Bryan Briney, PhD
Scripps Research Joint Appointments
Education
Ph.D. (Microbiology and Immunology), Vanderbilt University, 2012B.S. (Biochemistry and Cell Biology), University of California, San Diego, 2007
Professional Experience
2017-2018 Assistant Professor of Immunology and Microbiology, Immunology and Microbiology, Scripps Research2015-2017 Assistant Professor of IMS, Immunology and Microbial Science (IMS), Scripps Research
2012-2015 Postdoctoral Fellow, Scripps Research
Selected References
Briney, B., Inderbitzin, A., Joyce, C. & Burton, D. R. Commonality despite exceptional diversity in the baseline human antibody repertoire. (2019). Nature, 566(7744), 393-397.
Umotoy, J., Bagaya, B. S., Joyce, C., Schiffner, T., Menis, S., Saye-Francisco, K. L., Biddle, T., Mohan, S., Vollbrecht, T., Kalyuzhniy, O., Madzorera, S., Kitchin, D., et al. Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan. (2019). Immunity, 51(1), 141-154. PMCID: PMC6642152.
Voss, J. E., Gonzalez-Martin, A., Andrabi, R., Fuller, R. P., Murrell, B., McCoy, L. E., Porter, K., Huang, D., Li, W., Sok, D., Le, K., Briney, B., et al. Reprogramming the antigen specificity of B cells using genome-editing technologies. (2019). Elife, 8. PMCID: PMC6355199.
Andrabi, R., Su, C. Y., Liang, C. H., Shivatare, S. S., Briney, B., Voss, J. E., Nawazi, S. K., Wu, C. Y., Wong, C. H. & Burton, D. R. Glycans function as anchors for antibodies and help drive HIV broadly neutralizing antibody development. (2017). Immunity, 47(3), 524-537. PMCID: PMC5613947.
Magnani, D. M., Rogers, T. F., Beutler, N., Ricciardi, M. J., Bailey, V. K., Gonzalez-Nieto, L., Briney, B., Sok, D., Le, K., Strubel, A., Gutman, M. J., Pedreno-Lopez, N., et al. Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques. (2017). Science Translational Medicine, 9.
Rogers, T. F., Goodwin, E. C., Briney, B., Sok, D., Beutler, N., Strubel, A., Nedellec, R., Le, K., Brown, M. E., Burton, D. R. & Walker, L. M. Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors. (2017). Science Immunology, 2. PMCID: PMC5892203.
Havenar-Daughton, C., Carnathan, D. G., Torrents de la Peña, A., Pauthner, M., Briney, B., Reiss, S. M., Wood, J. S., Kaushik, K., van Gils, M. J., Rosales, S. L., van der Woude, P., Locci, M., et al. Direct probing of germinal center responses reveals immunological features and bottlenecks for neutralizing antibody responses to HIV Env trimer. (2016). Cell Reports, 17(9), 2195-2209. PMCID: PMC5142765.
Steichen, J. M., Kulp, D. W., Tokatlian, T., Escolano, A., Dosenovic, P., Stanfield, R. L., McCoy, L. E., Ozorowski, G., Hu, X., Kalyuzhniy, O., Briney, B., Schiffner, T., et al. HIV vaccine design to target germline precursors of glycan-dependent broadly neutralizing antibodies. (2016). Immunity, 45(3), 483-496. PMCID: PMC5040827.
Jardine, J. G., Kulp, D. W., Havenar-Daughton, C., Sarkar, A., Briney, B., Sok, D., Sesterhenn, F., Ereno-Orbea, J., Kalyuzhniy, O., Deresa, I., Hu, X., Spencer, S., et al. HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogene. (2016). Science, 351(6280), 1458-1463. PMCID: PMC4872700.
Stapleton, J. A., Kim, J., Hamilton, J. P., Wu, M., Irber, L. C., Maddamsetti, R., Briney, B., Newton, L., Burton, D. R., Brown, C. T., Chan, C., Buell, C. R., et al. Haplotype-phased synthetic long reads from short-read sequencing. (2016). PLoS One, 11. PMCID: PMC4720449.