Jonathan Edward McDunn

Studies in Antibody Catalysis:
I. Preparation and Evaluation of an Activatable Insulin Prodrug
II. Physiological Roles for the Antibody-Catalyzed Oxidation of Water

Advisor: Richard A. Lerner, president of TSRI

Michael L. Mitchell

I. Design and Synthesis of Mechanism-Based Inhibitors of Glycosyl Transferases
II. Stereochemical Determination of 2-Deoxyribose-5-Phosphate Aldolase (DERA)

Advisor: Chi-Huey Wong, professor, Department of Chemistry

Kenji Namoto

Design, Synthesis, and Biological Evaluation of 12, 13-Cycloalkyl Epothilones

Advisor: K. C. Nicolaou, professor and chair, Department of Chemistry

Brian Eric Nordin

RNA-Dependent Amino Acid Discrimination in Translation

Advisor: Paul R. Schimmel, professor, Department of Molecular Biology

Thomas K. Ritter

Inhibiting Bacterial Transglycosylation: From Small Molecules to a Library of Vancomycin Analogs

Advisor: Chi-Huey Wong, professor, Department of Chemistry

Alan Saghatelian

Emergence of Higher Order Function Through the Expression of Chemical Information

Advisor: M. Reza Ghadiri, professor, Department of Chemistry

Jason Ronald Schnell

NMR Studies of Backbone and Side-Chain Dynamics in Dihydrofolate Reductase

Advisor: Peter E. Wright, professor and chair, Department of Molecular Biology

Steven P. Sholly

The Mechanism of Dynamin's Assembly Dependent GAP Activity and Its Role in Endocytosis

Advisor: Sandra L. Schmid, professor and chair, Department of Cell Biology

Beth Stroupe

Making and Using Siroheme: the X-ray Crystallographic Structures of Siroheme Synthase and Sulfite Reductase

Advisor: Elizabeth Getzoff, professor, Department of Molecular Biology

Junko Tamiya

Part I. Total Synthesis of Hispidospermidin
Part II. Redirecting the Specific Reactivity of a Natural Product and its Application to Functional Proteomics

Advisor: Erik J. Sorensen, associate professor, Department of Chemistry

Elizabeth H. Z. Thompson

Dissection of Polymerase and Exonuclease Site Binding, Match and Mismatch Recognition, and Active Site Switching of Klenow Fragment Polymerase

Advisor: David P. Millar, associate professor, Department of Molecular Biology

Michael James Thompson

Density Functional Model of Photoactive Yellow Protein

Advisor: Elizabeth Getzoff, professor, Department of Molecular Biology

James McKay Turner

Antibodies and Enzymes of Therapeutic Interest

Advisor: Richard A. Lerner, president of TSRI

Joleen T. White

Understanding Transthyretin Amyloid Formation to Promote Therapeutic Development

Advisor: Jeffery W. Kelly, professor, Department of Chemistry

Keith Mathew Wilcoxen

Investigations into the Biomimetic Synthesis, Structural Determination and Therapeutic Development of Antimicrobial Peptides

Advisor: M. Reza Ghadiri, professor, Department of Chemistry

Gordon D. Wilkie

Part I. 1,3,4-Oxadiazoles in Tandem Diels-Alder, 1,3-Dipolar Cycloaddition Reactions: A Rapid Synthesis of Vinca Alkaloid Motifs
Part II. Exceptionally Potent Inhibitors of Fatty Acid Amide Hydrolase

Advisor: Dale L. Boger, professor, Department of Chemistry