Chunlei Wu, PhD
Professor
Department of Integrative Structural and Computational Biology
Research Focus
Research areas
? Biomedical knowledgebase infrastructure and inference engine
? Semantic knowledge presentation and integration
? Biomedical resource discovery
? Clinical informatics
? Crowdsourcing in biological research
? Scientific data management
? Gene network and pathway analysis
? Large-scale genomic data analysis
Scientific applications developed
? http://biogps.org (Gene-centric resource portal)
? https://mygene.info (Gene-centric API, ~30M hits per month)
? https://myvariant.info (Genetic Variant API, ~7M hits per month)
? https://mychem.info (Chemical/drug-centric API)
? https://mydisease.info (Disease-centric API)
? https://biothings.io (Generic SDK to power APIs above)
? https://smart-api.info (Biomedical API registry and semantic integration)
? https://discovery.biothings.io (Biomedical resource discovery)
Select Publications
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Xin, Jiwen; Afrasiabi, C.; Lelong, S.; Adesara, J.; Tsueng, G.; Su, Andrew; Wu, Chunlei Cross-linking BioThings APIs through JSON-LD to facilitate knowledge exploration. BMC Bioinformatics 2018, 19.
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Xin, Jiwen; Mark, A.; Afrasiabi, C.; Tsueng, G.; Juchler, M.; Gopal, N.; Stupp, G. S.; Putman, T. E.; Ainscough, B. J.; Griffith, O. L.; Torkamani, Ali; Whetzel, P. L.; Mungall, C. J.; Mooney, S. D.; Su, Andrew; Wu, Chunlei High-performance web services for querying gene and variant annotation. Genome Biology 2016, 17.
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Liu, X.; Wu, Chunlei; Li, C.; Boerwinkle, E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice-site SNVs. Human Mutation 2016, 37, 235-241.
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Wu, Chunlei; Jin, Xuefeng; Tsueng, Ginger; Afrasiabi, Cyrus; Su, Andrew I. BioGPS: Building your own mash-up of gene annotations and expression profiles. Nucleic Acids Research 2016, 44, D313-D316.
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Tsunemoto, R.; Lee, Sohyon; Sztics, A.; Chubukov, Pavel A.; Sokolova, I.; Blanchard, Joel W.; Eadel, K. T.; Bruggemann, Jacob J.; Wu, Chunlei; Torkamani, Ali; Sanna, Pietro P.; Baldwin, Kristin K. Diverse reprogramming codes for neuronal identity. Nature 2018, 557, 375-380.
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Wu, Chunlei; Macleod, Ian; Su, Andrew I. BioGPS and MyGene.info: Organizing online, gene-centric information. Nucleic Acids Research 2013, 41, D561-D565.
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Wu, Chunlei; Orozco, Camilo; Boyer, Jason; Leglise, Marc; Goodale, James; Batalov, Serge; Hodge, Christopher L.; Haase, James; Janes, Jeff; Huss III, Jon W.; Su, Andrew I. BioGPS: an extensible and customizable portal for queryingand organizing gene annotation resources. Genome Biology 2009, 10, R130.
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Wu, Chunlei; Orozco, C.; Boyer, J.; Leglise, M.; Goodale, J.; Batalov, S.; Hodge, C. L.; Haase, J.; Janes, J.; Huss, J. W.; Su, Andrew Biogps: An extensible and customizable portal for querying and organizing gene annotation resources. Genome Biology 2009, 10, R130.
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