Mansun Law, PhD

Associate Professor
Department of Immunology and Microbiology
California Campus


 Email

Scripps Research Joint Appointments

Faculty, Graduate Program

Education

D.Phil. (Virology), University of Oxford, Sir William Dunn School of Pathology, 2001
M.Phil. (Molecular Biology), The University of Hong Kong, Department of Zoology, 1997
B.Sc., The University of Hong Kong, Faculty of Science, 1995

Professional Experience

2014-2017 Associate Professor, Immunology and Microbial Science (IMS), Scripps Research
2008-2014 Assistant Professor, Immunology and Microbial Science (IMS), Scripps Research
2004-2008 Research Associate and Senior Research Associate with Dr. Dennis R. Burton, Immunology and Microbial Science (IMS), Scripps Research
2001-2004 Postdoctoral Fellow with Dr. Geoffrey L. Smith, Imperial College London

Selected References

All Publications

Tzarum, N., Giang, E., Kong, L., He, L., Prentoe, J., Augestad, E., Hua, Y., Castillo, S., Lauer, G. M., Bukh, J., Zhu, J., Wilson, I. A., et al. Genetic and structural insights into broad neutralization of hepatitis C virus by human V(H)1-69 antibodies. (2019). Science Advances, 5. PMCID: PMC6314831.

Velazquez-Moctezuma, R., Galli, A., Law, M., Bukh, J. & Prentoe, J. Hepatitis C virus escape studies of human antibody AR3A reveal a high barrier to resistance and novel insights on viral antibody evasion mechanisms. (2019). Journal of Virology, 93. PMCID: PMC6364003.

Velazquez-Moctezuma, R., Galli, A., Law, M., Bukh, J. & Prentoe, J. Hepatitis C virus-escape studies for human monoclonal antibody AR4A reveal isolate-specific resistance and a high barrier to resistance. (2019). Journal of Infectious Diseases, 219(1), 68-79.

Prentoe, J., Velazquez-Moctezuma, R., Augestad, E. H., Galli, A., Wang, R., Law, M., Alter, H. & Bukh, J. Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations. (2019). Proceedings of the National Academy of Sciences of the United States of America, 116(20), 10039-10047.

Chen, F., Tzarum, N., Wilson, I. A. & Law, M. V(H)1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design. (2019). Current Opinion in Virology, 34, 149.

Aleman, F., Tzarum, N., Kong, L., Nagy, K., Zhu, J., Wilson, I. A. & Law, M. Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors. (2018). Proceedings of the National Academy of Sciences of the United States of America, 115(29), 7569-7574. PMCID: PMC6055136.

Bazzill, J. D., Ochyl, L. J., Giang, E., Castillo, S., Law, M. & Moon, J. J. Interrogation of antigen display on individual vaccine nanoparticles for achieving neutralizing antibody responses against hepatitis C virus. (2018). Nano Letters, 18(12), 7832-7838.

Tzarum, N., Wilson, I. A. & Law, M. The neutralizing face of hepatitis C virus E2 envelope glycoprotein. (2018). Frontiers in Immunology, 9.

Velazquez-Moctezuma, R., Law, M., Bukh, J. & Prentoe, J. Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A. (2017). PLoS Pathogens, 13.

Morris, C. D., Azadnia, P., de Val, N., Vora, N., Honda, A., Giang, E., Saye-Francisco, K., Cheng, Y. S., Lin, X., Mann, C. J., Tang, J., Sok, D., et al. Differential antibody responses to conserved HIV-1 neutralizing epitopes in the context of multivalent scaffolds and native-like gp140 trimers. (2017). mBio, 8(1), e00036-17. PMCID: PMC5347340.