Anton Maximov, PhD

Associate Professor
Department of Neuroscience
California Campus


 Email

Scripps Research Joint Appointments

Associate Professor, Dorris Neuroscience Center
Faculty, Graduate Program

Other Joint Appointments

Adjunct Professor, UCSD

Research Focus

Our unique memories make us who we are. Representations of the external world are stored in the brain by billions of neurons with diverse morphologies, molecular compositions and physiological roles. Each of these neurons forms up to several thousand synaptic contacts that transmit signals with remarkable speed and precision.

The Maximov laboratory seeks to uncover the mechanisms that regulate neuronal connectivity at molecular, cellular and circuit levels. We primarily focus on the hippocampus, a laminated structure within the limbic system of the brain that is critical for memory, emotions and navigation. We study the architecture and function of hippocampal circuits by using a variety of genetic, biophysical and behavioral techniques. We are particularly interested in understanding how synaptic networks of specific excitatory and inhibitory neuron subtypes are reorganized during learning, and how these experience-dependent events contribute to memory coding.

We heavily rely on optical imaging, serial electron microscopy and computational tools to define the role of experience in wiring of the hippocampal pathway at scales ranging from global to subcellular. In parallel, we elucidate the molecular bases of network plasticity and information storage by combining human genetics data, unbiased screens, and analysis of candidate genes in mouse models. As a part of this research program, we also design new tools to manipulate genetically-defined and behaviorally-relevant neural ensembles with small molecules.


Education

Ph.D., Biology, Russian Academy of Sciences, 1998
M.S., Biophysics/Biochemistry, St.-Petersburg State University, Russia, 1996

Professional Experience

1994 – 1998  Research Intern, Graduate Student. Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
1998 – 2002  Postdoctoral training. Department of Physiology, UT Southwestern Medical Center, Dallas, TX.
2002 – 2007  Postdoctoral training. Center for Basic Neuroscience, UT Southwestern Medical Center, Dallas, TX.
2008 – 2014  Assistant Professor. Department of Cell Biology, Department of Molecular and Cellular Neuroscience, The Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA.
2014 - present. Associate Professor (Tenured) Department of Neuroscience, The Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA.

Selected References

Zhu, Y., Huang, M., Bushong, E., Phan, S., Uytiepo, M., Beutter, E., Boemer, D., Tsui, K., Ellisman, M., and Maximov, A. (2019). Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription. Nature Communications 10, 3469.

Shimojo M, Madara J, Pankow S, Liu X, Yates J 3rd, Südhof TC, Maximov A (2019) Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity. Genes & Development 33(5-6):365-376.

Lobanova A, She R, Pieraut S, Clapp C, Maximov A*, Denchi EL* (2017) Different requirements of functional telomeres in neural stem cells and terminally differentiated neurons. Genes & Development 31(7): 639-647 (* Corresponding authors).

Sando R, Bushong E, Zhu Y, Huang M, Considine C, Phan S, Ju S, Uytiepo M, Ellisman M, Maximov A (2017) Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission. Neuron 94(2):312-321.

Kwon S-K, Sando R, Lewis TL, Hirabayashi Y, Maximov A, Polleux F (2016) LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons. PLoS Biology 14(7):e1002516. doi:10.1371/journal.pbio.1002516.

Shimojo M, Courchet J, Pieraut S, Torabi-Rander N, Sando R, Polleux F, Maximov A (2015) SNAREs controlling vesicular release of BDNF and development of callosal axons. Cell Reports 11(7):1054-66.

Pieraut S, Gounko N, Sando R 3rd, Dang W, Rebboah E, Panda S, Madisen L, Zeng H, Maximov A (2014) Experience-dependent remodeling of basket cell networks in the dentate gyrus. Neuron 84(1):107-22.

Sando R, Baumgaertel K, Pieraut S, Wandless T, Mayford M, Maximov A (2013) Inducible control of gene expression with destabilized Cre. Nature Methods 10(11):1085-8.

Courchet J, Mairet-Coello G, Pieraut S, Maximov A, Polleux F (2013) The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Amyloid-beta oligomers through Tau phosphorylation on S262. Neuron 78(1):94-108.

Sando R, Pieraut S, Gounko N, Liao L, Yates J, Maximov A (2012) HDAC4 governs a transcriptional program essential for synaptic plasticity and memory. Cell 151(4):821-834.

Cao P, Maximov A, Südhof TC (2011) Activity-dependent IGF-1 exocytosis is controlled by the Ca2+-sensor Synaptotagmin-10. Cell 145(2):300-311.

Maximov A, Tang J, Yang X, Pang Z, Südhof TC (2009) Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science 323(5913):516-521.

Tang J #, Maximov A #, Shin OH, Dai H, Rizo J, Südhof TC (2006) A complexin/synaptotagmin-1 switch controls fast synaptic vesicle exocytosis. Cell 126(6):1175-87 (# These authors contributed equally to this work).

Maximov A, Südhof TC (2005) Autonomous function of synaptotagmin-1 in triggering synchronous release independent of asynchronous release. Neuron 48(4):547-554.