Anne Hanneken, MD
Research Focus
The focus of our macular degeneration research program is on improving the function of the cells that support the chemistry of vision, the rod and cone photoreceptors. With a unique multidisciplinary team of ophthalmologists, computational chemists, cell biologists and biochemists, we are using advanced computer modeling technology to design a treatment that will protect visual pigments in the photoreceptor cells and improve visual function. The focus of the research is to identify a treatment that will stabilize the delicate opsin proteins that activate the visual transduction cascade (a series of biochemical steps that are responsible for vision in all vertebrate species).
Education
M.D., Medical College of Wisconsin, 1984B.S. (Chemistry), 1978
Rush University Medical Center, 1985
Harvard University, Harvard Medical School, Children's Hospital Medical Center, 1983
University of Wisconsin-Madison, 1982
Johns Hopkins University, The Wilmer Eye Institute, 1988
Professional Experience
2008-present Associate Professor, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA. Chairman: Dr. Jeffery Kelly
2002-2008 Associate Professor, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA. Chairman: Dr. Ernest Beutler
2000-2002: Associate Professor, Department of Cell Biology, The Scripps Research Institute, La Jolla, California. Chairman: Dr. Sandra Schmidt
1994-2000: Assistant Professor, Department of Cell Biology, The Scripps Research Institute, La Jolla, California. Chairman: Dr. Sandra Schmidt
1990-present: Vitreoretinal Surgeon, San Diego Vitreoretinal Associates, Scripps Memorial Hospital, La Jolla, California
1990-1994: Assistant Member and Head of Eye Research, Department of Molecular and Cellular Growth Biology, The Whittier Institute for Diabetes and Endocrinology, La Jolla, California, Chairman: Dr. Roger Guillemin
1990-2000: Assistant Adjunct Professor of Ophthalmology, Duke University, Durham, North Carolina.
1988-1990: Clinical Fellowship in Vitreoretinal Surgery, Duke University Eye Center, Durham, North Carolina.
1985-1988: Residency in Ophthalmology, Johns Hopkins, The Wilmer Eye Institute, Baltimore, Maryland.
2001-2002 Associate Professor, Cell Biology, Scripps Research
1994-2000 Assistant Professor, Cell Biology, Scripps Research
1990-2000 Assistant Adjunct Professor of Ophthalmology, Duke University
1990-1994 Assistant Member and Head of Eye Research, Scripps Whittier Diabetes Institute, Scripps Health
1988-1990 Clinical Fellowship in Vitreoretinal Surgery, Duke Eye Center, Duke University
Awards & Professional Activities
Hornaday Vitreoretinal AwardHeed Foundation Award
Marianna Mead Award
Knapp Fellowship Award
Fellow of the American Academy of Ophthalmology
Diplomat of the American Board of Ophthalmology
Member:
Association for Research in Vision and Ophthalmology
American Society of Retinal Specialists
The Retina Society
The Macula Society
The Campo Society
California Medical Association
San Diego Medical Society
Educational Lectures and Seminars:
October 15
American Academy of Ophthalmology: Neuroprotection for Retinal Detachment
June 9
National Eye Institute (NEI): The Retinal Origin of Visual Illusions in Age-Related Macular Degeneration Patients.
May 4
Association for Research in Vision and Ophthalmology (ARVO): Visual Hallucinations in Age-Related Macular Degeneration Patients are Induced by Proton Pump Inhibitors: Clinical and Electrophysiologic Studies.
March 19
Update on Age-Related Macular Degeneration - Scripps Mericos
March 16
Vail Vitrectomy Meeting: Neuroprotection for Retinal Detachment
January 15
Macula of Paris, France: Visual Perception Abnormalities in Macular Degeneration Patients
September 3
4th International Vitreoretinal Meeting, Vienna, Austria: Flavonoids protect Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Cell Death
June 18
Massachusetts Eye and Ear Infirmary, Fred Jacobiak Lecture, Harvard MEEI Graduation Lecture, Boston, Mass. Listen to your patients, they will teach you
June 19
Massachusetts Eye and Ear Infirmary, Boston, Mass. Harvard Mariana Mead Invited Lecture: The Retinal Origin of Visual Hallucinations in Age-Related Macular Degeneration Patients
April 9
Emory University Eye Center Vision Research Seminar. Atlanta, Georgia: Neuroprotection for Age-Related Macular Degeneration- a new perspective
Selected References
Anderson, D. M. G., Ablonczy, Z., Koutalos, Y., Hanneken, A. M., Spraggins, J. M., Calcutt, M. W., Crouch, R. K., Caprioli, R. M. & Schey, K. L. Bis(monoacylglycero) phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas. (2017). Scientific Reports, 7. PMCID: PMC5725462.
Adler, L., Boyer, N. P., Anderson, D. M., Spraggins, J. M., Schey, K. L., Hanneken, A., Ablonczy, Z., Crouch, R. K. & Koutalos, Y. Determination of N-retinylidene-N-retinylethanolamine (A2E) levels in central and peripheral areas of human retinal pigment epithelium. (2015). Photochemical & Photobiological Sciences, 14(11), 1983-1990. PMCID: PMC4626405.
Ablonczy, Z., Higbee, D., Anderson, D. M., Dahrouj, M., Grey, A. C., Gutierrez, D., Koutalos, Y., Schey, K. L., Hanneken, A. & Crouch, R. K. Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium. (2013). Investigative Ophthalmology and Visual Science, 54(8), 5535-5542. PMCID: PMC3747789.
Hanneken, A. M., Babai, N. & Thoreson, W. B. Oral proton pump inhibitors disrupt horizontal cell-cone feedback and enhance visual hallucinations in macular degeneration patients. (2013). Investigative Ophthalmology and Visual Science, 54(2), 1485-1489. PMCID: PMC3588886.
Gutierrez, D. B., Blakeley, L., Goletz, P. W., Schey, K. L., Hanneken, A., Koutalos, Y., Crouch, R. K. & Ablonczy, Z. Mass spectrometry provides accurate and sensitive quantitation of A2E. (2010). Photochemical & Photobiological Sciences, 9(11), 1513-1519. PMCID: PMC3013054.
Kalt, W., Hanneken, A., Milbury, P. & Tremblay, F. Recent research on polyphenolics in vision and eye health. (2010). Journal of Agricultural and Food Chemistry, 58(7), 4001-4007.
Johnson, J., Maher, P. & Hanneken, A. The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression. (2009). Investigative Ophthalmology & Visual Science, 50(5), 2398-2406. PMCID: PMC2672971.
Maher, P. & Hanneken, A. Flavonoids protect retinal ganglion cells from ischemia in vitro. (2008). Experimental Eye Research, 86(2), 366-374.
Hanneken, A. & Maher, P. The efficacy of flavonoids in the protection of retinal pigment epithelial cells. (2008). Agro Food Industry Hi-Tech, 19(2), 39-40.
Hanneken, A., Lin, F. F., Johnson, J. & Maher, P. Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death. (2006). Investigative Ophthalmology & Visual Science, 47(7), 3164-3177.
