Katja Lamia, PhD
Scripps Research Joint Appointments
Research Focus
Circadian clocks enable organisms to keep track of the time of day and to adjust their physiology to recurring, and therefore predictable, daily changes in the external environment. Our work has demonstrated that circadian clocks are critical regulators of mammalian metabolic physiology and the response to DNA damage. We are studying the molecular basis for the circadian control of metabolism, DNA damage response, and tumorigenesis to enable novel therapies to treat metabolic disease and cancer.
Education
Ph.D. (Biophysics), Harvard University, The Graduate School of Arts and Sciences, 2003B.A. (Physics), University of California, Berkeley, Department of Physics, 1996
Professional Experience
2017-2018 Assistant Professor, Molecular Medicine, Scripps Research2010-2017 Assistant Professor, Chemical Physiology, Scripps Research
2007-2010 Postdoctoral Fellow with Dr. Ronald M. Evans, Salk Institute for Biological Studies
2004-2006 Postdoctoral Fellow with Dr. Charles J. Weitz, Harvard Medical School, Harvard University
2001-2001 Teaching Fellow, Molecular Biology (BS52), Harvard University
1999-1999 Teaching Fellow, Biochemistry (BCMP 201), Harvard University
1997-1997 Teaching Fellow, Molecular Biology (SB46), Harvard University
Awards & Professional Activities
Selected References
Duglan D, Lamia KA. Clocking In, Working Out: Circadian Regulation of Exercise Physiology. Trends Endocrinol Metab. 2019 May 1.
Duglan D, Lamia KA. Clocking In, Working Out: Circadian Regulation of Exercise Physiology. Trends Endocrinol Metab. 2019 May 1.
Correia SP, Chan AB, Vaughan M, Zolboot N, Perea V, Huber AL, Kriebs A, Moresco JJ, Yates JR 3rd, Lamia KA. The circadian E3 ligase complex SCFFBXL3+CRY targets TLK2. Sci Rep. 2019 Jan 17
Lamia KA. Ticking time bombs: connections between circadian clocks and cancer. F1000Res. 2017 Oct
Henriksson E, Huber AL, Soto EK, Kriebs A, Vaughan ME, Duglan D, Chan AB, Papp SJ, Nguyen M, Afetian ME, Lamia KA. The liver circadian clock modulates biochemical and physiological responses to metformin. J Biol Rhythms. 2017 Aug
Kriebs A, Jordan SD, Soto E, Henriksson E, Sandate CR, Vaughan ME, Chan AB, Duglan D, Papp SJ, Huber AL, Afetian ME, Yu RT, Zhao X, Downes M, Evans RM, Lamia KA. Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. Proc Natl Acad Sci U S A. 2017 Aug 15
Jordan SD, Kriebs A, Vaughan M, Duglan D, Fan W, Henriksson E, Huber AL, Papp SJ, Nguyen M, Afetian M, Downes M, Yu RT, Kralli A, Evans RM, Lamia KA. CRY1/2 selectively repress PPARd and limit exercise capacity. Cell Metab. 2017 Jul 5
Huber AL, Papp SJ, Chan AB, Henriksson E, Jordan SD, Kriebs A, Nguyen M, Wallace M, Li Z, Metallo CM and Lamia KA. CRY2 and FBXL3 Cooperatively Degrade c-MYC. Mol Cell 2016 Nov 17
Zhao X, Hirota T, Han X, Cho H, Chong LW, Lamia K, Liu S, Atkins AR, Banayo E, Liddle C, Yu RT, Yates JR 3rd, Kay SA, Downes M, and Evans RM. Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation. Cell 2016 Jun 16
Henriksson E and Lamia KA. Adipose clocks – burning the midnight oil. J Biol Rhythms 2015 Apr 29
Papp SJ, Huber AL, Jordan SD, Kriebs A, Nguyen M, Moresco J, Yates III J, and Lamia KA. DNA damage shifts circadian clock time via Hausp-mediated Cry1 stabilization. ELife. 2015 Mar 10; 4. doi: 10.7554/eLife.04883, PMCID: PMC4352707
Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC. Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 2013 Nov 7;155(4):844-57. doi: 10.1016/j.cell.2013.09.057. PMID: 24209622, PMCID: PMC4070383
Jordan SD and Lamia KA. AMPK at the Crossroads of Circadian Clocks and Metabolism. Mol Cell Endocrinol. 2013 Feb 25;366(2):163-9. doi: 10.1016/j.mce.2012.06.017. Epub 2012 Jun 28. Review. PMID: 22750052, PMCID: PMC3502724
Lamia KA, Papp SJ, Yu RT, Barish GD, Uhlenhaut NH, Jonker JW, Downes M, Evans RM. Cryptochromes Mediate Rhythmic Repression of the Glucocorticoid Receptor. Nature. 2011 Dec 14;480(7378):552-6. doi: 10.1038/nature10700. PMID: 22170608, PMCID: PMC3245818
Sadacca LA, Lamia KA, deLemos AS, Blum B, Weitz CJ. An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice. Diabetologia. 2011 Jan;54(1):120-4. doi: 10.1007/s00125-010-1920-8. Epub 2010 Oct 3. PMID: 20890745, PMCID: PMC2995870
Lamia KA, Sachdeva UM, DiTacchio L, Williams EC, Alvarez JG, Egan DF, Vasquez DS, Juguilon H, Panda S, Shaw RJ, Thompson CB and Evans RM. AMPK Regulates Circadian Clocks by Phosphorylation and Degradation of Cryptochromes. Science 2009 Oct 16; 326(5951):437-40. PMID: 19833968, PMCID: PMC2819106.
Lamia KA and Evans RM. Tick, tock, a beta cell clock. Nature 2010 Jul 29; 466(7306):571-2. PMID: 20671699, PMCID: PMC3610560
Lamia KA, Storch KF and Weitz CJ. Physiological Importance of a Peripheral Tissue Circadian Clock. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15172-7. PMID: 18779586, PMCID: PMC2532700
Yang X, Lamia KA, Evans RM. Nuclear receptors, metabolism, and the circadian clock. Cold Spring Harb Symp Quant Biol. 2007;72:387-94. doi: 10.1101/sqb.2007.72.058. Review. PMID:18419296
Shaw RJ, Lamia KA, Vasquez D, Koo S-H, Bardeesy N, DePinho RA, Montminy M, and Cantley LC. The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin. Science. 2005 Dec 9;310(5754):1642-6. PMID: 16308421, PMCID: PMC3074427
Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB, Cantley LC. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Mol Cell Biol. 2004 Jun;24(11):5080-7. PMID: 15143198, PMCID: PMC416424