Michael J. Bollong, PhD
Scripps Research Joint Appointments
Research Focus
Using high throughput small molecule screens coupled with downstream target identification experiments, we identify new drug-like molecules and ligandable targets to study and to therapeutically target the biological responses governing mammalian regeneration and cell stress signaling.
We complement these efforts with an additional focus on developing new high throughput and molecular diversity-based methods to accelerate biological discovery. To this end, we are developing platforms for profiling inhibitor-enzyme interactions en masse, deconvoluting the cellular targets for bioactive small molecules and peptides, and leveraging the chemical diversity present in existing chemical libraries as a source of new reactivity for covalent inhibitor design.
Education
Ph.D. (Chemical Biology), Scripps Research, 2016B.S. (Biochemistry and Cell Biology), University of California, San Diego, 2009
Professional Experience
2017-2019 Scripps Fellow, Chemistry, Scripps ResearchSelected References
Zambaldo C, Vinogradova EV, Qi X, Iaconelli J, Suciu RM, Koh M, Senkane K, Chadwick SR, Sanchez BB, Chen JS, Chatterjee AK, Liu P, Schultz PG, Cravatt BF, Bollong MJ. 2-Sulfonyl pyridines as tunable, cysteine-reactive electrophiles. JACS. 2020 Apr 17.
Iaconelli J, Ibrahim L, Chen E, Hull M, Schultz PG, Bollong MJ. Small molecule stimulators of NRF1 transcriptional activity. Chembiochem. In press. PMID:31596542
Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. 2018 Oct;562(7728):600-604. PMID:30323285 *F1000 recommended
Bollong MJ, Pietilä M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. PNAS U S A. 2017 Oct 30. PMID:29087350
Bollong MJ, Yang B, Vergani N, Beyer BA, Chin EN, Zambaldo C, Wang D, Chatterjee AK, Lairson LL, Schultz PG. Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis. PNAS U S A. 2017 May 2;114(18):4679-4684. PMID:28416697 *F1000 recommended
Bollong MJ, Yun H, Sherwood L, Woods AK, Lairson LL, Schultz PG. A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer. ACS Chem Biol. 2015 Oct 16;10(10):2193-8. PMID:26270491