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Selected peer-reviewed publications

  1. Edgington, T.S., Glassock, R.J., Dixon, F.J. Autologous immune-complex pathogenesis of experimental allergic glomerulonephritis. Science 155:1432-4, 1967.
  2. Edgington, T.S., Ritt, D.J. Intrahepatic expression of serum hepatitis virus-associated antigens. J. Exp. Med. 134:871-85, 1971.
  3. Plow, E.F., Edgington, T.S. Discriminating neoantigenic differences between fibrinogen and fibrin derivatives. Proc. Natl. Acad. Sci. USA 70:1169-73, 1973.
  4. Edgington, T.S., Astarita, R.W., Plow, E.F. Association of an isomeric species of carcinoembryonic antigen with neoplasia of the gastrointestinal tract. N. Engl. J. Med. 293:103-7, 1975.
  5. Plow, E.F., Edgington, T.S. Isolation and characterization of a homogeneous isomeric species of carcinoembryonic antigen (CEA-S). Int. J. Cancer 15:748-61, 1975.
  6. Loskutoff, D.J., Edgington, T.S. Synthesis of a fibrinolytic activator and inhibitor by endothelial cells. Proc. Natl. Acad. Sci. USA 74:3903-7, 1977.
  7. Marguerie, G.A., Plow, E.F., Edgington, T.S. Human platelets possess an inducible and saturable receptor specific for fibrinogen. J. Biol. Chem. 254:5357-63, 1979.
  8. Leung, J.P., Nelson-Rees, W.A., Moore, G.E., Cailleau, R., Edgington, T.S. Characteristics of membrane and cytosol forms of the mammary tumor glycoprotein molecule MTGP in human breast carcinoma cell cultures and tumors. Int. J. Cancer 28:35-42, 1981.
  9. Soule, H.R., Linder E., Edgington, T.S. Membrane 126-kilodalton phospho-glycoprotein associated with human carcinomas identified by a hybridoma antibody to mammary carcinoma cells. Proc. Natl. Acad. Sci. USA 80:1332-6, 1983.
  10. Sun, N.C.J., Edgington, T.S., Carpentier, C.L., McAfee, W., Terry, R., Bateman, J. Immunohistochemical localization of carcinoembryonic antigen (CEA), CEA-S, and nonspecific cross-reacting antigen (NCA) in carcinomas of lung. Cancer 52:1632-41, 1983.
  11. Khaw, B.A., Strauss, H.W., Cahill, S.L., Soule, H.R., Edgington, T., Cooney, J. Sequential imaging of Indium-lll-labeled monoclonal antibody human mammary tumors hosted in nude mice. J. Nucl. Med. 25:592-603, 1984.
  12. Lando, P.A., Edgington, T.S. An innate host response to the neoplastic cell: Syngeneic rat tumor cells can elicit a rapid de novo lymphoid procoagulant response. J. Immunol. 135:3587-95, 1985.
  13. Morrissey, J.H., Fakhrai, H., Edgington, T.S. Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade. Cell 50:129-35, 1987.
  14. Mackman, N., Morrissey, J.H., Fowler, B., Edgington, T.S. Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade. Biochemistry 28:1755-62, 1989.
  15. Fan, S.-T., Edgington, T.S. Sufficiency of the CD8+ T cell lineage to mount an effective tumoricidal response to a syngeneic tumor bearing novel class I MHC antigen. J. Immunol. 143:4287-91, 1989.
  16. Altieri, D.C., Edgington, T.S. Identification of EPR-1: A leukocyte distributed receptor for serine proteases. J. Immunol. 145:246-53, 1990.
  17. Altieri, D.C., Etingin, O.R., Fair, D.S., Brunck, T.K., Geltosky, J.E., Hajjar, D.P., Edgington, T.S. Structural homologous ligand binding of integrin Mac-1 and viral glycoprotein C receptors. Science 254:1200-2, 1991.
  18. Mueller, B.M., Reisfeld, R.A., Edgington, T.S., Ruf, W. Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis. Proc. Natl. Acad. Sci. USA 89:11832-6, 1992.
  19. Carmeliet, P., Mackman, N., Moons, L., Luther, T., Gressens,P., Van Vlaenderen, I., Demunck, H., Kasper, M., Breier, G., Evrard, P., Müller, M., Risau, W., Edgington, T., Collen, D. Role of tissue factor in blood vessel development. Nature 383:73-5, 1996.
  20. Huang, X., Molema, G., King, S., Watkins, L., Edgington, T.S., Thorpe, P.E. Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature. Science 275:547-50, 1997.
  21. Huang, M., Syed, R., Stura, E.A., Stone, M.J., Stefanko, R.S., Ruf, W., Edgington, T.S., Wilson, I.A. The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF-5G9 complex. J. Mol. Biol. 275:873-94, 1998.
  22. Liu, C., Huang, H., Doñate, F., Dickinson, C., Santucci, R., EL-Sheikh, A., Vessella, R., Edgington, T.S. Prostate-specific membrane antigen directed selective thrombotic infarction of tumors. Cancer Res. 62:5470-5, 2002.
  23. EL-Sheikh, A., Liu, C., Huang, H., Edgington, T.S. A novel VEGF heparin binding domain substructure binds to glycosaminoglycans in vivo, and localizes to tumor microvascular endothelium. Cancer Res. 62:7118-23, 2002.
  24. Liu, C., Sun, C., Huang, H., Janda, K., Edgington, T. Over-expression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy. Cancer Res. 63:2957-64, 2003.
  25. Huang, H., Norledge, B.V., Liu, C., Olson, A.J., Edgington, T.S. Selective attenuation of the extrinsic limb of the tissue factor driven coagulation protease cascade by occupancy of a novel peptidyl docking site on tissue factor. Biochemistry 42(36):10619-26, 2003.
  26. Liu, C., Bhattacharjee, G., Boisvert, W., Dilley, R., Edgington, T.S. In vivo interrogation of the molecular display of atherosclerotic lesion surfaces. Am. J. Pathol. 163(5):1859-71, 2003.
  27. Liu, C., Dickinson, C., Shobe, J. Donate, F., Ruf, W., Edginton T.S. A hybrid fibronectin motif protein as an integrin targeting selective tumor vascular thrombogen. Mol. Cancer Therap. 3(7):793-801, 2004.
  28. Bhattacharjee, G., Ahamed, J., Pedersen, B., El-Sheikh, A., Mackman, N., Ruf, W., Edgington, T.S. Regulation of tissue factor mediated initiation of the coagulation cascade by cell surface Grp78. Arterioscler. Thromb. Vasc. Biol. 25:1737-43, 2005.
  29. El-Sheikh, A., Borgstrom, P., Bhattacharjee, G., Belting, M., Edgington, T.S. A selective tumor microvasculature thrombogen that targets a novel receptor complex in the tumor angiogenic microenvironment. Cancer Res. 65:11109-1117, 2005.
  30. Wu, W., Luo, Y., Sun, C., Liu, Y., Kuo, P., Varga, J., Xiang, R., Reisfeld, R., Janda, K.D., Edgington, T.S., and Liu, C. Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug resistant neoplasms. Cancer Res., in press, January 2006.
  31. Wu, W., Luo, Y., Sun, C., Liu, Y., Kuo, P., Varga, J., Xiang, R., Reisfeld, R., Janda, K.D., Edgington,T.S., Liu,C. Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug resistant neoplasms. Cancer Res.66(2):970-980, 2006.
  32. Bookbinder, L. H., Hofer, A., Haller, M. F., Zepeda, M. L., Kaller, G. A., Lim, J. E., Edgington, T. S., Shepard, H. M., Patton, J. S., Frost, G. I. A recombinant human enzyme for enhanced interstitial transport of therapeutics. J. Control Release.114(2) 230-241, 2006.
  33. Lin, R., Maeda, S., Liu, C., Karin, M., Edgington, T.S. A large non-coding RNA is a marker for murine and human hepatocellular carcinomas. Oncogene, 26:851-858, 2007.
  34. Bhattacharjee, G., Ahamed, J., Pawlinski, R., Liu, C., Mackman, N., Ruf, W., and Edgington, T. S. Factor Xa binding to annexin 2 mediates signal transduction via protease activated receptor 1. Circulation Res. 102:457-464, 2008.
  35. Wang, Y., Kelber, J.A., Cao, H. S. T., Cantin, G.T., Lin, R., Wang, W., Kaushal, S., Bristow, J. M., Edgington, T. S., Hoffman, R. M., Bouvet, M., Yates, J.R. III, Klemke, R. L. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression. Proc. Natl. Acad. Science 107:10920-25, 2010.
  36. Meisel, S.R., Ouyang, Y., Fishbein, M.C., Edgington, T.S., Ruan, X.M., Cercek, B., Shah, P.K., Chaux, A. Prolonged hypercholesterolemia-induced tissue factor expression in rabbit vein grafts: A potential mechanism for graft failure. Coron. Artery Dis. 21:97-103, 2010.
  37. Lin, R., Saha, M.R., Black, C., Watt, A., Marcusson, E., Freier, S.M., Edgington, T.S. Control of RNA Processing by a Large Noncoding RNA Over-expressed in Carcinomas. FEBS Letters. 585:671-676, 2011
  38. Meisel, S.R., Xu, Xiao-Ping, Edgington, Thomas S., Cerek, Bojan, Ong, John, Kaul, Sanjay, Shah, Prediman, K. Dose-dependent modulation of tissue factor protein and procoagulant activity in human monocyte-derived macrophages by oxidized low density lipoprotein. Journal of Atherosclerosis and Thrombosis 18:596-603, 2011
  39. Lin, Y., Peng, B., Chen, Xi, Lan, B., Xu, C., Lu, Z., Lu, D., Jiang, B., Edgington, T., Guo, Fang. Ubiquination of asparagine endopeptidase by TRAF6 promotes invasion and metastasis of breast cancer. Submitted.