Source: Interfolio F180


Katja Lamia

Associate Professor Tenure
Department of Molecular and Cellular Biology


 Email

Scripps Research Joint Appointments

Molecular & Cellular Biology
Skaggs Graduate School of Chemical and Biological Sciences

Research Focus

Circadian clocks enable organisms to keep track of the time of day and to adjust their physiology to recurring, and therefore predictable, daily changes in the external environment. Our work has demonstrated that circadian clocks are critical regulators of mammalian metabolic physiology and the response to DNA damage. We are studying the molecular basis for the circadian control of metabolism, DNA damage response, and tumorigenesis to enable novel therapies to treat metabolic disease and cancer.

Potential Thesis Projects

circadian regulation of HIF2a in renal cancer role of cryptochromes in suppressing mutations identify proteins secreted from lung tumors that influence cachexia interactions between circadian rhythms and HSF1

Education

Ph.D. (Biophysics), Harvard University, 2003
B.A. (Physics), University of California, Berkeley, 1996

Professional Experience

2004 – 2006 Postdoctoral Fellow with Charles Weitz (Harvard Medical School)
2007 – 2010 Postdoctoral Fellow with Ronald Evans (The Salk Institute)

Awards & Professional Activities

1995 Phi Beta Kappa, UC Berkeley, Physics

2005 Merck Fellowship from the Life Sciences Research Foundation

2012 Searle Scholars Award

2013 Sidney Kimmel Cancer Research Scholar Award
                       
2016 Aschoff’s Rule: annual award in honor of contributions to circadian biology

Selected Publications

Pariollaud, M.; Ibrahim, L. H.; Irizarry, E.; Mello, R. M.; Chan, A. B.; Altman, B. J.; Shaw, R. J.; Bollong, M. J.; Wiseman, R. L.; Lamia, K. A. Circadian disruption enhances HSF1 signaling and tumorigenesis in -driven lung cancer. 2022, 8, eabo1123.

Casanova-Vallve, N.; Duglan, D.; Vaughan, M. E.; Pariollaud, M.; Handzlik, M. K.; Fan, W.; Yu, R. T.; Liddle, C.; Downes, M.; Delezie, J.; Mello, R.; Chan, A. B.; Westermark, P. O.; Metallo, C. M.; Evans, R. M.; Lamia, K. A. Daily running enhances molecular and physiological circadian rhythms in skeletal muscle. 2022, 61, 101504.

Chan, A. B.; Parico, G.; Fribourgh, J. L.; Ibrahim, L. H.; Bollong, M. J.; Partch, C. L.; Lamia, K. A. missense mutations suppress P53 and enhance cell growth. 2021, 118.

Vaughan, M. E.; Wallace, M.; Handzlik, M. K.; Chan, A. B.; Metallo, C. M.; Lamia, K. A. Cryptochromes suppress HIF1a in muscles. iScience 2020, 23.
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Jordan, S. D.; Kriebs, A.; Vaughan, M. E.; Duglan, D.; Fan, W.; Henriksson, E.; Huber, A. L.; Papp, S. J.; Nguyen, M.; Afetian, M.; Downes, M.; Yu, R. T.; Kralli, A.; Evans, R. M.; Lamia, K. A. CRY1/2 selectively repress PPARd and limit exercise capacity. Cell Metabolism 2017, 26, 243-255.
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Huber, A. L.; Papp, S. J.; Chan, A. B.; Henriksson, E.; Jordan, S. D.; Kriebs, A.; Nguyen, M.; Wallace, M.; Li, Z.; Metallo, C. M.; Lamia, K. A. CRY2 and FBXL3 cooperatively degrade c-MYC. Molecular Cell 2016, 64, 774-789.
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