Sergio Catz, PhD

Department of Molecular Medicine



Ph.D., University of Buenos Aires, 1997
B.Sc., University of Buenos Aires, 1991

Professional Experience

2017-2017 Associate Professor, Molecular Medicine, Scripps Research
1998-2017 Associate Professor, Molecular and Experimental Medicine (MEM), Scripps Research

Selected References

All Publications

Johnson, J. L., Ramadass, M., Rahman, F., Meneses-Salas, E., Zgajnar, N. R., Gontijo, R. C., Zhang, J. Z., Kiosses, W. B., Zhu, Yfpp, Hedrick, C. C., Perego, M., Gunton, J. E., et al. The atypical small GTPase GEM/Kir is a negative regulator of the NADPH oxidase and NETs production through macroautophagy. (2021). Journal of Leukocyte Biology, 110(4), 629-649.

Zeng, F. R., Chen, Z. Z., Chen, R., Shufesky, W. J., Bandyopadhyay, M., Camirand, G., Oberbarnscheidt, M. H., Sullivan, M. L. G., Baty, C. J., Yang, M. Q., Calderon, M., Stolz, D. B., et al. Graft-derived extracellular vesicles transported across subcapsular sinus macrophages elicit B cell alloimmunity after transplantation. (2021). Science Translational Medicine, 13.

Rahman, F., Johnson, J. L., Zhang, J. Z., He, J., Pestonjamasp, K., Cherqui, S. & Catz, S. D. DYNC1LI2 regulates localization of the chaperone-mediated autophagy receptor LAMP2A and improves cellular homeostasis in cystinosis. (2021). Autophagy,

Karmakar, M., Minns, M., Greenberg, E. N., Diaz-Aponte, J., Pestonjamasp, K., Johnson, J. L., Rathkey, J. K., Abbott, D. W., Wang, K., Shao, F., Catz, S. D., Dubyak, G. R., et al. N-GSDMD trafficking to neutrophil organelles facilitates IL-1 beta release independently of plasma membrane pores and pyroptosis. (2020). Nature Communications, 11. PMCID: PMC7200749.

Catz, S. D. & McLeish, K. R. Therapeutic targeting of neutrophil exocytosis. (2020). Journal of Leukocyte Biology,

Rohwedder, I., Kurz, A. R. M., Pruenster, M., Immler, R., Pick, R., Eggersmann, T., Klapproth, S., Johnson, J. L., Alsina, S. M., Lowell, C. A., Mocsai, A., Catz, S. D., et al. Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration. (2019). Haematologica, 105(7), 1845-1856. PMCID: PMC7327629.

Zhang, J., He, J., Johnson, J. L., Napolitano, G., Ramadass, M., Rahman, F. & Catz, S. D. Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency. (2019). Autophagy, 15(10), 1738-1756.

Lobry, T., Miller, R., Nevo, N., Rocca, C. J., Zhang, J., Catz, S. D., Moore, F., Thomas, L., Pouly, D., Bailleux, A., Guerrera, I. C., Gubler, M. C., et al. Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis. (2019). Kidney International, 96(2), 350-362.

Ramadass, M., Johnson, J. L., Marki, A., Zhang, J., Wolf, D., Kiosses, W. B., Pestonjamasp, K., Ley, K. & Catz, S. D. The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration. (2019). Journal of Leukocyte Biology, 105(6), 1209-1224. PMCID: PMC6543538.

Zhang, J., He, J., Johnson, J. L., Rahman, F., Gavathiotis, E., Cuervo, A. M. & Catz, S. D. Chaperone-mediated autophagy upregulation rescues megalin expression and localization in cystinotic proximal tubule cells. (2019). Frontiers in Endocrinology, 10.