Conti Lab
Research Focus
Our laboratory is interested in the biological role of cytokines in the central nervous system and in the role of central thermoregulation in energy homeostasis and aging.
In particular, we are investigating the biology of interleukin 18 (IL-18) and of interleukin 13 (IL-13) in the central nervous system (CNS). These cytokines can participate in local inflammatory processes affecting neuronal survival and neurodegenerative diseases. In addition, since the IL-18, as well as the IL-13 receptors, is expressed in neurons, these interleukins can directly influence central functions and behavior. Using molecular techniques and animal models we hope to characterize the biology of these cytokines in the CNS and its significance in health and disease. For instance, we previously demonstrated that IL-18 participates in the regulation of energy homeostasis by influencing feeding and energy efficiency. We also recently showed tha the IL-13Ra1 system plays and important role in regulating the survival of dopaminergic neurons during neuroinflammation suggesting it may contribute to the pathogenesis or the progression of Parkinson's Disease.
In addition, the laboratory is also actively investigating the central mechanisms of thermoregulation and its involvement in influencing energy homeostasis, metabolism and aging. We showed that small but prolonged reduction of core body temperature prolongs lifespan. We are now actively investigating the mechanisms mediating these effects.