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Valente Lab Publications

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Takata H, Kessing C, Sy A, Lima N, Sciumbata J, Mori L, Jones RB, Chomont N, Michael NL, Valente S, Trautmann L. (2019) Modeling HIV-1 Latency Using Primary CD4+ T Cells from Virally Suppressed HIV-1-Infected Individuals on Antiretroviral Therapy Journal of Virology 2019 May 15;93(11). pii: e02248-18. doi: 10.1128/JVI.02248-18. Print 2019 Jun 1 (

Mediouni S, Kessing CF, Jablonski JA, Thenin-Houssier S, Clementz M, Kovach MD, Mousseau G, de Vera IMS, Li C, Kojetin DJ, Evans DT, Valente ST (2019) The Tat inhibitor didehydro-cortistatin A suppresses SIV replication and reactivation Faseb 2019;Apr 25:fj201801165R. doi: 10.1096/fj.201801165R. [Epub ahead of print] (

Li C, Mousseau G, Valente ST. (2019) Tat inhibition by didehydro-Cortistatin A promotes heterochromatin formation at the HIV-1 long terminal repeat. Epigenetics Chromatin 2019 Apr 16;12(1):23. doi: 10.1186/s13072-019-0267-8 (

Mediouni S, Chinthalapudi K, Ekka MK, Usui I, Jablonski JA, Clementz MA, Mousseau G, Nowak J, Macherla VR, Beverage JN, Esquenazi E, Baran P, de Vera IMS, Kojetin D, Loret EP, Nettles K, Maiti S, Izard T, Valente ST (2019) Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat. MBio 2019 Feb 5;10(1). pii: e02662-18. doi: 10.1128/mBio.02662-18 (

Mediouni S, Jablonski JA, Tsuda S, Richard A, Kessing C, Andrade MV, Biswas A, Even Y, Tellinghuisen T, Choe H, Cameron M, Stevenson M, Valente ST. (2018) Potent suppression of HIV-1 cell attachment by Kudzu root extract Retrovirology. 2018 Sep 20;15(1):64. doi: 10.1186/s12977-018-0446-x. (

Cari F. Kessing, Christopher C. Nixon, Chuan Li, Perry Tsai, Hiroshi Takata, Guillaume Mousseau, Phong T. Ho, Jenna B. Honeycutt, Mohammad Fallahi, Lydie Trautmann, J. Victor Garcia & Valente, S.T. (2017) In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a ‘‘Block-and-Lock’’ Strategy for HIV-1 Treatment. Cell Reports. 21-3:600-611(

Mousseau G.& Valente, S.T. (2017) Optimizing In Vitro Pre-mRNA 3′ Role of Host Factors on the Regulation of Tat-Mediated Transcription. Current Pharmaceutical Design. 2017;23(28):4079-4090 (

Mihwa Na, Susana T. Valente, & Kevin Ryan (2016) Optimizing In Vitro Pre-mRNA 3′ Cleavage Efficiency:Reconstitution from Anion-Exchange Separated HeLa Cleavage Factors and from Adherent HeLa Cell Nuclear Extract. Eukaryotic Transcriptional and Post-Transcriptional Gene Expression Regulation:Methods in Biology. 1507:179-198 (

Wu H, Mousseau G, Mediouni S, Valente ST, Kodadek T. (2016) Cell-Permeable Peptides Containing Cycloalanine Residues. 2016 Oct 4;55(41):12637-42. doi: 10.1002/anie.201605745. Epub 2016 Aug 16 (

Sonia Mediouni, Maria Cecilia Garibaldi Marcondes, Courtney Miller, Jay P. McLaughlin & Valente, S.T. (2015) The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders. Frontiers in Microbiology, section Virology. 6: 1164. (

Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. (2016) International AIDS Society global scientific strategy: towards an HIV cure 2016.  Nature Medicine 2016 Aug;22(8):839-50. doi: 10.1038/nm.4108. Epub 2016 Jul 11. (

Thenin-Houssier S, de Vera IM, Pedro-Rosa L, Brady A, Richard A, Konnick B, Opp S, Buffone C, Fuhrmann J, Kota S, Billack B, Pietka-Ottlik M, Tellinghuisen T, Choe H, Spicer T, Scampavia L, Diaz-Griffero F, Kojetin DJ, Valente ST. (2016) Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication.  AAC 2016 Mar 25;60(4):2195-208. doi: 10.1128/AAC.02574-15. Print 2016 Apr. (

Thenin-Houssier S. & Valente, S.T. (2015) HIV-1 capsid inhibitors as antiretroviral agents. Review. Curr HIV Res. 14(3):270-82. (

Mousseau G., Kessing C.F., Fromentin R., Trautmann L., Chomont N. & Valente, S.T. (2015) The Tat inhibitor didehydro-Cortistatin A prevents HIV-1 reactivation from latency. mBio 6(4): e00465-15 (

Mousseau, G. Mediouni, S. & Valente, S.T. (2015) Targeting HIV transcription: the quest for a functional cure. Current Topics in Microbiology and Immunology. Series on novel and future small molecule treatments for HIV 389:121-45. doi: 10.1007/82_2015_435 (

Mediouni, S., Jablonski, J., Paris, J.J., Clementz, M., Thenin-Houssier, S., McLaughlin, J.P. & Valente, S.T. (2015) Didehydro-Cortistatin A Inhibits HIV-1 Tat Mediated Neuroinflammation and Prevents Potentiation of Cocaine Reward in Tat Transgenic Mice. Current HIV Research 13(1):64-79 (

Jablonski, J., Clementz, M., Ryan, K., & Valente, S.T. (2014) Analysis of RNA processing reactions using cell free systems: 3' end cleavage of pre-mRNA substrates in vitro. Journal of Visualiized Experiments: JoVE (87), e51309, doi:10.3791/51309 (

Mousseau, G. & Valente, S.T. (2012) Strategies to block HIV transcription: focus on small molecule Tat inhibitors.  Biology 1(3):668-697. (

Mousseau, G., Clementz, M., Bakeman, W., Nagarsheth, N., Cameron, M., Shi, J., Baran, P. Fromentin, R., Chomont, N. & Valente, S.T. (2012) An analog of the Natural Steroidal Alkaloid Cortistatin A potently suppresses Tat-dependent HIV transcription. Cell Host and Microbe 12(1):97-108. (

Valente, S.T., Gilmartin, G.M., Venkataraman, K., Arriagada, G., & Goff, S.P. (2009) HIV-1 mRNA 3’ end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8. Molecular Cell 23;36(2):279-89. (

Valente, S.T., Gilmartin, G.M., Mott, C., Falkard, B., & Goff, S.P. (2009) Inhibition of HIV-1 replication by eIF3f. Proc Natl Acad Sci U S A 106:4071-4078. (

Valente, S.T. & Goff, S.P. (2009) Somatic Cell Genetic Analyses to Identify HIV-1 Host Restriction Factors. Methods Molecular Biology 485:235-255. (

Naghavi, M. H., Valente, S., Hatziioannou, T., de Los Santos, K., Wen, Y., Mott, C., Gundersen, G.G., & Goff, S.P. (2007) Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells.Embo Journal 26:41-52. (

Valente, S. & Goff, S.P. (2006) Inhibition of HIV-1 Gene Expression by a Fragment of hnRNP U. Molecular Cell 23:597-605. (

Hazan, U., Romero, I. A., Cancello, R., Valente, S., Perrin, V., Mariot, V., Dumonceaux, J., Gerhardt, C.C., Strosberg, A.D., Couraud, P.O., et al. (2002) Human adipose cells express CD4, CXCR4, and CCR5 [corrected] receptors: a new target cell type for the immunodeficiency virus-1? Faseb Journal 16:1254-1256. (

Valente, S.T., Chanel, C., Dumonceaux, J., Olivier, R., Marullo, S., Briand, P., & Hazan, U. (2001) CXCR4 is down-regulated in cells infected with the CD4-independent X4 human immunodeficiency virus type 1 isolate m7NDK. Journal of Virology 75:439-447.  (

Dumonceaux, J. Chanel, C., Valente, S., Quivet, L., Briand, P, & Hazan, U. (1999) Mutations in the env gene of human immunodeficiency virus type 1 NDK isolates and the use of African green monkey CXCR4 as a co-receptors in COS-7 cells. Journal of General Virology 80:1975-1982. (



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