Kim Janda, PhD
Professor
Department of Chemistry
Ely R. Callaway, Jr. Professor of Chemistry; Director, Worm Institute For Research & Medicine (WIRM); Skaggs Scholar, The Skaggs Institute For Chemical Biology
Research Focus
Our work encompasses the following areas: the development of methods for the detection of and protection against chemical/biological warfare agents, the preparation of combinatorial chemical libraries, the design/synthesis and evaluation of catalytic antibodies and enzyme inhibitors, solid-phase organic synthesis, antibody/peptide phage display libraries, the application of immunopharmacotherapy in the treatment of drug addiction and cancer, methods of prevention and treatment of obesity, diagnostic and therapeutic strategies towards neglected tropical diseases, and investigation and development of molecules that block quorum sensing in bacteria.
Select Publications
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Hart, J. R.; Garner, A. L.; Yu, J.; Ito, Y.; Sun, M. H.; Ueno, L.; Rhee, J. K.; Baksh, M. M.; Stefan, E.; Hartl, M.; Bister, Klaus; Vogt, Peter K.; Janda, Kim D. Inhibitor of MYC identified in a Krohnke pyridine library. Proceedings of the National Academy of Sciences of the United States of America 2014, 111, 12556-12561.
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Bremer, Paul T.; Kimishima, A.; Schlosburg, J. E.; Zhou, Bin; Collins, K. C.; Janda, Kim D. Combatting synthetic designer opioids: a conjugate vaccine ablates lethal doses of fentanyl class drugs. Angewandte Chemie-International Edition 2016, 55, 3772-3775.
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Bremer, Paul T.; Schlosburg, J. E.; Banks, M. L.; Steele, F. F.; Zhou, Bin; Poklis, J. L.; Janda, Kim D. Development of a clinically viable heroin vaccine. Journal of the American Chemical Society 2017, 139, 8601-8611.
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Teijaro, John R.; Teijaro, John R.; Shaabani, Namir; Paessler, Slobodan; Maruyama, Junki; Manning, John T.; Ji, Henry; Janda, Kim D.; Eubanks, Lisa M.; Blake, Steven; Beutler, Nathan Salicylanilides Reduce SARS-CoV-2 Replication and Suppress Induction of Inflammatory Cytokines in a Rodent Model.. ACS infectious diseases 2021, 7, 2229-2237.
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Wenthur, C. J.; Zhou, Bin; Janda, Kim D. Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity. Nature 2017, 548, 476-479.
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Olson, M. E.; Sugane, T.; Zhou, Bin; Janda, Kim D. Consequence of hapten stereochemistry: an efficacious methamphetamine vaccine. Journal of the American Chemical Society 2019, 141, 14089-14092.
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Eubanks, Lisa M.; Pholcharee, Tossapol; Oyen, David; Natori, Yoshihiro; Zhou, Bin; Wilson, Ian A.; Janda, Kim D. An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression. ACS Chem. Neurosci. 2023, 14, 2849–2856.
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