Mansun Law, PhD
Professor
Department of Immunology and Microbiology
Research Focus
The mission of the Law Laboratory is to generate foundational insights in virology and immunology that enable the eradication of HBV and HCV. Experimentally, we apply a wide range of cutting-edge technologies to the investigation of viral hepatitis, chronic Infection, antibody, B cell, and vaccine design.
Select Publications
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Chen, Fang; Nguyen, Yen Thi Kim; Lee, Yi-Zon Z.; Giang, Erick; Lau, Sing Cha C.; Koide, Yukiye; Hung, Shr-Ha H.; Ueno, Lynn; He, Linling; Fuerst, Thomas R.; Lauer, Georg M.; Stanfield, Robyn L.; Zhu, Jiang; Wilson, Ian A.; Law, Mansun The conserved bridging domain on HCV E1E2 glycoprotein complex is targeted by neutralizing antibodies from diverse lineages. 2025.
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Chen, Fang; Giang, Erick; Natarajan, Padmaja; Mondala, Tony S.; Head, Steven R.; Lau, Sing Cha C.; Sundaresan, Aishwarya; Kulakova, Liudmila; Lin, Xiaohe; Aneja, Jasneet; Andrabi, Raiees; Zhang, Yun; Scheuermann, Richard H.; Toth, Eric A.; Fuerst, Thomas R.; Lewis-Ximenez, Lia; Kim, Arthur Y.; Pockros, Paul; Lauer, Georg M.; Law, Mansun B cell transcriptomics reveals lasting dysregulation and rapid decline of protective memory after hepatitis C cure. 2025.
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Nguyen, Yen T K; Chen, Fang; Giang, Erick; Saha, Swati; Ueno, Lynn A.; Chen, Christopher; Watson, Corey T.; Tzarum, Netanel; Wilson, Ian A.; Law, Mansun; Stanfield, Robyn L. Structural and genetic signatures of two classes of HCV E2 neutralizing face antibodies from non-human primates immunized with a recombinant E1E2. 2026.
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Chen, Fang; Tzarum, Netanel; Lin, Xiaohe; Giang, Erick; Velazquez-moctezuma, Rodrigo; Augestad, Elias H.; Nagy, Kenna; He, Linling; Hernandez, Mayda; Fouch, Mallorie E.; Grinyo, Ariadna; Chavez, Deborah; Doranz, Benjamin J.; Prentoe, Jannick; Stanfield, Robyn L.; Lanford, Robert E.; Bukh, Jens; Wilson, Ian A.; Zhu, Jiang; Law, Mansun Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins. Immunity 2021, 781-796.e4.
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Tzarum, N.; Giang, E.; Kong, L.; He, L.; Prentoe, J.; Augestad, E.; Hua, Y.; Castillo, S.; Lauer, G. M.; Bukh, J.; Zhu, Jiang; Wilson, Ian A.; Law, Mansun Genetic and structural insights into broad neutralization of hepatitis C virus by human V(H)1-69 antibodies. Science Advances 2019, 5.
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Kong, L.; Giang, E.; Nieusma, T.; Kadam, R. U.; Cogburn, K. E.; Hua, Y.; Dai, X.; Stanfield, Robyn L.; Burton, Dennis R.; Ward, Andrew B.; Wilson, Ian A.; Law, Mansun Hepatitis C virus E2 envelope glycoprotein core structure. Science 2013, 342, 1090-1094.
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