Source: Interfolio F180
Hiroshi Asahara, MD, PhD
Research Focus
As a molecular biologist and orthopedic surgeon, Dr. Asahara's research focuses on examining the precise mechanism of chromatin-dependent gene regulation related to limb development. Combining these new findings in molecular and developmental biology, with clinical research in the field of locomotive science, our aim is to develop innovative new therapies that will benefit patients with arthritis, bone tumor and spinal cord injuries.
Education
Ph.D., Okayama University, 1997
M.D. (Medicine), Okayama University, Medical School, 1992
Professional Experience
2017-2023 Professor of MCB, Molecular and Cellular Biology (MCB), Scripps Research
2015-2017 Professor of Molecular and Experimental Medicine, Molecular and Experimental Medicine (MEM), Scripps Research
2008-2015 Associate Professor of Molecular and Experimental Medicine, Molecular and Experimental Medicine (MEM), Scripps Research
2002-2008 Assistant Professor of Molecular and Experimental Medicine, Molecular and Experimental Medicine (MEM), Scripps Research
2000-2002 Staff Scientist, Salk Institute for Biological Studies
-2000 Postdoctoral Fellow, Salk Institute for Biological Studies
-1999 Postdoctoral Fellow, Harvard Medical School, Harvard University
Awards & Professional Activities
2000, Arthritis National Research Foundation Grant Award
2002, Hulda Irene Arthritis Investigator Award
2002, Arthritis Investigator Award, Arthritis Foundation
2004, Arthritis Foundation, Molecular Immunology Study Section
2004, Ad Hoc member, NIH MOSS Study Section, NIH SBDD Study Section
Selected Publications
Asahara, Hiroshi; Chiba, Tomoki; D’Lima, Darryl; Fuku, Noriyuki; Kurimoto, Ryota; Lotz, Martin; Ma, Shang; Morrison, Errol; Nakamichi, Ryo; Nonoyama, Takayuki; Ohzono, Hiroki; Olmer, Merissa; Ozaki, Toshifumi; Patapoutian, Ardem; Pitsiladis, Yannis P.; Shukunami, Chisa; Wang, Guan The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance. Science Translational Medicine 2022, 14.
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Tsutsumi, Hiroki; Tanaka, Yoko; Tabata, Yusuke; Shinohara, Masahiro; Nishida, Keiichiro; Nakamichi, Ryo; Mokuda, Sho; Matsuzaki, Tokio; Matsushima, Takahide; Lotz, Martin K.; Liu, Lin; Kurimoto, Ryota; Ito, Yoshiaki; Inotsume, Maiko; Ayabe, Fumiaki; Asahara, Hiroshi Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2a expression and coordinately regulate cartilage homeostasis.. Nature communications 2021, 4148.
Asahara, Hiroshi; Chiba, Tomoki; Ito, Yoshiaki; Kurimoto, Ryota; Matsushima, Takahide; Miyata, Kohei; Suzuki, Tsutomu; Tomita, Kozo; Yano, Yuki; Yashiro, Yuka The tRNA pseudouridine synthase TruB1 regulates the maturation of let-7 miRNA.. EMBO Journal 2020, 39, e104708.
Mochizuki, Y.; Chiba, T.; Kataoka, K.; Yamashita, S.; Sato, T.; Kato, T.; Takahashi, K.; Miyamoto, T.; Kitazawa, M.; Hatta, T.; Natsume, T.; Takai, S.; Asahara, Hiroshi Combinatorial CRISPR/Cas9 approach to elucidate a far-upstream enhancer complex for tissue-specific Sox9 expression. Developmental Cell 2018, 46, 794-806.
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Inui, M.; Mokuda, S.; Sato, T.; Tamano, M.; Takada, S.; Asahara, Hiroshi Dissecting the roles of miR-140 and its host gene. Nature Cell Biology 2018, 20, 516-518.
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Ito, Y.; Inoue, A.; Seers, T.; Hato, Y.; Igarashi, A.; Toyama, T.; Taganov, K. D.; Boldin, M. P.; Asahara, Hiroshi Identification of targets of tumor suppressor microRNA-34a using a reporter library system. Proceedings of the National Academy of Sciences of the United States of America 2017, 114, 3927-3932.
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