Mansun Law, PhD

Associate Professor
Department of Immunology and Microbiology
California Campus

Scripps Research Joint Appointments

Faculty, Graduate Program


D.Phil. (Virology), University of Oxford, Sir William Dunn School of Pathology, 2001
M.Phil. (Molecular Biology), The University of Hong Kong, Department of Zoology, 1997
B.Sc., The University of Hong Kong, Faculty of Science, 1995

Professional Experience

2014-2017 Associate Professor, Immunology and Microbial Science (IMS), Scripps Research
2008-2014 Assistant Professor, Immunology and Microbial Science (IMS), Scripps Research
2004-2008 Research Associate and Senior Research Associate with Dr. Dennis R. Burton, Immunology and Microbial Science (IMS), Scripps Research
2001-2004 Postdoctoral Fellow with Dr. Geoffrey L. Smith, Imperial College London

Selected References

All Publications

Aleman, F., Tzarum, N., Kong, L., Nagy, K., Zhu, J., Wilson, I. A. & Law, M. Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors. (2018). Proceedings of the National Academy of Sciences of the United States of America, 115(29), 7569-7574. PMCID: PMC6055136.

Bazzill, J. D., Ochyl, L. J., Giang, E., Castillo, S., Law, M. & Moon, J. J. Interrogation of antigen display on individual vaccine nanoparticles for achieving neutralizing antibody responses against hepatitis C virus. (2018). Nano Letters, 18(12), 7832-7838.

Tzarum, N., Wilson, I. A. & Law, M. The neutralizing face of hepatitis C virus E2 envelope glycoprotein. (2018). Frontiers in Immunology, 9.

Velazquez-Moctezuma, R., Law, M., Bukh, J. & Prentoe, J. Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A. (2017). PLoS Pathogens, 13.

Morris, C. D., Azadnia, P., de Val, N., Vora, N., Honda, A., Giang, E., Saye-Francisco, K., Cheng, Y. S., Lin, X., Mann, C. J., Tang, J., Sok, D., et al. Differential antibody responses to conserved HIV-1 neutralizing epitopes in the context of multivalent scaffolds and native-like gp140 trimers. (2017). mBio, 8(1), e00036-17. PMCID: PMC5347340.

Logan, M., Law, J., Wong, J. A., Hockman, D., Landi, A., Chen, C., Crawford, K., Kundu, J., Baldwin, L., Johnson, J., Dahiya, A., LaChance, G., et al. Native folding of a recombinant gpE1/gpE2 heterodimer vaccine antigen from a precursor protein fused with Fc IgG. (2017). Journal of Virology, 91. PMCID: PMC5165201.

Gopal, R., Jackson, K., Tzarum, N., Kong, L., Ettenger, A., Guest, J., Pfaff, J. M., Barnes, T., Honda, A., Giang, E., Davidson, E., Wilson, I. A., et al. Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis. (2017). PLoS Pathogens, 13. PMCID: PMC5749897.

Prentoe, J., Velazquez-Moctezuma, R., Foung, S. K. H., Law, M. & Bukh, J. Hypervariable region 1 shielding of hepatitis C virus is a main contributor to genotypic differences in neutralization sensitivity. (2016). Hepatology, 64(6), 1881-1892. PMCID: PMC5115964.

O'Shea, D., Law, J., Egli, A., Douglas, D., Lund, G., Forester, S., Lambert, J., Law, M., Burton, D. R., Tyrrell, D. L. J., Houghton, M., Humar, A., et al. Prevention of hepatitis C virus infection using a broad cross-neutralizing monoclonal antibody (AR4A) and epigallocatechin gallate. (2016). Liver Transplantation, 22(3), 324-332. PMCID: PMC4769112.

Kong, L., Lee, D. E., Kadam, R. U., Liu, T., Giang, E., Nieusma, T., Garces, F., Tzarum, N., Woods Jr., V. L., Ward, A. B., Li, S., Wilson, I. A., et al. Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen. (2016). Proceedings of the National Academy of Sciences of the United States of America, 113(45), 12768-12773. PMCID: PMC5111675.