Mia Huang, PhD

Assistant Professor
Department of Molecular Medicine
Florida Campus


 Email

Scripps Research Joint Appointments

TSRI Graduate Program
Assistant Professor, Department of Chemistry
Faculty, Graduate Program

Research Focus

Glycans are important biomolecular regulators, yet their structural complexity often precludes detailed analysis of their functions. The Huang Lab investigates questions in chemical glycobiology related to the study of stem cell differentiation, musculoskeletal research, or cancer. We seek to develop strategies to illuminate the mechanisms through which glycans orchestrate these biological events. The Lab employs techniques in synthetic chemistry, mass spectrometry, and protein engineering to illuminate fundamental mechanisms involved in glycan-protein biology. 


Education

Ph.D., Chemistry, New York University, 2012
B.A., Chemistry, CUNY Queens College, 2007

Professional Experience

Aug 2018 Assistant Professor, Scripps Research
July 2013 Postdoctoral Scholar, UC San Diego
July 2012 Postdoctoral Associate, Yale University

Awards & Professional Activities

July 2017 NIH K99/R00 Pathway to Independence Award

Selected References

Huang ML, Tota EM, Lucas TM, Godula K. Influencing Early Stages of Neuromuscular Junction Formation through Glycocalyx Engineering. ACS Chem Neurosci. 2018 Aug 28. doi: 10.1021/acschemneuro.8b00295. [Epub ahead of print] PubMed PMID: 30095249.

Raitman I, Huang ML, Williams SA, Friedman B, Godula K, Schwarzbauer JE. Heparin-fibronectin interactions in the development of extracellular matrix insolubility. Matrix Biol. 2018 Apr;67:107-122. doi: 10.1016/j.matbio.2017.11.012. Epub 2017 Dec 6. PubMed PMID: 29223498; PubMed Central PMCID: PMC5910196.

Huang ML, Michalak AL, Fisher CJ, Christy M, Smith RAA, Godula K. Small Molecule Antagonist of Cell Surface Glycosaminoglycans Restricts Mouse Embryonic Stem Cells in a Pluripotent State. Stem Cells. 2018 Jan;36(1):45-54. doi: 10.1002/stem.2714. Epub 2017 Oct 27. PubMed PMID: 28984039.

Huang ML, Purcell SC, Verespy S III, Wang Y, Godula K. Glycocalyx scaffolding with synthetic nanoscale glycomaterials. Biomater Sci. 2017 Jul 25;5(8):1537-1540. doi: 10.1039/c7bm00289k. PubMed PMID: 28616946; PubMed Central PMCID: PMC5560263.

Smith PT, Huang ML, Kirshenbaum K. Osmoprotective polymer additives attenuate the membrane pore-forming activity of antimicrobial peptoids. Biopolymers. 2015 Apr;103(4):227-36. doi: 10.1002/bip.22588. PubMed PMID: 25403751.

Huang ML, Cohen M, Fisher CJ, Schooley RT, Gagneux P, Godula K. Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays. Chem Commun (Camb). 2015 Mar 28;51(25):5326-9. doi: 10.1039/c4cc08613a. PubMed PMID: 25574528; PubMed Central PMCID: PMC4359031.

Huang ML, Smith RA, Trieger GW, Godula K. Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells. J Am Chem Soc. 2014 Jul 30;136(30):10565-8. doi: 10.1021/ja505012a. Epub 2014 Jul 17. PubMed PMID: 25019314; PubMed Central PMCID: PMC4121001.

Huang ML, Ehre D, Jiang Q, Hu C, Kirshenbaum K, Ward MD. Biomimetic peptoid oligomers as dual-action antifreeze agents. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):19922-7. doi: 10.1073/pnas.1212826109. Epub 2012 Nov 19. PubMed PMID: 23169638; PubMed Central PMCID: PMC3523862.

Huang ML, Shin SB, Benson MA, Torres VJ, Kirshenbaum K. A comparison of linear and cyclic peptoid oligomers as potent antimicrobial agents. ChemMedChem. 2012 Jan 2;7(1):114-22. doi: 10.1002/cmdc.201100358. Epub 2011 Sep 23. PubMed PMID: 21990117.