Source: Interfolio F180
Renan V.H. de Carvalho, PhD
Research Focus
The Laboratory of Immune Longevity (LIL) focuses on uncovering the drivers of long-lived immune responses. Our research spans a range of interests, but our top priority is understanding plasma cell longevity and the determinants of durable humoral immunity. Using transgenic mouse models alongside infection and immunization strategies, we aim to identify the mechanisms that lead to successful, long-lived immunity - and why such outcomes often fail to be accomplished.
Education
2014-2019 Ph.D. (Sciences, focused on Basic and Applied Immunology), University of São Paulo, Brazil
2008-2014 B.S. (Pharmacy/Biochemistry), Federal University of Juiz de Fora (UFJF), Brazil
Professional Experience
2025-Current Tenure-track Assistant Professor, Head of the Laboratory of Immune Longevity, Department of Microbiology & Immunology, The Scripps Research Institute, La Jolla, CA, USA.
2020-2025 Postdoctoral Fellow, The Rockefeller University, New York, NY, USA.
2019-2020 Postdoctoral Fellow, University of São Paulo, São Paulo. Brazil.
Awards & Professional Activities
2025- IUIS Rising Star Award, The International Union of Immunological Societies
2023- Cancer Research Institute (CRI), Irvington Postdoctoral Fellowship.
2020- Human Frontier Science Program (HFSP), Long-term Postdoctoral Fellowship.
2020- The Great CAPES Thesis Award, “Carlos Ribeiro Justiniano Chagas Award”, in Life Sciences.
2019- Walter Colli Award, Brazilian Society of Protozoology.
2018- Society of Leukocyte Biology Award, Brazilian Society of Immunology.
2017- Thereza Kipnis Award, Brazilian Society of Immunology.
2017- Ziegman Brenner Award, Brazilian Society of Protozoology.
Selected Publications
Zhang, Fengwen; Jenkins, Jesse; de Carvalho, Renan V H; Nakandakari-Higa, Sandra; Chen, Teresia; Abernathy, Morgan E.; Baharani, Viren A.; Nyakatura, Elisabeth K.; Andrew, David; Lebedeva, Irina V.; Lorenz, Ivo C.; Hoffmann, H-Heinric H.; Rice, Charles M.; Victora, Gabriel D.; Barnes, Christopher O.; Hatziioannou, Theodora; Bieniasz, Paul D. Pan-sarbecovirus prophylaxis with human anti-ACE2 monoclonal antibodies. Nature Microbiology 2023, 8, 1051-1063.
de Carvalho, Renan V H; Ersching, Jonatan; Barbulescu, Alexandru; Hobbs, Alvaro; Castro, Tiago B R; Mesin, Luka; Jacobsen, Johanne T.; Phillips, Brooke K.; Hoffmann, Hans-Heinric H.; Parsa, Roham; Canesso, Maria Cecilia C; Nowosad, Carla R.; Feng, Allan; Leist, Sarah R.; Baric, Ralph S.; Yang, Emily; Utz, P J.; Victora, Gabriel D. Clonal replacement sustains long-lived germinal centers primed by respiratory viruses. Cell 2023, 186, 131-146.e13.
de Carvalho, Renan V H; Lima-Junior, Djalma S.; da Silva, Marcus Vinícius G; Dilucca, Marisa; Rodrigues, Tamara S.; Horta, Catarina V.; Silva, Alexandre L N; da Silva, Patrick F.; Frantz, Fabiani G.; Lorenzon, Lucas B.; Souza, Marcos Miche M.; Almeida, Fausto; Cantanhêde, Lilian M.; Ferreira, Ricardo de Godoi M; Cruz, Angela K.; Zamboni, Dario S. Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition. Nature Communications 2019, 10, 5273.
de Castro-Jorge, Luiza* A.; de Carvalho, Renan V H*; Klein, Taline M.; Hiroki, Carlos H.; Lopes, Alexandre H.; Guimarães, Rafaela M.; Fumagalli, Marcílio Jorg J.; Floriano, Vitor G.; Agostinho, Mayara R.; Slhessarenko, Renata Dezengrin D.; Ramalho, Fernando Silv S.; Cunha, Thiago M.; Cunha, Fernando Q.; da Fonseca, Benedito A L; Zamboni, Dario S. *co first author. The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus. PLoS Pathogens 2019, 15, e1007934.
de Carvalho, Renan V H; Andrade, Warrison A.; Lima-Junior, Djalma S.; Dilucca, Marisa; de Oliveira, Caroline V.; Wang, Kun; Nogueira, Paula M.; Rugani, Jeronimo N.; Soares, Rodrigo P.; Beverley, Stephen M.; Shao, Feng; Zamboni, Dario S. Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome. Cell Reports 2019, 26, 429-437.e5.