Larry Gerace, PhD

Department of Molecular Medicine
California Campus

Scripps Research Joint Appointments

Faculty, Graduate Program

Research Focus

We are interested in how the functional organization of the cell nucleus governs animal physiology and human disease.  A major focus of our research group involves the nuclear envelope (NE), the membranous sub-domain of the ER that forms the nuclear boundary and regulates information flow between the nucleus and cytoplasm.  We are particularly interested in understanding a protein meshwork lining the NE- the nuclear lamina (NL)- that controls signaling for gene regulation, interphase chromosome organization and nuclear mechanics.  We seek to unravel the core functions of NL proteins, and to determine how mutations in these components lead to “laminopathies,” a spectrum of diseases that include muscular dystrophies, metabolic disorders, neuropathies and premature aging.  We also are pursuing discovery-based approaches to unveil new regulatory pathways modulated by the NL.  We are analyzing NL functions in stem cells and mouse genetic models with a spectrum of biochemical, imaging and molecular approaches. In some of our recent studies, for example, we have found that disruption of the NL-associated protein Lem2 in different mouse tissues leads to metabolic abnormalities, muscle degeneration and other abnormalities reminiscent of laminopathies.



Ph.D., The Rockefeller University, 1979

Professional Experience

2013-2017 Professor, Cell and Molecular Biology (CMB), Scripps Research
1987-2012 Professor, Cell Biology, Scripps Research

Awards & Professional Activities

1982-85 Searle Scholars Award; 1984-89, NIH Research Career Development Award; 1987-1990 & 1992-present Monitoring Editor, Journal of Cell Biology; 1986 Outstanding Young Scientist of Maryland; 1987 RR Bensley Award; 1988-1990 Section Editor, Current Opinion in Cell Biology; 1990 Co-chair, Program Committee for Annual Meeting of American Society for Cell Biology; 1991 Nominations Committee, American Society for Cell Biology; 1994 Co-chair, Molecular Cell Biology Gordon Conference; 1997 Organizer, Keystone Symposium on Functional Organization of the Nucleus; 1998-2005 Editorial Board, Molecular Biology of the Cell; 2000-2003 Keystone Symposia Advisory Board; 2002-2003 Editorial Board, Journal of Biological Chemistry; 2004-2008 Editorial Board, BMC Cell Biology; 2008-present, Associate Editor, BMC Cell Biology; 2011-present, Editorial Board, Nucleus; 2013-present, Member, Nuclear and Cytoplasmic Structure/Function and Dynamics NIH Study Section.

Selected References

All Publications

For a complete list of publications:

Huber, M.D., Vesely, P.W., Datta, K. and Gerace L. (2013) Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis. J. Cell Biol. 11:427-36. 

Naji, S., Ambrus, G., Cimermančič, P., Reyes, J.R., Johnson, J.R., Filbrandt, R., Huber, M.D. Vesely, P., Krogan, N.J., Yates III, J.R., Saphire, A.C. and Gerace, L.  (2012) Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. Mol. Cell Proteomics. 4:M111.015313

Hintersteiner, M., Ambrus-Aikelin, G., Bednenko, J., Schmied, M., Gstach, H., Seifert, J., Singer E., Gerace, L. and Auer, M. (2010) Identification of a small molecule inhibitor of importin beta mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries. ACS Chem. Biol. 5:967-79.

Huber, M., Guan, T. and Gerace, L. (2009) Overlapping functions of nuclear membrane proteins NET25 (Lem2) and emerin in regulation of ERK signaling in myoblast differentiation. Mol. Cell Biol. 29:5718-5728. 

Liu, G.H., Guan T., Datta K., Coppinger J., Yates J.,III. and Gerace, L. (2009) Regulation of myoblast differentiation by the nuclear envelope protein NET39. Mol. Cell Biol. 29:5800-5812.

Wodrich H., Cassany A., D’Angelo M.A., Guan T., Nemerow G. and Gerace L. (2006) Adenovirus core protein pVII is translocated  into the nucleus by multiple import receptor  pathways. J. Virology. 80:9608-9618.

Ohba, T., Schirmer, E.C., Nishimoto, T. and Gerace, L. (2004) Energy and temperature dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore. J. Cell Biol. 167:1051-1062.

Schirmer, E., Florens, L., Guan, T., Yates, J.R. and Gerace, L. (2003) Nuclear membrane proteins with potential disease links found by subtractive proteomics. Science. 301:1380-1382.

Cingolani, G., Bednenko, J., Gillespie, M.T. and Gerace, L.  (2002) Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta. Mol. Cell. 10:1345-1353.

Mahajan, R., Gerace, L. and Melchior, F. (1998) Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association. J. Cell Biol. 140:259-270.