Source: Interfolio F180

Anne Hanneken

Associate Professor of Molecular Medicine
Department of Molecular Medicine


Research Focus

The focus of our macular degeneration research program is on improving the function of the cells that support the chemistry of vision, the rod and cone photoreceptors. With a unique multidisciplinary team of ophthalmologists, computational chemists, cell biologists and biochemists, we are using advanced computer modeling technology to design a treatment that will protect visual pigments in the photoreceptor cells and improve visual function. The focus of the research is to identify a treatment that will stabilize the delicate opsin proteins that activate the visual transduction cascade (a series of biochemical steps that are responsible for vision in all vertebrate species).


B.S. (Chemistry), Marquette University, 1978
M.D. (Medicine), Medical College of Wisconsin, 1984

Professional Experience


Associate Professor of Molecular Medicine, The Scripps Research Institute, La Jolla, CA.  Chairman:  Dr. Jim Paulson 

Associate Professor of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.  Chairman:  Drs. Ernest Beutler & Jeffery Kelly 

Associate Professor, Department of Cell Biology, The Scripps Research Institute, La Jolla, California. Chairman:  Dr. Sandra Schmidt 

Assistant Professor, Department of Cell Biology, The Scripps Research Institute, La Jolla, California. Chairman:  Dr. Sandra Schmidt 


Vice-President, Retina Consultants San Diego, California 

Physician & Surgeon: Scripps Memorial Hospital, La Jolla, California 

Vitreoretinal Surgeon, San Diego Vitreoretinal Associates

Assistant Adjunct Professor of Ophthalmology, Duke University, Durham, North Carolina

Other Joint Appointments Partner, Retina Consultants San Diego
Scripps Memorial Hospital, Vitreoretinal Surgeon

Awards & Professional Activities

2023: Castle Connolly Regional Top Doctor 2023

2022: Castle Connolly Regional Top Doctor 2022

2022: Wall Street Journal profile, “The Future of Everything”, A Spark of Life After Death in Sight Research (September 8th, 2022) by Ron Winslow. Overview of the research surrounding the 2022 Nature paper, Revival of light signaling in the postmortem mouse and human retina.   

Top 99% of all science publications, and top 95% of all Nature papers     

2021: Castle Connolly Regional Top Doctor 2021

2021: Castle Connolly Exceptional Women in Medicine

2021: Castle Connolly Regional Top Doctor 2021

2020: Castle Connolly Regional Top Doctor 2020

2020:  San Diego Top Doctor Award 2020

2019: Castle Connolly Regional Top Doctor 2019

2018: Castle Connolly Regional Top Doctor 2018

2017: Castle Connolly Regional Top Doctor 2017

2016:  Marquette University Distinguished Alumnus of the Year Award

2011:  Arnold P. Gold Foundation Award

1989:  Hornaday Vitreoretinal Award, Duke Eye Center

1988:  Heed Foundation/Knapp Fellowship Award

1978:  Phi Beta Kappa-Magna cum laude graduate

Selected Publications

Abbas, Fatima; Becker, Silke; Jones, Bryan W.; Mure, Ludovic S.; Panda, Satchidananda; Hanneken, Anne; Vinberg, Frans Revival of light signalling in the postmortem mouse and human retina. 2022, 606, 351-357.

Hanneken, Anne; Mercado, Maluz; Maher, Pamela Constitutive and Regulated Shedding of Soluble FGF Receptors Releases Biologically Active Inhibitors of FGF-2.. International Journal of Molecular Sciences 2021, 22, 2712.

Mure, Ludovic S.; Vinberg, Frans; Hanneken, Anne; Panda, Satchidananda Functional diversity of human intrinsically photosensitive retinal ganglion cells.. Science (New York, N.Y.) 2019, 366, 1251-1255.

Hanneken, Anne; Neikirk, Thomas; Johnson, Jennifer; Kono, Masahiro Biochemical Measurements of Free Opsin in Macular Degeneration Eyes: Examining the 11-CIS Retinal Deficiency Hypothesis of Delayed Dark Adaptation (An American Ophthalmological Society Thesis).. Transactions of the American Ophthalmological Society 2017, 115, T1.

Anderson, D. M.; Ablonczy, Z.; Koutalos, Y.; Hanneken, Anne M.; Spraggins, J. M.; Calcutt, M. W.; Crouch, R. K.; Caprioli, R. M.; Schey, K. L. Bis(monoacylglycero) phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas. Scientific Reports 2017, 7, 17352.

Adler, L.; Boyer, N. P.; Anderson, D. M.; Spraggins, J. M.; Schey, K. L.; Hanneken, Anne M.; Ablonczy, Z.; Crouch, R. K.; Koutalos, Y. Determination of N-retinylidene-N-retinylethanolamine (A2E) levels in central and peripheral areas of human retinal pigment epithelium. Photochemical & Photobiological Sciences 2015, 14, 1983-1990.