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Authors, Title
Journal, Volume, Pages, (Year)
Nguyen, J.D., Grant, Y., Creehan, K.M., Hwang, C.S., Vanderwater, S.A., Janda, K.D., Cole, M., Taffe, M.A., "∆9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions"
Neuropharmacology, 151, 127 (2019)
Wenthur, C.J., Gautam, R., Zhou, B., Vendruscolo, L.F., Leggio, L., Janda, K.D., "Ghrelin receptor influence on cocaine reward is not directly dependent on peripheral acyl-ghrelin"
Nature Scientific Reports, 9, 1841 (2019)
Banks, M.L., Olson, M.E., Janda, K.D., "Immunopharmacotherapies for treating opioid use disorder"
Trends Pharmacol. Sci., 39(11), 908 (2018)
Kallupi, M., Xue, S., Zhou, B., Janda, K.D., George, O., "An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse"
Sci. Adv., 4(10), 4751 (2018)
Olson, M.E., Eubanks, L.M., Janda, K.D., "Chemical interventions for the opioid crisis: Key advances and remaining challenges"
J. Am. Chem. Soc., 141, 1798 (2019)
Hwang, C.S., Ellis, B., Zhou, B., Janda, K.D., "Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin"
Bioorg. & Med. Chem., 27, 125 (2018)
Smith, L.C., Lin, L., Hwang, C.S., Zhou, B., Kubitz, D.M., Wang, H., Janda, K.D., "Lateral flow assessment and unanticipated toxicity of krater"
Chem. Res. Tox., 32, 113 (2019)
Shirey, R.J., Globisch, D., Eubanks, L.M., Hixon, M.S., Janda, K.D., "Noninvasive urine biomarker lateral flow immunoassay for monitoring active Onchocerciasis"
ACS Infect. Dis., 4, 1423 (2018)
Hwang, C.S., Smith, L.C., Natori, Y., Ellis, B., Zhou, B., Janda, K.D., "Improved admixture vaccine of fentanyl and heroin hapten immunoconjugates: Antinociceptive evaluation of fentanyl-contaminated heroin"
ACS Omega, 3, 11537 (2018)
Jacob, N.T., Miranda, P.O., Shirey, R.J., Gautam, R., Zhou, B., de Orbe Izquierdo, M.E., Hixon, M.S., Hart, J.R., Ueno, L., Vogt, P.K., Janda, K.D., "Synthetic molecules for disruption of the MYC protein-protein interface"
Bioorg. & Med. Chem., 26, 4234 (2018)
Nguyen, J.D., Hwang, C.S., Grant, Y., Janda, K.D., Taffe, M.A., "Prophylactic vaccination protects against the development of oxycodone self-administration"
Neuropharmacology, 138, 292 (2018)
Taraina, M.A., Xue, S., Smith, L.C., Muellers, S.N., Miranda, P.O., Janda, K.D., "Crystallography coupled with kinetic analysis provides mechanistic underpinnings of a nicotine-degrading enzyme"
Biochemistry, 57, 3741 (2018)
Hwang, C.S., Smith, L.C., Natori, Y., Ellis, B., Zhou, B., Janda, K.D., "Efficacious vaccine against heroin contaminated with fentanyl"
ACS Chem. Neurosci., 9(6), 1269 (2018)
Kimishima, A., Olson, M.E., Natori, Y., Janda, K.D., "Efficient syntheses of cocaine vaccines and their in vivo evaluation"
ACS Med. Chem. Lett., 9(5), 411 (2018)
Miranda, P.O., Cubitt, B., Jacob, N.T., Janda, K.D., Carlos de la Torre, J., "Mining a Kröhnke pyridine library for anti-arenavirus activity"
ACS Infec. Dis., 4(5), 815 (2018)
Hwang, C.S., Bremer, P.T., Wenthur, C.J., Ho, S.O., Chiang, S., Ellis, B., Zhou, B., Fujii, G., Janda, K.D., "Enhancing efficacy and stability of an antiheroin vaccine: Examination of antinociception, opioid binding profile, and lethality"
Mol. Pharmaceutics, 15(3), 1062 (2018)
Olson, M.E., Janda, K.D., "Vaccines to combat the opioid crisis"
EMBO reports, 19(1), 5 (2018)
Kimishima, A., Olson, M.E., Janda, K.D., "Investigations into the efficacy of multi-component cocaine vaccines"
Bioorg. Med. Chem. Lett., 28, 2779 (2018)
Xue, S., Kallupi, M., Zhou, B., Smith, L.C., Miranda, P.O., George, O., Janda, K.D., "An enzymatic advance in nicotine cessation therapy"
Chem. Commun., 54(14), 1686 (2018)
Xue, S., Seki, H., Remes, M., Silhar, P., Janda, K., "Examination of alpa-exosite inhibitors against Botulinum neurotoxin A protease through structure-activity relationship studies of chicory acid"
Bioorg. Med. Chem. Lett., 27, 4956 (2017)
Hwang, C.S., Janda, K.D., "A vision for vaccines: Combating the opioid epidemic"
Biochemistry, 56(42), 5625 (2017)
Wenthur, C.J., Zhou, B., Janda, K.D., "Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity"
Nature, 548, 476 (2017)
Wenthur, C.J., Cai, X., Ellis, B.A., Janda, K.D., "Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric happen design and combinatorial vaccination"
Bioorg. Med. Chem. Lett., 27(16), 3666 (2017)
Globisch, D., Eubanks, L.M., Shirey, R.J., Pfarr, K.M., Wanji, S., Debrah, A.Y., Hoerauf, A., Janda, K.D., "Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG)"
Bioorg. Med. Chem. Lett., 27(15), 3426 (2017)
Kimishima, A., Wenthur, C.J., Zhou, B., Janda, K.D., "An advance in prescription opioid vaccines: Overdose mortality reduction and extraordinary alteration of drug half-life"
ACS Chem. Biol., 12, 36 (2017)
Taraina, M.A., Janda, K.D., Allen, K.N., "Structural analysis provides mechanistic insight into nicotine oxidoreductase from Pseudomonas putida"
Biochemistry, 55, 6595 (2016)
Jacob, N.T., Anraku, K., Kimishima, A., Zhou, B., Collins, K.C., Lockner, J.W., Ellis, B.A., Janda, K.D., "A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior"
Chem. Commun., 53(58), 8156 (2017)
Bremer, P.T., Janda, K.D., "Conjugate vaccine immunotherapy for substance use disorder"
Pharmacological Review, 69(3), 298 (2017)
Bremer, P.T., Schlosburg, J.E., Banks, M.L., Steele, F.F., Zhou, B., Polkis, J.L., Janda, K.D., "Development of a clinically viable heroin vaccine"
J. Am. Chem. Soc., 139(25), 8601 (2017)
Bremer, P.T., Pellett, S., Carolan, J.P., Tepp, W.H., Eubanks, L.M., Allen, K.N., Johnson, E.A., Janda, K.D., "Metal ions ablate the action of Botulinum Neurotoxin A"
J. Am. Chem. Soc., 139(21), 7264 (2017)
Nguyen, J.D., Bremer, P.T., Hwang, C.S., Vanderwater, S.A., Collins, K.C., Creehan, K.M., Janda, K.D., Taffe, M.A., "Effective active vaccination against methamphetamine in female rats"
Drug & Alcohol Dependence, 175, 179 (2017)
Anraku, K., Sato, S., Jacob, N.T., Eubanks, L.M., Ellis, B.A., Janda, K.D., "The design and synthesis of an alpha-Gal trisaccharide epitope that provides a highly specific anti-Gal immune response"
Org. Biomol. Chem., 15(14), 2979 (2017)
Srinivasulu, V., Janda, K.D., Abu-Yousef, I.A., O'Connor, M.J., Al-Tel, T.H., "A modular CuI-L-proline catalyzed one-pot route for the rapid access of constrained hetero-atom-linked medium-sized ring systems"
Tetrahedron, 73, 2139 (2017)
Mandyam, C., Galinato, M., Lockner, J., Fannon, M., Sobieraj, J., Staples, M., Somkuwar, S., Ghofranian, A., Chaing, S., Navarro, A., Joea, A., Luikart, B., Janda, K.D., Heyser, C., Koob, G., "A synthetic small molecule Isoxazole-9 protects against methamphetamine relapse"
Mol. Psychiatry, 23(3), 629 (2017)
Gooyit, M., Miranda, P.O., Wenthur, C.J., Ducime, A., Janda, K.D., "Influencing antibody-mediated attenuation of methamphetamine CNS distribution through vaccine linker design"
ACS Chemical Neuroscience, 8, 468 (2017)
Bremer, P., Adler, M., Phung, C., Singh, A., Janda, K.D., "Newly designed qunolinol inhibitors mitigate the effects of Botulinum Neurotoxin A in enzymatic, cell-based and ex vivo assays"
J. Med. Chem., 60, 338 (2017)
Nguyen, J.D., Bremer, P.T., Ducime, A., Creehan, K.M., Kisby, B.R., Taffe, M.A., Janda, K.D., "Active vaccination attenuates the psychostimulant effects of alpha-PVP and MDPV in rats"
Neuropharmacology, 116, 1 (2017)
Kimishima, A., Wenthur, C.J., Eubanks, L.M., Sato, S., Janda, K.D., "Cocaine vaccine development: Evaluation of carrier and adjuvant combinations that activate toll-like receptors"
Mol. Pharmaceutics, 13, 3884 (2016)
Evans, S.M., Foltin, R.W., Hicks, M.J., Rosenberg, J.B., De, B.P., Janda, K.D., Kaminsky, S.M., Crystal, R.G., "Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacquisition using a choice procedure in rhesus macaques"
Pharmacology, Biochemistry and Behavior, 150-151, 76 (2016)
Bremer, P.T., Xue, S., Janda, K.D., "Picolinic acids as beta-exosite inhibitors of Botulinum neurotoxin A light chain"
Chem. Commun., 52, 12521 (2016)
Zhou, B., Eubanks, L.M., Jacob, N.T., Ellis, B., Roberts, A.J., Janda, K.D., "Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose"
Bioorg. Med. Chem. Lett., 26, 5078 (2016)
Gooyit, M., Janda, K.D., "Reprofiled anthelmintics abate dormant and hypervirulent Clostridium difficile"
Nature Scientific Report, 6:33642, doi: 10.1038/srep33642 (2016)
Gooyit, M.D., Janda, K.D., "Modulation of the surface-layer protein of Clostridium difficile through Cwp84 inhibition"
ACS Infect. Dis., 2, 465 (2016)
Bremer, P.T., Kimishima, A., Schlosburg, J.E., Zhou, B., Collins, K.C., Janda, K.D., "Combatting synthetic designer opioids: A conjugate vaccine ablates lethal doses of fentanyl class drugs"
Angew. Chem. Int. Ed. Engl., 55, 3772 (2016)
Seki, H., Xue, S., Pellett, S., Silhar, P., Johnson, E.A., Janda, K.D., "Cellular protection of SNAP-25 against Botulinum Neurotoxin/A: Inhibition of thioredoxin reductase through a suicide substrate mechanism"
J. Am. Chem. Soc., 138, 5568 (2016)
Collins, K.C., Schlosburg, J.E., Bremer, P.T., Janda, K.D., "Methamphetamine vaccines: Improvement through hapten design"
J. Med. Chem., 59, 3878 (2016)
Tsuchikama, K., Gooyit, M., Harris, T.L., Zhu, J., Globisch, D., Kaufmann, G.F., Janda, K.D., "Glycation reactivity of a quorum-sensing signaling molecule"
Angew. Chem., 128, 4070 (2016)
Jacob, N.T., Lockner, J.W., Schlosburg, J.E., Ellis, B.A., Eubanks, L.M., Janda, K.D., "Investigations of enantiopure nicotine haptens using an adjuvanting carrier in anti-nicotine vaccine development"
J. Med. Chem., 59, 2523 (2016)
Harris, T.L., Wenthur, C.J., Diego-Taboada, A., MacKenzie, G., Corbitt, T.S., Janda, K.D., "Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-Diaminopyridine for treatment of Botulinum neurotoxin A intoxication"
Chem. Comm., 52, 4187 (2016)
Hart, J.R., Weinberg, M.S., Morris, K.V., Roberts, T.C., Janda, K.D., Garner, A.L., Vogt, P.K., "MINCR is not a MYC-induced IncRNA"
PNAS, 113(5), E496 (2016)
Collins, K.C., Janda, K.D., ""Hapten Design for Anti-addiction Vaccine Development""
in Biologics to treat Substance Abuse Disorders; Vaccines, Monoclonal Antibodies, and Enzymes, ed., Ivan D. Montoya, 327-365 (2015)
Globisch, D., Specht, S., Pfarr, K.M., Eubanks, L.M., Hoerauf, A., Janda, K.D., "Litomosoides sigmodontis: A jird urine metabolome study"
Bioorg. Med. Chem. Lett., 25, 5804 (2015)
Collins, K.C., Tsuchikama, K., Lowery, C.A., Zhu, J., Janda, K.D., "Dissecting AI-2-mediated quorum sensing through C5-analogue synthesis and biochemical analysis"
J. Am. Chem. Soc., 72, 3593 (2016)
Xue, S., Schlosburg, J.E., Janda, K.D., "A New Strategy for Smoking Cessation: Characterization of a Bacterial Enzyme for the Degradation of Nicotine"
J. Amer. Chem. Soc., 137, 10136 (2015)
Miller, M.L., Aarde, S.M., Moreno, A.Y., Creehan, K.M., Janda, K.D., Taffe, M.A., "Effects of active anti-methamphetamine vaccination on intravenous self-administration in rats"
Drug & Alcohol Dependence, 153, 29 (2015)
Cai, X., Globisch, D., Thompson, P., Lin, J., Toader, D., Dimasi, N., Gao, C., Janda, K.D., "A chemoenzymatic approach toward the preparation of site-specific antibody-drug conjugates"
Tetrahedron Lett., 56, 3172 (2015)
Zhu, J., Cai, X., Harris, T.L., Gooyit, M., Wood, M., Lardy, M., Janda, K.D., "Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model"
Chemistry & Biology, 22, 483 (2015)
Gooyit, M., Harris, T.L., Tricoche, N., Javor, S., Lustigman, S., Janda, K.D., "Onchocerca volvulus molting inhibitors identifeied through scaffold hopping"
ACS Infect. Dis., 1, 198 (2015)
Seki, H., Xue, S., Hixon, M.S., Pellett, S., Remes, M., Johnson, E.A., Janda, K.D., "Toward the discovery of dual inhibitors for botulinum nerotoxin A: concomitant targeting of endocytosis and light chain protease activity"
Chem. Commun., 51, 6226 (2015)
Gooyit, M., Tricoche, N., Javor, S., Lustigman, S., Janda, K.D., "Exploiting the polypharmacology of ß-carbolines to disrupt O. volvulus molting"
ACS Med. Chem. Lett., 6, 339 (2015)
Lockner, J.W., Eubanks, L.M., Choi, J.L., Lively, J.M., Schlosburg, J.E., Collins, K.C., Globisch, D., Rosenfeld-Gunn, R.J., Wilson, I.A., Janda, K.D., "Flagellin as carrier and adjuvant in cocaine vaccine development"
Mol. Pharmaceutics, 12, 653 (2015)
Lockner J.W., Lively, J.M., Collins, K.C., Vendruscolo, J.C.M., Azar, M.R., Janda, K.D., "A conjugate vaccine using enantiopure hapten imparts superior nicotine-binding capacity"
J. Med. Chem., 58, 1005 (2015)
Xue, S., Javor, S., Hixon, M.S., Janda, K.D., "Probing BoNT/A protease exosites: Implications for inhibitor design and light chain longevity"
Biochemistry, 53, 6820 (2014)
Hart, J.R., Garner, A.L., Yu, J., Ito, Y., Sun, M., Ueno, L., Rhee, J.-K., Baksh, M., Stefan, E., Hartl, M., Bister, K., Vogt, P.K., Janda, K.D., "Inhibitor of MYC identified in a Krohnke pyridine library"
PNAS, 111(34), 12556 (2014)
Raffeiner, P., Rock, R., Schraff, A., Hartl, M., Hart, J.R., Janda, K.D., Vogt, P.K., Stefan, E., Bister, K., "In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential"
Oncotarget, 5(19), 8869 (2014)
Eubanks, L.M., Ellis, B.A., Cai, X., Schlosburg, J.E., Janda, K.D., "A human recombinant monoclonal antibody to cocaine: Preparation, characterization and behavioral studies"
Bioorg. Med. Chem. Lett., 24, 4664 (2014)
Harris, T.L., Lowery, C.A., Hixon, M.S., Janda, K.D., "A Platform stratifying a sequestering agent and a pharacological antagonist as a means to negate Botulinum neurotoxicity"
ACS Chem. Neurosci., 5, 632 (2014)
Jacob, N.T., Lockner, J.W., Kravchenko, V.V., Janda, K.D., "Pharmacophore reassignment for induction of immunosurveillance cytokine TRAIL"
Angew. Chem. Int. Ed., 53, 6628 (2014)
Hicks, M.J., Kaminsky, S.M., De, B.P., Rosenberg, J.B., Evans, S.M., Foltin, R.W., Andrenyak, D.M., Moody, D.E., Koob, G.F., Janda, K.D., Ricart Arbona, R.J., Lepherd, M.L., Crystal, R.G., "Fate of systematically administered cocaine in nonhuman primates treated with the dAd5GNE anti-cocaine vaccine"
Hum. Gene Ther. Clin. Dev., 25(1), 40 (2014)
Collins, K.C., Schlosburg, J.E., Lockner, J.W., Bremer, P.T., Ellis, B.A., Janda, K.D., "Liquid tucaresol as an adjuvant for methamphetamine vaccine development"
Chem. Commun., 50, 4079 (2014)
Collins, K.C., Janda, K.D., "Investigating hapten clustering as a strategy to enhance vaccines against drugs of abuse"
Bioconjugate Chem., 25, 593 (2014)
Bremer, P.T., Hixon, M.S., Janda, K.D., "Benzoquinones as inhibitors of botulinum neurotoxin serotype A"
Bioorg. Med. Chem., 22, 3971 (2014)
Gooyit, M., Tricoche, N., Lustigman, S., Janda, K.D., "Dual protonophore - chitinase inhibitors dramatically affect O. volvulvus molting"
J. Med. Chem., 57, 5792 (2014)
Bremer P.T., Schlosburg, J.E., Lively, J.M., Janda, K.D., "Injection route and TLR9 agonist addition significantly impact heroin vaccine efficacy"
Mol. Pharmaceutics, 11, 1075 (2014)
Seki, H., Pellett, S., Silhar, P., Stowe, G.N., Blanco, B., Lardy, M.A., Johnson, E.A., Janda, K.D., "Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain"
Bioorg. Med. Chem., 22, 1208 (2014)
Silhar, P., Eubanks, L.M., Seki, H., Pellett, S., Javor, S., Tepp, W.H., Johnson, E.A., Janda, K.D., "Targeting Botulinum A cellular toxicity: A prodrug approach"
Bioorg. Med. Chem., 56, 7870 (2013)
Lowery, C.A., Adler, M., Borrell, A., Janda, K.D., "Scorpion toxins for the reversal of BoNT-induced paralysis"
Bioorg. Med. Chem. Lett., 23, 6743 (2013)
Cai, X., Whitfield, T.,Moreno, A.Y., Grant, Y., Hixon, M.S., Koob, G.F., Janda, K.D., "Probing the effects of hapten stability on cocaine vaccine immunogenicity"
Mol. Pharm. , 10, 4176 (2013)
Garner, A.L., Fullagar, J.L., Day, J.A., Cohen, S.M., Janda, K.D., "Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors"
J. Am. Chem. Soc., 135, 10014 (2013)
Lowery, C.A., Matamouros, S., Niessen, S., Zhu, J., Scolnick, J., Lively, J.M., Cravatt, B.F., Miller, S.I., Kaufmann, G.F., Janda, K.D., "A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level"
Chemistry & Biology, 20(7), 903 (2013)
Zhu, J., Hixon, M.S., Globisch, D., Kaufmann, G.F., Janda, K.D., "Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation"
J. Am. Chem. Soc., 135(21), 7827 (2013)
Maoz, A., Hicks, M.J., Vallabhjosula, S., Synan, M., Kothari, P.J., Dyke, J.P., Ballon, D.J., Kaminsky, S.M., De, B.P., Rosenburg, J.B., Martinez, D., Koob, G.F., Janda, K.D., Crystal, R.G., "Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter"
Neuropsychopharmacology, 38, 2170 (2013)
Schlosburg, J.E., Vendruscolo, L.F., Bremer, P.T., Lockner, J.W., Wade, C.L., Nunes, A.A., Stowe, G.N., Edwards, S., Janda, K.D., Koob, G.F., "Dynamic vaccine blocks relapse to compulsive intake of heroin"
PNAS, 110(22), 9036 (2013)
Matyas G.R., Mayorov, A.V., Rice, K.C., Jacobson, A.E., Cheng, K., Iyer, M.R., Li, F., Beck, Z., Janda, K.D., Alving, C.R., "Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs"
Vaccine, 31(26), 2804 (2013)
Cai, X., Whitfield, T., Hixon, M.S., Grant, Y., Koob, G.F., Janda, K.D., "Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design"
J. Med. Chem., 56(9), 3701 (2013)
Cai, X., Tsuchikama, K., Janda, K.D., "Modulating cocaine vaccine potency through hapten fluorination"
J. Am. Chem. Soc., 135, 2971 (2013)
Struss, A.K., Nunes, A., Waalen, J., Lowery, C.A., Pullanikat, P., Denery, J.R., Conrad, D.J., Kaufmann, G.F., Janda, K.D., "Toward implementation of quorum sensing autoinducers as biomarkers for infectious disease states"
Anal. Chem., 85, 3355 (2013)
De, B.P., Pagovich, O.E., Hicks, M.J., Rosenberg, J.B., Moreno, A.Y., Janda, K.D., Koob, G.F., Worgall, S., Kaminsky, S.M., Sondhi, D., Crystal, R.G., "Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity"
Human Gene Therapy, 24, 58 (2013)
Rosenberg, J.B., De, B.P., Hicks, M.J., Janda, K.D., Kaminsky, S.M., Worgall, S., Crystal, R.G., "Suppression of nicotine-induced pathophysiology by an adenovirus hexon-based anti-nicotine vaccine"
Human Gene Therapy, 24(6), 595 (2013)
Kravchenko V., Garner, A.L., Mathison, J., Seit-Nebi, A., Yu, J., Gileva, I.P., Ulevitch, R., Janda, K.D., "Facilitating cytokine-mediated cancer cell death by proteobacterial N-Acylhomoserine lactones"
ACS Chem. Biol., 8, 1117 (2013)
Globisch, D., Moreno, A.Y., Hixon, M.S., Nunes, A.A.K., Denery, J.R., Specht, S., Hoerauf, A., Janda, K.D., "Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness"
PNAS, 110(11), 4218 (2013)
Fullagar, J.L., Garner, A.L., Struss, A.K., Day, J.A., Martin, D.P., Yu, J., Cai, X., Janda, K.D., Cohen, S.M., "Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: Tropolones as inhibitors of P. aeruginosa elastase"
Chem. Commun., 49(31), 3197 (2013)
Silhar, P., Lardy, M.A., Hixon, M.S., Shoemaker, C.B., Barbieri, J.Y., Struss, A.K., Lively, J.M., Javor, S., Janda, K.D., "The C-Terminus of Botulinum A protease has profound and unanticipated kinetic consequences upon the catalytic cleft"
Med. Chem. Lett., 4(2), 283 (2013)
Silhar, P., Sivaggi, N.R., Pellett, S., Capkova, K., Johnson, E.A., Allen, K.N., Janda, K.D., "Evaluation of adamantane hydroxymates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies"
Bioorg. Med. Chem., 21, 1344 (2013)
Garner, A.L., Yu, J., Struss, A.K., Kaufmann, G.F., Kravchenko, V.V., Janda, K.D., "Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development"
Chem. Commun., 49, 1515 (2013)
Lockner, J.W., Ho, S.O., McCague, K.C., Chiang, S.M., Do, T.Q., Fujii, G., Janda, K.D., "Enhancing nicotine vaccine immunogenicity with liposomes"
Bioorg. Med. Chem. Lett., 23, 975 (2013)
Bremer, P.T., Janda, K.D., "Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance"
J. Med. Chem., 55, 10776 (2012)
Miller, M.L., Moreno, A.Y., Aarde, S.M., Creehan, K.M., Vanderwater, S.A., Vaillancourt, B.D., Wright, Jr., M.J., Janda, K.D., Taffe, M.A., "A methamphetamine vaccine attenuates methamphetamine-induced disruptions in thermoregulation and activity in rats"
Biol. Psychiatry, 73, 721 (2013)
von Hoven, G., Kloft, N., Neukirch, C., Ebinger, S., Bobkiewicz, W., Weis, S., Boller, K., Janda, K.D., Husman, M., "Modulation of translation and induction of autophagy by bacterial exoproducts"
Med. Microbiol. Immunol., 201(4), 409 (2012)
Moreno, A.Y., Azar, M.R., Koob, G.F., Janda, K.D., "Probing the protective effects of a conformationally constrained nicotine vaccine"
Vaccine, 30, 6665 (2012)
Hicks, M.J., Rosenberg, J.B., De, B.P., Pagovich, O.E., Young, C.N., Qiu, J., Kaminsky, S.M., Hackett, N.R., Worgall, S., Janda, K.D., Davisson, R.L., Crystal, R.G., "AAV-Directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation"
Science Translational Medicine, 4(140), 140ra87 (2012)
Garner, A.L., Struss, A.K., Fullagar, J.L., Agrawal, A., Moreno, A.Y., Cohen, S.M., Janda, K.D., "3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa virulence factor LasB"
Med. Chem. Lett., 3, 668 (2012)
Kirchdoerfer, R.F., Garner, A.L., Flack, C.E., Mee, J.M., Horswill, A.R., Janda, K.D., Kaufmann, G.F., "Structural basis for ligand recognition and discrimination of a quorum-quenching antibody"
J. Biol. Chem., 286(19), 17351 (2012)
Treweek, J.B., Janda, K.D., "An antidote for acute cocaine toxicity"
Mol. Pharmaceutics, 9(4), 969 (2012)
Zakhari, J.S., Zorrilla, E.P., Zhou, B., Mayorov, A.V., Janda, K.D., "Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice"
Pharmoceutics, 9, 281 (2012)
Globisch, D., Lowery, C.A., McCague, K.C., Janda, K.D., "Uncharacterized 4,5-Dihydroxy-2,3-pentanedione (DPD) molecules revealed through NMR spectroscopy: Implications for a greater signaling diversity in bacterial species"
Angew. Chem. Int. ed., 51, 4204 (2012)
Rosenberg, J.B., Hicks, M.J., De, B.P., Pagovich, O., Frenk, E., Janda, K.D., Wee, S., Koob, G.F., Hackett, N.R., Kaminsky, S.M., Worgall, S., Tignor, N., Mezey, J.G., Crystal, R.G., "AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that supresses cocaine-induced behavior"
Human Gene Therapy, 23, 451 (2012)
Kravchenko, V.V., Gloeckner, C., Stowe, G.N., Kang, Y.J., Tobias, .S., Mathison, J.C., Ulevitch, R.J., Kaufmann, G.F., Janda, K.D., "The use of small molecule probes to study spatially separated stimulus-induced signaling pathways"
Bioorg. Med. Chem. Lett., 22, 2043 (2012)
Romano, A.A., Hahn, T., Davis, N., Lowery, C.A., Struss, A.K., Janda, K.D., Bottger, L.H., Matznke, B.F., Carrano, C.J., "The Fe(III) and Ga(III) coordination chemistry of a 3-(1-hydroxymethylidene) and 3-(1-hydroxydecylidene)-5-(2-hydroxyethyl)pyrrolidine-2,4-dione: Novel tetramic acid degradation products of homoserine lactone bacterial quorum sensing molecules"
Journal of Inorganic Biochemistry, 107, 96 (2012)
Koob, G., Hicks, M.J., Wee, S., Rosenburg, J.B., De, B.P., Kaminsky, S.M., Moreno, A., Janda, K.D., Crystal, R.G., "Anti-cocaine analog to a disrupted adenovirus"
CNS Neurol. Disord. Drug targets, 10(8), 899 (2011)
Janda, K.D., Treweek, J.B., "Vaccines targeting drugs of abuse: is the glass half-empty or half-full?"
Nat. Rev. Immunol., 12(1), 67 (2011)
Stowe, G.N., Schlosburg, J.E., Vendruscolo, L.F., Edwards, S., Misra, K.K., Schulteis, G., Zakhari, J.S., Koob, G.F., Janda, K.D., "Developing a vaccine against multiple psycoactive targets: A case study of heroin"
CNS & Neurological Disorders - Drug Targets , 10, 865 (2011)
LI, Z., Garner, A.L., Gloeckner, C., Janda, K.D., Carlow, C.K., "Targeting the Wolbachia cell division protein FtsZ as a new approach for antifilarial therapy"
PLoS Neglected Tropical Diseaeses, 5(11), e1411 (2011)
Hoon, S., Zhou, B., Janda, K.D., Brenner, S., Scolnick, J., "Aptamer selection by high-throughput sequencing and informatics analysis"
Biotechniques, 51(6), 413 (2011)
Moreno, A.Y., Janda, K.D., "Current challenges for the creation of effective vaccines against drugs of abuse"
Expert Rev. Vaccines, 10(12), 1637 (2011)
Zakhari, J.S., Kinoyama, I., Hixon, M.S., Di Mola, A., Globisch, D., Janda, K.D., "Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization"
Bioorg. Med. Chem., 19, 6203 (2011)
Eubanks, L.E., Stowe, G.N., De Lamo Marin, S., Mayorov, A.V., Hixon, M.S., Janda, K.D., "Identification of alpha(2) macroglobulin as a major serum ghrelin esterase"
Angew. Chem. Int. Ed. Engl., 50, 10699 (2011)
Wee, S., Hicks, M.J., De, B.P., Rosenberg, J.B., Moreno, A.Y., Kaminsky, S.M., Janda, K.D., Crystal, R.G., Koob, G.F., "Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects"
Neuropsychopharmacology, 1 (2011)
Garner, A.L., Park, J., Zakhari, J.S., Lowery, C.A., Struss, A.K., Sawada, D., Kaufmann, G.F., Janda, K.D., "A multivalent probe for AI-2 quorum sensing receptors"
J. Am. Chem. Soc., 133, 15934 (2011)
Liu, Y., Jiang, P., Capkova, K., Xue, D., Ye, L., Sinha, S.C., Mackman, N., Janda, K.D., Liu, C., "Tissue factor activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy"
Cancer. Res., 71(20), 6492 (2011)
Tsuchikama, K., Lowery, C.A., Janda, K.D., "Probing autoinducer-2 based quorum sensing: the biological consequences of molecules unable to traverse equilibrium states"
J. Org. Chem., 76(17), 6981 (2011)
Stowe, G.N., Vendruscolo, L.F., Edwards, S., Schlosburg, J.E., Misra, K.K., Schulteis, G., Mayorov, A.V., Zakhari, J.S., Koob, G.F., Janda, K.D., "A vaccine strategy that induces protective immunity against heroin"
J. Med. Chem., 54(14), 5195 (2011)
Garner, A.L., Janda, K.D., "A small molecule antagonist of ghrelin O-acyltransferase (GOAT)"
Chem. Commun., 47, 7512 (2011)
Garner, A.L., Gloeckner, C., Trioche, N., Zakhari, J.S., Samje, M., Cho-Ngwa, F., Lustigman, S., Janda, K.D., "Design, synthesis, and biological activities of Closantel analogues: Structural promiscuity and its impact on Onchocerca vovulus"
J. Med. Chem., 54, 3963 (2011)
Moreno, A.Y., Mayorov, A.V., Janda, K.D., "Impact of distant chemical structures for the development of a methamphetamine vaccine"
J. Am. Chem. Soc., 133, 6587 (2011)
Uckun, F.M., Qazi, Z.O., Garner, A.L., Pitt, J., Ma, H., Janda, K.D., "Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signaling network"
British Journal of Haematology, 153, 741 (2011)
Janda, K.D., "Editor's Note"
Bioorg. Med. Chem., 19(1), 20 (2011)
Silhar, P., Alakurtti, S., Capkova, K., Xiaochuan, F., Shoemaker, C.B., Yli-Kauhaluoma, J., Janda, K.D., "Synthesis and evaluation of library of betulin derivitives against the botulinum neurotoxin A protease"
Bioorg. Med. Chem. Lett., 21, 2229 (2011)
Zakhari, J.S., Kinoyama, I., Struss, A.K., Pullanikat, P., Lowery, C.A., Lardy, M., Janda, K.D., "Synthesis and molecular modeling provide insight into a Pseudomonas aeruginosa quorum sensing conundrum"
J. Am. Chem. Soc., 133(11), 3840 (2011)
Treweek, J.B., Roberts, A.J., Janda, K.D., "Immunopharmacotherapeutic manifolds and modulation of cocaine overdose"
Pharmacol. Biochem. Behav., 98, 474 (2011)
Garner, A.L., Janda, K.D., "Shedding light on the Ghrelin/GOAT metabolism saga"
ChemBioChem, 12, 523 (2011)
Salzameda, N.T., Eubanks, L.M., Zakhari, J.S., Tsuchikama, K., DeNunzio, N.J., Allen, K.A., Hixon, M.S., Janda, K.D., "A cross-over inhibitor of the botulinum neurotoxin light chain B: A natural product implicating an exosite mechanism of action"
Chem. Commun., 47, 1713 (2011)
Hicks, M.J., Bishnu, P.D., Rosenberg, J.B., Davidson, J.T., Moreno, A.Y., Janda, K.D., Wee, S., Koob, G.F., Hackett, N.R., Kaminsky, S.M., Worgall, S., Toth, M., Mezey, J.G., Crystal, R.G., "Cocaine analog coupled to disrupted adenovirus: A vaccine strategy to evoke high-titer immunity against addictive drugs"
Molecular Therapy, 19(3), 612 (2011)
Garner, A.L., Yu, J., Struss, A.K., Lowery, C.A., Zhu, J., Kim, S.K., Park, J., Mayorov, A.V., Kaufmann, G.F., Kravchenko, V.V., Janda, K.D., "Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: Unanticipated effects on mammalian cell activation"
Bioorg. Med. Chem. Lett., 21, 2702 (2011)
Pier, C.L., Chen, C., Tepp, W.H., Lin, G., Janda, K.D., Barbieri, J.T., Pellett, S., Johnson, E.A., "Botulinum neurotoxin subtype A2 enters cells faster than subtype A1"
FEBS Letters, 585, 199 (2011)
Garner, A.L., Janda, K.D., "Protein-protein interactions and cancer: Targeting the central dogma"
Curr. Top. Med. Chem., 11, 258 (2011)
Kaufmann, G.F., Park, J., Mayorov,A.V., Kubitz, D.M., Janda, K.D., "Generation of quorum quenching antibodies"
Methods Mol. Biol., 692, 299-311 (2011)
Lowery, C.A., Kaufmann, G.F., Janda, K.D., "Determination of acyl homoserine lactone and tetramic acid concentrations in biological samples"
Methods Mol. Biol., 692, 101-111 (2011)
Stowe, G.N., Janda, K.D., "A Diels-Alder reaction conducted within the parameters of aqueous organocatalysis: Still just smoke and mirrors"
Tetrahedron Lett., 52, 2085 (2011)
Denery, J.R., Nunes, A.A., Hixon, M.S., Dickerson, T.J., Janda, K.D., "Metabolomics-based discovery of diagnostic biomarkers for onchocerciasis"
PLoS Negl. Trop. Dis., 4(10), e834 (2010)
Treweek, J.B., Roberts, A.J., Janda, K.D., "Superadditive effects of ethanol and flunitrazepam: Implications of using immunopharmacotherapy as a therapeutic"
Mol. Pharm., 7(6), 2056 (2010)
Garner, A.L., Janda, K.D., "cat-ELCCA: A robust method to monitor the fatty acid acyltransferase activity of Ghrelin O-Acyltransferase (GOAT)"
Angew. Chem. Int. Ed., 49(50), 9630 (2010)
Mayorov, A.V., Willis, B., Di Mola, A., Adler, D., Borgia, J., Jackson, O., Wang, J., Luo, Y., Tang, L., Knapp, R.J., Natarajan, C., Goodnough, M.C., Zilberberg, N., Simpson, L.L., Janda, K.D., "Symptomatic relief of Botulinum Neurotoxin/A intoxication with aminopyridines: A new twist on an old molecule"
ACS Chemical Biology, 5(12), 1183 (2010)
Eubanks, L.M., Silhar, P., Salzameda, N.T., Zakhari, J.S., Xiaochuan, F., Barbieri, J.T., Shoemaker, C.B., Hixon, M.S., Janda, K.D., "Identification of a natural product antagonist against the Botulinum neurotoxin light chain protease"
ACS Med. Chem. Lett., 1, 268 (2010)
Steiniger, S., Janda, K.D., "The good, the bad, and the very bad: A new platform strategy to identify drug targets in cancer stem cells"
Laboratory-Journal.com, (2010)
Lowery, C.A., Salzameda, N.T., Sawada, D., Kaufmann, G.F., Janda, K.D., "Medicinal chemistry as a conduit for the modulation of quorum sensing"
J. Med. Chem., 1, 268 (2010)
Thyagarajan, B., Potian, J.G., Garcia, C.C., Hognason, K., Capkova, K., Moe, S.T., Jacobson, A.R., Janda, K.D., McArdle, J.J., "Effects of hydroxamate mettalloprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions"
Neuropharmacology, 58, 1189 (2010)
Moreno, A.Y., Azar, M.R., Warren, N.A., Dickerson, T.J., Koob, G.F., Janda, K.D., "A critical evaluation of a nicotine vaccine within a self-administration behavioral model"
Molecular Pharmaceutics, 7(2), 431 (2010)
Staflin, K., Krueger, J.S., Hachman, J., Forsyth, J.S., Lorger, M., Steiniger, S.C.J., Mee, J., Pop, C., Salvesen, G.S., Janda, K.D., Felding-Habermann, B., "Targeting activated integrin alpha-v-beta-3 with patient-derived antibodies impacts late-stage multiorgan metastasis"
Clin. Exp. Metastasis, 27(4), 217 (2010)
Gloeckner, C., Garner, A., Mersha, F., Oksov, Y., Tricoche, N., Eubanks, L., Lustigman, S., Kaufmann, G., Janda, K.D., "Repositioning of an old drug for the neglected tropical disease Onchocerciasis"
PNAS, 107(8), 3424 (2010)
Silhar, P., Capkova, K., Salzameda, N.T., Barbieri, J.T., Hixon, M.S., Janda, K.D., "Botulinum neurotoxin A protease: Discovery of natural product exosite inhibitors"
J. Am. Chem. Soc., 132, 2868 (2010)
Stowe, G.N., Silhar, P., Hixon, M.S., Silvaggi, N.R., Allen, K.N., Moe, S.T., Jacobson, A.R., Barbieri, J.T., Janda, K.D., "Chirality holds the key for potent inhibition of the Botulinum Neurotoxin serotype A protease"
Org. Lett., 12(4), 756 (2010)
Nakai, Y., Tepp, W.H., Dickerson, T.J., Johnson, E.A., Janda, K.D., "Toosendanin: Synthesis of the AB-ring and investigations of its anti-Botulinum properties (part II)"
Bioorg. Med. Chem., 18, 1280 (2010)
Fukuchi, K., Steiniger, S.C.J., Deryungina, E., Liu, Y., Lowery, C.A., Gloeckner, C., Zhou, B., Kaufmann, G.F., Quigley, J.P., Janda, K.D., "Inhibition of tumor metastasis: Functional immune modulation of the CUB domain containing protein 1"
Molecular Pharmaceutics, 7(1), 245 (2010)
Capkova, K., Hixon, M.S., Pellet, ., Barbieri, J.T., Johnson, E.A., Janda, K.D., "Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase"
Bioorg. Med. Chem. Lett., 20, 206 (2010)
Lowery, C.A., Park, J., Gloeckner, C., Meijler, M.M., Mueller, R.S., Boshoff, H.I., Ulrich, R.L., Barry III, C.E., Bartlett, D.H., Kravchenko, V.V., Kaufmann, G.F., Janda, K.D., "Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals"
J. Am. Chem. Soc., 131, 14473 (2009)
Lowery, C.A., Abe, T., Park, J., Eubanks, L.M., Sawada, D., Kaufmann, G.F., Janda, K.D., "Revisiting AI-2 quorum sensing inhibitors: Direct comparison of alkyl-DPD analogues and a natural product Fimbrolide"
J. Am. Chem. Soc., 131, 15584 (2009)
Salzameda, N.T., Barbieri, J.T., Janda, K.D., "Synthetic substrate for application in both high and low throughput assays for botulinum neurotoxin B protease inhibitors"
Bioorg. Med. Chem. Lett., 19, 5848 (2009)
Steiniger, S., Janda, K.D., "The good, the bad, and the very bad: A new platform strategy to identify drug targets in cancer stem cells"
BIOforum Europe, 6, 25 (2009)
Capkova, K., Salzameda, N.T., Janda, K.D., "Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins"
Toxicon, 54, 575 (2009)
Pires-Alves, M., Ho, M., Aberle, K.K., Janda, K.D., Wilson, B.A., "Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity"
Toxicon, 53, 392 (2009)
Fischer, ., Nakai, Y., Eubanks, L.M., Clancy, C.M., Tepp, W.H., Pellett, S., Dickerson, T.J., Johnson, E.A., Janda, K.D., Montal, M., "Bimodal modulation of the botulinum neurotoxin protein-conducting channel"
PNAS, 106, 1330 (2009)
Treweek, J.B., Moreno, A.Y., Janda, K.D. , "SLEEPLESS-ness and insomnia in fruit flies"
Angew. Chem. Int. Ed., 48, 438 (2009)
Treweek, J.B., Dickerson, T.J., Janda, K.D., "Drugs of abuse that mediate advanced glycation end product formation: A chemical link to disease pathology"
Accounts of Chemical Research, 42(5), 659 (2009)
Frederick, M.O., De Lamo Marin, S., Janda, K.D., Nicolaou, K.C., Dickerson, T.J., "Monoclonal antibodies with orthoganal azaspiracid epitopes"
ChemBioChem, 10, 1625 (2009)
Moreno, A.Y., Janda, K.D., "Immunopharmacotherapy: Vaccination stratagies as a treatment for drug abuse and dependence"
Pharmacology, Biochemistry, and Behavior, 92, 199 (2009)
Nakai, Y., Tepp, W.H., Dickerson, T.J., Johnson, E.A., Janda, K.D., "Function-oriented synthesis applied to the anti-botulinum natural product toosendanin"
Bioorg. Med. Chem., 17, 1152 (2009)
Zhou, H., Zhou, B., Pellett, S., Johnson, E.A., Janda, K.D., "Selection and characterization of a human monoclonal neutralizing antibody for Clostridium Botulinum neurotoxin serotype B"
Bioorg. Med. Chem. Lett., 19, 662 (2009)
Sheng, J., Oyler, G., Zhou, B., Janda, K., Shoemaker, C.B., "Identification and characterization of a novel cell-penetrating peptide"
Biochemical and Biophysical Research Coomunications, 382, 236 (2009)
Brogan, A.P., Dickerson, T.J., Janda, K.D., "Catalytic Antibodies (Abzymes), Synthetic"
Wiley Encyclopedia of Chemical Biology, (2008)
Treweek, J.B., Sun, C., Mayorov, A.V., Qi, L., Levy, C.L., Roberts, A.J., Dickerson, T.J., Janda, K.D., "Prevention of drug-induced memory impairment by immunopharmacotherapy"
J. Med. Chem., 51, 6866 (2008)
Willis, B., Eubanks, L.M., Dickerson, T.J., Janda, K.D., "The strange case of the Botulinum neurotoxin: Using chemistry and biology to modulate the most deadly poison"
Angew. Chem. Int. Ed., 47, 8360 (2008)
Mayorov, A.V., Amara, N., Chang, J.Y., Moss, J.A., Hixon, M.S., Ruiz, D.I., Meijler, M.M., Zorilla, E.P., Janda, K.D., "Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice"
PNAS, 105(45), 17487 (2008)
Steiniger, S.C.J., Coppinger, J.A., Kruger, J.A., Yates III, J., Janda, K.D., "Quantitative mass spectrometry identifiies drug targets in cancer stem cell containing side population"
Stem Cells, 26(12), 3037 (2008)
Park, J., Dickerson, T.J., Janda, K.D., "Major sperm protein as a diagnostic antigen for onchocerciasis"
Bioorg. Med. Chem., 16, 7206 (2008)
Capkova, K., Hixon, M.S., McAllister,L.A., Janda, K.D., "Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations"
Chem. Commun., 3525 (2008)
Park, J., Kaufmann, G.F., Bowen, J.P., Arbiser, J.L., Janda, K.D., " Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aerginosa"
JID, 198, 1198 (2008)
Lowery, C.A., Park, J., Kaufmann, G.F., Janda, K.D., "An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-Dihydroxy-2,3-pentanedione analogues"
J. Am. Chem. Soc., 130(29), 9200 (2008)
Lowery, C.A., Dickerson, T.J., Janda, K.D., "Interspecies and interkingdom communication mediated by bacterial quorum sensing"
Chem. Soc. Rev., 37(7), 1337 (2008)
Kravchenko, V.V., Kaufmann, G.F., Mathison, J.C., Scott, D.A., Katz, A.Z., Grauer, D.C., Lehmann, M., Meijler, M.M., Janda, K.D., Ulevitch, R.J., "Modulation of gene expression via disruption of NF-kB signaling by a bacterial small molecule"
Science, 321, 259 (2008)
Debler, E.W., Kaufmann, G.F., Meijler, M.M., Heine, A., Mee, J.M., Pljevaljcic, G., Di Bilio, A.J., Schultz, P.G., Millar, D.P., Janda, K.D., Wilson, I.A., Gray, H.B., Lerner, R.A., "Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex"
Science, 319(5867), 1232 (2008)
Kaufmann, G.F., Park, J., Janda, K.D., "Bacterial quorum sensing: a new target for anti-infective immunotherapy"
Expert Opin. Biol. Ther., 8(6), 719 (2008)
Zhou, B., Pellett, S., Tepp, W.H., Zhou, H., Johnson, E.A., Janda, K.D., "Delineating the susceptibility of botulinum neurotoxins to denaturation through thermal effects"
FEBS Letters, 582, 1526 (2008)
Kaufmann, G.F., Park, J., Mee, J.M., Ulevitch, R.J., Janda, K.D., "The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone"
Molecular Immunology, 45, 2710 (2008)
Yoneda, Y., Steiniger, S.C.J., Capkova, K., Mee, J.M., Liu, Y., Kaufmann, G.F., Janda, K.D., "A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy"
Bioorg. Med. Chem. Lett., 18, 1632 (2008)
Zhou, B., Carney, C., Janda, K.D., "Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin"
Bioorg. Med. Chem., 16, 1903 (2008)
Willis, B., Eubanks, L.M., Wood, M.R., Janda, K.D., Dickerson, T.J., Lerner, R.A.L., "Biologically templated organic polymers with nanoscale order"
PNAS, 105(5), 1416 (2008)
Zarebski, L.M., Vaughan, K., Sidney, J., Peters, B., Grey, H., Janda, K.D., Casadevall, A., Sette, A., "Analysis of epitope information related to Bacillus anthracis and Clostridium botulinum"
Expert Rev. Vaccines, 7(1), 55 (2008)
Richardson, H.N., Zhao, Y., Fekete, E.M., Funk, C.K., Wirsching, P., Janda, K.D., Zorrilla, E.P., Koob, G.F., "MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist"
Pharmacology, Biochemistry and Behavior, 88, 497 (2008)
Brogan, A.P., Dickerson, T.J., Janda, K.D., "Nornicotine-organocatalyzed aqueous reduction of alpha, beta-unsaturated aldehydes"
Chem. Commun., 46, 4952 (2007)
Dickerson, T.J., McKenzie, K.M., Hoyt, A.S., Wood, M.R., Janda, K.D., Brenner, S.B., Lerner, R.A., "Phage escape libraries for checkmate analysis"
PNAS, 104(31), 12703 (2007)
Zhou, H., Zhou, B., Ma, H., Carney, C., Janda, K.D.,, "Selection and characterization of human monoclonal antibodies against Abrin by phage display"
Bioorg. Med. Chem. Lett., 17, 5690 (2007)
Park, J., Jagasia, R., Kaufmann, G.F., Mathison, J.C., Ruiz, D.I., Moss, J.A., Meijler, M.M., Ulevitch, R.J., Janda, K.D., "Infection control by antibody disruption of bacterial quorum sensing signaling"
Chemistry & Biology, 14, 1119 (2007)
Capkova, K., Yoneda, Y., Dickerson, T.J., Janda, K.D., "ynthesis and structure-activity relationships of second-generation hydroxymate botulinum neurotoxin A protease inhibitors"
Bioorg. Med. Chem. Lett., 17, 6463 (2007)
Xu, Y., Hixon, M.S., Dawson, P.E., Janda, K.D., "Development of a FRET assay for monitoring of HIV gp41 core disruption"
J. Org. Chem., 72(18), 6700 (2007)
Treweek, J., Wee, S., Koob, G.F., Dickerson, T.J., Janda, K.D., "Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease"
PNAS, 104(28), 11580 (2007)
Ino, A., Dickerson, T.J., Janda, K.D., "Positional linker effects in haptens for cocaine immunopharmacotherapy"
Bioorg. Med. Chem. Lett., 17, 4280 (2007)
Dickerson, T.J., Janda, K.D.,, "The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication"
Chem. Biol., 2(4), 359 (2007)
Debler, E.W., Kaufmann,G.F., Kirchdoerfer, R.N., Mee, J.M., Janda, K.D., Wilson, I.A., "Crystal structures of a quorum-quenching antibody"
J. Mol. Bio., 368(5), 1392 (2007)
Silvaggi, N.R., Boldt, G.E., Hixon, M.S., Kennedy, J.P., Tzipori, S., Janda, K.D., "Structures of Clostridium botulinum neurotoxin serotype A light chain complexed with small-molecule inhibitors highlight active-site flexibility"
Chemistry & Biology, 14, 533 (2007)
Eubanks, L.E., Dickerson, T.J., Janda, K.D., "Technological advancements for the detection of and protection against biological and chemical warfare agents"
Chem. Soc. Rev., 36(3), 441 (2007)
Liu, Y., Steiniger, S.C.J., Kim, Y., Kaufmann, G.F., Felding-Habermann, B., Janda, K.D., "Mechanistic studies of a peptidic GRP78 ligand for cancer celll-specific drug delivery"
Molecular Pharmaceutics, 4(3), 435 (2007)
Brogan, A.P., Eubanks, L.M., Koob, G.F., Dickerson, T.J., Janda, K.D., "Antibody-catalyzed oxidation of delta-9-tetrahydrocannabinol"
J. Am. Chem. Soc., 129, 3698 (2007)
De Lamo Marin, S., Xu, X., Meijler, M.M., Janda, K.D., , "Antibody catalyzed hydrolysis of a quorum sensing signal found in Gram-negative bacteria"
Bioorg. Med. Chem. Lett., 17, 1549 (2007)
McAllister, L.A., Hixon, M.S., Schwartz, R., Kubitz, D.S., Janda, K.D., "Synthesis and application of a novel ligand for affinity chromatography based removal of endotoxin from antibodies, "Synthesis and application of a novel ligand for affinity chromatography based removal of endotoxin from antibodies"
Bioconjugate Chem., 18, 559 (2007)
Xu, Y., Hixon, M.S., Yamamoto, N., McAllister, L.A., Wentworth, A.D., Wentworth, Jr., P., Janda, K.D., , "Antibody-catalyzed anaerobic destruction of methamphetamine"
PNAS, 104(10), 3681 (2007)
Steiniger, S.C.J., Altobell III, L., Zhou, B., Janda, K.D., "Selection of human antibodies against cell surface-associated oligomeric anthrax protective antigen"
Molecular Immunology, 44, 2749 (2007)
Eubanks, L.M., Hixon, M.S., Jin, W., Hong, S., Clancy, C.M., Tepp, W.H., Baldwin, M.R., Malizio, C.J., Goodnough, M.C., Barbieri, J.T., Johnson, E.A., Boger, D.L., Dickerson, T.J., Janda, K.D., "An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists"
PNAS, 104(8), 2602 (2007)
Rogers, C.J., Eubanks, L.M., Dickerson, T.J., Janda, K.D., "Unexpected acetylcholinesterase activity of cocaine esterases"
J. Am. Chem. Soc., 128, 15364 (2006)
McKenzie, K.M., Mee, J.M., Rogers, C.J., Hixon, M.S., Kaufmann, G.F., Janda, K.D., "Identification and characterization of single chain anti-cocaine catalytic antibodies"
J. Mol. Biol., 365, 722 (2006)
Kravchenko, V.V., Kaufmann, G.F., Mathison, J.C., Scott, D.A., Katz, A.Z., Woood, M.R., Brogan, A.P., Lehmann, M., Mee, J.M., Iwata, K., Pan, Q., Fearns, C., Knaus, U.G., Meijler, M.M., Janda, K.D., Ulevitch, R.J., "N-(3-Oxo-acyl)homoserine llactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways"
Journal of Biological Chemistry, 281(39), 28822 (2006)
Eubanks, L.M., Rojers, C.J., Beuscher IV, A.E., Koob, G.F., Olson, A.J., Dickerson, T.J., Janda, K.D., "A molecular link between the active component of marijuana and Alzheimer's disease pathology"
Molecular Pharmaceutics, 3(6), 773 (2006)
Brogan, A.P., Dickerson, T.J., Janda, K.D., "Enamine-based aldol organocatalysis in water: Are they really "all wet"?"
Angew. Chem. Int. Ed., 45, 8100 (2006)
Zorilla, E.P., Iwasaki, S., Moss, J.A., Chang, J., Otsuji, J., Inoue, K., Meijler, M.M., Janda, K.D., "Vaccination against weight gain"
PNAS, 103(35), 13226 (2006)
Kim, Y., Lillo, A.M., Steiniger, S.C.J., Liu, Y., Ballatore, C., Anichini, A., Mortarini, R., Kaufmann, G.F., Zhou, B., Felding-Habermann, B., Janda, K.D., "Targeting heat shock protiens on cancer cells: Selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand"
Biochemistry, 45, 9434 (2006)
Dickerson, T.J., Janda, K.D., "The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication"
ACS Chemical Biology, 1(6), 359 (2006)
Boldt, G.E., Eubanks, L.M., Janda, K.D., "Identification of a botulinum A protease inhibitor displaying efficacy in a cellular model, "Identification of a botulinum A protease inhibitor displaying efficacy in a cellular model"
Chem. Commun., 3063 (2006)
Ma, H., Zhou, B., Kim, Y., Janda, K.D., "A cyclic peptide-polymer probe for the detection of Clostridium botulinum neurotoxin serotype A"
Toxicon, 47, 901 (2006)
Fu, Z., Chen, S., Baldwin, M.R., Boldt, G.E., Crawford, A., Janda, K.D., Barbieri, J.T., Kim, J.-J.P., "Light chain of botulinum neurotoxin serotype A: Structural resolution of a catalytic intermediate"
Biochemistry, (ASAP), (2006)
Boldt, G.E., Kennedy, J.P., Hixon, M.S., Mcallister, L.A., Barbieri, J.T., Tzipori, S., Janda, K.D., "Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin A inhibitors"
J. Comb. Chem., 8, 513 (2006)
Xu, Y., Lu, H., Kennedy, J.P., Yan, X., McAllister, L.A., Yamamoto, N., Moss, J.A., Boldt, G.E., Jiang, S., Janda, K.D., "Evaluation of "credit-card" libraries for inhibition of HIV-1 gp41 fusogenic core formation"
J. Comb. Chem., 8, 531 (2006)
Boldt, G.E., Kennedy, J.P., Janda, K.D., "Identification of a potent botulinum neurotoxin A protease inhibitor using in situ lead identification chemistry"
Organic Lett., 8, 1729 (2006)
Xu, Y., Shi, J., Yamamoto, N., Moss, J.A., Vogt, P.K., Janda, K.D., "A credit-card library approach for disrupting protein-protein interactions"
Bioorg. Med. Chem., 14, 2660 (2006)
Kaufmann, G.F., Sartorio, R., Lee, S.-H., Mee, J.M., Altobell, III, L.J., Kujawa, D.P., Jeffries, E., Clapham, B., Meijler, M.M., Janda, K.D., "Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing"
J. Am. Chem. Soc., 128, 2802 (2006)
McAllister, L.A., Hixon, M.S., Kennedy, J.P., Dickerson, T.J., Janda, K.D., "Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: A new wrinkle in botulinum neurotoxin"
J. Am. Chem. Soc., 128, 4176 (2006)
Zhu, X., Dickerson, T.J., Rogers, C.J., Kaufmann, G.F., Mee, J.M., McKenzie, K.M., Janda, K.D., Wilson, I.A., "Complete reaction cycle of a cocaine catalytic antibody at atomic resolution"
Structure, 14, 205 (2006)
Shigenaga, S., Moss, J.A., Ashley, F.T., Kaufmann, G.F., Janda, K.D., "Solid-phase synthesis and cyclative cleavage of quorum sensing depsipeptide analogues by acylphenyldiazene activation"
SYNLETT, 4, 551 (2006)
Moss, J.A., Stokols, S., Hixon, M.S., Ashley, F.T., Chang, J.Y., Janda, K.D., "Solid-phase synthesis and kinetic characterization of fluorogenic enzyme-degradable hydrogel cross-linkers"
Biomacromolecules, 7, 1011 (2006)
Boldt, G.E., Dickerson, T.J., Janda, K.D., "Emerging chemical and biological approaches for the preparation of discovery libraries"
Drug Disc. Today, 11, 143 (2006)
Rogers, C.J., Dickerson, T.J., Janda, K.D., , "Kinetic isotope and thermodynamic analysis of the nornicotine-catalyzed aqueous aldol reaction"
Tetrahedron, 62, 352 (2006)
Zhang, L., Long, H., Boldt, G.E., Janda, K.D., Schatz, G.C., Lewis, F.D., "alpha- and beta-Stilbenosides as base-pair surrogates in DNA hairpins"
Org. Biomol. Chem., 4, 314 (2006)
Wu, W., Luo, Y., Sun, C., Liu, Y., Kuo, P., Varga, J., Xiang, R., Reisfeld, R., Janda, K.D., Edgington, T.S., Liu, C., "Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms"
Cancer Res., 66(2), 1 (2006)
Lillo, A.M., McKenzie, K.M., Janda, K.D., "Phage-Displayed Antibody Libraries"
In: Cell Biology: A Laboratory Handbook, ed. J.E. Celis, Elsevier Academic, USA, Chapter 59, pp. 491-496 (2006)
Dickerson, T.J., Janda, K.D., "Recent advances for the treatment of cocaine abuse: Central nervous system immunopharmacotherapy"
The AAPS Journal, 7(3), Article 59, E579 (2005)
Shimomura, O., Lee, B.S., Meth, S., Suzuki, H., Mahajan, S., Nomura, R., Janda, K.D., "Synthesis and application of polytetrahydrofuran-grafted polystyrene (PS-PTHF) resin supports for organic synthesis"
Tetrahedron, 61, 12160 (2005)
Rogers, C.J., Mee, J.M., Kaufmann, G.F., Dickerson, T.J., Janda, K.D., "A high-swelling reagent scaffold suitable for use in aqueous and organic solvents"
Tetrahedron, 61, 12140 (2005)
Kim, Y., Lillo, A., Moss, J.A., Janda, K.D., "A contiguous stretch of methionine residues mediates the energy-dependent internalization mechanism of a cell-penetrating peptide"
Molecular Pharmaceutics, 2(6), 528 (2005)
Meijler, M.M., Kaufmann, G.F., Qi, L., Mee, J.M., Coyle, A.R., Moss, J.A., Wirsching, P., Matsushita, M., Janda, K.D., "Fluorescent cocaine probes: A tool for the selection and engineering of therapeutic antibodies"
J. Am. Chem. Soc., 127, 2477 (2005)
Qi, L., Yamamoto, N., Meijler, M.M., Altobell, III, L.J., Koob, G.F., Wirsching, P., Janda, K.D., "Delta-9-tetrahydrocannabinol immunochemical studies: Haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta-9-tetrahydrocannabinol"
J. Med. Chem., 48, 7389 (2005)
Dickerson, T.J., Beuscher IV, A.E., Rogers, C.J., Hixon, M.S., Yamamoto, N., Xu, Y., Olson, A.J., Janda, K.D. , "Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library"
Biochemistry, 44, 14845 (2005)
Shute, T.S., Matsushita, M., Dickerson, T.J., La Clair, J.J., Janda, K.D., Burkart, M.D., "A site-specific bifunctional protein labeling system for affinity and fluorescent analysis"
Bioconjugate Chem., 16, 1352 (2005)
Matsushita, M., Meijler, M.M., Wirsching, P., Lerner, R.A., Janda, K.D., "A blue fluorescent antibody-cofactor sensor for mercury"
Org. Lett., 7, 4943 (2005)
Eubanks, L.M., Dickerson, T.J., Janda, K.D., "Vitamin B2-mediated cellular photoinhibition of botulinum neurotoxin A"
FEBS Letters, 579, 5361 (2005)
Carrera, M.R.A., Trigo, J.M., Wirsching,P., Roberts, A.J., Janda, K.D., "Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose"
Pharmacology, Biochemistry and Behavior, 81, 709 (2005)
McKenzie, K.M., Meijler, M.M., Lowery, C.A., Boldt, G.E., Janda, K.D., "A furanosyl-carbonate autoinducer in cell-to-cell communication of V. harveyi"
Chem. Commun., 4863 (2005)
Toker, J.D., Tremblay, M.R., Yli-Kauhaluoma, J., Wentworth, A.D., Zhou, B., Wentworth, Jr., P., Janda, K.D., "Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction"
J. Org. Chem., 70, 7810 (2005)
Xu, Y., Yamamoto, N., Ruiz, D.I., Kubitz, D.S., Janda, K.D., "Squaric monoamide monoester as a new class of reactive immunization hapten for catalytic antibodies"
Bioorg. Med. Chem. Lett., 15, 4304 (2005)
Yamashita, M., Lee, S.-H., Koch, G., Zimmermann, J., Clapham, B., Janda, K.D., "Solid-phase synthesis of oxazolones and other heterocycles via Wang resin-bound diazocarbonyls"
Tetrahedron Lett., 46, 5495 (2005)
Rogers, C.J., Mee, J.M., Kaufmann, G.F., Dickerson, T.J., Janda, K.D., "Toward cocaine esterase therapeutics"
J. Am. Chem. Soc., 127(28), 10016 (2005)
Brogan, A.P., Dickerson, T.J., Boldt, G.E., Janda, K.D., "Altered retinoid homeostasis catalyzed by a nicotine metabolite: Implications in macular degeneration and normal development"
Proc. Natl. Acad. Sci. U.S.A., 102(30), 10433 (2005)
Lee, B.S., Mahajan, S., Janda, K.D., "Molecular iodine-catalyzed imine activation for three-component nucleophilic addition reactions"
Synlett, 8, 1325 (2005)
Lee,B.S., Mahajan, S., Janda, K.D., "Asymmetric dihydroxylation catalyzed by ionic polymer-supported osmium tetroxide"
Tetrahedron Lett., 46, 4491 (2005)
Dickerson, T.J., Kaufmann, G.F., Janda, K.D., "Bacteriophage-mediated protein delivery into the central nervous system and its application in immunopharmacotherapy"
Expert Opin. Biol. Ther., 5(6), 773 (2005)
Lowery, C.A., McKenzie, K.M., Qi, L., Meijler, M.M., Janda, K.D., "Quorum sensing in Vibrio harveyi: probing the specificity of the LuxP binding site"
Bioorg. Med. Chem. Lett., 15, 2395 (2005)
Rogers, C.L., Dickerson, T.J., Brogan, A.P., Janda,K.D., "Hammett correlation of nornicotine analogues in the aqueous aldol reaction: Implications for green organocatalysis"
J. Org. Chem., 70(9), 3705 (2005)
Kaufmann, G.F., Meijler, M.M., Sun, C., Chen, D.-W., Kujawa, D.P., Mee, J.M., Hoffman, T.Z., Wirsching, P., Lerner, R.A., Janda, K.D., "Enzymatic incorporation of an antibody-activated blue fluorophore into DNA"
Angew. Chem. Int. Ed., 44, 2144 (2005)
Lee, B.S., Mahajan, S., Janda, K.D., "Cross-linked poly(4-vinylpyridine/styrene) copolymers as a support for immobilization of ytterbium triflate"
Tetrahedron, 61, 3081 (2005)
Reed, N.N., Dickerson, T.J., Boldt, G.E., Janda, K.D., "Enantioreversal in the Sharpless asymmetric epoxidation reaction controlled by the molecular weight of a covalently appended achiral polymer"
J. Org. Chem., 70, 1728 (2005)
Moss, J.A., Lillo, A., Kim, Y.S., Gao, C., Ditzel, H., Janda, K.D., "A dimerization 'switch' in the internalization mechanism of a cell-penetrating peptide"
J. Am. Chem. Soc., 127, 538 (2005)
Lee, B.S., Mahajan, S., Janda, K.D., "Novel method for catalyst immobilization using an ionic polymer: A case study using recyclable yttterbium triflate"
Tetrahedron Lett., 46, 807 (2005)
Kaufmann, G.F., Sartorio, R., Lee, S.-H., Rogers, C.J., Meijler, M.M., Moss, J.A., Clapham, B., Brogan, A.P., Dickerson, T.J., Janda, K.D., "Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones"
Proc. Natl. Acad. Sci. U.S.A., 102, 309 (2005)
Felding-Habermann, B., Lerner, R.A., Lillo, A., Zhuang, S., Weber, M.R., Arrues, S., Gao, C., Mao, S., Saven, A., Janda, K.D., "Combinatorial antibody libraries from cancer patients yield ligand mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis"
Proc. Natl. Acad. Sci. USA, 101, 17210 (2004)
Dickerson, T.J., Reed, N.N., La Clair, J.J., Janda, K.D., "A precipitator for the detection of thiophilic heavy metals in aqua"
J. Am. Chem. Soc., 126, 16582 (2004)
Lee, S.-H., Yoshida, K., Matsushita, H., Clapham, B., Koch, G., Zimmermann, J., Janda, K.D., "N-H insertion reactions of primary ureas: The synthesis of highly substituted imidazolones and imidazoles from diazocarbonyls"
J. Org. Chem., 69, 8829 (2004)
Matsushita, H., Lee, S.-H., Yoshida, K., Clapham, B., Koch, G., Zimmermann, J., Janda, K.D., "N-H insertion reactions of Boc-amino acid amides: Solution- and solid-phase synthesis of pyrazinones and pyrazines"
Organic Lett., 6, 4627 (2004)
Kim, Y.S., Moss, J.A., Janda, K.D., "Biological tuning of synthetic tactics in solid-phase synthesis: Application to Ab(1-42)"
J. Org. Chem., 69, 7776 (2004)
Qi, L., Meijler, M.M., Lee, S.-H., Sun, C., Janda, K.D., "Solid-phase synthesis of anandamide analogues"
Organic Lett., 6, 1673 (2004)
McDunn, J.E., Dickerson, T.J., Janda, K.D., "Antibody Catalysis of Disfavored Chemical Reactions"
Catalytic Antibodies, ed. Ehud Keinan, Wiley-VCH Verlag Gmbh & Co., Weinheim, Germany, pp. 184-216 (2004)
Xu, Y., Yamamoto, N., Janda, K.D., "Catalytic antibodies: Hapten design stratagies and screening methods"
Bioorg. Med. Chem., 12, 5247 (2004)
Dickerson, T.J., Yamamoto, N., Janda, K.D., "Antibody-catalyzed oxidative degradation of nicotine using riboflavin"
Bioorg. Med. Chem., 12, 4981 (2004)
Dickerson, T.J., Lovell, T., Meijler, M.M., Noodleman, L., Janda, K.D., "Nornicotine aqueous aldol reactions: Synthetic and theoretical investigations into origins of catalysis"
J. Org. Chem., 69, 6603 (2004)
Carrera, M.R.A., Meijler, M.M., Janda, K.D., "Cocaine pharmacology and current pharmacotherapies for its abuse"
Bioorg. Med. Chem., 12, 5019 (2004)
Dickerson, T.J., Yamamoto, N., Ruiz, D.I., Janda, K.D., "Immunological consequences of methamphetamine protein glycation"
J. Am. Chem. Soc., 126, 11446 (2004)
Lillo, A.M., Sun, C., Gao, C., Ditzel, H., Parrish, J., Gauss, C.-M., Moss, J., Felding-Habermann, B., Wirsching, P., Boger, D.L., Janda, K.D., "A human single-chain antibody specific for integrin alpha-3-beta-1 capable of cell internalization and delivery of antitumor agents"
Chemistry & Biology, 11, 897 (2004)
Carrera, M.R.A., Kaufmann, G.F., Mee, J.M., Meijler, M.M., Koob, G.F., Janda, K.D., "Treating cocaine addiction with viruses"
Proc. Natl. Acad. Sci. U.S.A., 101, 10416 (2004)
Lee, S.-H., Matsushita, H., Koch, G., Zimmermann, J., Clapham, B., Janda, K.D., "Smart cleavage reactions: the synthesis of an array of ureas from polymer-bound carbamates"
J. Comb. Chem., 6, 822 (2004)
Chen, D.-W., Janda, K.D., , "Catalytic Antibodies"
Encyclopedia of Supramolecular Chemistry, Marcel Dekker, New York, NY, P. 193 (2004)
Meijler, M.M., Hom, L.G., Kaufmann, G.F., McKenzie, K.M., Sun, C., Moss, J.A., Matsushita, M., Janda, K.D., "Synthesis and biological validation of a ubiquitous quorum-sensing molecule"
Angew. Chem. Int. Ed., 43, 2106 (2004)
Lee, B.-S., Mahajan, S., Clapham, B., Janda, K.D., "Suspension ring-opening metathesis polymerization: The preparation of norbornene-based resins for application in organic synthesis"
J. Org. Chem., 69, 3319 (2004)
Lee, S.-H., Matsushita, H., Clapham, B., Janda, K.D., "The direct conversion of carbamates to ureas using aluminum amides"
Tetrahedron, 60, 3439 (2004)
Meijler, M.M., Matsushita, M., Wirsching, P., Janda, K.D., "Development of immunopharmacotherapy against drugs of abuse"
Current Drug Discovery Technologies, 1, 77 (2004)
Ahn, J.-M., Wentworth, Jr., P., Janda, K.D., "Probing lipase/esterase libraries for lipid A hydrolysis - discovery of biocatalysts for the detoxification of bacterially-expressed recombinant protein"
Chem. Commun., 364 (2004)
Matsushita, H., Lee, S.-H., Joung, M., Clapham, B., Janda, K.D., "Smart cleavage reactions: the synthesis of benzimidazoles and benzothiazoles from polymer-bound esters"
Tetrahedron Lett., 45, 313 (2004)
Carrera, M.R.A., Ashley, J.A., Hoffman, T.Z., Isomura, S., Wirsching, P., Koob, G.F., Janda, K.D., "Investigations using immunization to attenuate the psychoactive effects of nicotine"
Bioorg. Med. Chem., 12, 563 (2004)
Zorilla, E., Fekete, E., Mason, B.J., Wirsching, P., Janda, K.D., Kooob, G.F., "CRF-1 antagonists for anxiety"
European Neuropsychopharmacology, 13(Suppl. 4), S130 (2003)
Matsushita, M., Yoshida, K., Yamamoto, N., Wirsching, P., Lerner, R.A., Janda, K.D., "High-throughput screening by using a blue-fluorescent antibody sensor"
Angew. Chemie, Int. Ed., 42, 5984 (2003)
Dickerson, T.J., Tremblay, M.R., Hoffman, T.Z., Ruiz, D.I., Janda, K.D., "Catalysis of the Photo-Fries reaction: Antibody-mediated stabilization of high energy states"
J. Amer. Chem. Soc., 125, 15395 (2003)
Moss, J.A., Coyle, A.R., Ahn, J.-A., Meijler, M.M., Offer, J., Janda, K.D., "Tandem IMAC-HPLC purification of a cocaine-binding scFv antibody"
Journal of Immunological Methods, 281, 143 (2003)
Wentworth, Jr., P., Nieva, J., Takeuchi, C., Galve, R., Wentworth, A.D., Dilley, R.B., DeLaria, G.A., Saven, A., Babior, B.M., Janda, K.D., Eschenmoser, A., Lerner, R.A., "Evidence for ozone formation in human atherosclerotic arteries"
Science, 302, 1053 (2003)
Chen, Y., Gambs, C., Abe, Y., Wentworth, P., Jr., Janda, K.D., " Total synthesis of the depsipeptide FR-901375"
J.Org. Chem., 68, 8902 (2003)
Lee, S.-H., Clapham, B., Koch, G., Zimmerman, J., Janda, K.D., "Solid-phase rhodium carbenoid N-H insertion reactions: the synthesis of a diverse array of indoles"
J. Comb. Chem., 5, 188 (2003)
Fujimori, T., Wirsching, P., Janda, K.D., "Preparation of a Krohnke pyridine combinatorial library suitable for solution-phase biological screening"
J. Comb. Chem., 5, 625 (2003)
Hasserodt, J., Janda, K.D., "Catalytic Antibodies"
In: Encyclopedia of Catalysis, ed. I.T. Horvath, Wiley, N.Y., pp. 440-476 (2003)
Dickerson, T.J., Reed, N.N., Janda, K.D., "Soluble polymers as catalyst and reagent platforms: Liquid-phase methodologies"
In: Polymeric Materials in Organic Synthesis and Catalysis ed. M.R. Buchmeiser, Wiley-VCH Verlag Gmbh, Weinheim, Germany, pp 241-276 (2003)
Dickerson, T.J., Janda, K.D., "Glycation of the amyloid beta-protein by a nicotine metabolite: A fortuitous chemical dynamic between smoking and Alzheimer's disease"
Proc. Natl. Acad. Sci. USA, 100(14), 8182 (2003)
Meijler, M.M., Matsushita, M., Altobell, III, L.J., Wirsching, P., Janda, K.D., "A new stategy for improved nicotine vaccines using conformationally constrained haptens"
J. Amer. Chem. Soc., 125(24), 7164 (2003)
Liu C., Sun, C., Huang, H., Janda, K., Edgington, T., "Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy"
Cancer Research, 63, 2957 (2003)
Gambs, C., Dickerson, T.J., Mahajan, S., Pasternack, L.B., Janda, K.D., "High-resolution diffusion-ordered spectroscopy to probe the microenvironment of JandaJel and Merrifield resins"
J. Org. Chem., 68(9), 3673 (2003)
Redwan, E-R.,M., Larsen, N.A., Zhou, B., Wirsching, P., Janda, K.D., Wilson, I.A., "Expression and characterization of a humanized cocaine-binding antibody"
Biotechnology and Bioengineering, 82(5), 612 (2003)
Zhu, X., Heine, A., Monnat, F., Houk, K.N., Janda, K.D., Wilson, I.A., "Structural basis for antibody catalysis of a cationic cyclization"
J. Mol. Bio., 329, 69 (2003)
Sun, C., Wirsching, P., Janda, K.D., "Enabling ScFvs as muti-drug carriers: A dendritic approach"
Bioorg. Med. Chem., 11, 1761 (2003)
Gao, C., Mao, S., Ronca, F., Zhuang, S., Quaranta, V., Wirsching, P., Janda, K.D., "De novo identification of tumor-specific internalizing human antibody-receptor pairs by phage-display methods"
Journal of Immunological Methods, 274, 185 (2003)
Wentworth, Jr., P., Wentworth, A.D., Zhu, X., Wilson, I.A., Janda, K.D., Eschenmoser, A., Lerner, R.A., "Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens"
Proc. Nat. Acad. Sci. USA, 100, 1490 (2003)
Ahn, J.-A., Wentworth, Jr., P., Janda, K.D., "Soluble polymer-supported convergent parallel library synthesis"
Chem. Commun., 480 (2003)
Cannizzaro, C.E., Ashley, J.A., Janda, K.D., Houk, K.N., "Experimental determination of the absolute enantioselectivity of an antibody-catalyzed Diels-Alder reaction and theoretical explorations of the origins of stereoselectivity"
J. Am. Chem. Soc., 125, 2489 (2003)
Lee, S.-H., Clapham, C., Koch, G., Zimmermann, J., Janda, K.D., "Rhodium carbenoid N-H insertion reactions of primary ureas: Solution and solid-phase synthesis of imidazolones"
Organic Lett., 5, 511 (2003)
Wang, Q., Krishnaswami, S.R., Janda, K.D., Lin, T., Finn, M.G., "Blue fluorescent antibodies as reporters of steric accessibility in virus conjugates"
Bioconjugate Chem., 14, 38 (2003)
Dickerson, T., Cordova, A., Chen, D.-W., Janda, K.D., "The Use of Enzymes and Catalytic Antibodies in the Asymmetric Aldol Reaction"
In: Encyclopedia of Catalysis, ed. I.T. Horvath, Wiley, N.Y., (2002)
Wentworth, Jr., P., McDunn, J.E., Wentworth, A.D., Takeuchi, C., Nieva, J., Jones, T., Bautista, C., Ruedi, J.M., Gutierrez, A., Janda, K.D., Babior, B.M., Eschenmoser, A., Lerner, R.A., "Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation"
Science, 298, 2195 (2002)
Gao, C., Mao, S., Ditzel, H.J., Farnaes, L., Wirsching, P., Lerner, R.A., Janda, K.D., "A cell-penetrating peptide from a novel pVII-pIX phage-displyed random peptide library"
Bioorg. Med. Chem., 10, 4057 (2002)
Dickerson, T.J., Janda, K.D., "A previously undescribed chemical link between smoking and metabolic disease"
Proc. Nat. Acad. Sci. USA, 99, 15084 (2002)
Lee, K.J., Mao, S., Sun C., Gao, C., Blixt, O., Arrues, S., Hom, L.G., Kaufmann, G.F., Hoffman, T.Z., Coyle, A.R., Paulson, J., Felding-Habermann, B., Janda, K.D., "Phage-display selection of a human single-chain Fv antibody highly specific for melanoma and breast cancer cells using a chemoenzymatically synthesized GM3-carbohydrate antigen"
J. Am. Chem. Soc., 124, 12439 (2002)
Jones, L.H., Altobell III, L.J., MacDonald, M.T., Boyle, N.A., Wentworth, Jr., P., Lerner, R.A., Janda, K.D., "Active immunization with a glycolipid transition state analogue protects against endotoxic shock"
Angew. Chem. Int. Ed., 41, 4241 (2002)
Dickerson, T.J., Reed, N.N., Janda, K.D., "Soluble polymers as scaffolds for recoverable catalysts and reagents"
Chem. Rev., 102, 3325 (2002)
Gao, C., Mao, S., Kaufmann, G., Wirsching, P., Lerner, R.A., Janda, K.D., "A method for the generation of combinatorial antibody libraries using pIX phage display"
Proc. Nat. Acad. Sci. USA, 99, 12612 (2002)
Shimomura, O., Clapham, B., Spanka, C., Mahajan, S., Janda, K.D., "Application of microgels as polymer supports for organic synthesis: Preparation of a small phthalide library, a scavenger, and a borohydride reagent"
J. Comb. Chem., 4, 436 (2002)
Clapham, B., Lee, S.-H., Koch, G., Zimmermann, J., Janda, K.D., "The preparation of polymer bound Beta-ketoesters and their conversion into an array of oxazoles"
Tetrahedron Lett., 43, 5407 (2002)
Ahn, J.-M., Boyle, N.A., MacDonald, M.T., Janda, K.D., "Peptidomimetics and peptide backbone modifications"
Mini Reviews in Medicinal Chemistry, 2, 463 (2002)
Sun, C., Wirsching, P., Janda, K.D., "Syntheses of dendritic linkers containing chlorambucil residues for the preparation of antibody-multidrug immunoconjugates"
Bioorg. Med. Chem. Lett., 12, 2213 (2002)
Delgado, M., Janda, K.D., "Polymeric supports for solid phase organic synthesis"
Current Organic Chemistry, 6, 1031 (2002)
Reed, N.N., Delgado, M., Hereford, K., Clapham, B., Janda, K.D., "Preparation of soluble and insoluble polymer supported IBX reagents"
bioorg. Med. Chem. Lett., 12, 2047 (2002)
Janda, K.D., "(Preface) Polymer supported catalysts and reagents in synthetic organic chemistry"
Bioorg. Med. Chem. Lett., 12, vii (2002)
Spanka, C. Wentworth, Jr., P., Janda, K.D., "Developing soluble polymers for high-throughput synthetic chemistry"
Combinatorial Chemistry and High Throughput Screening, 5, 233 (2002)
Delgado, M., Lee, K.J., Altobell, III, L., Spanka, C., Wentworth, Jr., P., Janda, K.D., "A parallel approach to the discovery of carrier delivery vehicles to enhance antigen immunogenicity"
J. Am. Chem. Soc., 124, 4946 (2002)
Spanka, C., Clapham, B., Janda, K.D., "reparation of new microgel polymers and their application as supports in organic synthesis"
J. Org. Chem., 67, 3045 (2002)
Boyle, N.A., Janda, K.D., "Formats for combinatorial synthesis: solid-phase, liquid-phase and surface"
Current opinion in Chemical Biology, 6, 339 (2002)
Zhou, B., Wirsching, P., Janda, K.D., "Human antibodies against spores of the genus Bacillus: A model study for the detection of and protection against anthrax and the bioterrorist threat"
Proc. Nat. Acad. Sci., 99, 5421 (2002)
Isomura, S., Ashley, J.A., Wirsching, P., Janda, K.D., "Antibody-catalyzed cleavage of the D-Ala-D-Lac depsipeptide: An immunological approach to the problem of vancomycin resistance"
Bioorg. Med. Chem. Lett., 12, 861 (2002)
Reger, T.S., Janda, K.D., "Parallel suspension polymerization for high-throughput resin synthesis"
Biorg. Med. Chem., 12, 837 (2002)
Kim, G.-T., Wenz, M., Park, J.-I., Hasserodt, J., Janda, K.D., "Polyene substrates with unusual methylation patterns to probe the active sites of three catalytic antibodies"
Bioorg. Med. Chem., 10, 1249 (2002)
Isomura, S., Hoffman, T.Z., Wirsching, P., Janda, K.D., "Synthesis, properties, and reactivity of cocaine benzoylthio ester possessing the cocaine absolute configuration"
J. Amer. Chem. Soc., 124, 3661 (2002)
Dickerson, T.J., Janda, K.D., "Aqueous aldol catalysis by a nicotine metabolite"
J. Am. Chem. Soc., 124, 3220 (2002)
Nicholas, K.M., Wentworth, Jr., P., Harwig, C.W., Wentworth, A.D., Shafton, A., Janda, K.D., "A cofactor approach to copper-dependent catalytic antibodies"
Biomacromolecules, 99, 2648 (2002)
Delgado, M., Spanka, C., Kerwin, L.D., Wentworth, Jr., P., Janda, K.D., "A tunable hydrogel for encapsulation and controlled release of bioactive proteins"
Biomacromolecules, 3, 262 (2002)
Matsushita, M., Janda, K.D., "Histidine kinases as targets for new antimicrobial agents"
Bioorg. Med. Chem. Lett., 10, 855 (2002)
Moss, J.A., Dickerson, T.J., Janda, K.D., "Solid phase peptide synthesis on JandaJel resin"
Tetrahedron Lett., 43, 37 (2002)
Larsen, N.A., Zhou, b., Heine, a., Wirsching, P., Janda, K.D., Wilson, I.A., "Crystal structure of a cocaine-binding antibody"
J.Mol. Bio., 9, 311 (2001)
Wentworth Jr., P., Jones, L.H., Wentworth, A.D., Zhu, X., Larsen, N.A., Wilson, I.A., Xu, X., Goddard III, W.A., Janda, K.D., Eschenmoser, A., Lerner, R.A., "Antibody catalysis of the oxidation of water"
Science, 293, 1806 (2001)
Kozlov, I.A., Mao, S., Xu, Y., Huang, X., Lee, L., Sears, P.S., Gao, C., Coyle, A.R., Janda, K.D., Wong, C.-H., "Synthesis of solid-supported mirror-image sugars: A novel method for selecting receptors for cellular-surface carbohydrates"
ChemBioChem, 2, 741 (2001)
Brummer, O., Hoffman, T.Z., Janda, K.D., "Metalloantibodies: Mercury(II)-dependent acyl transferases"
Bioorg. Med. Chem., 9, 2253 (2001)
Chen, D.-W., Kubiak, R.J., Ashley, J.A., Janda, K.D., "Reactive immunization elicits catalytic antibodies for polyester hydrolysis"
J. Chem. Soc., Perkin Trans., 1, 2796 (2001)
Tremblay, M.R., Dickerson, T.J., Janda, K.D., "Advances in antibody catalysis of cycloaddition reactions"
Adv. Synth. Catal., 343, 577 (2001)
Cordova, A., Tremblay, M.R., Clapham, B., Janda, K.D., "A sequential application of kinetic resolution and polymer-supported scavenging for the isolation of chiral secondary alcohols"
J. Org. Chem., 66, 5645 (2001)
Clapham, B., Spanka, C., Janda, K.D., "Solid-phase rhodium carbenoid reactions: An N-H insertion route to a diverse series of oxazoles"
Org. Lett., 3, 2173 (2001)
Cordova, A., Janda, K.D., "Synthesis and catalytic antibody functionalization of dendrimers"
J. Am. Chem. Soc., 123, 8248 (2001)
Lee, K.J., Janda, K.D., "Traceless solid-phase synthesis of 5-Benzoylbenzimidazoles"
Can. J. Chem., 79, 1556 (2001)
Dickerson, T., Reed, N.N., Janda, K.D., "Regio-reactive resin: A platform for orthogonal loading using the polymer backbone and cross-linker"
Bioorg. Med. Chem. Lett., 11, 1507 (2001)
Isomura, S., Wirsching, P., Janda, K.D., "An immunotherapeutic program for the treatment of nicotine addiction: Hapten design and synthesis"
J. Org. Chem., 66, 4115 (2001)
Wentworth, P. Jr., Janda, K.D., "Catalytic antibodies: Structure and function"
Cell Biochem. Biophys., 35, 63 (2001)
Brummer, O., La Clair, J.J., Janda, K.D., "Practical screening of mercury contamination in fish tissues"
Bioorg. Med. Chem. Lett., 9, 1067 (2001)
Clapham, B., Reger, T.S., Janda, K.D., "Polymer-supported catalysis in synthetic organic chemistry"
Tetrahedron, 57, 4637 (2001)
Brummer, O., Clapham, B., Janda, K.D., "Solid-phase synthesis of oligoesters using a JandaJel resin"
Tetrahedron Letters, 42, 2257 (2001)
Jones, L.H., Harwig, C.W., Wentworth, P. Jr., Simeonov, A., Wentworth, A.D., Py, S., Ashley, J.A., Lerner, R.A., Janda, K.D., "Conversion of enediynes into quinones by antibody catalysis and in aqueous buffers: Implications for an alternative enediyne therapeutic mechanism"
J. Am. Chem. Soc., 123, 3607 (2001)
Wen, K., Han, H., Hoffman, T.Z., Janda, K.D., Orgel, L.E., "The synthesis of beta-peptides containing guanidino groups"
Bioorg. Med. Chem. Lett., 11, 689 (2001)
Cordova, A., Janda, K.D., "A highly chemo- and stereoselective synthesis of beta-keto esters via a polymer-supported lipase catalyzed transesterification"
J. Org. Chem., 66, 1906 (2001)
Chen, D.-W., Beuscher IV, A.E., Stevens, R.C., Wirsching, P., Lerner, R.A., Janda,K.D., "Preparation of stilbene-tethered nonnatural nucleosides for use with blue-fluorescent antibodies"
J. Org. Chem., 66, 1725 (2001)
Matsushita, M., Hoffman, T.Z., Ashley, J.A., Zhou, B., Wirsching, P., Janda, K.D., "Cocaine catalytic antibodies: The primary importance of linker effects"
Bioorg. Med. Chem. Lett., 11, 87 (2001)
Carrera, M.R.A., Ashley, J.A., Wirsching, P., Koob, G.F., Janda,K.D., "A second-generation vaccine protects against the psychoactive effects of cocaine"
Proc. Natl. Acad. Sci. USA, 98, 1988 (2001)
Clapham, B., Cho, C.-W., Janda, K.D., "A polymer-supported proline-based diamine catalyst for the kinetic resolution of racemic secondary alcohols"
J. Org. Chem., 66, 868 (2001)
Toy, P.H., Reger, T.S., Garibay, P., Garno, J.C., Malikayil, J.A., Liu, G.-Y., Janda, K.D., "Polytetrahydrofuran cross-linked polystyrene resins for solid-phase organic synthesis"
J. Comb. Chem., 3, 117 (2001)
Brummer, O., Hoffman, T.Z., Chen, D.-W., Janda, K.D., "Antibody-catalyzed hydrolysis of oligomeric esters: A model for the degradation of polymeric materials"
Chem. Commun., 1, 19 (2001)
Toy, P.H., Reger, T.S., Janda, K.D., "Tailoring polystyrene solid-phase synthesis resins: Incorporation of flexible cross-linkers"
Aldrichimica Acta, 33, 87 (2000)
Manzotti, R., Reger, T.S., Janda, K.D., "Improved synthesis of (4-ethenylphenyl)diphenyl methanol and its application in the preparation of trityl functionalized polystyrene resin containing tetrahydrofuran derived cross-linker"
Tetrahedron Letters, 41, 8417 (2000)
Lopez-Pelegrin, J.A., Wentworth, P. Jr., Sieber, F., Metz, W.A., Janda, K.D., "Soluble polymer-supported chemoenzymatic synthesis of the C21-C27 fragment of the Bryostatins"
J. Org. Chem., 65, 8527 (2000)
Tremblay, M.R., Wentworth, P. Jr., Lee, G.E. Jr., Janda, K.D., "Parallel solid-phase synthesis and structural characterization of a library of highly substituted chiral 1,3-oxazolidines"
J. Comb. Chem., 2, 698 (2000)
Sieber, F., Wentworth, P. Jr., Janda, K.D., "Exploiting poly(ethylene glycol) as a matrix for liquid-phase organic synthesis"
Molecules, 5, 1018 (2000)
Simeonov, A., Matsushita, M., Juban, E.A., Thompson, E.H.Z., Hoffman, T.Z., Beuscher IV, A.E., Taylor, M.J., Wirsching, P., Rettig, W., McCusker, J.K., Stevens, R.C., Millar, D.P., Schultz, P.G., Lerner, R.A., Janda, K.D., "Blue-fluorescent antibodies"
Science, 290, 307 (2000)
Wentworth, A.D., Jones, L.H., Wentworth, P. Jr., Janda, K.D., Lerner, R.A., "Antibodies have the intrinsic capacity to destroy antigens"
Proc. Natl. Acad. Sci. USA, 97, 10930 (2000)
Manzotti, R., Tang, S.-Y., Janda, K.D., "Improved synthesis of prostanoids on a non-cross-linked polystyrene soluble support"
Tetrahedron, 56, 7885 (2000)
Vaino, A.R., Janda, K.D., "Solid phase organic synthesis: A critical understanding of the resin"
J. Comb. Chem., 2, 579 (2000)
Wentworth, P. Jr., Janda, K.D., "A tool-box of polymer matrices for the combinatorial chemist / biotechnologist"
International Convention on Agriculture, Biotechnology and Chemistry; Rome, Italy, p. 211 (2000)
Manzotti, R., Janda, K.D., "Solid and liquid phase chemistry: Development of new supports for solid phase organic synthesis and for liquid phase chemistry"
Chimica Oggi/Chemistry Today, 18, 14 (2000)
Reed, N.N., Janda, K.D., "A one step synthesis of monoprotected polyethylene glycol ethers"
J. Org. Chem., 65, 5843 (2000)
Hasserodt, J., Janda, K.D., Lerner, R.A., "A class of 4-aza-lithocholic acid-derived haptens for the generation of catalytic antibodies with steroid synthase capabilities"
Bioorg. Med. Chem., 8, 995 (2000)
Harwig, C.W., Hoffman, T.Z., Wentworth, A.D., Janda, K.D., "A one-pot multistep approach to alpha-azido-phospohonate and phosphonothioate diesters: Key intermediates in the synthesis of haptens for the generation of antibody ligases"
Bioorg. Med. Chem. Lett., 10, 915 (2000)
Vaino, A.R., Goodin, D.B., Janda, K.D., "Investigating resins for solid phase organic synthesis: The relationship between swelling and microenvironment as probed by EPR and fluorescence spectroscopy"
J. Comb. Chem., 2, 330 (2000)
Janda, K.D., "New Directions in Immunopharmacotherapy""
In: The Role of Natural Products in Drug Discovery (Ernest Schering Research Foundation Workshop S32) eds., J. Mulzer, R. Bohlmann, Springer-Verlag, Berlin, Heidelberg, New York, (2000)
Vaino, A.R., Janda, K.D., "Euclidean shape-encoded combinatorial chemical libraries"
Proc. Natl. Acad. Sci. USA, 97, 7692 (2000)
Toy, P.H., Reger, T.S., Janda, K.D., "Soluble polymer bound cleavage reagents: A multipolymer strategy for the cleavage of tertiary amines from REM resin"
Org. Lett., 2, 2205 (2000)
Brummer, O., Clapham, B., Janda, K.D., "Recent developments and applications of polymer-supported reagents in synthetic organic chemistry"
Current Opinion in Drug Discovery & Dev., 3, 462 (2000)
Toy, P.H., Janda, K.D., "Soluble polymer-supported organic synthesis"
Acc. Chem. Res., 33, 546 (2000)
Reger, T.S., Janda, K.D., "Polymer-supported (Salen)Mn catalysts for asymmetric epoxidation: A comparison between soluble and insoluble matrices"
J. Am. Chem. Soc., 122, 6929 (2000)
Carrera, M.R.A., Ashley, J.A., Zhou, B., Wirsching, P., Koob, G.F., Janda, K.D., "Cocaine vaccines: Antibody protection against relapse in a rat model"
Proc. Natl. Acad. Sci. USA, 97, 6202 (2000)
Lopez-Pelegrin, J.A., Janda, K.D., "Solution- and soluble-polymer supported asymmetric syntheses of six-membered ring prostanoids"
Chem. Eur. J., 6, 1917 (2000)
Reed, N.N., Janda, K.D., "Stealth star polymers: A new high-loading scaffold for liquid-phase organic synthesis"
Org. Lett., 2, 1311 (2000)
Toker, J.D., Wentworth, P. Jr., Hu, Y., Houk, K.N., Janda, K.D., "Antibody catalysis of a bimolecular asymmetric 1,3-Dipolar cycloaddition reaction"
J. Am. Chem. Soc., 122, 3244 (2000)
Wentworth, A.D., Wentworth, P. Jr., Mansoor, F.U., Janda, K.D., "A soluble polymer-supported triflating reagent: A high-throughput synthetic approach to aryl and enol triflates"
Org. Lett., 2, 477 (2000)
Hasserodt, J., Janda, K.D., Lerner, R.A., "Antibodies mimic natural oxidosqualene-cyclase action in steroid ring A formation"
J. Am. Chem. Soc., 122, 40 (2000)
Sieber, F., Wentworth, P. Jr., Janda, K.D., "Exploring the scope of poly(ethylene glycol) (PEG) as a soluble matrix for the Stille cross-coupling reaction"
J. Comb. Chem., 1, 540 (1999)
Datta, A., Wentworth, P. Jr., Shaw, J.P., Simeonov, A., Janda, K.D., "Catalytically distinct antibodies prepared by the reactive immunization versus transition state analogue hapten manifolds"
J. Am. Chem. Soc., 121, 10461 (1999)
Lee, K.J., Angulo, A., Ghazal, P., Janda, K.D., "Soluble-polymer supported synthesis of a prostanoid library: Identification of antiviral activity"
Org. Lett., 1, 1859 (1999)
Wentworth, P. Jr., Janda, K.D., "Liquid-phase chemistry: Recent advances in soluble polymer-supported catalysts, reagents and synthesis"
Chem. Commun., 1917 (1999)
Cordova, A., Reed, N.N., Ashley, J.A., Janda, K.D., "Convenient synthesis of L-proline benzyl ester"
Bioorg. Med. Chem. Lett., 9, 3119 (1999)
Brummer, O., Wentworth, P. Jr., Weiner, D.P., Janda, K.D., "Phosphorodithioates: Synthesis and evaluation of new haptens for the generation of antibody acyl transferases"
Tetrahedron Letters, 40, 7307 (1999)
Brummer, O., Gao, C., Mao, S., Weiner, D.P., Janda, K.D., "Design, synthesis and characterization of panning agents for the selection of metalloantibodies"
Letters in Peptide Science, 6, 295 (1999)
Gao, C., Brummer, O., Mao, S., Janda, K.D., "Selection of human metalloantibodies from a combinatorial phage single-chain antibody library"
J. Am. Chem. Soc., 121, 6517 (1999)
Garibay, P., Toy, P.H., Hoeg-Jensen, T., Janda, K.D., "Application of a new solid-phase resin: Benzamide ortho-lithiation and the synthesis of a phthalide library"
Synlett, 9, 1438 (1999)
Toy, P.H., Janda, K.D., "New supports for solid-phase organic synthesis: Development of polystyrene resins containing tetrahydrofuran derived cross-linkers"
Tetrahedron Letters, 40, 6329 (1999)
Janda, K.D., Wentworth, A.D., "A merging of chemistry and biology in terms of antibody catalysis"
Phosphorus, Sulfur and Silicon, 144-146, 117 (1999)
Wentworth, P., Janda, K.D., "Antibody catalysis of phosphodiester hydrolysis: A survey of hapten strategies"
Phosphorus, Sulfur and Silicon, 144-146, 247 (1999)
Mao, S., Gao, C., Lo, C.-H.L., Wirsching, P., Wong, C.-H., Janda, K.D., "Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewis-x and Lewis-x"
Proc. Natl. Acad. Sci. USA, 96, 6953 (1999)
Sieber, F., Wentworth, P. Jr., Toker, J.D., Wentworth, A.D., Metz, W.A., Reed, N.N., Janda, K.D., "Development and application of a poly(ethylene glycol)-supported triarylphosphine reagent: Expanding the sphere of liquid-phase organic synthesis"
J. Org. Chem., 64, 5188 (1999)
Taylor, M.J., Yli-Kauhaluoma, J.T., Ashley, J.A., Wirsching, P., Lerner, R.A., Janda, K.D., "The alpha-ketoamide group: A new motif for the elicitation of catalytic antibodies for acyl-transfer reactions"
J. Chem. Soc., Perkin Trans., 1, 1133 (1999)
Gao, C., Mao, S., Lo, C.-H.L., Wirsching, P., Lerner, R.A., Janda, K.D., "Making artificial antibodies: A format for phage display of combinatorial heterodimeric arrays"
Proc. Natl. Acad. Sci. USA, 96, 6025 (1999)
Ashley, J.A., Lin, C.-H., Wirsching, P., Janda, K.D., "Monitoring chemical warfare agents: A new method for the detection of methylphosphonic acid"
Angew. Chem. Int. Ed., 38, 1793 (1999)
Brummer, O., La Clair, J.J., Janda, K.D., "A colorimetric ligand for mercuric ion"
Org. Lett., 1, 415 (1999)
Paschall, C.M., Hasserodt, J., Jones, T., Lerner, R.A., Janda, K.D., Christianson, D.W., "Convergence of catalytic antibody and terpene cyclase mechanisms: Polyene cyclization directed by carbocation-pi interactions"
Angew. Chem. Int. Ed., 38, 1743 (1999)
Spivak, D.A., Hoffman, T.Z., Moore, A.H., Taylor, M.J., Janda, K.D., "A comparison of flexible and constrained haptens in eliciting antibody catalysts for paraoxon hydrolysis"
Bioorg. Med. Chem., 7, 1145 (1999)
Han, H., Cho, C.-W., Janda, K.D., "A substrate-based methodology that allows the regioselective control of the catalytic aminohydroxylation reaction"
Chem. Eur. J., 5, 1565 (1999)
Wentworth, P. Jr., Janda, K.D., "Catalytic Antibodies"
In: Comprehensive Asymmetric Catalysis, eds., E.N. Jacobsen, A. Pfaltz, H. Yamamoto, Springer-Verlag, N.Y., Vol. III, p. 1403 (1999)
Han, H., Yoon, J., Janda, K.D., "Azatides as Peptidomimetics / Solution and Liquid Phase Syntheses"
In: Peptidomimetics Protocols, (Methods in Molecular Medicine series), ed. W.M. Kazmierski, Humana Press, Totowa, N.J., Vol. 23, p. 87 (1999)
Yoon, J., Han, H., Janda, K.D., "Solution and Soluble Polymer Syntheses of Azatides and Azapeptides"
In: Advances in Amino Acid Mimetics and Peptidomimetics, ed., A. Abell , JAI Press, Inc., Stamford, CT., Vol. 2, p. 247 (1999)
Harwig, C.W., Gravert, D.J., Janda, K.D., "Soluble polymers: New options in both traditional and combinatorial synthesis"
Org. Chem. Chemtracts, 12, 1 (1999)
Berg, T., Simeonov, A., Janda, K.D., "A combined parallel synthesis and screening of macrocyclic lanthanide complexes for the cleavage of phospho di- and triesters and double-stranded DNA"
J. Comb. Chem., 1, 96 (1999)
Zhao, X.-Y., Janda, K.D., "Soluble polymer traceless linker investigations: Solvent effects on the desulfonylation of polyethylene glycol (PEG) substituted aryl alkyl sulfones with sodium amalgam"
Bioorg. Med. Chem. Lett., 8, 2439 (1998)
Yoon, J., Cho, C.-W., Han, H., Janda, K.D., "Solution and soluble polymer synthesis of 3-aminoimidazoline-2,4-diones"
Chem. Commun., 2703 (1998)
Taylor, M.J., Hoffman, T.Z., Yli-Kauhaluoma, J.T., Lerner, R.A., Janda, K.D., "A light-activated antibody catalyst"
J. Am. Chem. Soc., 120, 12783 (1998)
Zhao, X.-Y., Metz, W.A., Sieber, F., Janda, K.D., "Expanding on the purification methodology of polyethylene glycol (PEG) bound molecules: The synthesis of 3,5-Pyrazolidinediones"
Tetrahedron Letters, 39, 8433 (1998)
Hori, M., Gravert, D.J., Wentworth, P. Jr., Janda, K.D., "Investigating highly crosslinked macroporous resins for solid phase synthesis"
Bioorg. Med. Chem. Lett., 8, 2363 (1998)
Gravert, D.J., Datta, A., Wentworth, P. Jr., Janda, K.D., "Soluble supports tailored for organic synthesis: Parallel polymer synthesis via sequential normal/living free radical processes"
J. Am. Chem. Soc., 120, 9481 (1998)
Wentworth, P. Jr., Liu, Y., Wentworth, A.D., Fan, P., Foley, M.J., Janda, K.D., "A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis"
Proc. Natl. Acad. Sci. USA, 95, 5971 (1998)
Lin, C.-H., Hoffman, T.Z., Xie, Y., Wirsching, P., Janda, K.D., "An antibody transesterase derived from reactive immunization that utilizes a wide variety of alcohol substrates"
Chem. Commun., 1075 (1998)
Lerner, R.A., Barbas III, C.F., Janda, K.D., "Making Enzymes, The Harvey Lectures"
Series 92, Wiley-Liss, Inc., p. 1 (1998)
Chen, S., Janda, K.D., "Total synthesis of naturally occurring prostaglandin F2-alpha on a non-cross-linked polystyrene support"
Tetrahedron Letters, 39, 3943 (1998)
Berg, T., Vandersteen, A.M., Janda, K.D., "High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal complexes"
Bioorg. Med. Chem. Lett., 8, 1221 (1998)
Yli-Kauhaluoma, J.T., Harwig, C.W., Wentworth, P. Jr., Janda, K.D., "Unexpected 1,3-oxazolidine formation in the attempted oxidation of N-aryl-N-methyl substituted Beta-amino alcohols using pyridinium dichromate"
Tetrahedron Letters, 39, 2269 (1998)
Gao, C., Lavey, B.J., Lo, C.-H.L., Datta, A., Wentworth, P. Jr., Janda, K.D., "Direct selection for catalysis from combinatorial antibody libraries using a boronic acid probe: Primary amide bond hydrolysis"
J. Am. Chem. Soc., 120, 2211 (1998)
Han, H., Yoon, J., Janda, K.D., "An efficient asymmetric route to 2,3-diaminobutanoic acids"
J. Org. Chem., 63, 2045 (1998)
Gravert, D.J., Janda, K.D., "Bifunctional initiators for free radical polymerization of non-crosslinked block copolymers"
Tetrahedron Letters, 39, 1513 (1998)
Heine, A., Stura, E.A., Yli-Kauhaluoma, J.T., Gao, C. Deng, Q., Beno, B.R., Houk, K.N., Janda, K.D., Wilson, I.A., "An antibody exo-Diels-Alderase inhibitor complex at 1.95 Angstrom resolution"
Science, 279, 1934 (1998)
Hori, M., Janda, K.D., "A soluble polymer approach to the "Fishing Out" principle: Synthesis and purification of Beta-Amino alcohols"
J. Org. Chem., 63, 889 (1998)
Wentworth, P. Jr., Janda, K.D., "Catalytic antibodies"
Current Opinion in Chemical Biology, 2, 138 (1998)
Han, H., Yoon, J., Janda, K.D., "Investigations of azapeptides as mimetics of leu-enkephalin"
Bioorg. Med. Chem. Lett, 8, 117 (1998)
Wentworth, P. Jr., Janda, K.D., "Generating and analyzing combinatorial chemistry libraries"
Current Opinion in Biotechnology, 9, 109 (1998)
Gravert, D.J., Janda, K.D., "Synthesis on soluble polymers: New reactions and the construction of small molecules"
Current Opinion in Chemical Biology, 1, 107 (1997)
Han, H., Vandersteen, A., Janda, K.D., "Combinatorics, Peptide Mimetics and Combizymes"
In: Peptides: Frontiers of Peptide Science (Proceedings of the 15th American Peptide Symposium) eds., J.P. Tam , T. Pravin, P. Kaumaya, Kluwer/Escom, Nashville, TN., p.22 (1997)
Janda, K.D., Gravert, D.J., "Organic reactions on soluble polymer supports as an alternative methodology for combinatorial solid-phase synthesis"
Biotechnology Internl., 169 (1997)
Gravert, D.J., Janda, K.D., "Soluble polyethylene glycol supports for liquid-phase combinatorial synthesis"
Drugs of the Future, 22, 1147 (1997)
Lin, C.-H., Hoffman, T.Z., Wirsching, P., Barbas III, C.F., Janda, K.D., Lerner, R.A., "On roads not taken in the evolution of protein catalysts: Antibody steroid isomerases that use an enamine mechanism"
Proc. Natl. Acad. Sci. USA, 94, 11773 (1997)
Gao, C., Lin, C.-H., Lo, C.-H.L., Mao, S., Wirsching, P., Lerner, R.A., Janda, K.D., "Making chemistry selectable by linking it to infectivity"
Proc. Natl. Acad. Sci. USA, 94, 11777 (1997)
Lo, C.-H.L., Wentworth, P. Jr., Jung, K.W., Yoon, J., Ashley, J.A., Janda, K.D., "Reactive immunization strategy generates antibodies with high catalytic proficiencies"
J. Am. Chem. Soc., 119, 10251 (1997)
Chen, S., Janda, K.D., "Synthesis of prostaglandin E2 methyl ester on a soluble-polymer support for the construction of prostanoid libraries"
J. Am. Chem. Soc., 119, 8724 (1997)
Hasserodt, J., Janda, K.D., Lerner, R.A., "Formation of bridge-methylated decalins by antibody-catalyzed tandem cationic cyclization"
J. Am. Chem. Soc., 119, 5993 (1997)
Hasserodt, J., Janda, K.D., "Syntheses of octahydroquinoline-N-oxides: Haptens designed to elicit catalytic antibodies that control a terpenoid-like cascade cyclization"
Tetrahedron, 53, 11237 (1997)
Han, H., Janda, K.D., "Multipolymer-supported substrate and ligand approach to the Sharpless asymmetric dihydroxylation,"
Angew. Chem. Int. Ed., 36, 1731 (1997)
Zhao, X.-Y., Janda, K.D., "Syntheses of alkylated malonates on a traceless linker derived soluble polymer support"
Tetrahedron Letters, 38, 5437 (1997)
Wentworth, P. Jr., Janda, K.D., "Synthesis of oxorhenium (V) and oxotechnetium (V) complexes as inhibitors of ribonucleases and for the generation of catalytic antibodies"
Synlett, 5, 537 (1997)
Gravert, D.J., Janda, K.D., "Organic synthesis on soluble polymer supports: Liquid-phase methodologies"
Chemical Reviews, 97, 489 (1997)
Jung, K.W., Zhao, X.-Y., Janda, K.D., "Development of new linkers for the formation of aliphatic C-H bonds on polymeric supports"
Tetrahedron, 53, 6645 (1997)
Weiner, D.P., Wiemann, T., Wolfe, M.M., Wentworth, P. Jr., Janda, K.D., "A pentacoordinate oxorhenium (V) metallochelate elicits antibody catalysts for phosphodiester cleavage"
J. Am. Chem. Soc., 119, 4088 (1997)
Wentworth, P. Jr., Vandersteen, A.M., Janda, K.D., "Poly(ethylene glycol) (PEG) as a reagent support: The preparation and utility of PEG-triarylphosphine conjugate in liquid-phase organic synthesis (LPOS)"
Chem. Commun., 759 (1997)
Janda, K.D., A Book Review on, "Combinatorial Peptide and Nonpeptide Libraries : A Handbook by G. Jung, pub: VCH (1996)"
J. Amer. Chem. Soc., 119, 3848 (1997)
Han, H., Janda, K.D., "A soluble polymer-bound approach to the Sharpless catalytic asymmetric dihydroxylation (AD) reaction: Preparation and application of a [(DHQD)2 PHAL-PEG-OMe] ligand"
Tetrahedron Letters, 38, 1527 (1997)
Li, T., Lerner, R.A., Janda, K.D., "Antibody-catalyzed cationic reactions: The rerouting of chemical transformations via antibody catalysis"
Acc. Chem. Res., 30, 115 (1997)
Zhao, X.-Y., Jung, K.W., Janda, K.D., "Soluble polymer synthesis: An improved traceless linker methodology for aliphatic C-H bond formation"
Tetrahedron Letters, 38, 977 (1997)
Janda, K.D., Lo, L.-C., Lo, C.-H.L., Sim, M.-M., Wang, R., Wong, C.-H., Lerner, R.A., "Chemical selection for catalysis in combinatorial antibody libraries"
Science, 275, 945 (1997)
Gravert, D.J., Janda, K.D., "Organic Reactions on Soluble Polymer Supports as an Alternative Methodology for Combinatorial Solid-Phase Synthesis"
In: Biotechnology International , eds., T.H. Connor, and R.J. Hairi, (1997)
Wentworth, P. Jr., Wiemann, T., Janda, K.D., "A new class of pentacoordinate ribonuclease inhibitors: Synthesis, characterization and inhibition studies of ribonucleoside and anhydropentofuranose oxorhenium (V) complexes"
J. Am. Chem. Soc., 118, 12521 (1996)
Hasserodt, J., Janda, K.D., Lerner, R.A., "Antibody catalyzed terpenoid cyclization"
J. Am. Chem. Soc., 118, 11654 (1996)
Lo, C.-H.L., Gao, C., Mao, S., Matsui, K., Janda, K.D., "Chain shuffling: Investigations into the specificity and selectivity of antibody catalysis"
Israel Journal of Chemistry, 36, 195 (1996)
Vandersteen, A.M., Han, H., Janda, K.D., "Liquid phase combinatorial synthesis: In search of small-molecule enzyme mimics"
Molecular Diversity, 2, 89 (1996)
Vandersteen, A.M., Janda, K. D., "A re-examination of two linear pentapeptides claimed to be serine protease mimics"
J. Am. Chem. Soc., 118, 8787 (1996)
Lavey, B.J., Janda, K.D., "Catalytic antibody mediated hydrolysis of paraoxon"
J. Org. Chem., 61, 7633 (1996)
Wentworth, P. Jr., Janda, K.D., "A facile and efficient route to 3',5'-diamino-3',5'-dideoxynucleosides"
Chem. Commun., 2097 (1996)
Sakurai, M., Wirsching, P., Janda, K.D., "Design and synthesis of a cocaine-diamide hapten for vaccine development"
Tetrahedron Letters, 37, 5479 (1996)
Janda, K.D., Shevlin, C.G., Lo, C.-H.L., "Catalytic Antibodies: Chemical and Biological Approaches"
In: Comprehensive Supramolecular Chemistry, eds., J.M. Lehn, J.C. Atwood, J.E.D. Davies, D.D. MacNicol, F. Vogtle, Pergamon, UK, USA, Vol. 4, p. 43 (1996)
Han, H., Yoon, J., Janda, K.D., "Azatides: Solution and Liquid phase Syntheses"
In: Peptidomimetics, Methods in Molecular Biology series, Humana Press, Inc., eds. W.M. Kazmierski, (1996)
Jung, K.W., Sanfilippo, P.J., Wachter, M., Janda, K.D., "Syntheses and biological evaluation of two new naproxen analogs"
Bioorg. Med. Chem. Lett., 6, 2281 (1996)
Lo, L.-C., Lo, C.-H.L., Kassel, D.B., Raushel, F.M., Janda, K.D., "A versatile mechanism based reaction probe for the direct selection of biocatalysis"
Bioorg. & Med. Chem. Lett., 6, 2117 (1996)
Jung, K.W., Zhao, X.-Y., Janda, K.D., "A linker that allows efficient formation of aliphatic C-H bonds on polymeric supports"
Tetrahedron Letters, 37, 6491 (1996)
Yli-Kauhaluoma, J.T., Janda, K.D., "Catalytic antibodies: The rerouting of chemical reactions towards electrophilic aromatic substitution by carbon dioxide"
N.Y. Academy of Sciences, 799, 26 (1996)
Lavey, B.J., Janda, K.D., "Antibody catalyzed hydrolysis of a phosphotriester"
Bioorg. Med. Chem. Lett., 6, 1523 (1996)
Han, H., Janda, K.D., "Soluble polymer-bound ligand-accelerated catalysis: Asymmetric dihydroxylation"
J. Am. Chem. Soc., 118, 7632 (1996)
Janda, K.D., Han, H., "Combinatorial Chemistry: A Liquid-Phase Approach"
In: Methods in Enzymology, eds., J.N. Abelson, Academic Press, San Diego/London, Vol. 267, p. 234 (1996)
Gravert, D.J., Janda, K.D., "Liquid-Phase Combinatorial Synthesis"
In: Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery, eds., I.M. Chaiken and K.D. Janda, A.C.S. Conference Proceedings, Chapter 11, p. 118 (1996)
Yli-Kauhaluoma, J.T., Ashley, J.A., Lo, C.-H.L., Coakley, J., Wirsching, P., Janda, K.D., "Catalytic antibodies with peptidyl-prolyl cis-trans isomerase activity"
J. Am. Chem. Soc., 118, 5496 (1996)
Sakurai, M., Wirsching, P., Janda, K.D., "Synthesis of a nucleoside hapten with a [P(O)-O-N] linkage to elicit catalytic antibodies with phosphodiesterase activity"
Bioorg. Med. Chem. Lett., 6, 1055 (1996)
Gravert, D.J., Janda, K.D., "Developing small molecule libraries for drug discovery"
Trends in Biotechnology (TIBTECH), 14, 110 (1996)
Han, H., Janda, K.D., "Azatides: Solution and liquid phase syntheses of a new peptidomimetic"
J. Am. Chem. Soc., 118, 2539 (1996)
Li, T., Janda, K.D., Lerner, R.A., "Cationic cyclopropanation by antibody catalysis"
Nature, 379, 326 (1996)
Carrera, M.R.A., Ashley, J.A., Parsons, L.H., Wirsching, P., Koob, G.F., Janda, K.D., "Suppression of psychoactive effects of cocaine by active immunization"
Nature, 378, 727 (1995)
Wirsching, P., Ashley, J.A., Lo, C.-H.L., Janda, K.D., Lerner, R.A., "Reactive immunization"
Science, 270, 1775 (1995)
Lerner, R.A., Janda, K.D., "Catalytic Antibodies: Evolution of Protein Function in Real Time"
In: Interface Between Chemistry and Biology eds., P. Jolles and H. Jornvall, Verlag, Berlin, p.121 (1995)
Rosenblum, J.S., Lo, L.-C., Li, T., Janda, K.D., Lerner, R.A., "Antibody catalyzed phosphate triester hydrolysis"
Angew. Chem. Int. Ed. Engl., 34, 2275 (1995)
Li, T., Janda, K.D., "Synthesis of a bifunctional hapten designed to mimic both transition state and to induce "bait and switch" catalysis"
Bio. Med. Chem. Lett., 5, 2001 (1995)
Lavey, B.J., Janda, K.D., "Applying Antibody Catalysis to Organic Synthesis"
In: Antibody Expression and Engineering, ACS Symposium Series 604, eds., H.Y. Wang, T. Imanaka, Chapter 10, p.123 (1995)
Yli-Kauhaluoma, J.T., Ashley, J.A., Lo, C.-H., Tucker, L., Wolfe, M.M., Janda, K.D., "Anti-metallocene antibodies: A new approach to enantioselective catalysis of the Diels-Alder reaction"
J. Am. Chem. Soc., 117, 7041 (1995)
Han, H., Wolfe, M.M., Brenner, S., Janda, K.D., "Liquid-phase combinatorial synthesis"
Proc. Natl. Acad. Sci. USA, 92, 6419 (1995)
Janda, K.D., "Drug discovery and delivery: Exploiting biological diversity, libraries and mutations for research and drug development"
Molecular Medicine Today, 1, 4 (1995)
Li, T., Hilton, S., Janda, K.D., "Remarkable ability of different antibody catalysts to control and diversify the product outcome of cationic cyclization reactions"
J. Am. Chem. Soc., 117, 3308 (1995)
Janda, K.D., Shevlin, C.G., Lerner, R.A., "Oxepane synthesis along a disfavored pathway: The rerouting of a chemical reaction using a catalytic antibody"
J. Am. Chem. Soc., 117, 2659 (1995)
Li, T., Janda, K.D., Hilton, S., Lerner, R.A., "An antibody-catalyzed nucelophilic substitution reaction at a primary carbon that appears to proceed by an ionization mechanism"
J. Am. Chem. Soc., 117, 2367 (1995)
Fenniri, H., Janda, K.D., Lerner, R.A., "Encoded reaction cassette for the highly sensitive detection of the making and breaking of chemical bonds"
Proc. Natl. Acad. Sci. USA, 92, 2278 (1995)
Li, T., Hilton, S., Janda, K.D., "The potential application of catalytic antibodies to protecting group removal: Catalytic antibodies with broad substrate tolerance"
J. Am. Chem. Soc., 117, 2123 (1995)
Janda, K.D., "Tagged versus untagged libraries: Methods for the generation and screening of combinatorial libraries"
Proc. Natl. Acad. Sci. USA, 91, 10779 (1994)
Erb, E., Janda, K.D., Brenner, S., "Recursive deconvolution of combinatorial chemical libraries"
Proc. Natl. Acad. Sci. USA, 91, 11422 (1994)
Janda, K.D., "Catalytic antibodies and enzyme inhibitors"
Pure & Appl. Chem., 66, 703 (1994)
Cravatt, B.F., Ashley, J.A., Janda, K.D., Boger, D.L., Lerner, R.A., "Crossing extreme mechanistic barriers by antibody catalysis: Syn elimination to a cis olefin"
J. Am. Chem. Soc., 116, 6013 (1994)
Yli-Kauhaluoma, J., Janda, K.D., "An expedient synthesis of isopropyl anisoles and veratroles"
Tetrahedron Letters, 35, 4509 (1994)
Li, T., Janda, K.D., Ashley, J.A., Lerner, R.A., "Antibody catalyzed cationic cyclization"
Science, 264, 1289 (1994)
Yli-Kauhaluoma, J., Janda, K.D., "Twisted alpha-keto amides as transition-state analogues for acyl-transfer reactions: Synthesis of the immunoconjugates"
Bioorg. Med. Chem., 2, 521 (1994)
Nielsen, J., Janda, K.D., "Toward chemical implementation of encoded combinatorial libraries"
Methods, 6, 361 (1994)
Janda, K.D., Lo, C.-H.L., Li, T., Barbas III, C.F., Wirsching, P., Lerner, R.A., "Direct selection for a catalytic mechanism from combinatorial antibody libraries"
Proc. Natl. Acad. Sci. USA, 91, 2532 (1994)
Shevlin, C.G., Hilton, S., Janda, K.D., "Automation of antibody catalysis: A practical methodology for the use of catalytic antibodies in organic synthesis"
Bioorg. Med. Chem. Lett., 4, 297 (1994)
Janda, K.D., Chen, Y.-C.J., "Chemical and Biological Approaches to Catalytic Antibodies"
In: Handbook of Experimental Pharmacology : The Pharmacology of Monoclonal Antibodies, eds. M. Rosenberg and G. Moore, Vol. 113, pp. 209-241 (1994)
Gouverneur, V.E., Houk, K.N., de Pascual-Teresa, B., Beno, B., Janda, K.D., Lerner, R.A., "Control of the exo and endo pathways of the Diels-Alder reaction by antibody catalysis"
Science, 262, 204 (1993)
Janda, K.D., "Catalytic antibodies: The rerouting of chemical reactions"
Biochem. Soc. Trans., 21, 1090 (1993)
Nielsen, J., Brenner, S., Janda, K.D., "Synthetic methods for the implementation of encoded combinatorial chemistry"
J. Am. Chem. Soc., 115, 9812 (1993)
Na, J., Houk, K.N., Shevlin, C.G., Janda, K.D., Lerner, R.A., "The energetic advantage of 5-exo versus 6-endo epoxide openings: A preference overwhelmed by antibody catalysis"
J. Am. Chem. Soc., 115, 8453 (1993)
Wade, W.S., Ashley, J.A., Jahangiri, G.K., McElhaney, G., Janda, K.D., Lerner, R.A., "A highly specific metal-activated catalytic antibody"
J. Am. Chem. Soc., 115, 4906 (1993)
Ashley, J.A., Lo, C.-H.L., McElhaney, G., Wirsching, P., Janda, K.D., "A catalytic antibody model for PLP-dependent decarboxylases"
J. Am. Chem. Soc, 115, 2515 (1993)
Janda, K.D., Book Review on, "Studies in Organic Chemistry 46. Biocatalysts in Organic Synthesis by J. Halgas, pub: Elsevier (1992)"
J. Am. Chem. Soc., 115, 8888 (1993)
Ikeda, S., Janda, K.D., " Recent development on the research of catalytic antibodies and their applications"
J. Synth. Org. Chem., (Japan), 51, 284 (1993)
Chen, Y.-C.J., Danon, T., Sastry, L., Mubaraki, M., Janda, K.D., Lerner, R.A., "Catalytic antibodies from combinatorial libraries"
J. Am. Chem. Soc., 115, 357 (1993)
Janda, K.D., Shevlin, C.G., Lerner, R.A., "Antibody catalysis of a disfavored chemical transformation"
Science, 259, 490 (1993)
Weinhouse, M.I., Janda, K.D., "A new methodology for the preparation of vinyl esters"
Synthesis, 1, 81 (1993)
Gibbs, R.A., Benkovic, P.A., Janda, K.D., Lerner, R.A., Benkovic, S.J., "Substituent effects on an antibody-catalyzed hydrolysis of phenyl esters; further evidence for an acyl intermediate"
J. Am. Chem. Soc., 114, 3528 (1992)
Fernholz, E., Schloeder, D., Liu, K.-K.C., Bradshaw, C.W., Huang, H., Janda, K.D., Lerner, R.A., Wong, C.-H., "Specificity of antibody-catalyzed transesterifications using enol esters: A comparison with lipase reactions"
J. Org. Chem., 57, 4756 (1992)
Ashley, J.A., Janda, K.D., "Antibody catalysis in low water content media"
J. Org. Chem., 57, 6691 (1992)
Ikeda, S., Ashley, J.A., Wirsching, P., Janda, K.D., "Psi [PO2-CH2N+] A new amide bond replacement: Potent, slow-binding inhibition of the HIV-Protease"
J. Am. Chem. Soc., 114, 7604 (1992)
Reymond, J.-L., Janda, K.D., Lerner, R.A., "Highly enantioselective protonation catalyzed by an antibody"
J. Am. Chem. Soc., 114, 2257 (1992)
Chen, Y.-C.J., Janda, K.D., "A new approach toward the inhibition of ribonucleases: A water stable ribonucleoside-technetium chelate"
J. Am. Chem. Soc., 114, 1488 (1992)
Sastry, L., Mubaraki, M., Janda, K.D., Benkovic, S.J., Lerner, R.A., "Screening combinatorial antibody libraries for catalytic acyl transfer reactions"
Ciba Foundation Symposium, 159, 145 (1991)
Benkovic, S.J., Adams, J., Janda, K.D., Lerner, R.A., "A catalytic antibody uses a multistep kinetic sequence"
Ciba Foundation Symposium, 159, 9 (1991)
McLeod, D.A., Brinkworth, R.I., Ashley, J.A., Janda, K.D., Wirsching, P., "Phosphonamidates and phosphonamidate esters as HIV-1 protease inhibitors"
Bioorg. Med. Chem. Lett., 1, 653 (1991)
Hein, M.B., Tang, Y., McLeod, D.A., Janda, K.D., Hiatt, A., "Evaluation of immunoglobulins from plant cells"
Biotechnol. Prog., 7, 455 (1991)
Reymond, J.-L., Janda, K.D., Lerner, R.A., "Antibody catalysis of glycosidic bond hydrolysis"
Angew. Chem. Int. Ed. Engl., 30, 1711 (1991)
Harada, A., Janda, K.D., Lerner, R.A., "Abzymes to enzymes"
Kagaku to Kogyo (Japan), 44, 1108 (1991)
Fujii, I., Lerner, R.A., Janda, K.D., "Enantiofacial protonation by catalytic antibodies"
J. Am. Chem. Soc., 113, 8528 (1991)
Ikeda, S., Weinhouse, M.I., Janda, K.D., Lerner, R.A., Danishefsky, S.J., "Asymmetric induction via a catalytic antibody"
J. Am. Chem. Soc., 113, 7763 (1991)
Janda, K.D., Weinhouse, M.I., Danon, T., Pacelli, K.A., Schloeder, D.M., "Antibody bait and switch catalysis: A survey of antigens capable of inducing abzymes with acyl-transfer properties"
J. Am. Chem. Soc., 113, 5427 (1991)
Kang, A.S., Barbas, C.F., Janda, K.D., Benkovic, S.J., Lerner, R.A., "Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces"
Proc. Natl. Acad. Sci. USA, 88, 4363 (1991)
Chen, Y.-C.J., Hansske, F., Janda, K.D., Robbins, M.J., "Nucleic acid related compounds. 64. Synthesis of 2',3'-diazido-2',3'-dideoxyadenosine and 2',3'-diamino-2',3'-dideoxyadenosine from 9-(-Beta-D-Arabinofuranosyl) adenine"
J. Org. Chem., 56, 3410 (1991)
Wirsching, P., Ashley, J.A., Benkovic, S.J., Janda, K.D., Lerner, R.A., "An unexpectedly efficient catalytic antibody operating by ping-pong and induced fit mechanisms"
Science, 252, 680 (1991)
Janda, K., "Opportunities in organic synthesis for catalytic antibodies"
Proceedings of 15th ABC Symposium: Kyoto, Japan, 3, 63 (1991)
Janda, K.D., Benkovic, S.J., McLeod, D.A., Schloeder, D.M., Lerner, R.A., "Substrate attenuation: An approach to improve antibody catalysis"
Tetrahedron, 47, 2503 (1991)
Janda, K.D., Ashley, J.A., Jones, T.M., McLeod, D.A., Schloeder, D.M., Weinhouse, M.I., Lerner, R.A., Gibbs, R.A., Benkovic, P.A., Hilhorst, R., Benkovic, S.J., "Catalytic antibodies with acyl-transfer capabilities: Mechanistic and kinetic investigations"
J. Am. Chem. Soc., 113, 291 (1991)
Janda, K.D., Ashley, J.A., Jones, T.M., McLeod, D.A., Schloeder, D.M., Weinhouse, M.I., "Immobilized catalytic antibodies in aqueous and organic solvents"
J. Am. Chem. Soc., 112, 8886 (1990)
Benkovic, S.J., Adams, J.A., Borders, C.L. Jr., Janda, K.D., Lerner, R.A., "The enzymic nature of antibody catalysis: Development of multistep kinetic processing"
Science, 250, 1135 (1990)
Janda, K.D., "New strategies for the design of catalytic antibodies"
Biotechnol. Prog., 6, 178 (1990)
Janda, K.D., Ashley, J.A., "Syntheses of the saturated analogues of 4-nitrophenol and 4-nitroaniline"
Synth. Commun., 20, 1073 (1990)
Janda, K.D., Weinhouse, M.I., Schloeder, D.M., Lerner, R.A., "Bait and switch strategy for obtaining catalytic antibodies with acyl-transfer capabilities"
J. Am. Chem. Soc., 112, 1274 (1990)
Janda, K.D., Benkovic, S.J., Lerner, R.A., "Catalytic antibodies with lipase activity and R and S substrate selectivity"
Science, 244, 437 (1989)
Sastry, L., Alting-Mees, M., Huse, W.D., Short, J.M., Sorge, J.A., Hay, B.N., Janda, K.D., Benkovic, S.J., Lerner, R.A., "Cloning of the immunological repertoire in E. coli for generation of monoclonal catalytic antibodies: Construction of a heavy chain variable region-specific cDNA library"
Proc. Natl. Acad. Sci. USA, 86, 5728 (1989)
Janda, K.D., Schloeder, D., Benkovic, S.J., Lerner, R.A., "Induction of an antibody that catalyzes the hydrolysis of an amide bond"
Science, 241, 1188 (1988)
Janda, K.D., Lerner, R.A., Tramontano, A., "Antibody catalysis of bimolecular amide formation"
J. Am. Chem. Soc., 110, 4835 (1988)
Tramontano, A., Janda, K.D., Napper, A.D., Benkovic, S.J., Lerner, R.A., "Catalytic antibodies"
Cold Spring Harbor Symp., Quant. Biol., 52, 91 (1987)
Tramontano, A., Janda, K.D., Lerner, R.A., "Catalytic antibodies"
Science, 234, 1566 (1986)
Tramontano, A., Janda, K.D., Lerner, R.A., "Chemical reactivity at an antibody binding site elicited by mechanistic design of a synthetic antigen"
Proc. Natl. Acad. Sci. USA, 83, 6736 (1986)
Bates, R.B., Janda, K.D., Wright, M.E., "N-Isobutyrylbenzamide, C11H13NO2"
Acta. Cryst., C41, 263 (1985)
Bates, R.B., Janda, K.D., "A convenient synthesis of alpha-acyl amino alcohols from azlactones"
Synthesis, 4, 310 (1984)
Bates, R.B., Fletcher, F.A., Janda, K.D., Miller, W.A., "A convenient synthesis of unsymmetrical acyclic imides"
J. Org. Chem., 49, 3038 (1984)
Bates, R.B., Gin, S.L., Hassen, M.A., Hruby, V.J., Janda, K.D., Kriek, G.R., Michaud, J.-P., Vine, D.B., "Synthesis of Cyclo-N-Methyl-L-Tyr-N-Methyl-L-Tyr-D-Ala-L-Ala-O,N-Dimethyl-L-Tyr-L-Ala, a cyclic hexapeptide related to the anti-tumor agent deoxybouvardin"
Heterocycles, 22, 785 (1984)
Janda, K.D., McConnell, W.W., Nelson, G.O., Wright, M.E., "Preparation and reactivity of the new cyclopentadienyl-bridged complex (Me2SiCH2CH2SiMe2) (C5H4Fe(CO)2)2"
J. Organomet. Chem., 259, 139 (1983)
Bates, R.B., Janda, K.D., "High-yield benzyne synthesis of diaryl ethers"
J. Org. Chem., 47, 4374 (1982)