Sergio Catz, PhD

Department of Molecular Medicine
California Campus


Ph.D., University of Buenos Aires, 1997
B.Sc., University of Buenos Aires, 1991

Professional Experience

2017-2017 Associate Professor, Molecular Medicine, Scripps Research
1998-2017 Associate Professor, Molecular and Experimental Medicine (MEM), Scripps Research

Selected References

All Publications

Ley, K., Hoffman, H. M., Kubes, P., Cassatella, M. A., Zychlinsky, A., Hedrick, C. C. & Catz, S. D. Neutrophils: New insights and open questions. (2018). Science Immunology, 3.

Kurz, A. R. M., Catz, S. D. & Sperandio, M. Noncanonical hippo signalling in the regulation of leukocyte function. (2018). Trends in Immunology, 39(8), 656-669.

Zhang, J., Johnson, J. L., He, J., Napolitano, G., Ramadass, M., Rocca, C., Kiosses, W. B., Bucci, C., Xin, Q., Gavathiotis, E., Cuervo, A. M., Cherqui, S., et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. (2017). Journal of Biological Chemistry, 292(25), 10328-10346. PMCID: PMC5481548.

Catz, S. D. Editorial: The secrets of secretion. (2017). Journal of Leukocyte Biology, 102(1), 4-6.

Johnson, J. L., Ramadass, M., Haimovich, A., McGeough, M. D., Zhang, J., Hoffman, H. M. & Catz, S. D. Increased neutrophil secretion induced by NLRP3 mutation links the inflammasome to azurophilic granule exocytosis. (2017). Frontiers in Cellular and Infection Microbiology, 7.

Ramadass, M., Johnson, J. L. & Catz, S. D. Rab27a regulates GM-CSF-dependent priming of neutrophil exocytosis. (2017). Journal of Leukocyte Biology, 101(3), 693-702.

Rega, L. R., Polishchuk, E., Montefusco, S., Napolitano, G., Tozzi, G., Zhang, J., Bellomo, F., Taranta, A., Pastore, A., Polishchuk, R., Piemonte, F., Medina, D. L., et al. Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells. (2016). Kidney International, 89(4), 862-873.

Johnson, J. L., Ramadass, M., He, J., Brown, S. J., Zhang, J., Abgaryan, L., Biris, N., Gavathiotis, E., Rosen, H. & Catz, S. D. Identification of neutrophil exocytosis inhibitors (Nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: druggability of the small GTPase Rab27a. (2016). Journal of Biological Chemistry, 291(50), 25965-25982. PMCID: PMC5207069.

Kurz, A. R. M., Pruenster, M., Rohwedder, I., Ramadass, M., Schafer, K., Harrison, U., Gouveia, G., Nussbaum, C., Immler, R., Wiessner, J. R., Margraf, A., Lim, D. S., et al. MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. (2016). Journal of Clinical Investigation, 126(11), 4125-4139. PMCID: PMC5096904.

Ramadass, M. & Catz, S. D. Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation. (2016). Immunological Reviews, 273(1), 249-265.