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Complete Publications

1. Wilson, M.R., Arroyave, C.M., Miles, L.A. and Tan, E.M. Immunereac¬tants in cryoproteins. Ann. Rheum. Dis., 1977, 36:540-548.

2. Bouma, B.N., Miles, L.A., Beretta, G. and Griffin, J.H. Human plasma prekallikrein. Studies of its activation by activated Factor XII and of its inactivation by diisopropyl phosphofluoridate. Biochemistry, 1980, 19:1151-1160.

3. Miles, L.A., Burnier, J.P., Verlander, M.S., Goodman, M., Kleiss, A.J. and Griffin, J.H. Inactivation of purified human alpha2-antiplasmin and purified human C1 inhibitor by synthetic fibrinolytic agents. Blood, 1981, 57:1015-1026.

4. Miles, L.A., Plow, E.F., Donnelly, K.J., Hougie, C. and Griffin, J.H. A bleeding disorder due to deficiency of alpha2-antiplasmin. Blood, 1982, 59:1246-1251.

5. Miles, L.A. Mechanisms of intrinsic fibrinolysis. Ph.D. Dissertation, University of California, San Diego, 1982.

6. Miles, L.A., Rothschild, Z. and Griffin, J.H. Dextran-sulfate-¬dependent fibrinolysis in whole human plasma: Dependence on Factor XII and Prekallikrein. J. Lab. Clin. Med, 1983, 101:214-225.

7. Miles, L.A., Greengard, J.S. and Griffin, J.H. A simultaneous comparison of the abilities of plasma kallikrein, beta-Factor XIIa, Factor XIa and urokinase to activate plasminogen. Thromb. Res, 1983, 29:407-417.

8. Miles, L.A. and Plow, E.F. Binding and activation of plasminogen on the platelet surface. J. Biol. Chem., 1985, 260:4303-4311.

9. Miles, L.A., Ginsberg, M.H., White, J.G. and Plow, E.F. Plasminogen interacts with human platelets through two distinct mechanisms. J. Clin. Invest., 1986, 77:2001-2009.

10. Miles, L.A. and Plow, E.F. Topography of the high affinity lysine binding site of plasminogen as defined with a specific antibody probe. Biochemistry, 1986, 25:6926-6933.

11. Plow, E.F., Freaney, D.E. Plescia, J. and Miles, L.A. The plasminogen system and cell surfaces: Evidence for plasminogen and urokinase receptors. J. Cell Biol, 1986, 103:2411-2420.

12. Miles, L.A. and Plow, E.F. Receptor mediated binding of the fibrinolytic components, plasminogen and urokinase, to peripheral blood cells. Thromb. Haemost. 1987, 58:936-942.

13. Miles, L.A., Levin, E.G., Plescia, J., Collen, D. and Plow, E.F. Plasminogen receptors, urokinase receptors and their modulation on human endothelial cells. Blood, 1988, 72:628-635.

14. Miles, L.A., Dahlberg, C.M. and Plow, E.F. The cell-binding domains of plasminogen and their function in plasma. J. Biol. Chem., 1988, 263:11928-11934.

15. Beebe, D.P., Miles, L.A. and Plow, E.F. A linear amino acid sequence involved in the interaction of t-PA with its endothelial cell receptor. Blood, 1989, 74:2034-2037.

16. Miles, L.A., Dahlberg, C.M., Levin, E.G. and Plow, E.F. Gangliosides interact directly with plasminogen and urokinase and may mediate binding of these fibrinolytic components to cells. Biochemistry, 1989, 28:9337-9343.

17. Miles, L.A., Fless, G.M., Levin, E.G., Scanu, A.M. and Plow, E.F. A potential basis for the thrombotic risks associated with lipoprotein(a). Nature, 1989, 339:301-303.

18. Felez, J., Miles, L.A., Plescia, J. and Plow, E.F. Regulation of plasminogen receptor expression on human monocytes and monocytoid cell lines. J. Cell Biol., 1990, 111:1673-1683.

19. Miles, L.A., Dahlberg, C.M., Plescia, J., Felez, J., Kato, K. and Plow, E.F. Role of cell-surface lysines in plasminogen binding to cells: Identification of a-enolase as a candidate plasminogen receptor. Biochemistry, 1991, 30:1682-1691.

20. Felez, J., Chanquia, C.J., Levin, E.G., Miles, L.A. and Plow, E.F. Binding of tissue plasminogen activator to human monocytes and monocytoid cells. Blood, 1991, 78:2318-2327.

21. Felez, J. Chanquia, C., Plow, E.F. and Miles, L.A. Competition between plasminogen and t-PA for cellular binding sites. Blood, 1993, 82:2433-2441.

22. Scanu, A.M., Miles, L.A., Fless, G.M., Pfaffinger, D., Eisenbart, J., Jackson, E., Hoover-Plow, J.L., Brunck, T. and Plow, E.F. Rhesus Monkey lipoprotein(a) binds to lysine Sepharose and U937 monocytoic cells less efficiently than human lipoprotein(a). Evidence for the dominant role of Kringle 437. J. Clin. Invest., 1993, 91:283-291.

23. Levin, E.G., Miles, L.A., Fless, G.M., Scanu, A.M., Baynham, P., Curtiss, L.K. and Plow, E.F. Lipoproteins inhibit the secretion of tissue plasminogen activator from human endothelial cells. Arteriosclerosis & Thromb., 1994, 14:438-442.

24. Miles, L.A., Fless, G.M., Scanu, A.M., Baynham, P., Sebald, M.T., Skocir, P., Crutiss, L.K., Levin, E.G., Hoover-Plow, J.L. and Plow, E.F. Interaction of Lp(a) with plasminogen binding sites on cells. Thrombosis and Haemostasis, 1995, 73(3):458-465.

25. Redlitz, A., Fowler, B.J., Plow, E.F. and Miles, L.A. The role of an enolase-related molecule in plasminogen binding to cells. Eur. J. Biochem., 1995, 227:407-415.

26. Almenar-Queralt, A., Duperray, A., Miles, L.A., Felez, J. and Altieri, D.C. Apical topography and modulation of ICAM-1 expression on activated endothelium. Am. J. Pathol., 1995, 147:1278-1288.

27. Felez, J., Miles, L.A., Fabregas, P., Jardi, M., Plow, E.F. and Lijnen, H.R. Characterization of cellular receptors and interactive regions within reactants required for enhancement of plasminogen activation by tPA on the surface of leukocytic cells. Thrombosis and Haemostasis, 1996, 76:577-585.

28. Kim, Sun-Ok, Plow, E.F. and Miles, L.A. Regulation of plasminogen receptor expression on monocytoid cells by b1-integrin-dependent cellular adherence to extracellular matrix proteins. J. Biol. Chem., 1996, 271(39):23761-23767.

29. Jardí, M., Inglés-Esteve, J., Burgal, M., Azqueta, C., Velasco, F., Miles, L.A. and Felez, J. Distinct patterns of urokinase receptor (uPAR) expression by leukemic cells and peripheral blood cells. Thromb. Hemostasis, 1996, 76(6):1009-1019.

30. Parmer, R.J., Mahata, M., Mahata, S., Sebald, M.T., O'Connor, D.T. and Miles, L.A. Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway: Catecholamine storage vesicles as a reservoir for the rapid release of t-PA. J. Biol. Chem., 1997, 272(3):1976-1982.

31. Jenkins, G.R.E., Seiffert, D., Parmer, R.J. and Miles, L.A. Regulation of plasminogen gene expression by interleukin-6 in hepatoma and murine liver cells. Blood, 1997, 89(7):2394-2403.

32. Arza, B., Félez, J., Miles, L.A., Lopez-Alemany, R. and Muñoz-Cánoves, P. Identification of an epitope of a-enolase (A candidate plasminogen receptor) by phage display. Thrombosis and Haemostasis, 1997, 78:1097-1103.

33. Miles, L.A., Sebald, M.T., Fless, G.M., Scanu, A.M., Curtiss, L.K., Plow, E.F. and Hoover-Plow, J.L. Interaction of lipoprotein(a) [Lp(a)] with the extracellular matrix. Fibrinolysis and Proteolysis, 1998, 12:79-87.

34. Fowler, B., Mackman, N., Parmer, R.J., and Miles, L.A. Binding of human single chain urokinase to Chinese hamster ovary cells and cloning of hamster u-PAR. Thrombosis and Haemostasis, 1998, 80:148-154.

35. Xue, S., Green, M.A., LaGrasso, P.V., Boettcher, B.R., Madison, E.L., Curtiss, L.K. and Miles, L.A. Comparison of the effects of apo(a) kringle IV-10 and plasminogen kringles on the interactions of lipoprotien(a) with regulatory molecules. Thrombosis and Haemostasis, 1999, 81:428-435.

36. Oka, H., Kugiyama, K., Doi, H., Sugiyama, S., Matsumura, T., Ogata, N., Miles, L.A. and Yasue, H. Lysophosphatidylcholine induces Urokinase-type plasminogen activator and its receptor in human macrophages through a redox-sensitive pathway. Arterioscler Thrombosis and Vascular Biology, 2000, 20:244-250.

37. Pozzi, A., Moberg, P.E., Miles, L.A., Soloway, P., Wagner, S. and Gardner, H. Integrin a 1-null mice show reduced tumor angiogenesis due to increased metalloprotease and angiostatin sythesis. Proc. Natl. Acad. Sci., 2000, 5:2202-2207. (Identified as one of the most cited papers in the research area of matrix metalloprotease inhibition)

38. Parmer, R.J., Mahata, M., Gong, Y., Mahata, S.R., Jiang, Q., O’Connor, D.T., Xi, X-P., and Miles, L.A. Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion. J. Clin. Invest., 2000, 106:907-915.

39. Hawley, S.B., Green, M.A. and Miles, L.A. Discriminating between cell surface and intracellular plasminogen binding proteins reveals the presence of previously unrecognized plasminogen receptors. Thrombosis and Haemastasis, 2000, 84:882-890.

40. Hawley, S.B., Tamura, T.-A., and Miles, L.A. Purification, cloning and characterization of a profibrinolytic plasminogen binding protein: TIP49a. J. Biol. Chem., 2001, 276:179-186.

41. Schleef, R.R., Olman, M.A., Miles, L.A., and Chuang, J.L. Modulating the fibrinolytic system of peripheral blood mononuclear cells with adenovirus. Human Gene Therapy, 2001, 12:439-445.

42. Gong, Y., Kim, S-O., Felez, J., Grella, D.K., Castellino, F.J. and Miles, L.A. Conversion of glu-plasminogen to lys-plasminogen accounts for stimulation of plasminogen activation on the cell surface. J. Biol. Chem, 2001, 276:19078-19083.

43. Jiang, Q., Taupenot, L., Mahata, S.K., O’Connor, D.T., Miles, L.A., Parmer, R.J. Proteolytic cleavage of chromogranin A (CgA) by plasmin: selective liberation of a specific bioactive CgA fragment that regulates catecholamine release. J. Biol. Chem, 2001, 276(27):25022-25029.

44. Xue, S., Madison, E.L.and Miles, L.A. The Kringle V-protease domain is a fibrinogen binding region within Apo(a). Thrombosis and Haemostasis, 2001, 86:1229-1237.

45. Tarui, T., Miles, L.A., and Takada, Y. Specific interaction of angiostatin with integrin ανβ3 in endothelial cells. J. Biol. Chem, 2001, 276(43):39562-39568.

46. Zhang, L., Seiffert, D., Fowler, B.J., Jenkins, G.R., Thinnes, T.D., Loskutoff, D.J., Parmer, R.J., and Miles, L.A. Plasminogen has a broad extrahepatic distribution in vivo. Thrombosis and Haemostasis, 2002, 87:493-501.

47. Yoshinaga, H., Nakahara, M., Koyama, T., Shibamiya, A., Nakazawa, F., Miles, L.A., Hirosawa, S., and Aoki, N. A single thymine nucleotide deletion responsible for congenital deficiency of plasmin inhibitor. Thrombosis and Haemostasis, 2002, 88:144-148.

48. Tarui, T., Manjumdar, M., Miles, L. A., Ruf, W., and Takada, Y. Plasmin-induced migration of endothelial cells: a potential target for the anti-angiogenic action of angiostatin, J. Biol. Chem, 2002, 277:33564-33570.

49. Garcia-Bannch, F., Fowler, B.J., Gutierrez, A., Bugge, T.H., Degen, J.L., Parmer, R.J., and Miles, L.A. Localization of Regulatory Elements Mediating Constitutive and Cytokine Plasminogen Gene Expression. J. Biol. Chem. 2002, 277:38579-38588.

50. Albrecht, S., Magdolen, V., Herzog, U., Miles, L. A., Kirschenhofer, A., Baretton, G., and Luther, T. Soluble tissue factor interferes with plasminogen- and angiostatin-mediated effects on adhesion and proliferation of endothelial cells, Thrombosis and Haemostasis, 2002, 88:1054-1059.

51. López-Alemany, R., Longstaff, C., Hawley, S., Mirshahi, M., Fábregas, P., Jardi, M., Merton, E., Miles, L. A., Félez, J., Inhibition of cell surface plasminogen activation by a monoclonal antibody against ∀-enolase, Am. J. Hematology, 2003, 72:234-242.

52. Zhang, L., Gong, Y., Grella, D., Castellino, F.J., and Miles, L.A. Role of endogenous plasminogen in conversion of glu-plasminogen to lys-plasminogen on the monocytoid cell surface. Thromb. Haemost., 2003, 1:2164-1270.

53. Wang, N., Zhang, L., Miles, L. A. and Hoover-Plow, J., Plasminogen regulates pro-ipiomelanocortin processing, J. Thromb. Haemost., 2004, 2:785-796.

54. Garcia-Bannach, F., Gutierrez-Fernandez, A., Parmer, R. J., Miles, L. A. Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein β(C/EBPβ), J. Thromb. Haemost., 2004, 2:2205-2212

55. Griffin, M. O, Jinno, M., Miles, L. A., Villarreal, F.J., Reduction of myocardial infarct size by doxycycline: a role for plasmin inhibition, Mol. Cell Biochem., 2005, 270:1-11.

56. Mitchell, J.W., Baik, N. Castellino, F. J., Miles, L. A. Plasminogen inhibits TNFα apoptosis in monocytes, Blood, 107(11):4383-4390, 2006.

57 Miles, L. A., Andronicos, N. M., Baik, N., Parmer, R. J. Cell surface actin binds plasminogen and modulates neurotransmitter release from catecholaminergic cells, J. Neurosci., 26: 13017-13024, 2006.


Reviews & Invited Presentations

1. Miles, L.A., Griffin, J.H., and Bouma, B.N. Some considerations of factor XII-dependent fibrinolytic pathways. In: International Workshop on Regulation of Coagulation, F. Taylor and K. Mann (Eds.) Elsevier, p. 543, 1979.

2. Miles, L.A., Rothschild, Z., and Griffin, J.H. Dextran sulfate-¬dependent fibrinolytic activity in whole human plasma. In: Progress in Fibrino¬lysis, Vol VI, p. 58-61, Churchill Livingstone, London, 1983.

3. Miles, L.A. and Plow, E.F. Fibrinolysis and cell surfaces. In: Fundamental and Clinical Fibrinolysis, Castellino et al, (Eds.) Elsevier Science Publishers BV, p. 111-123, 1987.

4. Miles, L.A. and Griffin, J.H. The role of molecules immunologically related to urokinase in contact system-dependent fibrinolysis. In: Fundamental and Clinical Fibrinolysis, Castellino et al, (Eds.) Elsevier Science Publishers BV, p. 45-55, 1987.

5. Plow, E.F. and Miles, L.A. Fibrinolytic mechanisms of polymorphonuclear leukocytes. In: Fibrinolysis: Current Prospects, P.J. Gaffney, J.F. Castellino, E.F. Plow and A. Takada (Eds.) John Libbey & Co. Ltd, England, p. 81-86, 1988.

6. Miles, L.A. and Plow, E.F. Plasminogen receptors: Ubiquitous sites for cellular regulation of fibrinolysis. Fibrinolysis 2:61-71, 1988.

7. Plow, E.F., Miles, L.A. and Collen, D. Platelet Alpha2-Antiplasmin. In: Methods in Enzymology, J. Hawiger (Ed.) Academic Press, 169:296-300, 1988.

8. Plow, E.F. and Miles, L.A. Relationship between plasminogen receptors and Lp(a). In: Lipoprotein(a), A.M. Scanu (Ed.) Academic Press, p. 117-128, 1990.

9. Miles, L.A. and Plow, E.F. Lp(a): An interloper into the fibrinolytic system? Thromb. Haemost. 63:331-335, 1990.

10. Plow, E.F. and Miles, L.A. Plasminogen receptors in the mediation of pericellular proteolysis. Cell Differ. Dev., 32:293-298, 1990.

11. Plow, E.F., Felez, J. and Miles, L.A. Cellular regulation of fibrinolysis. Thromb. Haemost., 66:32-36, 1991.

12. Miles, L.A. Lipoprotein(a) fibrinolysis and thrombosis. Sangre, 37(Suppl 1):37-41, 1992.

13. Plow, E.F. and Miles, L.A. The role of platelet receptors for components of the plasminogen dystem in the regulation of fibrinolysis. In: Thrombosis: An Update, G.G.N. Serneri et al., (Eds.) Scientific Press, Florence, Italy, p. 119-132, 1992.

14. Wasi, S., Murray, S., Dahlberg, C.M., Plow, E.F. and Miles, L.A. Receptors for plasminogen on bovine lymphatic endothelial cells. Progress in Lymphology-XII, R.V. Cluzan, A.P. Pecking, F.M. Lokiec, eds. Elsevier Science Publishers B.V., p. 75-76, 1992.

15. Parmer, R.J., Miles, L.A., Xi, X-P, Gill, B.M., Wu, H-J and O'Connor, D.T. Processing of chromaffin granule proteins: A profusion of proteases? Neurochem. Intl., 22:361-367, 1993.

16. Plow, E.F. and Miles, L.A. Interaction of the fibrinolytic system with the vessel wall. In: Thrombosis and Hemorrhage, J. Loscalzo and A.I. Schafer (Eds.) Blackwell Scientific Publishers, Boston, MA, p. 339-348, 1994.

17. Miles, L.A. Regulation of fibrinolysis and proteolysis by plasminogen receptors. Biol. Clin. Hematol., 15:107-115, 1993.

18. Miles, L.A. and Plow, E.F. Lipoprotein(a) and fibrinolysis. In: Fibrinolysis in Disease, Glas-Greenwalt, P. (Ed.), CRC Press, Inc., Chapter 8, p. 70-77, 1995.

19. Plow, E.F., Herren, T., Redlitz, A., Miles, L.A. and Hoover-Plow, J.L. The cell biology of the plasminogen system. FASEB J., 9:939-945, 1995.

20. Todd, R.F., III, Barnathan, J., Bohuslav, J., Chapman, H.A., Cohen, R.L., Felez, J., Howell, A., Johnson, J.G., Knapp, W., Kramer, M., Miles, L.A., Nykjaer, A., Ralfkiaer, E. and Schuren, E. M15 Cluster Report: CD87. In: Leucocyte Typing V: White Cell Differentiation Antigens, Schlossman, S.F., Boumsell, L., Gilks, W., Harlan, J.M., Kishimoto, T., Morimoto, C., Ritz, J., Shaw, S., Silverstein, R.L., Springer, T.A., Tedder, T.F., Todd, R.F. III (Eds.), Oxford University Press, 1995, p. 932-939.

21. Plow, E.F., Ugarova, T. and Miles, L.A. Interaction of the fibrinolytic system with the vessel wall. In Press, Throm. & Hemorrhage, Second Edition, J. Loscalzo, A. Schafer, Eds., Chapter 18:373-385, 1998.

22. Parmer, R.J. and Miles, L.A. Targeting of tissue plasminogen activator to the regulated pathway of secretion. Trends in Cardiovascular Medicine, 8:306-312, 1998.

23. Parmer, R.J., Mahata, S.K., Jiang, Q., Taupenot, L., Gong, Y., Mahata, M., O’Connor, D. T., and Miles, L.A. Tissue plasminogen activator and chromaffin cell function. Adv. Exp. Med. Biol, 2000, 482:179-192.

24. Plow, E.F., Redlitz, A., Hawley, S.B., Xue, S., Herrin, T., Hoover-Plow, J.L. and Miles, L.A. Assembly of the plasminogen system on cell surfaces. In: Handbook of Experimental Pharmacology. Fibrinolytics and Antifibrinolytics, Bachmann, F. (Ed.), Springer-Verlag: Berlin, Chapter 6, pp 141-170, 2000.

25. Jiang, Q., Yasothornsrikul, S., Taupenot, L., Miles, L. A., Parmer, R. J. The local chromaffin cell plasminogen/plasmin system and the regulation of catechomine secretion, Vol. 791 Annals of the New York Academy of Science Daniel T. O’Conner, Lee E. Eden, Eds.

26. Parmer, R.J., Mahata, S.K., Jiang, Q., Taupenot, L., Gong, Y., Mahata, M., O’Connor, D. T., and Miles, L.A. Tissue plasminogen activator and chromaffin cell function. In: Chromogranins: Functional and Clinical Aspects, Helle, K and Aunis, D. Kluwer (Eds.) Academic/Plenum Publishers: New York, 2000, Chapter 14, pp 179-192.

27. Felez, J., Jardi, M., Rodriguez-Lambies, N., Rabaneda, M., Berlanga, J.J., Sarra, J., Green, M.A., Gong, Y. and Miles, L.A. Cell surface associated fibrinolysis: Its role in acute promyelocytic leukemia. Haemostasis, 2001.

28. Miles, L. A., Hawley, S. B., Parmer, R. J., Chromaffin cell plasminogen receptors, Vol. 971, The Annals of the New York Academy of Science, pp 497-501, 2002.

29. Jiang, Q., Yasothornsrikul, S., Taupenot, L., Miles, L. A., and Parmer, R. J. The local chromaffin cell plasminogen/plasmin system and the regulation of catecholamine secretion, Vol. 971, The Annals of the New York Academy of Science, pp 445-449, 2002.

30. Miles, L. A., Castellino, F. J., Gong,Y., Critical role for conversion of Glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces, Trends in Cardiovascular Medicine, 13:21-30, 2003.

31. Miles, L.A., Andronicos, N. M., Felez, J., Grella, D. K., Castellino F.J. and Gong, Y. The Role of lys-pg in cell-mediated plasmin production. In: Plasminogen Regulation, Waisman, D. (Ed.) Academic/Plenum Publishers, New York. pp. 103-119, 2003.

32. Gutierrez, A., Garcia-Bannach, F., Zhang, L., Jenkins, G.R., Parmer, R.J., and Miles, L.A. Regulation of plasminogen gene expression. In: Plasminogen Regulation, Waisman, D. (Ed.) Academic/Plenum Publishers, New York. pp. 67-80, 2003.

33. Miles, L.A., Ellis, V. α-enolase comes muscling in on plasminogen activation, Thrombosis and Haemostasis, 90: 564-565, 2003.

34. Miles, L.A., Hawley, S. B., Baik, N., Andronicos, N. M., Castellino, F. J. and Parmer, R. J.. Plasminogen receptors: the sine qua non of cell surface plasminogen activation, Frontiers in Bioscience, 10:1754-1762 2005