The Cravatt Lab
Protein and Ligand Discovery on a Global Scale
Genomics has revolutionized our understanding of the genetic basis of human physiology and disease. Nonetheless, many disease-relevant genes code for proteins that remain poorly characterized and therapeutically unactionable due, in large part, to a dearth of selective chemical tools. Our research aims to address this challenge by developing and applying innovative chemical proteomic platforms, such as activity-based protein profiling, to enrich our understanding of disease-relevant proteins and to accelerate the discovery of chemical probes for these proteins.
Recent Publications
Chemical proteomic discovery of isotype-selective covalent inhibitors of the RNA Methyltransferase NSUN2. Angew Chem Int Ed Engl, e202311924. https://doi.org/10.1002/anie.202311924
Assigning functionality to cysteines by base editing of cancer dependency genes. Nature Chemical Biology, 19(11), 1320-1330. https://doi.org/10.1038/s41589-023-01428-w
Proteomic discovery of chemical probes that perturb protein complexes in human cells. Molecular Cell. https://doi.org/10.1016/j.molcel.2023.03.026
Remodeling oncogenic transcriptomes by small molecules targeting NONO. Nature Chemical Biology. https://doi.org/10.1038/s41589-023-01270-0
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids. Nature Chemical Biology. https://doi.org/10.1038/s41589-022-01253-7
Cover Illustration by David S. Goodsell, RCSB Protein Data Bank. doi: 10.2210/rcsb_pdb/goodsell-gallery-041