Publications

 

2017

• Bortell, N., Flynn, C., Conti, B., Fox, H. S. & Marcondes, M. C. G. Osteopontin Impacts West Nile virus Pathogenesis and Resistance by Regulating Inflammasome Components and Cell Death in the Central Nervous System at Early Time Points. Mediators of inflammation https://doi.org/10.1155/2017/7582437 (2017). [PDF]
• Carvalho, G. B., Drago, I., Hoxha, S., Yamada, R., Mahneva, O., Bruce, K. D., Soto Obando, A., Conti, B. & Ja, W. W. The 4E-BP growth pathway regulates the effect of ambient temperature on Drosophila metabolism and lifespan. Proc Natl Acad Sci U S A 114, 9737-9742 (2017).
• Cintron-Colon, R., Sanchez-Alavez, M., Nguyen, W., Mori, S., Gonzalez-Rivera, R., Lien, T., Bartfai, T., Aid, S., Francois, J. C., Holzenberger, M. & Conti, B. Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction. Proc Natl Acad Sci U S A 114, 9731-9736 (2017).
• Maher, P. & Conti, B. Deciphering the pathways that protect from IL-13-mediated potentiation of oxidative stress-induced dopaminergic nerve cell death. Cytokine,  S1043-4666(17)30275-2 (2017).
• Mori, S., Sugama, S., Nguyen, W., Michel, T., Sanna, M. G., Sanchez-Alavez, M., Cintron-Colon, R., Moroncini, G., Kakinuma, Y., Maher, P. & Conti, B. Lack of interleukin-13 receptor alpha1 delays the loss of dopaminergic neurons during chronic stress. J Neuroinflammation 14, 88 (2017).

 

2016

• Conti, B.Prostaglandin E2 that triggers fever is synthesized through an endocannabinoid- dependent pathway. Temperature 3, 25-27 (2016).

• Francesconi, W., Sanchez-Alavez, M., Berton, F., Alboni, S., Benatti, C., Mori, S., Nguyen, W., Zorrilla, E., Moroncini, G., Tascedda, F. & Conti, B. The Proinflammatory Cytokine Interleukin 18 Regulates Feeding by Acting on the Bed Nucleus of the Stria Terminalis. J Neurosci 36, 5170-5180 (2016).
• Mori, S., Maher, P. & Conti, B. Neuroimmunology of the Interleukins 13 and 4. Brain sciences 6 (2016).
• Ogasawara, D., Deng, H., Viader, A., Baggelaar, M. P., Breman, A., den Dulk, H., van den Nieuwendijk, A. M., Soethoudt, M., van der Wel, T., Zhou, J., Overkleeft, H. S., Sanchez-Alavez, M., Mo, S., Nguyen, W., Conti, B., Liu, X., Chen, Y., Liu, Q. S., Cravatt, B. F. & van der Stelt, M. Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. Proc Natl Acad Sci U S A 113, 26-33 (2016).
• Sugama, S., Sekiyama, K., Kodama, T., Takamatsu, Y., Takenouchi, T., Hashimoto, M., Bruno, C. & Kakinuma, Y. Chronic restraint stress triggers dopaminergic and noradrenergic neurodegeneration: Possible role of chronic stress in the onset of Parkinson's disease. Brain Behav Immun 51, 39-46 (2016).
• Viader, A., Ogasawara, D., Joslyn, C. M., Sanchez-Alavez, M., Mori, S., Nguyen, W., Conti, B. & Cravatt, B. F. A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation. Elife 5, e12345 (2016).

 

2015

• Sanchez-Alavez, M., Nguyen, W., Mori, S., Moroncini, G., Viader, A., Nomura, D. K., Cravatt, B. F. & Conti, B. Monoacylglycerol Lipase Regulates Fever Response. PLoS ONE (2015) [PDF]
• Sugama, S., Seikiyama, K., Takenouchi, T., Hashimoto, M., Conti, B. & Kakinuma, Y. Chronic Restraint Stress Triggers the Dopaminergic and Noradrenergic Neurodegeneration: Possible Role for the Onset of Parkinson's Disease. Brain Behav Immun In Press (2015)
  
  

2014

• Zorilla, E. P. & Conti, B. Interleukin-18 Null Mutation Increases Weight and Food Intake and Reduces Energy Expenditure and Lipid Substrate Utilization in High-Fat Diet Fed Mice. Brain Behav Immun 37, 45-53 (2014) 
• Sanchez-Alavez, M., Bortell, N., A, G., Conti, B. & Marcondes, M. Reactive Oxygen Species scavenger N-Acetyl Cysteine reduces Methamphetamine-induced hyperthermia without affecting motor activity in mice. Temperature In Press (2014)
• Hale, M. W., Spencer, S. J., Conti, B., Jasoni, C. L., Kent, S., Radler, M., Reyes, T. M., Sominsky, L. Diet, behavior and immunity across the lifespan. Neuroscience & Biobehavioral Reviews (2014)
• Marcondes, M. C., Ojakian, R., Bortell, N., Flynn, C., Conti, B., Fox, H. S. Osteopontin expression in the brain triggers localized inflammation and cell death when immune cells are activated by pertussis toxin. Mediators of Inflammation (2014)
• Alboni, S., Montanari, C., Benatti, C., Sanchez-Alavez, M., Rigillo, G., Blom, J., Brunello, N., Conti B, Pariante, M. & Tascedda, F. Interleukin 18 activates MAPKs and STAT3 but not NF-kB in hippocampal HT-22 cells. Brain, behavior, and immunity In Press (2014)

2013

• Sugama, S., Takenouchi, T., Fujita, M., Kitani, H., Conti, B. & Hashimoto, M. Corticosteroids Limit Microglia Activation Occurring During Acute Stress. Neuroscience 232, 13-20 (2013)
• Sanchez-Alavez, M., Conti, B., Wood, M., Bortell, N., Bustamante, E., Saez, E., HS, F. & Marcondes, M. ROS and Sympathetically Mediated Mitochondria Activation in Brown Adipose Tissue Contribute to Methamphetamine-Induced Hyperthermia. Front Endocrinol (Lausanne), 4:44 (2013)
• Conti, B. & Hansen, M. A Cool Way to Live Long.  Cell  152, 671-672 (2013)

2012

• Morrison, B. E., Marcondes, M. C., Nomura, D. K., Sanchez-Alavez, M., Sanchez-Gonzalez, A., Saar, I., Kim, K. S., Bartfai, T., Maher, P., Sugama, S. & Conti, B. Cutting Edge: IL-13Ralpha1 Expression in Dopaminergic Neurons Contributes to Their Oxidative Stress-Mediated Loss following Chronic Peripheral Treatment with Lipopolysaccharide. J Immunol   189, 5498-5502 (2012)
• Dubins, J. S., Sanchez-Alavez, M., Zhukov, V., Sanchez-Gonzalez, A., Moroncini, G., Carvajal-Gonzalez, S., Hadcock, J. R., Bartfai, T. & Conti, B. Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin. Metabolism: clinical and experimental 61, 1486-1493 (2012)
• Bartfai, T., & Conti, B. Molecules affecting hypothalamic control of core body temperature in response to calorie intake. Frontiers in Genetics, 3, 184 (2012)

2011

• Takenouchi, T., Iwamaru, Y., Sugama, S., Tsukimoto, M., Fujita, M., Sekigawa, A., Sekiyama, K., Sato, M., Kojima, S., Conti, B., Hashimoto, M. & Kitani, H. The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1beta under acidic extracellular pH in LPS-primed microglial cells. J Neurochem 117, 712-723 (2011)
• Dinarello, C., Arend, W., Sims, J., Smith, D., Blumberg, H., O'Neill, L., Goldbach-Mansky, R., Pizarro, T., Hoffman, H., Bufler, P., Nold, M., Ghezzi, P., Mantovani, A., Garlanda, C., Boraschi, D., Rubartelli, A., Netea, M., van der Meer, J., Joosten, L., Mandrup-Poulsen, T., Donath, M., Lewis, E., Pfeilschifter, J., Martin, M., Kracht, M., Muehl, H., Novick, D., Lukic, M., Conti, B., Solinger, A., Kelk, P., van de Veerdonk, F. & Gabel, C. IL-1 family nomenclature.  Nat Immunol  11, 973 (2011)
• Nomura, D. K., Morrison, B., Blankman, J. L., Long, J. Z., Kinsey, S. G., Marcondes, M. C., Ward, A. M., Lichtman, A. H., Hahn, J. K., Conti, B. & Cravatt, B. F. Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. Science 334, 809-813 (2011)
• Sabino, V., Cottone, P., Blasio, A., Iyer, M. R., Steardo, L., Rice, K. C., Conti, B., Koob, G. F. & Zorrilla, E. P. Activation of sigma-receptors induces binge-like drinking in Sardinian alcohol-preferring rats. Neuropsychopharmacology 36, 1207-1218 (2011).
• Marcondes, M. C., Zhukov, V., Bradlow, H., Sanchez-Alavez, M., Gonzalez, A. S., Curtiss, L. K. & Conti, B. Effects of chronic mental stress and atherogenic diet on the immune inflammatory environment in mouse aorta. Brain Behav Immun 25, 1649-1657 (2011)
• Sanchez-Alavez, M., Alboni, S., Conti, B. Sex- and age-specific differences in core body temperature of C57Bl/6 mice. Age 33.1, 89-99 (2011)
• Klein, I., Sanchez-Alavez, M., Tabarean, I., Schaefer, J., Holmberg, K. H., Klaus, J., Xia, F., Marcondes, M. C., Dubins, J. S., Morrison, B., Zhukov, V., Sanchez-Gonzalez, A., Mitsukawa, K., Hadcock, J. R., Bartfai, T. & Conti, B. AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin. Brain Res 1423, 1-9 (2011)
• Alboni, S., Montanari, C., Benatti, C., Blom, J. M., Simone, M. L., Brunello, N., Caggia, F., Guidotti, G., Marcondes, M. C., Sanchez-Alavez, M., Conti, B. & Tascedda, F. Constitutive and LPS-regulated expression of interleukin-18 receptor beta variants in the mouse brain. Brain Behav Immun 25, 483-493 (2011)

2010

• Alboni, S., Cervia, D., Sugama, S., & Conti, B. Interleukin 18 in the CNS. Journal of Neuroinflammation 7, 9 (2010)
• Sanchez-Alavez, M., Tabarean, I. V., Osborn, O., Mitsukawa, K., Schaefer, J., Dubins, J., Holmberg, K. H., Klein, I., Klaus, J., Gomez, L. F., Kolb, H., Secrest, J., Jochems, J., Myashiro, K., Buckley, P., Hadcock, J. R., Eberwine, J., Conti, B. & Bartfai, T. Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons. Diabetes 59, 43-50 (2010)
• Brownell, S. E. & Conti, B. Age- and gender-specific changes of hypocretin immunopositive neurons in C57Bl/6 mice. Neurosci Lett 472, 29-32 (2010)
• Bartfai, T. & Conti, B. Fever. ScientificWorldJournal 10, 490-503 (2010)
• Osborn, O., Sanchez-Alavez, M., Brownell, S. E., Ross, B., Klaus, J., Dubins, J., Beutler, B., Conti, B. & Bartfai, T. Metabolic characterization of a mouse deficient in all known leptin receptor isoforms. Cell Mol Neurobiol 30, 23-33 
• Tabarean, I., Morrison, B., Marcondes, M. C., Bartfai, T. & Conti, B. Hypothalamic and dietary control of temperature-mediated longevity. Ageing Res Rev 9, 41-50 (2010)
• Ali, S. S., Marcondes, M. C., Bajova, H., Dugan, L. L. & Conti, B. Metabolic depression and increased ROS production by isolated mitochondria at moderately low temperatures. J Biol Chem 285, 32522-32528 (2010)

2009

• Cottone, P., Sabino, V., Roberto, M., Bajo, M., Pockros, L., Frihauf, J. B., Fekete, E. M., Steardo, L., Rice, K. C., Grigoriadis, D. E., Conti, B., Koob, G. F. & Zorrilla, E. P. CRF system recruitment mediates dark side of compulsive eating. Proc Natl Acad Sci U S A 106, 20016-20020 (2009)
• Sabino, V., Cottone, P., Zhao, Y., Iyer, M. R., Steardo, L., Jr., Steardo, L., Rice, K. C., Conti, B., Koob, G. F. & Zorrilla, E. P. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology 34, 1482-1493 (2009)
• Sugama, S., Takenouchi, T., Fujita, M., Conti, B. & Hashimoto, M. Differential microglial activation between acute stress and lipopolysaccharide treatment. J Neuroimmunol 207, 24-31 (2009)
• Alboni, S., Cervia, D., Ross, B., Montanari, C., Gonzalez, A. S., Sanchez-Alavez, M., Marcondes, M. C., De Vries, D., Sugama, S., Brunello, N., Blom, J., Tascedda, F. & Conti, B. Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain. J Neuroimmunol 214, 43-54 (2009)

2008

• Sugama, S. & Conti, B. Interleukin-18 and stress. Brain Res Rev 58, 85-95 (2008)
• Conti, B. Considerations on temperature, longevity and aging. Cell Mol Life Sci 65, 1626-1630 (2008)
• Sanchez-Alavez, M., Criado, J. R., Klein, I., Moroncini, G. & Conti, B. Hypothalamic-pituitary-adrenal axis disregulation in PrPC-null mice. Neuroreport 19, 1473-1477 (2008)
• Osborn, O., Gram, H., Zorrilla, E. P., Conti, B. & Bartfai, T. Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance. Swiss Med Wkly 138, 665-673 (2008)

2007

• Zorrilla, E. P., Sanchez-Alavez, M., Sugama, S., Brennan, M., Fernandez, R., Bartfai, T. & Conti, B. Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Proc Natl Acad Sci U S A 104, 11097-11102 (2007)
• Sugama, S., Fujita, M., Hashimoto, M. & Conti, B. Stress induced morphological microglial activation in the rodent brain: involvement of interleukin-18. Neuroscience 146, 1388-1399 (2007)
• Sotgiu, S., Sannella, A. R., Conti, B., Arru, G., Fois, M. L., Sanna, A., Severini, C., Morale, M. C., Marchetti, B., Rosati, G. & Musumeci, S. Multiple sclerosis and anti-Plasmodium falciparum innate immune response. J Neuroimmunol 185, 201-207 (2007)
• Sanna, M. V., Clemente, M. G., Bartfai, T., Conti, B. & Sanna, P. P. Potential role for the plague as a selective forse in Sardinia. L'Igiene Moderna 127, 15-42 (2007)
• Sanchez-Alavez, M., Klein, I., Brownell, S. E., Tabarean, I. V., Davis, C. N., Conti, B. & Bartfai, T. Night eating and obesity in the EP3R-deficient mouse. Proc Natl Acad Sci U S A 104, 3009-3014 (2007)
• Sanchez-Alavez, M., Conti, B., Moroncini, G. & Criado, J. R. Contributions of neuronal prion protein on sleep recovery and stress response following sleep deprivation. Brain Res 1158, 71-80 (2007)
• Conti, B., Tabarean, I., Sanchez-Alavez, M., Davis, C., Brownell, S., Behrens, M. M. & Bartfai, T. in Neuroimmune Biology; Cytokines in the Brain Vol. 6  (ed I. Berczi and A. Szentivanyi)  21-38 (Elsevier, 2007)
• Conti, B., Maier, R., Barr, A. M., Morale, M. C., Lu, X., Sanna, P. P., Bilbe, G., Hoyer, D. & Bartfai, T. Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine. Mol Psychiatry 12, 167-189 (2007)

2006

• Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R., Morale, M. C., Lucero, J., Brownell, S., Fabre, V., Huitron-Resendiz, S., Henriksen, S., Zorrilla, E. P., de Lecea, L. & Bartfai, T. Transgenic mice with a reduced core body temperature have an increased life span. Science 314, 825-828 (2006)

2005

• Conti, B., Sugama, S., Lucero, J., Winsky-Sommerer, R., Wirz, S. A., Maher, P., Andrews, Z., Barr, A. M., Morale, M. C., Paneda, C., Pemberton, J., Gaidarova, S., Behrens, M. M., Beal, F., Sanna, P. P., Horvath, T. & Bartfai, T. Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity. J Neurochem 93, 493-501 (2005)

2004

• Solforosi, L., Criado, J. R., McGavern, D. B., Wirz, S., Sanchez-Alavez, M., Sugama, S., DeGiorgio, L. A., Volpe, B. T., Wiseman, E., Abalos, G., Masliah, E., Gilden, D., Oldstone, M. B., Conti, B. & Williamson, R. A. Cross-linking cellular prion protein triggers neuronal apoptosis in vivo. Science 303, 1514-1516 (2004)

For a full list of publications please click here.