2023

Long non-coding RNAs as “MYC Facilitators”. (2023) García Caballero D, Hart JR, Vogt PK. Pathophysiology, in press.

Structural insights into the interaction of three Y-shaped ligends with PI3Kα. (2023) Zhou Q, Liu X, Neri D, Li W, Favalli N, Bassi G, Yang S, Yang D, Vogt PK, Wang MW. Proc Natl Acad Sci USA 120(34):e2304071120. PMID: 37585458. PMID: 37585458.

Structural and mechanistic insights provided by single particle cryo-EM analysis of phosphoinositide 3-kinase (PI3Kα). Vogt PK, Hart JR, Yang S, Zhou Q, Yang D, Wang M-W. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2023;1878(5):188947. PMID: 37394020. DOI: 10.1016/j.bbcan.2023.188947

The MYC-regulated lncRNA LNROP (ENSG00000254887) enables MYC-driven cell proliferation by controlling the expression of OCT2. Garcia-Caballero D, Hart JR, Vogt PK. Cell Death Dis 2023;14(2):168. PMID: 36849510.

2022

Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα. Liu X, Zhou Q, Hart JR, Xu Y, Yang S, Yang D, Vogt PK, Wang MW. Proc Natl Acad Sci USA. 2022 Nov 16;119(46):e2215621119. PMID: 36343266.

Nanobodies and chemical cross-links advance the structural and functional analysis of PI3Kalpha. Hart JR, Liu X, Pan C, Liang A, Ueno L, Xu Y, Quezada A, Zou X, Yang S, Zhou Q, Schoonooghe S, Hassanzadeh-Ghassabeh G, Xia T, Shui W, Yang D, Vogt PK, Wang MW. Proc Natl Acad Sci USA. 2022;119(38):e2210769119. PMID: 36095215.

2021

Cryo-EM structures of PI3Kα reveal conformational changes during inhibition and activation. (2021) Liu X, Yang S, Hart JR, Xu Y, Zou X, Zhang H, Zhou Q, Xia T, Zhang Y, Yang D, Wang M-W, Vogt PK. Proc Natl Acad Sci USA. 118(45):e2109327118. PMID: 34725156

Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay. (2021) Shirey RJ, Hart JR, Sridharan B, Novick SJ, Turner LD, Zhou B, Nielsen AL, Eubanks LM, Ueno L, Hixon MS, Lairson LL, Spicer TP, Scampavia LD, Griffin PR, Vogt PK, Janda KD. Bioorg Med Chem 42:116246. PMID: 34130216

Stereo- and regio-defined DNA-encoded chemical libraries enable efficient tumour-targeting applications. (2021) Favalli N, Bassi G, Pellegrino C, Millul J, De Luca R, Cazzamalli S, Yang S, Trenner A, Mozzafari NL, Myburgh R, Moroglu M, Conway SJ, Sartori AA, Manz MG, Lerner RA, Vogt PK, Scheuermann J, Neri D. Nat Chem, 13(6):540-548. PMID: 33833446

2020

A single-stranded DNA-encoded chemical library based on a stereoisomeric scaffold enables ligand discovery by modular assembly of building blocks. (2020) Bassi G, Favalli N, Vuk M, Catalano M, Martinelli A, Trenner A, Porro A, Yang S, Tham CL, Moroglu M, Yue WW, Conway SJ, Vogt PK, Sartori AA, Scheuermann J, Neri D. Adv Sci, 7(22): 2001970. PMID: 33240760

An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation. (2020) Raffeiner P, Hart JR, García-Caballero D, Bar-Peled L, Weinberg MS, Vogt PK. Proc Nat Acad Sci USA, 117(12): 6571-9. PMID: 32156728

➡ Available on the journal website.

2019

From Viruses to Genes to Cells. (2019) Vogt PK. Annu Rev Virol, 6(1): 31-47. PMID: 31567064

➡ Available on the journal website.

PIK3CA Cooperates with KRAS to Promote MYC Activity and Tumorigenesis via the Bromodomain Protein BRD9. (2019) Bell CM, Raffeiner P, Hart JR, Vogt PK. Cancers (Basel), 11(11): 1634. PMID: 31652979

➡ Available on the journal website.

The Importance of Being Non-Defective: A Mini Review Dedicated to the Memory of Jan Svoboda. (2019) Vogt PK. Viruses, 11(1): 80. PMID: 30669277

➡ Available on the journal website.

2018

Isoform-specific activities of the regulatory subunits of phosphatidylinositol 3-kinases - potentially novel therapeutic targets. (2018) Ito Y, Hart JR, Vogt PK. Expert Opin Ther Targets, 22(10): 869-77. PMID: 30205700

Synthetic molecules for disruption of the MYC protein-protein interface. (2018) Jacob NT, Miranda PO, Shirey RJ, Gautam R, Zhou B, de Orbe Izquierdo ME, Hixon MS, Hart JR, Ueno L, Vogt PK, Janda KD. Bioorg Med Chem, 26(14): 4234-9. PMID: 30037753

2017

tsRNA signatures in cancer. (2017) Balatti V, Nigita G, Veneziano D, Drusco A, Stein GS, Messier TL, Farina NH, Lian JB, Tomasello L, Liu C-g, Palamarchuk A, Hart JR, Bell C, Carosi M, Pescarmona E, Perracchio L, Diodoro M, Russo A, Antenucci A, Visca P, Ciardi A, Harris CC, Vogt PK, Pekarsky Y, Croce CM. Proc Natl Acad Sci USA, 114(30): 8071-6. PMID: 28696308

Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β. (2017) Ito Y, Vogt PK, Hart JR. Oncotarget, 8(34): 55863-76. PMID: 28915558

2016

A butterfly effect in cancer. (2016) Vogt PK, Hart JR, Yates JR, 3rd. Mol Cell Oncol, 3(1): e1029063. PMID: 27308543

MINCR is not a MYC-induced lncRNA. (2016) Hart JR, Weinberg MS, Morris KV, Roberts TC, Janda KD, Garner AL, Vogt PK. Proc Natl Acad Sci USA, 113(5): E496-7. PMID: 26811502

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling. (2016) Athuluri-Divakar SK, Vasquez-Del Carpio R, Dutta K, Baker SJ, Cosenza SC, Basu I, Gupta YK, Reddy MV, Ueno L, Hart JR, Vogt PK, Mulholland D, Guha C, Aggarwal AK, Reddy EP. Cell, 165(3): 643-55. PMID: 271980