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Scripps Laboratories for tRNA Synthetase Research

Ze Liu, Ph.D.

Contact: zeliu@scripps.edu

Photo of Ze Liu, Ph.D.

Education:
Ph.D. School of Medicine, Nankai University, Tianjin, 300071, P.R. China 2013                   
B.Sc. College of Life Science, Nankai University, Tianjin, 300071, P.R. China  2008

Current Research Focus:
A unique nucleus-directing domain (UNE-S), added at the invertebrate-to-vertebrate transition, confers a non-translational activity of Seryl-tRNA synthetase (SerRS) in modulating VEGF expression. This role is independent of the aminoacylation function of SerRS. My project is focused on understanding the suppressing molecular mechanisms of SerRS in cancer.

Publications:
Liu, Z., Xiong, M., Gong, J. B., Zhang, Y., Bai, N., Luo, Y. P., Li, L. Y., Liu, Y. H., Tan, X. Y., and Xiang, R. (2014). Legumain protease-activated TAT-liposome cargo for targeting tumors and their microenvironment. Nature Communications 5: 4280.

Dong, Y., Xiong, M., Duan, L., Liu, Z., Niu, T., Luo, Y., Wu, X., Xu, C., Lu, C. (2014). H2AX phosphorylation regulated by p38 is involved in Bim expression and apoptosis in chronic myelogenous leukemia cells induced by imatinib. Apoptosis 8: 1281-1292.

Zhang, Y., Guo, Q., Zhang, Z., Bai, N., Liu, Z., Xiong, M., Wei, Y., Xiang, R., and Tan, X. Y. (2014). VDR status arbitrates the pro-metastatic effects of tumor-associated macrophages. Mol Cancer Res. 8: 1181-1191.

Liu, Z., Lv, D., Liu, S., Gong, J. B., Wang, D., Xiong, M., Chen, X. N., Xiang, R., and Tan, X. Y. (2013). Alginic acid-coated chitosan nanoparticles loaded with legumain DNA vaccine: Effect against breast cancer in mice. PLoS One. 4: e60190.

Su, W., Wang, L., Zhou, M., Liu, Z., Hu, S., Tong, L., Liu, Y., Fan, Y., Kong, D., Zheng, Y., Han, Z., Wu, J. C., Xiang, R., and Li, Z. (2012). Human embryonic stem cell-derived endothelial cells as cellular delivery vehicles for treatment of metastatic breast cancer. Cell Transplant. 11: 2079-2090.

Lv, D., Chen, S., Tan, X., Li, N., Liu, C., Li, Z., Liu, Z., Stupack, D. G., Reisfeld, R. A., and Xiang, R. (2012). Fra-1 promotes breast cancer chemosensitivity by driving cancer stem cells from dormancy. Cancer Res. 72: 3451-3456.

Wang, L., Su, W., Liu, Z., Zhou, M., Chen, S., Chen, Y., Lu, D., Liu, Y., Fan, Y., Zheng, Y., Han, Z., Kong, D., Wu, J. C., Xiang, R., and Li, Z. (2012). CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma. Biomaterials 33: 5107-5114.

Shi, Q., Hou, Y., Hou, J., Pan, P., Liu, Z., Jiang, M., Gao, J., and Bai, G. (2012). Glycyrrheti  acid synergistically enhances β-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts. PLoS One 7: e44921.

Pan, P. W., Zhang, Q., Hou, J., Liu, Z., Bai, F., Cao, M. R., Sun, T., and Bai, G. (2012). Cell surface glycoprotein profiling of cancer cells based on bioorthogonal chemistry. Anal Bioanal Chem. 403: 1661-1670.

Liao, D.*, Liu, Z.*, Wrasidlo, W., Chen, T., Luo, Y., Xiang, R., and Reisfeld, R. A. (2011). Synthetic enzyme inhibitor: a novel targeting ligand for nano-therapeutic drug delivery inhibiting tumor growth without systemic toxicity. Nanomedicine 7: 665-673. (*Co-first author).

Liao, D.*, Liu, Z.*, Wrasidlo, W. J., Luo, Y., Nguyen, G., Chen, T., Xiang, R., and Reisfeld, R. A. (2011). Targeted therapeutic remodeling of the tumor micro-environment improves an HER-2 DNA vaccine and prevents recurrence in a murine breast cancer model. Cancer Res. 71: 5688-5696. (*Co-first author).

Yang, Y., Shi, Q., Liu, Z., Li, R. J., Pan, P. W., Hou, Y. Y., Lu, W. G., and Bai, G. (2010). The synergistic antiasthmatic effects of glycyrrhizin and salbutamol. Acta Pharmacol Sin. 31: 443-449.

Shi, Q., Liu, Z., Yang, Y., Geng, P., Zhu, Y. Y., Zhang, Q., Bai, F., and Bai, G. (2009). Identification of anti-asthmatic compounds in pericarpium citri reticulatae and evaluation of their synergistic effects. Acta Pharmacol Sin. 30: 567-575 .

Bai, G., Yang, Y., Shi, Q., Liu, Z., Zhang, Q., Zhu, Y. Y. (2008). Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist1. Acta Pharmacol Sin. 29: 1187-1194. 

Patents:
Liu, Z., Tan, X., Liu, S., Xiong, M., Lv, D., and Xiang, R. An oral anti-tumor DNA vaccine with pH sensitivity and anti- acidic property  and its preparation method .  2012 Aug. 1st. Patent Publication No. CN102614527 A
Liu, Z., Tan, X., Xiong, M., Liu, S., Lv, D., and Xiang, R. A multifunctional nanoparticle carrier targeting tumor and tumor-associated macrophage and its preparation method, 2012 Sep. 26th. Patent Publication No. CN102688495 A
Reisfeld, R. A., Xiang, R., Luo, Y., Liao, D., Liu, Z., Chen, T., Chen, S., and Lu, D. Nanoparticle- based tumor-targeted drug delivery. 2012 Mar. 8th. US Patent Publication No. CA2809617 A

Scholarships and Honors:
2012 National Scholarship
2012 Tianjin Merit Scholarship
2011 Premier Zhou Scholarship
2011 First Tier Academic Scholarship
2008, 2009, 2011, 2012 First Tier Scholarship for Outstanding Students

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