Source: Interfolio F180
Anne Hanneken
Research Focus
The focus of our macular degeneration research program is on improving the function of the cells that support the chemistry of vision, the rod and cone photoreceptors. With a unique multidisciplinary team of ophthalmologists, computational chemists, cell biologists and biochemists, we are using advanced computer modeling technology to design a treatment that will protect visual pigments in the photoreceptor cells and improve visual function. The focus of the research is to identify a treatment that will stabilize the delicate opsin proteins that activate the visual transduction cascade (a series of biochemical steps that are responsible for vision in all vertebrate species).
Education
B.S. (Chemistry), Marquette University, 1978M.D. (Medicine), Medical College of Wisconsin, 1984
Professional Experience
Research
2008-present
Associate Professor of Molecular Medicine, The Scripps Research Institute, La Jolla, CA. Chairman: Dr. Jim Paulson
2002-2008
Associate Professor of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA. Chairman: Drs. Ernest Beutler & Jeffery Kelly
2000-2002
Associate Professor, Department of Cell Biology, The Scripps Research Institute, La Jolla, California. Chairman: Dr. Sandra Schmidt
1994-2000
Assistant Professor, Department of Cell Biology, The Scripps Research Institute, La Jolla, California. Chairman: Dr. Sandra Schmidt
Clinical
2017-present
Vice-President, Retina Consultants San Diego, California
1990-present
Physician & Surgeon: Scripps Memorial Hospital, La Jolla, California
1990-2017
Vitreoretinal Surgeon, San Diego Vitreoretinal Associates
1990-2000
Assistant Adjunct Professor of Ophthalmology, Duke University, Durham, North Carolina
Scripps Memorial Hospital, Vitreoretinal Surgeon
Awards & Professional Activities
2023: Castle Connolly Regional Top Doctor 2023
2022: Castle Connolly Regional Top Doctor 2022
2022: Wall Street Journal profile, “The Future of Everything”, A Spark of Life After Death in Sight Research (September 8th, 2022) by Ron Winslow. Overview of the research surrounding the 2022 Nature paper, Revival of light signaling in the postmortem mouse and human retina.
Top 99% of all science publications, and top 95% of all Nature papers
2021: Castle Connolly Regional Top Doctor 2021
2021: Castle Connolly Exceptional Women in Medicine
2021: Castle Connolly Regional Top Doctor 2021
2020: Castle Connolly Regional Top Doctor 2020
2020: San Diego Top Doctor Award 2020
2019: Castle Connolly Regional Top Doctor 2019
2018: Castle Connolly Regional Top Doctor 2018
2017: Castle Connolly Regional Top Doctor 2017
2016: Marquette University Distinguished Alumnus of the Year Award
2011: Arnold P. Gold Foundation Award
1989: Hornaday Vitreoretinal Award, Duke Eye Center
1988: Heed Foundation/Knapp Fellowship Award
1978: Phi Beta Kappa-Magna cum laude graduate
Selected Publications
Abbas, F.; Becker, S.; Jones, B. W.; Mure, L. S.; Panda, S.; Hanneken, A.; Vinberg, F. Revival of light signalling in the postmortem mouse and human retina. 2022, 606, 351-357.
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Hanneken, A.; Mercado, M.; Maher, P. Constitutive and Regulated Shedding of Soluble FGF Receptors Releases Biologically Active Inhibitors of FGF-2.. International Journal of Molecular Sciences 2021, 22, 2712.
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Mure, L. S.; Vinberg, F.; Hanneken, A.; Panda, S. Functional diversity of human intrinsically photosensitive retinal ganglion cells.. Science (New York, N.Y.) 2019, 366, 1251-1255.
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Hanneken, A.; Neikirk, T.; Johnson, J.; Kono, M. Biochemical Measurements of Free Opsin in Macular Degeneration Eyes: Examining the 11-CIS Retinal Deficiency Hypothesis of Delayed Dark Adaptation (An American Ophthalmological Society Thesis).. Transactions of the American Ophthalmological Society 2017, 115, T1.
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Anderson, D. M.; Ablonczy, Z.; Koutalos, Y.; Hanneken, A. M.; Spraggins, J. M.; Calcutt, M. W.; Crouch, R. K.; Caprioli, R. M.; Schey, K. L. Bis(monoacylglycero) phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas. Scientific Reports 2017, 7, 17352.
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Adler, L.; Boyer, N. P.; Anderson, D. M.; Spraggins, J. M.; Schey, K. L.; Hanneken, A. M.; Ablonczy, Z.; Crouch, R. K.; Koutalos, Y. Determination of N-retinylidene-N-retinylethanolamine (A2E) levels in central and peripheral areas of human retinal pigment epithelium. Photochemical & Photobiological Sciences 2015, 14, 1983-1990.
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