Sergio Catz, PhD

Department of Molecular Medicine
California Campus



Ph.D., University of Buenos Aires, 1997
B.Sc., University of Buenos Aires, 1991

Professional Experience

2017-2017 Associate Professor, Molecular Medicine, Scripps Research
1998-2017 Associate Professor, Molecular and Experimental Medicine (MEM), Scripps Research

Selected References

All Publications

Zhang, J., He, J., Johnson, J. L., Rahman, F., Gavathiotis, E., Cuervo, A. M. & Catz, S. D. Chaperone-mediated autophagy upregulation rescues megalin expression and localization in cystinotic proximal tubule cells. (2019). Frontiers in Endocrinology, 10.

Zhang, J., He, J., Johnson, J. L., Napolitano, G., Ramadass, M., Rahman, F. & Catz, S. D. Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency. (2019). Autophagy, 15(10), 1738-1756.

Lobry, T., Miller, R., Nevo, N., Rocca, C. J., Zhang, J., Catz, S. D., Moore, F., Thomas, L., Pouly, D., Bailleux, A., Guerrera, I. C., Gubler, M. C., et al. Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis. (2019). Kidney International, 96(2), 350-362.

Ramadass, M., Johnson, J. L., Marki, A., Zhang, J., Wolf, D., Kiosses, W. B., Pestonjamasp, K., Ley, K. & Catz, S. D. The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration. (2019). Journal of Leukocyte Biology, 105(6), 1209-1224. PMCID: PMC6543538.

Ley, K., Hoffman, H. M., Kubes, P., Cassatella, M. A., Zychlinsky, A., Hedrick, C. C. & Catz, S. D. Neutrophils: New insights and open questions. (2018). Science Immunology, 3.

Kurz, A. R. M., Catz, S. D. & Sperandio, M. Noncanonical hippo signalling in the regulation of leukocyte function. (2018). Trends in Immunology, 39(8), 656-669.

Zhang, J., Johnson, J. L., He, J., Napolitano, G., Ramadass, M., Rocca, C., Kiosses, W. B., Bucci, C., Xin, Q., Gavathiotis, E., Cuervo, A. M., Cherqui, S., et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. (2017). Journal of Biological Chemistry, 292(25), 10328-10346. PMCID: PMC5481548.

Catz, S. D. Editorial: The secrets of secretion. (2017). Journal of Leukocyte Biology, 102(1), 4-6.

Johnson, J. L., Ramadass, M., Haimovich, A., McGeough, M. D., Zhang, J., Hoffman, H. M. & Catz, S. D. Increased neutrophil secretion induced by NLRP3 mutation links the inflammasome to azurophilic granule exocytosis. (2017). Frontiers in Cellular and Infection Microbiology, 7.

Ramadass, M., Johnson, J. L. & Catz, S. D. Rab27a regulates GM-CSF-dependent priming of neutrophil exocytosis. (2017). Journal of Leukocyte Biology, 101(3), 693-702.