Source: Interfolio F180

M. Reza Ghadiri

Darlene V. Shiley Chair in Chemistry
Department of Chemistry


Research Focus

Organic, Bioorganic, and Materials Chemistry.

Our group is involved in a multidisciplinary research effort that uses disciplines ranging from synthetic organic and inorganic chemistry to materials science and recombinant DNA technology to develop novel methods for the rational design and construction of functional biomaterial-based structures. Our goal is to provide novel applications in the field of molecular and system engineering as well as advance our fundamental understanding of living chemical processes. Currently, research projects in our laboratory deal with various aspects of peptide and protein architecture and folding, design of synthetic receptors and enzymes, fabrication of novel biosensor arrays, self-replicating molecular systems, and self-organized nonlinear autocatalytic chemical networks and ecosystems selected references.


New Study by Scientists at TSRI Suggests an Answer for One of the Oldest Questions in Biology

Three TSRI Faculty Members Elected to AAAS

The Skaggs Institute Scientific Report


B.A. (Chemistry), University of Wisconsin-Milwaukee, 1982
Ph.D. (Chemistry), University of Wisconsin-Madison, 1987

Professional Experience

1992-1994 Assistant Professor, Scripps Research Institute
1995-1997 Associate Professor, Scripps Research Institute
1998-Present Professor, Scripps Research Institute

Awards & Professional Activities

1991 Arnold and Mabel Beckman Young Investigator Award, Beckman Foundation
1991 Searle Scholars Award, Searle Scholars Program
1993 Alfred P. Sloan Research Fellow, Alfred P. Sloan Foundation
1994 Eli Lilly Grantee, Lilly Foundation
1995 American Chemical Society Award in Pure Chemistry
1998 Feynman Prize in Nanotechnology, Foresight Institute
1999 Arthur C. Cope Scholar Award, American Chemical Society 
2001 Elected Fellow, The American Association for the Advancement of Science
2010 Vincent du Vigneaud Award, The American Peptide Society
2022 Ronald Breslow Award for Achievement in Biomimetic Chemistry, American Chemical Society

Selected Publications

Lin, V. S.; Motesharei, K.; Dancil, K. P.; Sailor, M. J.; Ghadiri, M. R. A porous silicon-based optical interferometric biosensor. Science 1997, 278, 840-843.

Severin, K.; Lee, David H.; Kennan, A. J.; Ghadiri, M. R. A Synthetic Peptide Ligase. Nature 1997, 389, 706-709.

Lee, David H.; Severin, K.; Yokobayashi, Yohei; Ghadiri, M. R. Emergence of symbiosis in peptide self-replication through a hypercyclic network. Nature 1997, 390, 591-594.

Severin, K.; Lee, David H.; Martinez, J. A.; Vieth, Michal; Ghadiri, M. R. Dynamic error correction in autocatalytic peptide networks. Angewandte Chemie-International Edition 1998, 37, 126-128.