Xin Jin, PhD

Assistant Professor
Department of Neuroscience


 Email

Scripps Research Joint Appointments

Department of Neuroscience
Dorris Neuroscience Center
Faculty, Graduate Program

Other Joint Appointments

Neurosciences Graduate Program, UCSD

Research Focus

Approximately 1 in every 5 adults in the US will experience some form of serious mental illness in their lives. While genetic studies have identified numerous genes and loci contributing to the risk of these devastating psychiatric disorders, it remains a challenge to map their cellular mechanisms and determine the relevant tissue and cell type contexts. We are building in vivo genetic screens to allow massively parallel analyses of gene function to systematically assign their function in diverse cell types in the context of brain development and maturation. Our long-term goal is to invent and apply chemical biology and genomic technologies to study the interplay of genetic and physiology and how it impacts mammalian neurodevelopment as well as brain disorders such as autism spectrum disorder and developmental delay.

Xin Jin is an Assistant Professor of Neuroscience at Scripps Research. She obtained her B.Sc. in Chemistry from MIT and her Ph.D. in Biology from The Rockefeller University working in the Laboratory of Cori Bargmann. As a Junior Fellow at the Harvard Society of Fellows, she worked with Paola Arlotta, Feng Zhang, and Aviv Regev to develop and apply in vivo genetic screening tools to study brain development.


Education

Ph.D., Biology, The Rockefeller University, 2016
B.Sc., Chemistry, MIT, 2010

Professional Experience

Junior Fellow, Society of Fellows, Harvard University


Awards & Professional Activities

2022  ‘35 Innovators Under 35’ by MIT Technology Review
2022  One Mind Rising Star Award
2022  Klingenstein-Simons Fellowship Award in Neuroscience
2022  Larry L. Hillblom Foundation Start-up Award
2022  Donald E. and Delia B. Baxter Foundation Young Investigator Award
2022  International Society of Autism Research Early Career Investigator Award
2020  Intersections Science Fellows
2020  Presidential Member Award, Genetics Society of America
2019  Allison Doupe Fellowship, McKnight Endowment Fund
2019  NARSAD Young Investigator Award, Brain and Behavior Research Foundation
2018  William F. Milton Award, Harvard University
2017  Shark Tank Pilot Award, Broad Institute of Harvard and MIT
2016  Kaluza Prize finalist for graduate thesis, American Society of Cell Biology
2013  Blackstone Presentation Award, Champalimaud Neuroscience Symposium
2012  HHMI International Student Predoctoral Fellowship
2011  Women and Science Fellowship, The Rockefeller University
2010  Outstanding Research Award, Department of Chemistry, MIT
2010  Novartis Fellowship for Research, MIT
2009  Paul E. Grey Research Fellowship for Research, MIT


Selected References

Choi S, Zhang B, Ma S, Gonzalez-Celeiro M, Stein D, Jin X, Kim S, Kang Y-L, Besnard A, Rezza A, Grisanti L, Buenrostro J, Rendl M, Nahrendorf M, Sahay A, Hsu Y-C.
Stress hormone corticosterone governs hair follicle stem cell quiescence by suppressing a dermal niche activator Gas6. 
Nature 2021; 592:428-432.

Qiu M*, Glass Z*, Chen J, Haas M, Jin X, Zhao X, Rui X, Ye Z, Li Y, Zhang F, Xu Q.
Lipid nanoparticle-mediated delivery of Cas9 mRNA achieves organ-specific in vivo genome editing of Angptl3.
PNAS 2021; 118(10):e2020401118.

Jin X^, Simmons S, Guo A, Shetty AS, Ko M, Nguyen L, Robinson E, Oyler P, Curry N, Deangeli G, Lodato S, Levin JZ, Regev A^, Zhang F^, Arlotta P^.
In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with Autism risk genes.
Science 2020; 370 (6520):eaaz6063.

Dennis EJ, Dobosiewicz M, Jin X, Duvall LB, Hartman PS, Bargmann CI, Vosshall LB.
A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.
Nature 2018; 562:119-123.

Jin X, Pokala N, Bargmann CI.
Distinct Circuits for the Formation and Retrieval of an Imprinted Olfactory Memory.
Cell 2016; 164(4):632-643.

Abrahamsson S, Ilic R, Wisniewski J, Mehl B, Yu L, Chen L, Davanco M, Oudjedi L, Fiche J.B., Hajj B, Jin X, Pulupa J, Cho C, Mir M, El Beheiry M, Darzacq X, Nollmann M, Dahan M, Wu C, Lionnet T, Liddle JA, Bargmann CI.
Multifocus microscopy with precise color multi-phase diffractive optics applied in functional neuronal imaging.
Biomedical optics express 2016; 7(3):855-869.

Jin X*, Uttamapinant C*, Ting AY.
Synthesis of 7-aminocoumarin by Buchwald-Hartwig cross coupling for specific protein labeling in living cells.
Chembiochem 2011; 12(1):65-70.

Long JZ, Jin X, Adibekian A, Li W, Cravatt BF.
Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases.
Journal of Medicinal Chemistry 2010; 53(4):1830-1842.

Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF.
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.
PNAS 2009; 106(48):20270-20275.

(^ Corresponding authors; * Co-first authors)


Links

Full list of Publications

Jin Lab Website