Alexander Adibekian, PhD

Associate Professor
Department of Chemistry
Florida Campus


Scripps Research Joint Appointments

Faculty, Graduate Program


Ph.D. (Chemistry), Swiss Federal Institute of Technology Zurich (ETH), 2008
M.S. (Chemistry), Leibniz University of Hanover, 2004
B.Sc., Leibniz University of Hanover, 2002

Professional Experience

2013-2017 Assistant Professor, University of Geneva
2012-2013 Independent Researcher, University of Geneva
2009-2012 Postdoctoral Researcher, Scripps Research

Selected References

All Publications

Hoch, D. G., Abegg, D., Hannich, J. T., Pechalrieu, D., Shuster, A., Dwyer, B. G., Wang, C., Zhang, X. J., You, Q. D., Riezman, H. & Adibekian, A. Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex. (2020). Cell Chemical Biology, 27(5), 586-597.

Tessier, R., Nandi, R. K., Dwyer, B. G., Abegg, D., Sornay, C., Ceballos, J., Erb, S., Cianferani, S., Wagner, A., Chaubet, G., Adibekian, A., Waser, J. Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells. (2020). Angewandte Chemie-International Edition, 59(27), 10961-10970.

Liu, X. H., Haniff, H. S., Childs-Disney, J. L., Shuster, A., Aikawa, H., Adibekian, A. & Disney, M. D. Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands. (2020). Journal of the American Chemical Society, 142(15), 6970-6982.

Costales, M. G., Hoch, D. G., Abegg, D., Childs-Disney, J. L., Velagapudi, S. P., Adibekian, A. & Disney, M. D. A designed small molecule inhibitor of a non-coding RNA sensitizes HER2 negative cancers to herceptin. (2019). Journal of the American Chemical Society, 141(7), 2960-2974. PMCID: PMC6400281.

Wang, C., Abegg, D., Dwyer, B. G. & Adibekian, A. Discovery and evaluation of new activity-based probes for serine hydrolases. (2019). Chembiochem,

Hoch, D. G., Abegg, D. & Adibekian, A. Cysteine-reactive probes and their use in chemical proteomics. (2018). Chemical Communications, 54(36), 4501-4512.

Davis, D. C., Hoch, D. G., Wu, L., Abegg, D., Martin, B. S., Zhang, Z. Y., Adibekian, A. & Dai, M. Total synthesis, biological evaluation, and target identification of rare Abies sesquiterpenoids. (2018). Journal of the American Chemical Society, 140(50), 17465-17473.

Zong, L., Bartolami, E., Abegg, D., Adibekian, A., Sakai, N. & Matile, S. Epidithiodiketopiperazines: strain-promoted thiol-mediated cellular uptake at the highest tension. (2017). ACS Central Science, 3(5), 449-453. PMCID: PMC5445525.

Abegg, D., Gasparini, G., Hoch, D. G., Shuster, A., Bartolami, E., Matile, S. & Adibekian, A. Strained cyclic disulfides enable cellular uptake by reacting with the transferrin receptor. (2017). Journal of the American Chemical Society, 139(1), 231-238.

Dewhurst-Maridor, G., Abegg, D., David, F. P. A., Rougemont, J., Scott, C. C., Adibekian, A. & Riezman, H. The SAGA complex, together with transcription factors and the endocytic protein Rvs167p, coordinates the reprofiling of gene expression in response to changes in sterol composition in Saccharomyces cerevisiae. (2017). Molecular Biology of the Cell, 28(20), 2637-2649. PMCID: PMC5620372.