Source: Interfolio F180
Kim Janda, PhD
Scripps Research Joint Appointments
Research Focus
Merging of Chemistry and Biology
Our work encompasses the following areas: the development of methods for the detection of and protection against chemical/biological warfare agents, the preparation of combinatorial chemical libraries, the design/synthesis and evaluation of catalytic antibodies and enzyme inhibitors, solid-phase organic synthesis, antibody/peptide phage display libraries, the application of immunopharmacotherapy in the treatment of drug addiction and cancer, methods of prevention and treatment of obesity, diagnostic and therapeutic strategies towards neglected tropical diseases, and investigation and development of molecules that block quorum sensing in bacteria.
Education
B.S. (Clinical Chemistry), University of South Florida, 1980M.S. (Organic Chemistry), The University of Arizona, 1983
Ph.D. (Organic & Medicinal Chemistry), The University of Arizona, 1984
Professional Experience
Postdoctoral Fellow, Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA (1985-1986)
Adjunct Assistant Professor, Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA (1987-1988)
Assistant Professor, Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA (1989-1990)
Associate Professor, Departments of Molecular Biology and Chemistry, The Scripps Research Institute, La Jolla, CA (1991-1996, tenured 1993)
Associate Professor, The Skaggs Institute for Chemical Biology (joint appointment), The Scripps Research Institute, La Jolla, CA (1996)
Ely R. Callaway Jr. Chair in Chemistry and Professor, Department of Chemistry, The Scripps Research Institute, La Jolla, CA (since 1996)
Skaggs Scholar, The Skaggs Institute for Chemical Biology, La Jolla, CA (since 1996)
Professor, Department of Immunology and Microbial Science, (joint appointment), The Scripps Research Institute, La Jolla, CA (since 2005)
Director, The Worm Institute of Research & Medicine (WIRM), The Scripps Research Institute, La Jolla, CA (since 2005)
Awards & Professional Activities
1990 NIH FIRST Award, NIH1999 Arthur C. Cope Scholar Award, ACS
2001 Outstanding Alumnus in Chemistry, University of South Florida
2009 Doctor of Philosophy honoris causa, University of Helsinki, Finland
2015 Path to Recovery Honoree, ACS
2017 Alfred Bader Award in Bioorganic Chemistry, ACS
2019 Portoghese Lectureship Award, ACS Division of Medicinal Chemistry
2019 Tai Lectureship in Innovative Therapeutics Award, University of Kentucky
2021 NIH Director’s Lectureship (WALS)
Selected Publications
Hart, J. R.; Garner, A. L.; Yu, J.; Ito, Y.; Sun, M. H.; Ueno, L.; Rhee, J. K.; Baksh, M. M.; Stefan, E.; Hartl, M.; Bister, Klaus; Vogt, Peter K.; Janda, Kim D. Inhibitor of MYC identified in a Krohnke pyridine library. Proceedings of the National Academy of Sciences of the United States of America 2014, 111, 12556-12561.
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Bremer, Paul T.; Kimishima, A.; Schlosburg, J. E.; Zhou, Bin; Collins, K. C.; Janda, Kim D. Combatting synthetic designer opioids: a conjugate vaccine ablates lethal doses of fentanyl class drugs. Angewandte Chemie-International Edition 2016, 55, 3772-3775.
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Bremer, Paul T.; Schlosburg, J. E.; Banks, M. L.; Steele, F. F.; Zhou, Bin; Poklis, J. L.; Janda, Kim D. Development of a clinically viable heroin vaccine. Journal of the American Chemical Society 2017, 139, 8601-8611.
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Teijaro, John R.; Teijaro, John R.; Shaabani, Namir; Paessler, Slobodan; Maruyama, Junki; Manning, John T.; Ji, Henry; Janda, Kim D.; Eubanks, Lisa M.; Blake, Steven; Beutler, Nathan Salicylanilides Reduce SARS-CoV-2 Replication and Suppress Induction of Inflammatory Cytokines in a Rodent Model.. ACS infectious diseases 2021, 7, 2229-2237.
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Wenthur, C. J.; Zhou, Bin; Janda, Kim D. Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity. Nature 2017, 548, 476-479.
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Olson, M. E.; Sugane, T.; Zhou, Bin; Janda, Kim D. Consequence of hapten stereochemistry: an efficacious methamphetamine vaccine. Journal of the American Chemical Society 2019, 141, 14089-14092.
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Eubanks, Lisa M.; Pholcharee, Tossapol; Oyen, David; Natori, Yoshihiro; Zhou, Bin; Wilson, Ian A.; Janda, Kim D. An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression. ACS Chem. Neurosci. 2023, 14, 2849–2856.
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