Alexander Adibekian, PhD

Associate Professor
Department of Chemistry
Florida Campus


 Email

Scripps Research Joint Appointments

Faculty, Graduate Program

Education

Ph.D. (Chemistry), Swiss Federal Institute of Technology Zurich (ETH), 2008
M.S. (Chemistry), Leibniz University of Hanover, 2004
B.Sc., Leibniz University of Hanover, 2002

Professional Experience

2013-2017 Assistant Professor, University of Geneva
2012-2013 Independent Researcher, University of Geneva
2009-2012 Postdoctoral Researcher, Scripps Research

Selected References

All Publications

Costales, M. G., Hoch, D. G., Abegg, D., Childs-Disney, J. L., Velagapudi, S. P., Adibekian, A. & Disney, M. D. A designed small molecule inhibitor of a non-coding RNA sensitizes HER2 negative cancers to herceptin. (2019). Journal of the American Chemical Society, 141(7), 2960-2974. PMCID: PMC6400281.

Wang, C., Abegg, D., Dwyer, B. G. & Adibekian, A. Discovery and evaluation of new activity-based probes for serine hydrolases. (2019). Chembiochem,

Hoch, D. G., Abegg, D. & Adibekian, A. Cysteine-reactive probes and their use in chemical proteomics. (2018). Chemical Communications, 54(36), 4501-4512.

Davis, D. C., Hoch, D. G., Wu, L., Abegg, D., Martin, B. S., Zhang, Z. Y., Adibekian, A. & Dai, M. Total synthesis, biological evaluation, and target identification of rare Abies sesquiterpenoids. (2018). Journal of the American Chemical Society, 140(50), 17465-17473.

Zong, L., Bartolami, E., Abegg, D., Adibekian, A., Sakai, N. & Matile, S. Epidithiodiketopiperazines: strain-promoted thiol-mediated cellular uptake at the highest tension. (2017). ACS Central Science, 3(5), 449-453. PMCID: PMC5445525.

Abegg, D., Gasparini, G., Hoch, D. G., Shuster, A., Bartolami, E., Matile, S. & Adibekian, A. Strained cyclic disulfides enable cellular uptake by reacting with the transferrin receptor. (2017). Journal of the American Chemical Society, 139(1), 231-238.

Dewhurst-Maridor, G., Abegg, D., David, F. P. A., Rougemont, J., Scott, C. C., Adibekian, A. & Riezman, H. The SAGA complex, together with transcription factors and the endocytic protein Rvs167p, coordinates the reprofiling of gene expression in response to changes in sterol composition in Saccharomyces cerevisiae. (2017). Molecular Biology of the Cell, 28(20), 2637-2649. PMCID: PMC5620372.

Wang, C., Abegg, D., Hoch, D. G. & Adibekian, A. Chemoproteomics-enabled discovery of a potent and selective inhibitor of the DNA repair protein MGMT. (2016). Angewandte Chemie-International Edition, 55(8), 2911-2915.

Adibekian, A. & Stallforth, P. Cutting edge chemical biology: Report from the 2016 International Symposium on Chemical Biology, January 13-15, Geneva, Switzerland. (2016). ACS Chemical Biology, 11(4), 816-820.

Hoch, D. G., Abegg, D., Wang, C., Shuster, A. & Adibekian, A. Cysteine-specific chemical proteomics: from target identification to drug discovery. (2016). Chimia, 70(11), 764-767.