Mansun Law, PhD

Associate Professor
Department of Immunology and Microbiology
California Campus


 Email

Scripps Research Joint Appointments

Faculty, Graduate Program

Education

D.Phil. (Virology), University of Oxford, Sir William Dunn School of Pathology, 2001
M.Phil. (Molecular Biology), The University of Hong Kong, Department of Zoology, 1997
B.Sc., The University of Hong Kong, Faculty of Science, 1995

Professional Experience

2014-2017 Associate Professor, Immunology and Microbial Science (IMS), Scripps Research
2008-2014 Assistant Professor, Immunology and Microbial Science (IMS), Scripps Research
2004-2008 Research Associate and Senior Research Associate with Dr. Dennis R. Burton, Immunology and Microbial Science (IMS), Scripps Research
2001-2004 Postdoctoral Fellow with Dr. Geoffrey L. Smith, Imperial College London

Selected References

All Publications

Chen, F., Lairson, L. L. & Law, M. Into the Unknown: A Chemical Biology Approach Provides Mechanistic Insight into HCV Entry. (2020). Cell Chemical Biology, 27(7), 767-769.

Tzarum, N., Giang, E., Kadam, R. U., Chen, F., Nagy, K., Augestad, E. H., Velazquez-Moctezuma, R., Keck, Z. Y., Hua, Y. Z., Stanfield, R. L., Dreux, M., Prentoe, J., et al. An alternate conformation of HCV E2 neutralizing face as an additional vaccine target. (2020). Science Advances, 6. PMCID: PMC7380959.

He, L. L., Tzarum, N., Lin, X. H., Shapero, B., Sou, C., Mann, C. J., Stano, A., Zhang, L., Nagy, K., Giang, E., Law, M., Wilson, I. A., et al. Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. (2020). Science Advances, 6. PMCID: PMC7159917.

Chen, F., Nagy, K., Chavez, D., Willis, S., McBride, R., Giang, E., Honda, A., Bukh, J., Ordoukhanian, P., Zhu, J., Frey, S., Lanford, R., et al. Antibody responses to immunization with HCV envelope glycoproteins as a baseline for B-cell-based vaccine development. (2020). Gastroenterology, 158(4), 1058-1071.

Moreno, A. M., Palmer, N., Aleman, F., Chen, G., Pla, A., Jiang, N., Chew, W. L., Law, M. & Mali, P. Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy. (2019). Nature Biomedical Engineering, 3(10), 806-816. PMCID: PMC6783354.

Prentoe, J., Velazquez-Moctezuma, R., Augestad, E. H., Galli, A., Wang, R., Law, M., Alter, H. & Bukh, J. Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations. (2019). Proceedings of the National Academy of Sciences of the United States of America, 116(20), 10039-10047.

Velazquez-Moctezuma, R., Galli, A., Law, M., Bukh, J. & Prentoe, J. Hepatitis C virus escape studies of human antibody AR3A reveal a high barrier to resistance and novel insights on viral antibody evasion mechanisms. (2019). Journal of Virology, 93. PMCID: PMC6364003.

Chen, F., Tzarum, N., Wilson, I. A. & Law, M. V(H)1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design. (2019). Current Opinion in Virology, 34, 149.

Tzarum, N., Giang, E., Kong, L., He, L., Prentoe, J., Augestad, E., Hua, Y., Castillo, S., Lauer, G. M., Bukh, J., Zhu, J., Wilson, I. A., et al. Genetic and structural insights into broad neutralization of hepatitis C virus by human V(H)1-69 antibodies. (2019). Science Advances, 5. PMCID: PMC6314831.

Velazquez-Moctezuma, R., Galli, A., Law, M., Bukh, J. & Prentoe, J. Hepatitis C virus-escape studies for human monoclonal antibody AR4A reveal isolate-specific resistance and a high barrier to resistance. (2019). Journal of Infectious Diseases, 219(1), 68-79.