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102. Zhao, Y., Leman, L. J., Search, D. J., Garcia, R. A., Gordon, D. A., Maryanoff, B. E., and Ghadiri, M. R. "Self-Assembling Cyclic D,L-a-Peptides as Modulators of Plasma HDL Function. A Supramolecular Approach toward Antiatherosclerotic Agents." ACS Central Science, in press. http://dx.doi.org/10.1021/acscentsci.7b00154

 

101. Malins, L. R., deGruyter, J. N., Robbins, K. J., Scola, P. M., Eastgate, M. D., Ghadiri, M. R., and Baran, P. S. Peptide macrocyclization inspired by non-ribosomal imine natural products. J. Am. Chem. Soc. 2017, 139, 5233-5241.

 

100. Maolanon, A. R., Kristensen, H. M. E., Leman, L. J., Ghadiri, M. R., and Olsen, C. A. "Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes." ChemBioChem 2017, 18, 5-49.

 

99. Leman, L. J. and Ghadiri, M. R. Potentially prebiotic synthesis of α-amino thioacids in water. Synlett 2017, 28, 68-72.

 

98. Leman, L. J., Huang, Z.-Z., and Ghadiri, M. R. Peptide Bond Formation in Water Mediated by Carbon Disulfide. Astrobiology 2015, 15, 709-716.

 

97. Zhao, Y., Black, A. S., Bonnet, D. J., Maryanoff, B. E., Curtiss, L. K., Leman, L. J., and Ghadiri, M. R. "In vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I." J. Lipid Res. 2014, 55, 2053-2063.



96. Leman, L. J., Maryanoff, B. E., and Ghadiri, M. R. "Molecules That Mimic Apolipoprotein A-I: Potential Agents for Treating Atherosclerosis." J. Med. Chem. 2014, 57, 2169-2196.


         


95. Zhao, Y., Imura, T., Leman, L. J., Curtiss, L. K., Maryanoff, B. E., and Ghadiri, M. R. "Mimicry of High-Density Lipoprotein: Functional Peptide-Lipid Nanoparticles Based on Multivalent Peptide Constructs." J. Am. Chem. Soc. 2013, 135, 13414-13424.

         


94. Montenegro, J., Ghadiri, M. R., and Granja, J. R. "Ion Channel Models Based on Self-Assembling Cyclic Peptide Nanotubes." Acc. Chem. Res. 2013, 46, 2955-2965.

         
           

93. Vickers, C. J., Olsen, C. A., Leman, L. J., and Ghadiri, M. R. "Discovery of HDAC inhibitors that lack an active site Zn2+-binding functional group." ACS Med. Chem. Lett. 2012, 3, 505-508.

           
           

92. Olsen, C. A., Montero, A., Leman, L. J., and Ghadiri, M. R. "Macrocyclic peptoid-peptide hybrids as inhibitors of class I histone deacetylases." ACS Med. Chem. Lett. 2012, 3, 749-753.

           

           

91. Montero, A., Gastaminza, P., Law, M., Cheng, G., Chisari, F. V., and Ghadiri, M. R. "Self-assembling peptide nanotubes with antiviral activity against hepatitis C virus." Chem. Biol. 2011, 18, 1453-1462.
           http://www.sciencedirect.com/science/article/pii/S1074552111003462
           http://www.ncbi.nlm.nih.gov/pubmed/22118679

90. Hutt, D. M., Olsen, C. A., Vickers, C. J., Herman, D., Chalfant, M. A., Montero, A., Leman, L. J., Burkle, R., Maryanoff, B. E., Balch, W. E., et al. "Potential agents for treating cystic fibrosis: Cyclic tetrapeptides that restore trafficking and activity of ΔF508-CFTR." ACS Med. Chem. Lett. 2011, 2, 703-707.
           http://pubs.acs.org/doi/full/10.1021/ml200136e
           http://www.ncbi.nlm.nih.gov/pubmed/21984958

89. Chu, J., Gonzalez-Lopez, M., Cockroft, S., Amorin, M., Ghadiri, M. R. "Real-Time Monitoring of DNA Polymerase Function and Stepwise Single-Nucleotide DNA Strand Translocation through a Protein Nanopore." Angew. Chem., Int. Ed. 2010, 49, 10106-10109.
           http://onlinelibrary.wiley.com/doi/10.1002/anie.201005460/full
           http://www.ncbi.nlm.nih.gov/pubmed/21105031

88. Olsen, C. A., and Ghadiri, M. R. "Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha-3-beta-tetrapeptides." J. Med. Chem. 2009, 52, 7836-7846.
            http://pubs.acs.org/doi/full/10.1021/jm900850t
            http://www.ncbi.nlm.nih.gov/pubmed/19705846

87. Ura, Y., Al-Sayah, M., Montenegro, J., Beierle, J. M., Leman, L. J., and Ghadiri, M. R. "Dynamic polythioesters via ring-opening polymerization of 1,4-thiazine-2,5-diones." Org. Biomol. Chem. 2009, 7, 2878-2884.
            http://www.rsc.org/publishing/journals/OB/article.asp?doi=b903612a
            http://www.ncbi.nlm.nih.gov/pubmed/19582297

86. Ura, Y., Beierle, J. M., Leman, L. J., Orgel, L. E., and Ghadiri, M. R. "Self-assembling sequence-adaptive peptide nucleic acids." Science 2009, 325, 73-77.
            http://www.scienceonline.org/cgi/content/abstract/325/5936/73
            http://www.ncbi.nlm.nih.gov/pubmed/19520909?dopt=Abstract

85. Motiei, L., Rahimipour, S., Thayer, D. A., Wong, C.-H., and Ghadiri, M. R. "Antibacterial cyclic DL-alpha-glycopeptides." Chem. Commun. 2009, 3693-3695.
            http://www.rsc.org/publishing/journals/CC/article.asp?doi=b902455g
            http://www.ncbi.nlm.nih.gov/pubmed/19557251

84. Horne, W. S., Olsen, C. A., Beierle, J. M., Montero, A., and Ghadiri, M. R. "Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides." Angew. Chem., Int. Ed. 2009, 48, 4718-4724.
            http://www3.interscience.wiley.com/cgi-bin/fulltext/122243285/HTMLSTART
            http://www.ncbi.nlm.nih.gov/pubmed/19267380

83. Beierle, J. M., Horne, W. S., van Maarseveen, J. H., Waser, B., Reubi, J. C., and Ghadiri, M. R. "Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: receptor-selective somatostatin analogues." Angew. Chem., Int. Ed. 2009, 48, 4725-4729.
            http://www3.interscience.wiley.com/cgi-bin/fulltext/122240965/HTMLSTART
            http://www.ncbi.nlm.nih.gov/pubmed/19266506

82. Picuri, J. M., Frezza, B. M., and Ghadiri, M. R. "Universal translators for nucleic acid diagnosis." J. Am. Chem. Soc. 2009, 131, 9368-9377.
            http://pubs.acs.org/doi/full/10.1021/ja902490x
            http://www.ncbi.nlm.nih.gov/pubmed/19566101

81. Montero, A., Beierle, J. M., Olsen, C. A., and Ghadiri, M. R. "Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures." J. Am. Chem. Soc. 2009, 131, 3033-3041.
            http://pubs.acs.org/doi/full/10.1021/ja809508f
            http://www.ncbi.nlm.nih.gov/pubmed/19239270

80. Voelcker, N. H., Alfonso, I., and Ghadiri, M. R. "Catalyzed oxidative corrosion of porous silicon used as an optical transducer for ligand-receptor interactions." ChemBioChem 2008, 9, 1776-1786.
            http://www3.interscience.wiley.com/cgi-bin/fulltext/120118539/HTMLSTART
            http://www.ncbi.nlm.nih.gov/pubmed/18576449

79. Voelcker, N. H., Guckian, K. M., Saghatelian, A., and Ghadiri, M. R. "Sequence-addressable DNA logic." Small 2008, 4, 427-431.
            http://www3.interscience.wiley.com/cgi-bin/fulltext/117943315/HTMLSTART
            http://www.ncbi.nlm.nih.gov/pubmed/18350554

78. Cheng, G., Montero, A., Gastaminza, P., Whitten-Bauer, C., Wieland, S. F., Isogawa, M., Fredericksen, B., Selvarajah, S., Gallay, P. A., Ghadiri, M. R., and Chisari, F. V. "A virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in vitro." Proc. Natl. Acad. Sci. U. S. A. 2008, 105, 3088-3093.
            http://www.pnas.org/content/105/8/3088.long
            http://www.ncbi.nlm.nih.gov/pubmed/18287023

77. Huang, Z.-Z., Leman, L. J., and Ghadiri, M. R. "Biomimetic catalysis of diketopiperazine and dipeptide syntheses." Angew. Chem., Int. Ed. 2008, 47, 1758-1761.
            http://www3.interscience.wiley.com/cgi-bin/fulltext/117892450/HTMLSTART
            http://www.ncbi.nlm.nih.gov/pubmed/18213666

76. Cockroft, S. L., Chu, J., Amorin, M., and Ghadiri, M. R. "A single-molecule nanopore device detects DNA polymerase activity with single-nucleotide resolution." J. Am. Chem. Soc. 2008, 130, 818-820.
            http://pubs.acs.org/doi/full/10.1021/ja077082c
            http://www.ncbi.nlm.nih.gov/pubmed/18166054

75. Frezza, B. M., Cockroft, S. L., and Ghadiri, M. R. "Modular multi-level circuits from immobilized DNA-based logic gates." J. Am. Chem. Soc. 2007, 129, 14875-14879.
            http://pubs.acs.org/doi/full/10.1021/ja0710149
            http://www.ncbi.nlm.nih.gov/pubmed/17994734

74. Gianneschi, N. C., and Ghadiri, M. R. "Design of molecular logic devices based on a programmable DNA-regulated semisynthetic enzyme." Angew. Chem., Int. Ed. 2007, 46, 3955-3958.
            http://www3.interscience.wiley.com/cgi-bin/fulltext/114209550/HTMLSTART
            http://www.ncbi.nlm.nih.gov/pubmed/17427900

73. Fletcher, J. T., Finlay, J. A., Callow, M. E., Callow, J. A., and Ghadiri, M. R. "A combinatorial approach to the discovery of biocidal six-residue cyclic D,L-alpha-peptides against the bacteria methicillin-resistant Staphylococcus aureus (MRSA) and E. coli and the biofouling algae ulva linza and Navicula perminuta." Chem.–Eur. J. 2007, 13, 4008-4013.
            http://www3.interscience.wiley.com/cgi-bin/fulltext/114123285/HTMLSTART
            http://www.ncbi.nlm.nih.gov/pubmed/17304598

72. Leman, L. J., Weinberger, D. A., Huang, Z.-Z., Wilcoxen, K. M., and Ghadiri, M. R. "Functional and mechanistic analyses of biomimetic aminoacyl transfer reactions in de novo designed coiled coil peptides via rational active site engineering." J. Am. Chem. Soc. 2007, 129, 2959-2966.
            http://pubs.acs.org/doi/full/10.1021/ja068052x
            http://www.ncbi.nlm.nih.gov/pubmed/17302417

71. Wilcoxen, K. M., Leman, L. J., Weinberger, D. A., Huang, Z.-Z., and Ghadiri, M. R. "Biomimetic catalysis of intermodular aminoacyl transfer." J. Am. Chem. Soc. 2007, 129, 748-749.
            http://pubs.acs.org/doi/full/10.1021/ja067124h
            http://www.ncbi.nlm.nih.gov/pubmed/17243796

70. Yadav, M. K., Leman, L. J., Price, D. J., Brooks, C. L., III, Stout, C. D., and Ghadiri, M. R. "Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution." Biochemistry 2006, 45, 4463-4473.
            http://pubs.acs.org/doi/full/10.1021/bi060092q
            http://www.ncbi.nlm.nih.gov/pubmed/16584182

69. Ashkenasy, N., Horne, W. S., and Ghadiri, M. R. "Design of self-assembling peptide nanotubes with delocalized electronic states." Small 2006, 2, 99-102.
            http://www3.interscience.wiley.com/cgi-bin/fulltext/112137030/HTMLSTART
            http://www.ncbi.nlm.nih.gov/pubmed/17193563

68. Leman, L. J., Orgel, L. E., and Ghadiri, M. R. "Amino acid dependent formation of phosphate anhydrides in water mediated by carbonyl sulfide." J. Am. Chem. Soc. 2006, 128, 20-21.
            http://pubs.acs.org/doi/full/10.1021/ja056036e
            http://www.ncbi.nlm.nih.gov/pubmed/16390101

67. Nicolaou, K. C., Zak, M., Rahimipour, S., Estrada, A. A., Lee, S. H., O'Brate, A., Giannakakou, P., and Ghadiri, M. R. "Discovery of a biologically active thiostrepton fragment." J. Am. Chem. Soc. 2005, 127, 15042-15044.
            http://pubs.acs.org/doi/full/10.1021/ja0552803
            http://www.ncbi.nlm.nih.gov/pubmed/16248640

66. Van Maarseveen, J. H., Horne, W. S., and Ghadiri, M. R. "Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides." Org. Lett. 2005, 7, 4503-4506.
            http://pubs.acs.org/doi/full/10.1021/ol0518028
            http://www.ncbi.nlm.nih.gov/pubmed/16178569

65. Dartois, V., Sanchez-Quesada, J., Cabezas, E., Chi, E., Dubbelde, C., Dunn, C., Granja, J., Gritzen, C., Weinberger, D., Ghadiri, M. R., and Parr, T. R., Jr. "Systemic antibacterial activity of novel synthetic cyclic peptides." Antimicrob. Agents Chemother. 2005, 49, 3302-3310.
            http://aac.asm.org/cgi/content/full/49/8/3302?view=long&pmid=16048940
            http://www.ncbi.nlm.nih.gov/pubmed/16048940

64. Horne, W. S., Wiethoff, C. M., Cui, C., Wilcoxen, K. M., Amorin, M., Ghadiri, M. R., and Nemerow, G. R. "Antiviral cyclic D, L-alpha-peptides: Targeting a general biochemical pathway in virus infections." Bioorg. Med. Chem. 2005, 13, 5145-5153.
            http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF8-4GHRBY0-4&_
user=1018416&_coverDate=09%2F01%2F2005&_rdoc=19&_fmt=high&_orig=browse&_srch= doc-info(%23toc%235220% 232005%23999869982%23602846%23FLA%23display%23Volume)&_cdi=5220&_ sort=d&_docanchor=&_ ct=42&_acct=C000050428&_version=1&_urlVersion=0&_userid= 1018416&md5=72bd55cdf4dd27a7b70f9e6ad0988ed0

            http://www.ncbi.nlm.nih.gov/pubmed/15993611

63. Yadav, M. K., Redman, J. E., Leman, L. J., Alvarez-Gutierrez, J. M., Zhang, Y., Stout, C. D., and Ghadiri, M. R. "Structure-based engineering of internal cavities in coiled-coil peptides." Biochemistry 2005, 44, 9723-9732.
            http://pubs.acs.org/doi/full/10.1021/bi050742a
            http://www.ncbi.nlm.nih.gov/pubmed/16008357

62. Ashkenasy, N., Sanchez-Quesada, J., Bayley, H., and Ghadiri, M. R. "Recognizing a single base in an individual DNA strand: A step toward DNA sequencing in nanopores." Angew. Chem., Int. Ed. 2005, 44, 1401-1404.
            http://www3.interscience.wiley.com/cgi-bin/fulltext/109869340/HTMLSTART
            http://www.ncbi.nlm.nih.gov/pubmed/15666419

61. Horne, W. S., Ashkenasy, N., and Ghadiri, M. R. "Modulating charge transfer through cyclic D,L-alpha-peptide self-assembly." Chem.--Eur. J. 2005, 11, 1137-1144.
            http://www3.interscience.wiley.com/cgi-bin/fulltext/109861319/HTMLSTART
            http://www.ncbi.nlm.nih.gov/pubmed/15624124

60. Horne, W. S., Yadav, M. K., Stout, C. D., and Ghadiri, M. R. "Heterocyclic peptide backbone modifications in an alpha-helical coiled coil." J. Am. Chem. Soc. 2004, 126, 15366-15367.
            http://pubs.acs.org/doi/full/10.1021/ja0450408
            http://www.ncbi.nlm.nih.gov/pubmed/15563148

59. Leman, L., Orgel, L., and Ghadiri, M. R. "Carbonyl sulfide-mediated prebiotic formation of peptides." Science 2004, 306, 283-286.
            http://www.sciencemag.org/cgi/content/full/306/5694/283
            http://www.ncbi.nlm.nih.gov/pubmed/15472077

58. Ashkenasy, G., and Ghadiri, M. R. "Boolean logic functions of a synthetic peptide network." J. Am. Chem. Soc. 2004, 126, 11140-11141.
            http://pubs.acs.org/doi/full/10.1021/ja046745c
            http://www.ncbi.nlm.nih.gov/pubmed/15355081

57. Ashkenasy, G., Jagasia, R., Yadav, M., and Ghadiri, M. R. "Design of a directed molecular network." Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 10872-10877.
            http://www.pnas.org/content/101/30/10872.long
            http://www.ncbi.nlm.nih.gov/pubmed/15256596

56. Sanchez-Quesada, J., Saghatelian, A., Cheley, S., Bayley, H., and Ghadiri, M. R. "Single DNA rotaxanes of a transmembrane pore protein." Angew. Chem., Int. Ed. 2004, 43, 3063-3067.
            http://www3.interscience.wiley.com/cgi-bin/fulltext/108061229/HTMLSTART
            http://www.ncbi.nlm.nih.gov/pubmed/15188482

55. Horne, W. S., Stout, C. D., and Ghadiri, M. R. "A heterocyclic peptide nanotube." J. Am. Chem. Soc. 2003, 125, 9372-9376.
            http://pubs.acs.org/doi/full/10.1021/ja034358h
            http://www.ncbi.nlm.nih.gov/pubmed/12889966

54. Saghatelian, A., Voelcker, N. H., Guckian, K. M., Lin, V. S. Y., and Ghadiri, M. R. "DNA-based photonic logic gates: AND, NAND, and INHIBIT." J. Am. Chem. Soc. 2003, 125, 346-347.
            http://pubs.acs.org/doi/full/10.1021/ja029009m
            http://www.ncbi.nlm.nih.gov/pubmed/12517142

53. Saghatelian, A., Guckian, K. M., Thayer, D. A., and Ghadiri, M. R. "DNA detection and signal amplification via an engineered allosteric enzyme." J. Am. Chem. Soc. 2003, 125, 344-345.
            http://pubs.acs.org/doi/full/10.1021/ja027885u
            http://www.ncbi.nlm.nih.gov/pubmed/12517141

52. Redman, J. E., Wilcoxen, K. M., and Ghadiri, M. R. "Automated mass spectrometric sequence determination of cyclic peptide library members." J. Comb. Chem. 2003, 5, 33-40.
            http://pubs.acs.org/doi/full/10.1021/cc0200639
            http://www.ncbi.nlm.nih.gov/pubmed/12523832

51. Redman, J. E., and Ghadiri, M. R. "Synthesis of photoactive p-azidotetrafluorophenylalanine containing peptide by solid-phase Fmoc methodology." Org. Lett. 2002, 4, 4467-4469.
            http://pubs.acs.org/doi/full/10.1021/ol026998f
            http://www.ncbi.nlm.nih.gov/pubmed/12465914

50. Sanchez-Quesada, J., Isler, M. P., and Ghadiri, M. R. "Modulating ion channel properties of transmembrane peptide nanotubes through heteromeric supramolecular assemblies." J. Am. Chem. Soc. 2002, 124, 10004-10005.
            http://pubs.acs.org/doi/full/10.1021/ja025983%2B
            http://www.ncbi.nlm.nih.gov/pubmed/12188661

49. Fernandez-Lopez, S., Kim, H.-S., Choi, E. C., Delgado, M., Granja, J. R., Khasanov, A., Kraehenbuehl, K., Long, G., Weinberger, D. A., Wilcoxen, K. M., and Ghadiri, M. R. "Antibacterial agents based on the cyclic D,L-alpha-peptide architecture." Nature 2001, 412, 452-456.
            http://www.nature.com/nature/journal/v412/n6845/full/412452a0.html
            http://www.ncbi.nlm.nih.gov/pubmed/11473322

48. Sanchez-Quesada, J., Kim, H. S., and Ghadiri, M. R. "A synthetic pore-mediated transmembrane transport of glutamic acid." Angew. Chem., Int. Ed. 2001, 40, 2503-2506.
            http://www3.interscience.wiley.com/cgi-bin/fulltext/84503191/HTMLSTART
            http://www.ncbi.nlm.nih.gov/pubmed/11443679

47. Bong, D. T., and Ghadiri, M. R. "Chemoselective Pd(0)-catalyzed peptide coupling in water." Org. Lett. 2001, 3, 2509-2511.
            http://pubs.acs.org/doi/full/10.1021/ol016169e
            http://www.ncbi.nlm.nih.gov/pubmed/11483047

46. Bong, D. T., and Ghadiri, M. R. "Self-assembling cyclic peptide cylinders as nuclei for crystal engineering." Angew. Chem., Int. Ed. 2001, 40, 2163-2166.
            http://www3.interscience.wiley.com/journal/82003461/abstract
            http://www.ncbi.nlm.nih.gov/pubmed/11433476

45. Bong, D. T., Clark, T. D., Granja, J. R., and Ghadiri, M. R. "Self-assembling organic nanotubes." Angew. Chem., Int. Ed. 2001, 40, 988-1011.
            http://www3.interscience.wiley.com/cgi-bin/fulltext/78002565/HTMLSTART
            http://www.ncbi.nlm.nih.gov/pubmed/11268062

44. Saghatelian, A., Yokobayashi, Y., Soltani, K., and Ghadiri, M. R. "A chiroselective peptide replicator." Nature 2001, 409, 797-801.
            http://www.nature.com/nature/journal/v409/n6822/full/409797a0.html
            http://www.ncbi.nlm.nih.gov/pubmed/11236988

43. Kennan, A. J., Haridas, V., Severin, K., Lee, D. H., and Ghadiri, M. R. "A de novo designed peptide ligase: a mechanistic investigation." J. Am. Chem. Soc. 2001, 123, 1797-1803.
            http://pubs.acs.org/doi/full/10.1021/ja991266c
            http://www.ncbi.nlm.nih.gov/pubmed/11456796

42. Sanchez-Quesada, J., Ghadiri, M. R., Bayley, H., and Braha, O. "Cyclic Peptides as Molecular Adapters for a Pore-Forming Protein." J. Am. Chem. Soc. 2000, 122, 11757-11766.
            http://pubs.acs.org/doi/full/10.1021/ja002436k
           
41. Bong, D. T., Janshoff, A., Steinem, C., and Ghadiri, M. R. "Membrane partitioning of the cleavage peptide in flock house virus." Biophys. J. 2000, 78, 839-845.
            http://www.cell.com/biophysj/retrieve/pii/S0006349500766410
            http://www.ncbi.nlm.nih.gov/pubmed/10653796

40. Bong, D. T., Steinem, C., Janshoff, A., Johnson, J. E., and Ghadiri, M. R. "A highly membrane- active peptide in Flock House virus: implications for the mechanism of nodavirus infection." Chem. Biol. 1999, 6, 473-481.
            http://www.cell.com/chemistry-biology/abstract/S1074-5521(99)80065-9
           
39. Vollmer, M. S., Clark, T. D., Steinem, C., and Ghadiri, M. R. "Photoswitchable hydrogen-bonding in self-organized cylindrical peptide systems." Angew. Chem., Int. Ed. 1999, 38, 1598-1601.
            http://www3.interscience.wiley.com/journal/61501359/abstract
           
38. Granja, J. R., and Ghadiri, M. R. "Self-assembling peptide nanotubes." NATO ASI Ser., Ser. C 1999, 526, 61-66.
           
37. Steinem, C., Janshoff, A., Vollmer, M. S., and Ghadiri, M. R. "Reversible photoisomerization of self-organized cylindrical peptide assemblies at air-water and solid interfaces." Langmuir 1999, 15, 3956-3964.
            http://pubs.acs.org/doi/full/10.1021/la981624%2B
           
36. Janshoff, A., Bong, D. T., Steinem, C., Johnson, J. E., and Ghadiri, M. R. "An animal virus-derived peptide switches membrane morphology: possible relevance to nodaviral transfection processes." Biochemistry 1999, 38, 5328-5336.
            http://pubs.acs.org/doi/full/10.1021/bi982976i
            http://www.ncbi.nlm.nih.gov/pubmed/10220319

35. Clark, T. D., Kobayashi, K., and Ghadiri, M. R. "Covalent capture and stabilization of cylindrical beta-sheet peptide assemblies." Chem.--Eur. J. 1999, 5, 782-792.
            http://www3.interscience.wiley.com/journal/40003319/abstract
           
34. Rapaport, H., Kim, H. S., Kjaer, K., Howes, P. B., Cohen, S., Als-Nielsen, J., Ghadiri, M. R., Leiserowitz, L., and Lahav, M. "Crystalline cyclic peptide nanotubes at interfaces." J. Am. Chem. Soc. 1999, 121, 1186-1191.
            http://pubs.acs.org/doi/full/10.1021/ja982420i
           
33. Mutz, M. W., Case, M. A., Wishart, J. F., Ghadiri, M. R., and McLendon, G. L. "De novo design of protein function: predictable structure-function relationships in synthetic redox proteins." J. Am. Chem. Soc. 1999, 121, 858-859.
            http://pubs.acs.org/doi/full/10.1021/ja9828612
           
32. Janshoff, A., Dancil, K.-P. S., Steinem, C., Greiner, D. P., Lin, V. S. Y., Gurtner, C., Motesharei, K., Sailor, M. J., and Ghadiri, M. R. "Macroporous p-type silicon Fabry-Perot layers. Fabrication, characterization, and applications in biosensing." J. Am. Chem. Soc. 1998, 120, 12108-12116.
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31. Hartgerink, J. D., Clark, T. D., and Ghadiri, M. R. "Peptide nanotubes and beyond." Chem.–Eur. J. 1998, 4, 1367-1372.
            http://www3.interscience.wiley.com/journal/5008816/abstract
           
30. Clark, T. D., Buriak, J. M., Kobayashi, K., Isler, M. P., McRee, D. E., and Ghadiri, M. R. "Cylindrical beta-sheet peptide assemblies." J. Am. Chem. Soc. 1998, 120, 8949-8962.
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29. Kim, H. S., Hartgerink, J. D., and Ghadiri, M. R. "Oriented self-assembly of cyclic peptide nanotubes in lipid membranes." J. Am. Chem. Soc. 1998, 120, 4417-4424.
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28. Severin, K., Lee, D. H., Martinez, J. A., Vieth, M., and Ghadiri, M. R. "Dynamic error correction in autocatalytic peptide networks." Angew. Chem., Int. Ed. 1998, 37, 126-128.
            http://www3.interscience.wiley.com/journal/10004510/abstract
           
27. Lee, D. H., Severin, K., and Ghadiri, M. R. "Autocatalytic networks: the transition from molecular self-replication to molecular ecosystems." Curr. Opin. Chem. Biol. 1997, 1, 491-496.
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23999989995%23286663%23FLP%23display%23Volume)&_cdi=6246&_sort= d&_docanchor=&_ct=28&_acct= C000050428&_version=1&_urlVersion=0&_userid=1018416&md5=934484bddd3210fd12
ef1f4d772ed7ba

            http://www.ncbi.nlm.nih.gov/pubmed/9667892

26. Case, M. A., Ghadiri, M. R., Mutz, M. W., and McLendon, G. L. "Stereoselection in designed three-helix bundle metalloproteins." Chirality 1998, 10, 35-40.
            http://www3.interscience.wiley.com/journal/30003335/abstract
            http://www.ncbi.nlm.nih.gov/pubmed/9470207

25. Clark, T. D., Buehler, L. K., and Ghadiri, M. R. "Self-assembling cyclic beta-3-peptide nanotubes as artificial transmembrane ion channels." J. Am. Chem. Soc. 1998, 120, 651-656.
            http://pubs.acs.org/doi/full/10.1021/ja972786f
           
24. Lee, D. H., Severin, K., Yokobayashi, Y., and Ghadiri, M. R. "Emergence of symbiosis in peptide self-replication through a hypercyclic network." Nature 1997, 390, 591-594.
            http://www.nature.com/nature/journal/v390/n6660/full/390591a0.html
            http://www.ncbi.nlm.nih.gov/pubmed/9403686

23. Motesharei, K., and Ghadiri, M. R. "Diffusion-limited size-selective ion sensing based on SAM-supported peptide nanotubes." J. Am. Chem. Soc. 1997, 119, 11306-11312.
            http://pubs.acs.org/doi/full/10.1021/ja9727171
           
22. Lin, V. S. Y., Motesharei, K., Dancil, K.-P. S., Sailor, M. J., and Ghadiri, M. R. "A porous silicon-based optical interferometric biosensor." Science 1997, 278, 840-843.
            http://www.sciencemag.org/cgi/content/full/278/5339/840
            http://www.ncbi.nlm.nih.gov/pubmed/9346478

21. Severin, K., Lee, D. H., Kennan, A. J., and Ghadiri, M. R. "A synthetic peptide ligase." Nature 1997, 389, 706-709.
            http://www.nature.com/nature/journal/v389/n6652/full/389706a0.html
            http://www.ncbi.nlm.nih.gov/pubmed/9338780

20. Severin, K., Lee, D. H., Martinez, J. A., and Ghadiri, M. R. "Peptide self-replication via template-directed ligation." Chem.–Eur. J. 1997, 3, 1017-1024.
            http://www3.interscience.wiley.com/journal/112298409/abstract
           
19. Buriak, J. M., and Ghadiri, M. R. "Self-assembly of peptide based nanotubes."
Mater. Sci. Eng., C
1997, C4, 207-212.
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1018416&_coverDate=04%2F30%2F1997&_rdoc=2&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235590%231997%
23999959995%2359151%23FLP%23display%23Volume)&_cdi= 5590&_sort=d&_docanchor=&_ct=18&_acct=
C000050428&_version=1&_urlVersion=0&_userid=1018416&md5=778c3c5aebc9b1f1ce4
a9439f1d4714e

           
18. Dawson, P. E., Churchill, M., Ghadiri, M. R., and Kent, S. B. H. "Modulation of reactivity in native chemical ligation through the use of thiol additives." J. Am. Chem. Soc. 1997, 119, 4325-4329.
            http://pubs.acs.org/doi/full/10.1021/ja962656r
           
17. Lee, D. H., and Ghadiri, M. R. "Control of peptide architecture via self-assembly and self-organization processes." Compr. Supramol. Chem. 1996, 9, 451-481.
           
16. Lee, D. H., Granja, J. R., Martinez, J. A., Severin, K., and Ghadiri, M. R. "A self-replicating peptide." Nature 1996, 382, 525-528.
            http://www.nature.com/nature/journal/v382/n6591/abs/382525a0.html
           
15. Hartgerink, J. D., Granja, J. R., Milligan, R. A., and Ghadiri, M. R. "Self-assembling peptide nanotubes." J. Am. Chem. Soc. 1996, 118, 43-50.
            http://pubs.acs.org/doi/full/10.1021/ja953070s
           
14. Clark, T. D., and Ghadiri, M. R. "Supramolecular design by covalent capture. Design of a peptide cylinder via hydrogen-bond- promoted intermolecular olefin metathesis." J. Am. Chem. Soc. 1995, 117, 12364-12365.
            http://pubs.acs.org/doi/abs/10.1021/ja00154a051
           
13. Engels, M., Bashford, D., and Ghadiri, M. R. "Structure and dynamics of self-assembling peptide nanotubes and the channel-mediated water organization and self-diffusion. A molecular dynamics study." J. Am. Chem. Soc.
1995
, 117, 9151-9158.
            http://pubs.acs.org/doi/abs/10.1021/ja00141a005
           
12. Kobayashi, K., Granja, J. R., and Ghadiri, M. R. "Beta-sheet peptide architecture: measuring the relative stability of parallel vs. antiparallel beta-sheets." Angew. Chem., Int. Ed. Engl. 1995, 34, 95-98.
            http://www3.interscience.wiley.com/journal/106589725/abstract
           
11. Ghadiri, M. R., Kobayashi, K., Granja, J. R., Chadha, R. K., and McRee, D. E. "The structural and thermodynamic basis for the formation of self-assembled peptide nanotubes." Angew. Chem., Int. Ed. Engl. 1995, 34, 93-95.
            http://www3.interscience.wiley.com/journal/106589724/abstract
           
10. Granja, J. R., and Ghadiri, M. R. "Channel-mediated transport of glucose across lipid bilayers." J. Am. Chem. Soc. 1994, 116, 10785-10786.
            http://pubs.acs.org/doi/abs/10.1021/ja00102a054
           
9. Ghadiri, M. R., Granja, J. R., and Buehler, L. K. "Artificial transmembrane ion channels from self-assembling peptide nanotubes." Nature 1994, 369, 301-304.
            http://www.nature.com/doifinder/10.1038/369301a0
            http://www.ncbi.nlm.nih.gov/pubmed/7514275

8. Khazanovich, N., Granja, J. R., McRee, D. E., Milligan, R. A., and Ghadiri, M. R. "Nanoscale tubular ensembles with specified internal diameters. Design of a self-assembled nanotube with a 13-angstrom pore." J. Am. Chem. Soc. 1994, 116, 6011-6012.
            http://pubs.acs.org/doi/abs/10.1021/ja00092a079
           
7. Ghadiri, M. R., and Case, M. A. "De novo design of a novel hetero dinuclear metalloprotein with three parallel (bundled) helixes." Angew. Chem., Int. Ed. Engl. 1993, 32, 1594-1597.
            http://www3.interscience.wiley.com/journal/106588393/abstract
           
6. Ghadiri, M. R., Granja, J. R., Milligan, R. A., McRee, D. E., and Khazanovich, N. "Self-assembling organic nanotubes based on a cyclic peptide architecture." Nature 1993, 366, 324-327.
            http://www.nature.com/doifinder/10.1038/366324a0
            http://www.ncbi.nlm.nih.gov/pubmed/8247126

5. Ghadiri, M. R., Soares, C., and Choi, C. "Design of an artificial four-helix bundle metalloprotein via a novel ruthenium(II)-assisted self-assembly process." J. Am. Chem. Soc. 1992, 114, 4000-4002.
            http://pubs.acs.org/doi/abs/10.1021/ja00036a072
           
4. Ghadiri, M. R., Soares, C., and Choi, C. "A convergent approach to protein design. Metal ion-assisted spontaneous self-assembly of a polypeptide into a triple-helix bundle protein." J. Am. Chem. Soc. 1992, 114, 825-831.
            http://pubs.acs.org/doi/abs/10.1021/ja00029a004
           
3. Ghadiri, M. R., Choi, C., Fernholz, A. K., Ruan, F., Chen, Y., Hopkins, P. B., and Aube, J. "Peptide architecture: design of stabilized alpha-helical metallopeptides." Chemtracts Org. Chem. 1991, 4, 135-139.
           
2. Ghadiri, M. R., and Fernholz, A. K. "Peptide architecture. Design of stable alpha-helical metallopeptides via a novel exchange-inert ruthenium(III) complex." J. Am. Chem. Soc. 1990, 112, 9633-9635.
            http://pubs.acs.org/doi/abs/10.1021/ja00182a030
           
1. Ghadiri, M. R., and Choi, C. "Secondary structure nucleation in peptides. Transition metal ion stabilized alpha-helices." J. Am. Chem. Soc. 1990, 112, 1630-1632.
            http://pubs.acs.org/doi/abs/10.1021/ja00160a054

 

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