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The Elder Lab

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Dr. Ying-Chuan Lin
Phone: (858) 784-2374
FAX: (858) 784-2750
The Scripps Research Institute
Department of Immunology Microbial Science, IMM 215
10550 N. Torrey Pines Road
La Jolla, CA 92037


Hsu, P.L., Lin, Y.C., and Hsu, S.M. (1991). Expression of macrophage colony-stimulating factor in two Hodgkin's Rees-Sternberg (H-RS) cell lines, HDLM-1 and KM-H2, and in H-RS cells in tissues. Int. J. Hematol. 54:315-326.

Kamps, C.A., Lin, Y.C., and Wong, P.K.Y. (1991). Oligomerization of the envelope protein of Moloney murine leukemia virus-TB and of ts1, a neurovirulent temperature-sensitive mutant of MoMuLV-TB. Virology, 184:687-694.

Wong, P.K.Y., Shikova, E., Lin, Y.C., Saha, K., Szurek, P.F., Stoica, G., Madden, R., and Brook, B.R. (1992). Murine leukemia virus induced central nervous system diseases. Leukemia, 161S-165S.

Shikova, E., Lin, Y.C., Saha, K., Brooks, B.R., and Wong, P.K.Y. (1993). Astrocyte-specific defective gPr80env processing correlates with cytopathogenicity induced by ts1, a mutant of Moloney murine leukemia virus. J. Virol. 67:1137-1147.

Saha, K., Lin, Y.C., and Wong, P.K.Y. (1994). A simple method for obtaining highly viable virus from culture supernatant. J. Virol. Methods, 46:349-352.

Wong, P.K.Y., Saha, K., Lin, Y.C., Lynn, W.S., and Yuen, P.H. (1996). Long-term cultivation and production infection of primary thymocyte cultures by a thymocytopathic murine retrovirus. Virology, 215:203-206.

Lin, Y.C., Chow, C.W., Yuen, P.H., and Wong, P.K.Y. (1997). Establishment and characterization of conditionally immortalized astrocytes to study their interaction with ts1, a neuropathogenic mutant of Moloney murine leukemia virus. J. NeuroVirol.3:28-37.

Wong, P.K.Y., Lynn, W.S., Lin, Y.C., Choe, C.W., and Yuen, P.H. (1998). A murine model of neuroimmunodegeneration. In: Wong, P. K. Y., Lynn, W. S. (eds.). Neuroimmunodegeneration, PP 75-95. Berlin: Springer-Verlag Berlin Inc.

Lee, T., Le, V., Lim, D., Lin, Y.C., Morris, G.M., Wong, A.L., Olson, A.J., Elder, J.H., and Wong, C.H. (1999). Development of a new type of protease inhibitor, Efficacious against FIV and HIV variants. J. Am. Chem. Soc. 121:1145-1155.

Lin, Y.C., Beck, Z., Lee, T., Le, V., Morris, G.M., Olson, A.J. Wong, C.H., and Elder, J.H. (2000). Alteration of substrate and inhibitor specificity of Feline immunodeficiency virus protease. J. Virol. 74(10):4710-4720.

Le, V.D., Mak, C.C., Lin, Y.C., Elder, J.H., and Wong, C.H. (2001). Structure-activity studies of FIV and HIV protease inhibitors containing allophenylnorstatine. Bioorg. Med.
Chem. Lett. 9(5):1185-1195.

Mak, C.C., Le,V.D., Lin, Y.C., Elder, J.H., and Wong, C.H. (2001). Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3’ residue. Bioorg. Med. Chem. Lett.
11(2):219- 222.

Beck, Z.Q., Lin, Y.C., and Elder, J.H. (2001). Characterization of relative substrate specificity of HIV-1 and FIV proteases. J. Virol. 75(19): 9458-9469. Buehler, B., Lin, Y.C., Richman, D.D., Wong, C.H., Elder, J.H., and Torbett, B.E. (2001). Viral evolution in response to the broad-based retroviral protease inhibitor TL-3. J.Virol. 75(19): 9502-9508.

Brik, A., Lin, Y.C., Elder, J.H., and Wong, C.H. (2002). A quick
diversity-oriented amide forming reaction coupled with in situ screening as an approach to identify optimal p-subsite residues of HIV-1 protease inhibitors. Chemistry & Biology, (9):891-896.

Lin, Y.C., Beck, Z., Morris, G.M., Olson, A.J. Wong, C.H., and Elder, J.H. (2003). Structural basis for distinctions between substrate and inhibitor specificity for Feline immunodeficiency virus and human immunodeficiency virus proteases. J.Virol. 77(12):6589-6600.

Brik, A., Muldoon, J., Lin, Y.C., Elder, J.H., Goodsell, D., Olson, A.J., Fokin, V.V., Sharpless, K.B., and Wong, C.H. (2003). A rapid diversity-oriented synthesis and In Situ screening of HIV-1 protease inhibitors. Chem Bio Chem. 4:1246-1248.

Huitron-Resendiz, S., de Rozieres, S., Sanchez-Alavez, M., Buehler, B., Lin, Y.C., Lerner, D.A., Henriksen, N.W., Burudi, M., Fox, H.S., Torbett, B.E., Elder, J.H., and Henriksen, S. (2004). Resolution and prevention of FIV-induced neurological deficits by
treatment with the protease inhibitor, TL-3. J. Virol. 78(9):4525-4532.

de Rozieres, S., Swan, C.H., Sheeter, D.A., Clingerman, K.J., Lin, Y.C., Huitron-Resendiz, S., Torbett, B.E., and Elder, J.H. (2004). Assessment of FIV-C infection of cats as a function of treatment with the protease inhibitor, TL-3. Retrovirology 1(1): 38.

Brik, A., Alexandratos, J., Lin, Y.C., Elder, J.H., Olson, A.J., Wlodawer, A., Goodsell, D.S., and Wong, C.W. (2005). 1, 2, 3 triazole as a surrogate in the rapid synthesis of HIV protease inhibitors. Chem Bio Chem. 6:1167-1169.

Liang, F.S., Brik, A., Lin, Y.C., Elder, J.H., and Wong, C.H. (2006). Epoxide opening in water and screening in situ for rapid discovery of enzyme inhibitors in microtiter plates.
Bioorg Med Chem. 14(4): 1058-1062.

Whiting, M., Muldoon, J., Lin, Y.C., Silverman, S.M., Lindstrom, W., Olson, A.J., Kolb, H.C., Fin, M.G., Sharpless, K.B., Elder, J.H., and Fokin, V.V. (2006) Inhibitors of HIV-1 protease by using in situ click chemistry. Angew Chem Int Ed Engl. 45(9):1435-1439.

Heaslet, H. Kutilek, V., Morris, G.M., Lin, Y.C., Elder, J.H., Torbett, B.E., and Stout, C.D. (2006). Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3. J. Mol. Biol. 356(4): 967-981.

Whiting, M., Trip, J.C., Lin, Y.C., Lindstrom, W., Olson, A.J., Elder, J.H., Sharpless, K.B., and Fokin, V.V. (2006) Rapid discovery and structure-activity profiling of novel inhibitors of human immunodeficiency virus type 1 protease enabled by the
copper (I)-catalyzed synthesis of 1,2,3,-triazoles and their further functionalization. J. Med Chem. 49(26): 7697-7710.

Lin, Y.C., Brik, A., de Parseval, A., Tam, K., Torbett, B.E., Wong, C.H., and Elder, J.H. (2006). Altered Gag polyprotein cleavage specificity of feline immunodeficiency virus/human deficiency virus mutant proteases as demonstrated in a cell-based
expression system. (2006) J. Virol. 80(6): 7832-7843.

Heaslet, H. Lin, Y.C., Tam, K., Torbett, B.E., Elder, J.H., and Stout, C.D. (2007) Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-
3. Retrovirology 4: 1-11.

Elder, J.H., Sundstrom, M., de Rozieres, S., de Parseval, A., Grant, C.K., and Lin, Y.C. Molecular Mechanisms of FIV infection. (2008). VII special edition commemorating the 8th International Feline Retrovirus Research Symposium (IFRRS).

Giffin M.J., Heaslet H., Brik A., Lin Y.C., Cauvi G., Wong C.H., McRee D.E., Elder J.H., Stout C.D., Torbett B.E. (2008) A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click
compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant. J. Med Chem. 51(20): 6263-70.

Elder, J.H., Lin, Y.-C., Fink, E. and Grant, C.K. (2010) Feline Immunodeficiency Virus (FIV) as A Model for Study off Lentivirus Infections: Parallels with HIV. Curr. HIV Research 28; 8: 73-80.

Lin, Y.C., Torbett, B.E., Elder J.H. (2010) Generation of Infectious Feline Immunodeficiency Virus Encoding FIV/HIV Chimeric Protease. J. Virol. 84(13): 67-809.

Lin, Y.C., Perryman, A.L., Olson, A.J., Torbett, B.E., Elder, J.H., Stout, C.D. (2011) Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease Acta Cryst. D67, part 6, 540-548 

Lin, Y.-C., Happer, M., Elder, J.H. (2013)  Selection of Drug-resistant Feline Immunodeficiency Virus (FIV) Encoding FIV/HIV Chimeric Protease in The Presence of HIV-specific Protease Inhibitors, J. Virology. 87(15):8524-34.

Troyer, R.M., Thompson, J., Elder, J.H., VandeWoude, S. (2013) Accessory Genes Confer a High Replication Rate to Virulent Feline Immunodeficiency Virus, J. Virology, 87(14):7940-51




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