Publications
Complete Publication List of Xiang-Lei Yang, Ph.D.
49. Lee PS, Zhang HM, Marshall AG, Yang XL, Schimmel P. (2012) Uncovering of a short internal peptide activates a tRNA synthetase procytokine. J Biol Chem. [Epub ahead of print 2012 May 1].
48. Mathew, S, Zhou, Q, Kishi, S, Valdez Jr, DM, Kapoor, M, Guo, M, Lee, S, Kim, S, Yang, XL, Schimmel, P. (2012) Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. Nature Chem Biology, 8, 547-554
47. Park MC, Kang T, Jin D, Han JM, Kim SB, Park YJ, Cho K, Park YW, Guo M, He W, Yang XL, Schimmel P, Kim S. (2012) Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis. Proc Natl Acad Sci U S A. 109, E640-7. [Epub 2012 Feb 15].
46. Xu X, Shi Y, Zhang HM, Swindell EC, Marshall AG, Guo M, Kishi S, Yang XL. (2012) Unique domain appended to vertebrate tRNA synthetase is essential for vascular development. Nat Commun. 3, 681
45. Fu G, Xu T, Shi Y, Wei N, Yang XL.(2012) tRNA controlled nuclear import of a human tRNA synthetase. J Biol Chem.[Epub ahead of print]
44. Motley WW, Seburn KL, Nawaz MH, Miers KE, Cheng J, Antonellis A, Green ED, Talbot K, Yang XL, Fischbeck KH, Burgess RW. (2011) Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels. PLoS Genet. 7, e1002399. Epub 2011.
43. Yang, X.-L.* & Schimmel, P. (2011) Functional expansion of the tRNA world under stress. Mol. Cell 43, 500-502 (*Sole corresponding author)
42. He. W., Zhang, H.-M., Chong, Y. E., Guo, M., Marshall, A.G. & Yang, X.-L.* (2011) Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening. Proc. Natl. Acad. Sci. U S A 108, 12307-12312 (*Sole corresponding author)
41. Fang, P, Zhang, HM, Shapiro, R, Marshall, AG, Schimmel, P, Yang, XL, Guo, M. (2011) Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex. Proc. Natl. Acad. Sci. U S A 108, 8239-8244 (*Co-corresponding author)
40. Nawaz, M.H., Merriman, E., Yang, X.-L. & Schimmel, P. (2011) p23H implicated as cis/trans regulator of AlaXp-directed editing for mammalian cell homeostasis. Proc. Natl. Acad. Sci. U S A 108, 2723-2728
39. Vo, M.N., Yang, X.-L.* & Schimmel, P. (2011) Dissociating Quaternary Structure Regulates Cell-signaling Functions of a Secreted Human tRNA Synthetase. J. Biol. Chem. 286, 11563-11568(*Co-corresponding author)
38. Guo, M., Shapiro, R., Morris, G.M. Yang, X.-L. & Schimmel, P. (2010) Packaging HIV virion components through dynamic equilibria of a human tRNA synthetase. J. Phys. Chem. 114, 16273-16279.
37. Han, G.W., Yang, X.-L. et al. (2010) Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster. Acta. Cryst. F66, 1326-1334.
36. Guo, M., Yang, X.-L. & Schimmel, P. (2010) New functions of aminoacyl-tRNA synthetases beyond translation. Nat. Rev. Mol. Cell Biol. 11, 668-674.
35. Guo, M., Shapiro, R., Schimmel, P. & Yang, X.-L.* (2010). Introduction of a leucine half-zipper engenders multiple high quality crystals of a recalcitrant tRNA synthetase. Acta. Cryst. D66, 243-250 (*Corresponding author)
34. Guo, M., Schimmel, P. & Yang, X.-L.* (2010) Functional expansion of human tRNA synthetases achieved by structural inventions. FEBS Lett. 584, 434-442 (*Corresponding author)
33. Zhou, Q., Kapoor, M., Guo, M., Belani, R., Xu, X., Kiosses, W.B., Hanan M., ParK, C., Armour, E., Do, M.-H., Nangle, L. A., Schimmel, P. & Yang, X.-L.* (2010) Orthogonal use of a human tRNA synthetase active site to achieve multi-functionality. Nat. Struc. Mol. Biol. 17, 57-61(*Corresponding author)
32. Guo, M., Chong, Y. E., Shapiro, R., Beebe, K., Yang, X.-L. & Schimmel, P. (2009). Mistranslation from Serine Paradox Caused by AlaRS Recognition Dilemma. Nature, 462, 808-812.
31. Guo, R-T., Chong Y.E., Guo M. and Yang, X.-L.* (2009) Crystal Structures and Biochemical Analyses Suggest Unique Mechanism and Role For Human GlyRS in Ap4A Homeostasis , J. Biol. Chem. 284, 28968-28976 (*Corresponding author)
30. Guo, M., Chong, Y.E., Beebe, K., Shapiro, R., Yang, X.-L. & Schimmel, P. (2009) The C-Ala Domain Brings Together Editing and Aminoacylation Functions on One tRNA. Science 325, 744-747
29. Storkebaum, E., Leitão-Gonçalves, Ricardo., Godenschwege T., Nangle, L., Mejia, M., Bosmans, I., Ooms, T., Jacobs, A., Van Dijck, P., Yang, X.-L., Schimmel, P., Norga, K., Timmerman, V., Callaerts, P. & Jordanova A. (2009) Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy. Proc. Natl. Acad. Sci. U S A 106, 11782-11787
28. Kapoor, M., Otero, F. J., Slike, B. M., Ewalt, K. L., and Yang, X.-L.* (2009) Mutational separation of aminoacylation and cytokine activities of human tyrosyl-tRNA synthetase. Chem. Biol. 16, 531–539 (*Corresponding author)
27. Chong, Y.E., Yang, X.-L. & Schimmel, P. (2008) Natural homolog of tRNA synthetase editing domain rescues conditional lethality caused by mistranslation. J. Biol. Chem. 283, 30073-30078
26. Cheng, G., Zhang, H., Yang X.-L., Tzima, E., Ewalt, K.L., Schimmel, P. & Faber, J.E.(2008) Effect of Mini-tyrosyl-tRNA Synthetase on Ischemic Angiogenesis, Leukocyte Recruitment and Vascular Permeability. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295, R1138-1146
25. Guo, M., Ignatov, M., Musier-Forsyth, K., Schimmel, P. & Yang, X.-L.* (2008) Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation. Proc. Natl. Acad. Sci. U S A 105, 2331-2336 (*Corresponding author)
24. Greenberg, Y., Kiosses, W.B., Ewalt, K., Yang, X.-L.,Schimmel, P., Reader, J.S. & Tzima, E. (2008) The novel fragment of tyrosyl tRNA synthetase, mini-TyrRS, is secreted to induce an angiogenic response in endothelial cells, FASEB J. 22, 1597-1605
23. Kapoor, M., Zhou, Q., Otero, F., Myers, C.A., Bates, A., Belani, R., Liu, J., Luo, J.K., Tzima, E., Zhang, D.-E., Yang, X.-L.,Schimmel P. (2008) Evidence for annexin II/S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS, J. Biol. Chem. 283, 2070-2077
22. Yang, X.-L.*, Kapoor, M., Otero, F.J., Slike, B. Tsuruta, H., Frausto, R., Bates, A., Ewalt, K.L., Cheresh, D.A. & Schimmel, P. (2007). Gain-of-function mutational activation of human tRNA synthetase procytokine, Chem. Biol. 14, 1323-1333 (*Corresponding author)
21. Nangle, L.A., Zhang, W., Xie, W., Yang, X.-L.* & Schimmel, P. (2007). Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect, Proc. Natl. Acad. Sci. U S A 104, 11239-11244 (*Co-corresponding author)
20. Xie, W., Nangle, L.A., Zhang, W., Schimmel, P. & Yang, X.-L.* (2007). Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase, Proc. Natl. Acad. Sci. U S A 104, 9976-9981 (*Co-corresponding author)
19. Yang, X.-L.*, Guo, M., Kapoor, M., Ewalt, K.L., Otero, F.J., Robert J. Skene, R.J., McRee, D.E. & Schimmel, P. (2007). Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase, Structure 15, 793-805 (*Corresponding author)
18. Schimmel, P. & Yang, X.-L. (2006). Perfecting the genetic code with an RNP complex, Structure 14, 1729-1730
17. Xie, W., Schimmel, P. & Yang, X.-L.* (2006). Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease, Acta Crystallogr. F 62, 1243-1246 (*Corresponding author)
16. Yang, X.-L.*, Otero, F. J. , Ewalt, K. L., Liu, J., Swairjo, M. A., Kohrer, C., RajBhandary, U. L., Skene, R. J., McRee, D. E. & Schimmel, P. (2006). Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis, EMBO J. 25, 2919-2929 (*Corresponding author)
15. Ewalt, K. L., Yang, X.-L., Otero, F. J., Liu, J., Slike, B. & Schimmel, P. (2005). Variant of human enzyme sequesters reactive intermediate, Biochemistry 44, 4216-4221
14. Schimmel, P. & Yang, X.-L. (2004). Two classes give lessons about CCA, Nat. Struct. Mol. Biol. 11, 807-808
13. Yang, X.-L., Schimmel, P. & Ewalt, K. L. (2004). Relationship of two human tRNA synthetases used for cell signaling, Trends Biochem. Sci. 29, 250-256
12. Swairjo, M. A., Otero, F. J., Yang, X.-L., Lovato, M. A., Skene, R. J., McRee, D. E., Ribas de Pouplana, L. & Schimmel, P. (2004). Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition, Molecular Cell 13, 829-841
11. Yang, X.-L., Otero, F. J. , Skene, R. J., McRee, D. E., Schimmel, P. & Ribas de Pouplana, L.(2003). Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains, Proc. Natl. Acad. Sci. U S A 100, 15376-15380
10. Yang, X.-L, Liu, J., Skene, R. J., McRee, D. E. & Schimmel, P. (2003). Crystal structure of an EMAP-II-like cytokine released from a human aminoacyl-tRNA synthetase, Helvetica Chimica Acta 86, 1246-1257
9. Liu, J., Yang, X.-L, Ewalt, K. L. & Schimmel, P. (2002). Mutational switching of a Yeast tRNA synthetase into a mammalian-like synthetase cytokine, Biochemistry 41, 14232-14237
8. Yang, X.-L., Skene, R. J., McRee, D. E. & Schimmel, P. (2002). Crystal structure of a human aminoacyl-tRNA synthetase cytokine, Proc. Natl. Acad. Sci. U S A 99, 15369-15374
7. Robinson H, Gao, Y.-G., Yang, X.-L., Sanishvili, R., Joachimiak, A. & Wang, A. H.-J. (2001). Crystallographic analysis of a novel complex of actinomycin D bound to the DNA decamer CGATCGATCG, Biochemistry 40, 5587-5592
6. Yang, X.-L., Robinson H, Gao, Y.-G. & Wang, A. H.-J. (2000). Binding of a Macrocyclic Bisacridine and Ametantrone to CGTACG involves similar unusual intercalation platforms, Biochemistry 39, 10950-10957
5. Yang, X.-L., Hubbard IV, R. B., Lee, M., Tao, Z.-F., Sugiyama, H. & Wang, A. H.-J. (1999). Imidazole-imidazole pair as a minor groove recognition motif for T:G mismatch base pair, Nucleic Acids Res. 27, 4183-4190
4. Yang, X.-L. & Wang, A. H.-J. (1999). Structural studies of atom-specific anticancer drugs acting on DNA, Pharmacology & Therapeutics 83, 181-215
3. Yang, X.-L., Kaenzig, C., Lee, M. & Wang, A. H.-J. (1999). Binding of AR-1-144, a tri-imidazole DNA minor groove binder, to CCGG sequence analyzed by NMR spectroscopy, Eur. J. Biochem. 263, 646-655
2. Yang, X.-L., Sugiyama, H., Ikeda, S., Saito, I. & Wang, A. H.-J. (1998). Structural studies of a stable parallel-stranded DNA duplex incorporating isoguanine:cytosine and isocytosine:guanine base pairs by NMR, Biophysical J. 75, 1163-1171
1. Yang, X.-L. & Wang, A. H.-J. (1997). Structural analysis of Z-Z DNA junctions with A:A and T:T mismatched base pairs by NMR, Biochemistry 36, 4258-4267
- VISIT
- CA Campus:
- • Maps & Directions
- • Parking
- FL Campus:
- • Maps & Directions
- • Parking
- RESEARCH
- WORK
- CHALLENGE
California: 10550 North Torrey Pines Road, La Jolla, CA 92037 - (858) 784-1000
Florida: 130 Scripps Way, Jupiter, FL 33458 - (561) 228-2000
Copyright © 2013, The Scripps Research Institute (TSRI). All Rights Reserved.