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Scientific Report 2008


Cell Biology




Molecular Biology of Innate Behavior

L. Stowers, P. Chamero, K. Flanagan, D. Logan, T. Marton, F. Papes

Every breath samples the environment for olfactory chemical information, determining the quality of food, warning of danger, and confirming safety. The neurons that mediate olfaction are of 2 types: those that mediate an evocative perception that varies with an individual's experience and those that regulate stereotyped innate social behaviors such as aggression and mating in response to pheromones. The biochemical nature of the pheromone code that induces innate behavior in mammals is not known, and the sensory system responsible for the detection of pheromones is a matter of controversy. We expect that elucidating the stimulating ligands and responsive neurons will enable us to activate, study, and identify the mechanisms underlying neural information coding of defined behaviors.

We recently isolated novel mouse pheromones that mediate aggressive behavior and determined the identity of the aggression-promoting chemosensory neurons. We have taken a unique approach to decode olfaction; we are working forward from the behavioral activity to identify novel genetically encoded pheromones. These pheromone proteins reproducibly activate a subset of accessory olfactory neurons, enabling the molecular identification of those neurons that mediate the aggression-promoting behavior. This step is a fundamental one for understanding intraspecific communication in mammals and characterizing the neuronal circuit that regulates behavior.

The response of an individual to pheromones varies with the individual's age, sex, and dominance. We are using the purified aggression-promoting pheromone of mice to understand this plasticity. Interestingly, we found that whereas males have sensory neurons that respond to the pheromone, the sensory neurons in females are not activated by this cue. This lack of response suggests that males and females are sampling different features of the environment, a difference that in turn leads to different behavioral outcomes.

Our progress in discovering the ligands and sensory neurons that promote innate behaviors is enabling us to identify mechanisms of neural information coding. We have compiled a unique set of resources that will allow us to answer some of the fundamental unanswered questions about both specific and more general aspects of the neural coding of innate behavior.

Publications

Chamero, P., Marton, T.F., Logan, D.W., Flanagan, K., Cruz, J., Saghatelian, A., Cravatt, B.F., Stowers, L. Identification of protein pheromones that promote aggressive behaviour. Nature 450:899, 2007.

Logan, D.W., Marton, T.F., Stowers, L. Species specificity in major urinary proteins by parallel evolution. PLoS ONE 3:e3280, 2008.

 

Lisa Stowers, Ph.D.
Assistant Professor



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