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Valente Lab Publications

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Cari F. Kessing, Christopher C. Nixon, Chuan Li, Perry Tsai, Hiroshi Takata, Guillaume Mousseau, Phong T. Ho, Jenna B. Honeycutt, Mohammad Fallahi, Lydie Trautmann, J. Victor Garcia & Valente, S.T. (2017) In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a ‘‘Block-and-Lock’’ Strategy for HIV-1 Treatment. Cell Reports. 21-3:600-611(

Mousseau G.& Valente, S.T. (2017) Optimizing In Vitro Pre-mRNA 3′ Role of Host Factors on the Regulation of Tat-Mediated Transcription. Current Pharmaceutical Design. 2017;23(28):4079-4090 (

Mihwa Na, Susana T. Valente, & Kevin Ryan (2016) Optimizing In Vitro Pre-mRNA 3′ Cleavage Efficiency:Reconstitution from Anion-Exchange Separated HeLa Cleavage Factors and from Adherent HeLa Cell Nuclear Extract. Eukaryotic Transcriptional and Post-Transcriptional Gene Expression Regulation:Methods in Biology. 1507:179-198 (

Sonia Mediouni, Maria Cecilia Garibaldi Marcondes, Courtney Miller, Jay P. McLaughlin & Valente, S.T. (2015) The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders. Frontiers in Microbiology, section Virology. 6: 1164. (

Thenin-Houssier S. & Valente, S.T. (2015) HIV-1 capsid inhibitors as antiretroviral agents. Review. Curr HIV Res. 14(3):270-82. (

Mousseau G., Kessing C.F., Fromentin R., Trautmann L., Chomont N. & Valente, S.T. (2015) The Tat inhibitor didehydro-Cortistatin A prevents HIV-1 reactivation from latency. mBio 6(4): e00465-15 (

Mousseau, G. Mediouni, S. & Valente, S.T. (2015) Targeting HIV transcription: the quest for a functional cure. Current Topics in Microbiology and Immunology. Series on novel and future small molecule treatments for HIV 389:121-45. doi: 10.1007/82_2015_435 (

Mediouni, S., Jablonski, J., Paris, J.J., Clementz, M., Thenin-Houssier, S., McLaughlin, J.P. & Valente, S.T. (2015) Didehydro-Cortistatin A Inhibits HIV-1 Tat Mediated Neuroinflammation and Prevents Potentiation of Cocaine Reward in Tat Transgenic Mice. Current HIV Research 13(1):64-79 (

Jablonski, J., Clementz, M., Ryan, K., & Valente, S.T. (2014) Analysis of RNA processing reactions using cell free systems: 3' end cleavage of pre-mRNA substrates in vitro. Journal of Visualiized Experiments: JoVE (87), e51309, doi:10.3791/51309 (

Mousseau, G. & Valente, S.T. (2012) Strategies to block HIV transcription: focus on small molecule Tat inhibitors.  Biology 1(3):668-697. (

Mousseau, G., Clementz, M., Bakeman, W., Nagarsheth, N., Cameron, M., Shi, J., Baran, P. Fromentin, R., Chomont, N. & Valente, S.T. (2012) An analog of the Natural Steroidal Alkaloid Cortistatin A potently suppresses Tat-dependent HIV transcription. Cell Host and Microbe 12(1):97-108. (

Valente, S.T., Gilmartin, G.M., Venkataraman, K., Arriagada, G., & Goff, S.P. (2009) HIV-1 mRNA 3’ end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8. Molecular Cell 23;36(2):279-89. (

Valente, S.T., Gilmartin, G.M., Mott, C., Falkard, B., & Goff, S.P. (2009) Inhibition of HIV-1 replication by eIF3f. Proc Natl Acad Sci U S A 106:4071-4078. (

Valente, S.T. & Goff, S.P. (2009) Somatic Cell Genetic Analyses to Identify HIV-1 Host Restriction Factors. Methods Molecular Biology 485:235-255. (

Naghavi, M. H., Valente, S., Hatziioannou, T., de Los Santos, K., Wen, Y., Mott, C., Gundersen, G.G., & Goff, S.P. (2007) Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells.Embo Journal 26:41-52. (

Valente, S. & Goff, S.P. (2006) Inhibition of HIV-1 Gene Expression by a Fragment of hnRNP U. Molecular Cell 23:597-605. (

Hazan, U., Romero, I. A., Cancello, R., Valente, S., Perrin, V., Mariot, V., Dumonceaux, J., Gerhardt, C.C., Strosberg, A.D., Couraud, P.O., et al. (2002) Human adipose cells express CD4, CXCR4, and CCR5 [corrected] receptors: a new target cell type for the immunodeficiency virus-1? Faseb Journal 16:1254-1256. (

Valente, S.T., Chanel, C., Dumonceaux, J., Olivier, R., Marullo, S., Briand, P., & Hazan, U. (2001) CXCR4 is down-regulated in cells infected with the CD4-independent X4 human immunodeficiency virus type 1 isolate m7NDK. Journal of Virology 75:439-447.  (

Dumonceaux, J. Chanel, C., Valente, S., Quivet, L., Briand, P, & Hazan, U. (1999) Mutations in the env gene of human immunodeficiency virus type 1 NDK isolates and the use of African green monkey CXCR4 as a co-receptors in COS-7 cells. Journal of General Virology 80:1975-1982. (



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