Griffin, J. H. Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo. (2020). Arteriosclerosis Thrombosis and Vascular Biology, 40(4), 901-913. PMCID: PMC7135739.

Basu, S., Liang, H. P. H., Hernandez, I., Zogg, M., Fields, B., May, J., Ogoti, Y., Wyseure, T., Mosnier, L. O., Burns, R. T., Carlson, K., Weiler, H. Role of thrombomodulin expression on hematopoietic stem cells. (2020). Journal of Thrombosis and Haemostasis,

Cooke, E. J., Wyseure, T., Zhou, J. Y., Gopal, S., Nasamran, C. A., Fisch, K. M., Manon-Jensen, T., Karsdal, M. A., Mosnier, L. O. & von Drygalski, A. Mechanisms of vascular permeability and remodeling associated with hemarthrosis in factor VIII-deficient mice. (2019). Journal of Thrombosis and Haemostasis,

Wyseure, T., Yang, T., Zhou, J. Y., Cooke, E. J., Wanko, B., Olmer, M., Agashe, R., Morodomi, Y., Behrendt, N., Lotz, M., Morser, J., von Drygalski, A., et al. TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding. (2019). JCI Insight, 4.

Mosnier, L. O. Activated protein C in neuroprotection and malaria. (2019). Current Opinion in Hematology, 26(5), 320-330.