Edward Roberts, PhD

Professor
Department of Molecular Medicine
California Campus



Scripps Research Joint Appointments

Professor, Department of Chemistry

Education

Ph.D. (Organic Chemistry), Newcastle University, 1982
B.S. (Biochemistry), University of Sussex, 1979

Professional Experience

2003-2004 Senior Vice President and Chief Scientific Officer, F. Hoffmann-La Roche Ltd.
1999-2002 Senior Vice President and Head of Discovery Chemistry, F. Hoffmann-La Roche Ltd.
1994-1999 Director, Research and Development, AstraZeneca
1986-1993 Neuroscience Research Centre at Addenbrookes Hospital, Parke-Davis
1983-1985 Assistant Professor, University of Wales, Cardiff

Selected References

All Publications

Burkert, K., Zellmann, T., Meier, R., Kaiser, A., Stichel, J., Meiler, J., Mittapalli, G. K., Roberts, E. & Beck-Sickinger, A. G. A deep hydrophobic binding cavity is the main interaction for different Y2R antagonists. (2017). ChemMedChem, 12(1), 75-85.

Harris, R. A., Bajo, M., Bell, R. L., Blednov, Y. A., Varodayan, F. P., Truitt, J. M., de Guglielmo, G., Lasek, A. W., Logrip, M. L. & Vendruscolo, L. F. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents. (2017). Journal of Neuroscience, 37(5), 1139-1155. PMCID: PMC5296793.

Xie, J. Y., De Felice, M., Kopruszinski, C. M., Eyde, N., LaVigne, J., Remeniuk, B., Hernandez, P., Yue, X., Goshima, N., Ossipov, M., King, T., Streicher, J. M., et al. Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention. (2017). Cephalalgia, 37(8), 780-794.

Scott, F. L., Clemons, B., Brooks, J., Brahmachary, E., Powell, R., Dedman, H., Desale, H. G., Timony, G. A., Martinborough, E., Rosen, H., Roberts, E., Boehm, M. F., et al. Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P(1)) and receptor-5 (S1P(5)) agonist with autoimmune disease-modifying activity. (2016). British Journal of Pharmacology, 173(11), 1778-1792. PMCID: PMC4867749.

Dillmann, C., Ringel, C., Ringleb, J., Mora, J., Olesch, C., Fink, A. F., Roberts, E., Brüne, B. & Weigert, A. S1PR4 signaling attenuates ILT 7 internalization to limit IFN-α production by human plasmacytoid dendritic cells. (2016). Journal of Immunology, 196(4), 1579-1590.

Guerrero, M., Urbano, M. & Roberts, E. Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015). (2016). Expert Opinion on Therapeutic Patents, 26(4), 455-470.

Schreiber, S. L., Kotz, J. D., Li, M., Aube, J., Austin, C. P., Reed, J. C., Rosen, H., White, E. L., Sklar, L. A., Lindsley, C. W., Alexander, B. R., Bittker, J. A., et al. Advancing biological understanding and therapeutics discovery with small-molecule probes. (2015). Cell, 161(6), 1252-1265. PMCID: PMC4564295.

Urbano, M., Guerrero, M., Rosen, H. & Roberts, E. Antagonists of the kappa opioid receptor. (2014). Bioorganic & Medicinal Chemistry Letters, 24(9), 2021-2032.

Mittapalli, G. K. & Roberts, E. Ligands of the neuropeptide Y Y2 receptor. (2014). Bioorganic & Medicinal Chemistry Letters, 24(2), 430-441. PMCID: PMC4672871.

Mittapalli, G. K. & Roberts, E. Structure activity relationships of novel antiepileptic drugs. (2014). Current Medicinal Chemistry, 21(6), 722-754.