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The Duckett Laboratory

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Research Focus

Work in our laboratory is aimed at evaluating small molecule kinase inhibitors of biologic and therapeutic interest. We are currently involved in refining a novel class of kinase inhibitors aimed at the therapeutic treatment of human diseases such as Parkinson’s Disease and Cancer. Protein kinases are important components of signal transduction pathways and deregulation of kinase activity can lead to human disease. Kinases have therefore become one of the most important target classes for drug development. Working closely with other disciplines such as chemistry, pharmacology, and drug metabolism, we aim to optimize lead compounds for potency and selectivity while minimizing toxicity to generate candidate molecules with appropriate drug like properties suitable for IND enabling and first time in human studies.