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Scripps Laboratories for tRNA Synthetase Research

Ryan Shapiro

Contact: rshapiro@scripps.edu

Photo of Ryan Shapiro

Education:

B.S., University of California at San Diego, 2007

Current Focus:

My focus includes the preparation and characterization of AARS proteins and their derivatives for use in biochemical, cellular, and in vivo studies. These studies explore the possible therapeutic potential of AARS proteins.

Publications:

Guo, M., Chong, Y. E., Beebe, K., Shapiro, R., Yang, X.-L., and Schimmel, P. (2009). The C-Ala domain brings together editing and aminoacylation functions on one tRNA. Science 325: 744-747.

Guo, M., Chong, Y. E., Shapiro, R., Beebe, K., Yang, X.-L., and Schimmel, P. (2009). Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma. Nature 462:808-812.

Ofir-Birin, Y., Fang, P., Bennett, S. P., Zhang, H. M., Wang, J., Rachmin, I., Shapiro, R., Song, J., Dagan, A.,  Pozo, J., Kim, S., Marshall, A. G., Schimmel, P., Yang, X.-L., Nechushtan, H., Razin, E., and Guo, M. (2013). Structural switch of lysyl-tRNA synthetase between translation and transcription. Molecular cell 49:30-42.

Fang, P., Zhang, H. M., Shapiro, R., Marshall, A. G., Schimmel, P., Yang, X.-L., and Guo, M. (2011). Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex. Proceedings of the National Academy of Sciences 108:8239-8244.             

Guo, M., Shapiro, R., Morris, G. M., Yang, X.-L., and Schimmel, P. (2010). Packaging HIV virion components through dynamic equilibria of a human tRNA synthetase.  The Journal of Physical Chemistry B 114:16273-16279.

Guo, M., Shapiro, R., Schimmel, P., and Yang. X.-L. (2010).  Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetase. Acta Crystallographica Section D: Biological Crystallography 66:243-250

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