Source: Interfolio F180
Sumit Chanda
Research Focus
The Chanda Lab exploits systems-based approaches and cutting-edge technologies to study the virus-host interface and innate immunity, with a focus on RNA viruses that pose a pandemic threat. Basic findings drive drug discovery efforts through our group at Calibr, the translational research arm of Scripps, including the development of next-generation antivirals, adjuvants for vaccines, and immunotherapies. Our research efforts are supported by the Gates Foundation, the DoD, the Martin Delaney Collaboratory, AViDD and other NIH contracts, cooperative agreements and grants. The group has also partnered with major pharmaceutical and biotech companies for early-phase drug discovery in the field of antivirals and inflammatory diseases. Additionally, we are proud to be part of the development team behind Metascape, a web-based portal designed to provide a comprehensive gene list annotation and analysis resource for experimental biologists.
Education
Ph.D., Stanford University, 2001Professional Experience
2021, Professor, Immunology & Microbiology, Scripps Research2015, Director of the Immunity and Pathogenesis Program, Sanford-Burnham Medical Research Institute
2013, Professor, Sanford-Burnham Medical Research Institute
2007, Associate Professor, Sanford-Burnham Medical Research Institute
Group Leader, Division of Cellular Genomics, Genomics Institute of the Novartis Research Foundation
Postdoctoral training, Genomics Institute of the Novartis Research Foundation
Selected Publications
Juchem, K. W.; Gounder, A. P.; Gao, J. P.; Seccareccia, E.; Yeddula, N.; Huffmaster, N. J.; Côté-Martin, A.; Fogal, S. E.; Souza, D.; Wang, S. S.; Glynn, E.; Yung, I.; Ritchie, J.; Li, L.; Zheng, J.; Mbow, M. L.; Li, J.; Chanda, S. K. NFAM1 Promotes Pro-Inflammatory Cytokine Production in Mouse and Human Monocytes. 2021, 12, 773445.
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Chen, B. R.; Deshpande, A.; Barbosa, K.; Kleppe, M.; Lei, X.; Yeddula, N.; Vela, P. S.; Campos, A. R.; Wechsler-Reya, R. J.; Bagchi, A.; Meshinchi, S.; Eaves, C.; Jeremias, I.; Haferlach, T.; Frank, D. A.; Ronai, Z.; Chanda, S.; Armstrong, S. A.; Adams, P. D.; Levine, R. L.; Deshpande, A. J. A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML. 2021, 137, 3403-3415.
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Stoneham, C. A.; Langer, S.; De Jesus, P. D.; Wozniak, J. M.; Lapek, J.; Deerinck, T.; Thor, A.; Pache, L.; Chanda, S. K.; Gonzalez, D. J.; Ellisman, M.; Guatelli, J. A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor. 2021, 17, e1009409.
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Yuan, S.; Yin, X.; Meng, X.; Chan, J. F.; Ye, Z. W.; Riva, L.; Pache, L.; Chan, C. C.; Lai, P. M.; Chan, C. C.; Poon, V. K.; Lee, A. C.; Matsunaga, N.; Pu, Y.; Yuen, C. K.; Cao, J.; Liang, R.; Tang, K.; Sheng, L.; Du, Y.; Xu, W.; Lau, C. Y.; Sit, K. Y.; Au, W. K.; Wang, R.; Zhang, Y. Y.; Tang, Y. D.; Clausen, T. M.; Pihl, J.; Oh, J.; Sze, K. H.; Zhang, A. J.; Chu, H.; Kok, K. H.; Wang, D.; Cai, X. H.; Esko, J. D.; Hung, I. F.; Li, R. A.; Chen, H.; Sun, H.; Jin, D. Y.; Sun, R.; Chanda, S. K.; Yuen, K. Y. Clofazimine broadly inhibits coronaviruses including SARS-CoV-2. 2021, 593, 418-423.
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Madden, P. J.; Arif, M. S.; Becker, M. E.; McRaven, M. D.; Carias, A. M.; Lorenzo-Redondo, R.; Xiao, S.; Midkiff, C. C.; Blair, R. V.; Potter, E. L.; Martin-Sancho, L.; Dodson, A.; Martinelli, E.; Todd, J. M.; Villinger, F. J.; Chanda, S. K.; Aye, P. P.; Roy, C. J.; Roederer, M.; Lewis, M. G.; Veazey, R. S.; Hope, T. J. Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus Macaques. 2021, 12, 810047.
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Martin-Sancho, L.; Lewinski, M. K.; Pache, L.; Stoneham, C. A.; Yin, X.; Becker, M. E.; Pratt, D.; Churas, C.; Rosenthal, S. B.; Liu, S.; Weston, S.; De Jesus, P. D.; O'Neill, A. M.; Gounder, A. P.; Nguyen, C.; Pu, Y.; Curry, H. M.; Oom, A. L.; Miorin, L.; Rodriguez-Frandsen, A.; Zheng, F.; Wu, C.; Xiong, Y.; Urbanowski, M.; Shaw, M. L.; Chang, M. W.; Benner, C.; Hope, T. J.; Frieman, M. B.; García-Sastre, A.; Ideker, T.; Hultquist, J. F.; Guatelli, J.; Chanda, S. K. Functional landscape of SARS-CoV-2 cellular restriction. 2021, 81, 2656-2668.e8.
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