Source: Interfolio F180

Scott Henderson

Director, Core Microscopy Facility
Department of Molecular Medicine


Scripps Research Joint Appointments

Integrative Structural & Computational Biology

Research Focus

TSRI’s Microscopy Core Facility offers electron microscopy (TEM and SEM), confocal microscopy (both laser scanning and spinning disc) multi-photon, total internal reflection fluorescence (TIRF) and ‘super-resolution’ stochastic optical reconstruction microscopy (STORM) along with a full range of services including: consultation, experimental design, sample preparation, assistance with imaging & image analysis, user training, technical support, and assistance with research grant applications.


Scott Henderson joins Scripps as Director of Microscopy Core Facility


Ph.D. (Zoology / Cell Biology), University of Western Ontario, 1990

Professional Experience

Professor, Scripps Research Institute
Director, Microscopy Core Facility

Director, Microscopy Facility, Virginia Commonwealth University
Associate Professor in the Department of Anatomy and Neurobiology

Faculty Member, Mount Sinai School of Medicine, New York

Awards & Professional Activities

2005 National Aeronautics & Space Administration (NASA) - STS-107 Group Achievement Award - STS-107 Life Science Payload Team (MSSM)
1989 Award of Excellence in Graduate Teaching (UWO)
1988 Graduate Research Fellowship (UWO)
1985 Ontario Graduate Scholarship

Selected Publications

Mulhall, Eric M.; Gharpure, Anant; Lee, Rachel M.; Dubin, Adri E.; Aaron, Je S.; Marshall, Kara L.; Spencer, Kath R.; Reiche, Mich A.; Henderson, Scott C.; Chew, Teng- L.; Patapoutian, Ardem Direct observation of the conformational states of PIEZO1. Nature 2023.

allen, dale; askari, kasra; billadeau, daniel d.; catz, sergio d.; chen, danni; gontijo, raquel c.; grinstein, sergio; hedrick, catherine c.; henderson, scott c.; johnson, jennifer l.; kiosses, william b.; meneses-salas, elsa; monfregola, jlenia; osborne, douglas g.; pestonjamasp, kersi; rahman, farhana; ramadass, mahalakshmi; ursini, matilde v.; wineinger, nathan; yu, juan; zhang, jinzhong; zhu, yanfang p.

Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation

. Nature Communications 2022.

Deng, Yisong; Hammond, John A.; Pauszek, Raymond; Ozog, Stosh; Chai, Ilean; Rabuck-Gibbons, Jessica; Lamichhane, Rajan; Henderson, S C.; Millar, David P.; Torbett, Bruc E.; Williamson, James R. Discrimination between Functional and Non-functional Cellular Gag Complexes involved in HIV-1 Assembly. 2021, 433, 166842.

Mehta, Angad P.; Supekova, Lubica; Chen, Jian-hua; Pestonjamasp, Kersi; Webster, Paul; Ko, Yeonjin; Henderson, Scott C.; Mcdermott, Gerry; Supek, Frantisek; Schultz, Peter G.

Engineering yeast endosymbionts as a step toward the evolution of mitochondria.

. Proceedings of the National Academy of Sciences of the United States of America 2018, 115, 11796-11801.

dewey, william l.; halquist, matthew s.; henderson, scott c.; li, pin-lan; li, ningjun; xu, xiaoyang; yuan, xinxu; zhang, fan; zhang, aolin

Simvastatin promotes NPC 1-mediated free cholesterol efflux from lysosomes through CYP 7A1/ LXR a signalling pathway in ox LDL -loaded macrophages

. Journal of Cellular and Molecular Medicine 2017.

Jiang, Min; Zhang, Mei; Henderson, Scott C.; Gea-ny, Tseng

Probing the Trafficking Routes of KCNQ1 and KCNE1 After Their ER Exit

. Biophysical Journal 2015, 108, 196a.