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Authors, Title
Journal, Volume, Pages, (Year)
558
Hwang, C.S., Smith, L.C., Wenthur, C.J., Ellis, B., Zhou, B., Janda, K.D., "Heroin vaccine: Using titer, affinity, and antinociception as metrics when examining sex and strain differences"
Vaccine, XX, xxx (2019)
557
Natori, Y., Hwang, C.S., Lin, L., Smith, L.C., Zhou, B., Janda, K.D., "A chemically contiguous hasten approach for a heroin-fentanyl vaccine"
Beilstein J. Org. Chem., 15, 1020 (2019)
556
Townsend, E.A., Blake, S., Faunce, K.E., Hwang, C.S., Natori, Y., Zhou, B., Bremer, P.T., Janda, K.D., Banks, M.L., "Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats"
Neuropsychopharmacoloy, doi.org/10.1038/s41386-019-0385-9, (2019)
555
Nguyen, J.D., Grant, Y., Creehan, K.M., Hwang, C.S., Vanderwater, S.A., Janda, K.D., Cole, M., Taffe, M.A., "∆9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions"
Neuropharmacology, 151, 127 (2019)
554
Wenthur, C.J., Gautam, R., Zhou, B., Vendruscolo, L.F., Leggio, L., Janda, K.D., "Ghrelin receptor influence on cocaine reward is not directly dependent on peripheral acyl-ghrelin"
Nature Scientific Reports, 9, 1841 (2019)
553
Banks, M.L., Olson, M.E., Janda, K.D., "Immunopharmacotherapies for treating opioid use disorder"
Trends Pharmacol. Sci., 39(11), 908 (2018)
552
Kallupi, M., Xue, S., Zhou, B., Janda, K.D., George, O., "An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse"
Sci. Adv., 4(10), 4751 (2018)
551
Olson, M.E., Eubanks, L.M., Janda, K.D., "Chemical interventions for the opioid crisis: Key advances and remaining challenges"
J. Am. Chem. Soc., 141, 1798 (2019)
550
Hwang, C.S., Ellis, B., Zhou, B., Janda, K.D., "Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin"
Bioorg. & Med. Chem., 27, 125 (2018)
549
Smith, L.C., Lin, L., Hwang, C.S., Zhou, B., Kubitz, D.M., Wang, H., Janda, K.D., "Lateral flow assessment and unanticipated toxicity of krater"
Chem. Res. Tox., 32, 113 (2019)
548
Shirey, R.J., Globisch, D., Eubanks, L.M., Hixon, M.S., Janda, K.D., "Noninvasive urine biomarker lateral flow immunoassay for monitoring active Onchocerciasis"
ACS Infect. Dis., 4, 1423 (2018)
547
Hwang, C.S., Smith, L.C., Natori, Y., Ellis, B., Zhou, B., Janda, K.D., "Improved admixture vaccine of fentanyl and heroin hapten immunoconjugates: Antinociceptive evaluation of fentanyl-contaminated heroin"
ACS Omega, 3, 11537 (2018)
546
Jacob, N.T., Miranda, P.O., Shirey, R.J., Gautam, R., Zhou, B., de Orbe Izquierdo, M.E., Hixon, M.S., Hart, J.R., Ueno, L., Vogt, P.K., Janda, K.D., "Synthetic molecules for disruption of the MYC protein-protein interface"
Bioorg. & Med. Chem., 26, 4234 (2018)
545
Nguyen, J.D., Hwang, C.S., Grant, Y., Janda, K.D., Taffe, M.A., "Prophylactic vaccination protects against the development of oxycodone self-administration"
Neuropharmacology, 138, 292 (2018)
544
Taraina, M.A., Xue, S., Smith, L.C., Muellers, S.N., Miranda, P.O., Janda, K.D., "Crystallography coupled with kinetic analysis provides mechanistic underpinnings of a nicotine-degrading enzyme"
Biochemistry, 57, 3741 (2018)
543
Hwang, C.S., Smith, L.C., Natori, Y., Ellis, B., Zhou, B., Janda, K.D., "Efficacious vaccine against heroin contaminated with fentanyl"
ACS Chem. Neurosci., 9(6), 1269 (2018)
542
Kimishima, A., Olson, M.E., Natori, Y., Janda, K.D., "Efficient syntheses of cocaine vaccines and their in vivo evaluation"
ACS Med. Chem. Lett., 9(5), 411 (2018)
541
Miranda, P.O., Cubitt, B., Jacob, N.T., Janda, K.D., Carlos de la Torre, J., "Mining a Kröhnke pyridine library for anti-arenavirus activity"
ACS Infec. Dis., 4(5), 815 (2018)
540
Hwang, C.S., Bremer, P.T., Wenthur, C.J., Ho, S.O., Chiang, S., Ellis, B., Zhou, B., Fujii, G., Janda, K.D., "Enhancing efficacy and stability of an antiheroin vaccine: Examination of antinociception, opioid binding profile, and lethality"
Mol. Pharmaceutics, 15(3), 1062 (2018)
539
Olson, M.E., Janda, K.D., "Vaccines to combat the opioid crisis"
EMBO reports, 19(1), 5 (2018)
538
Kimishima, A., Olson, M.E., Janda, K.D., "Investigations into the efficacy of multi-component cocaine vaccines"
Bioorg. Med. Chem. Lett., 28, 2779 (2018)
537
Xue, S., Kallupi, M., Zhou, B., Smith, L.C., Miranda, P.O., George, O., Janda, K.D., "An enzymatic advance in nicotine cessation therapy"
Chem. Commun., 54(14), 1686 (2018)
536
Xue, S., Seki, H., Remes, M., Silhar, P., Janda, K., "Examination of alpa-exosite inhibitors against Botulinum neurotoxin A protease through structure-activity relationship studies of chicory acid"
Bioorg. Med. Chem. Lett., 27, 4956 (2017)
535
Hwang, C.S., Janda, K.D., "A vision for vaccines: Combating the opioid epidemic"
Biochemistry, 56(42), 5625 (2017)
534
Wenthur, C.J., Zhou, B., Janda, K.D., "Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity"
Nature, 548, 476 (2017)
533
Wenthur, C.J., Cai, X., Ellis, B.A., Janda, K.D., "Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric happen design and combinatorial vaccination"
Bioorg. Med. Chem. Lett., 27(16), 3666 (2017)
532
Globisch, D., Eubanks, L.M., Shirey, R.J., Pfarr, K.M., Wanji, S., Debrah, A.Y., Hoerauf, A., Janda, K.D., "Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG)"
Bioorg. Med. Chem. Lett., 27(15), 3426 (2017)
531
Kimishima, A., Wenthur, C.J., Zhou, B., Janda, K.D., "An advance in prescription opioid vaccines: Overdose mortality reduction and extraordinary alteration of drug half-life"
ACS Chem. Biol., 12, 36 (2017)
530
Taraina, M.A., Janda, K.D., Allen, K.N., "Structural analysis provides mechanistic insight into nicotine oxidoreductase from Pseudomonas putida"
Biochemistry, 55, 6595 (2016)
529
Jacob, N.T., Anraku, K., Kimishima, A., Zhou, B., Collins, K.C., Lockner, J.W., Ellis, B.A., Janda, K.D., "A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior"
Chem. Commun., 53(58), 8156 (2017)
528
Bremer, P.T., Janda, K.D., "Conjugate vaccine immunotherapy for substance use disorder"
Pharmacological Review, 69(3), 298 (2017)
527
Bremer, P.T., Schlosburg, J.E., Banks, M.L., Steele, F.F., Zhou, B., Polkis, J.L., Janda, K.D., "Development of a clinically viable heroin vaccine"
J. Am. Chem. Soc., 139(25), 8601 (2017)
526
Bremer, P.T., Pellett, S., Carolan, J.P., Tepp, W.H., Eubanks, L.M., Allen, K.N., Johnson, E.A., Janda, K.D., "Metal ions ablate the action of Botulinum Neurotoxin A"
J. Am. Chem. Soc., 139(21), 7264 (2017)
525
Nguyen, J.D., Bremer, P.T., Hwang, C.S., Vanderwater, S.A., Collins, K.C., Creehan, K.M., Janda, K.D., Taffe, M.A., "Effective active vaccination against methamphetamine in female rats"
Drug & Alcohol Dependence, 175, 179 (2017)
524
Anraku, K., Sato, S., Jacob, N.T., Eubanks, L.M., Ellis, B.A., Janda, K.D., "The design and synthesis of an alpha-Gal trisaccharide epitope that provides a highly specific anti-Gal immune response"
Org. Biomol. Chem., 15(14), 2979 (2017)
523
Srinivasulu, V., Janda, K.D., Abu-Yousef, I.A., O'Connor, M.J., Al-Tel, T.H., "A modular CuI-L-proline catalyzed one-pot route for the rapid access of constrained hetero-atom-linked medium-sized ring systems"
Tetrahedron, 73, 2139 (2017)
522
Mandyam, C., Galinato, M., Lockner, J., Fannon, M., Sobieraj, J., Staples, M., Somkuwar, S., Ghofranian, A., Chaing, S., Navarro, A., Joea, A., Luikart, B., Janda, K.D., Heyser, C., Koob, G., "A synthetic small molecule Isoxazole-9 protects against methamphetamine relapse"
Mol. Psychiatry, 23(3), 629 (2017)
521
Gooyit, M., Miranda, P.O., Wenthur, C.J., Ducime, A., Janda, K.D., "Influencing antibody-mediated attenuation of methamphetamine CNS distribution through vaccine linker design"
ACS Chemical Neuroscience, 8, 468 (2017)
520
Bremer, P., Adler, M., Phung, C., Singh, A., Janda, K.D., "Newly designed qunolinol inhibitors mitigate the effects of Botulinum Neurotoxin A in enzymatic, cell-based and ex vivo assays"
J. Med. Chem., 60, 338 (2017)
519
Nguyen, J.D., Bremer, P.T., Ducime, A., Creehan, K.M., Kisby, B.R., Taffe, M.A., Janda, K.D., "Active vaccination attenuates the psychostimulant effects of alpha-PVP and MDPV in rats"
Neuropharmacology, 116, 1 (2017)
518
Kimishima, A., Wenthur, C.J., Eubanks, L.M., Sato, S., Janda, K.D., "Cocaine vaccine development: Evaluation of carrier and adjuvant combinations that activate toll-like receptors"
Mol. Pharmaceutics, 13, 3884 (2016)
517
Evans, S.M., Foltin, R.W., Hicks, M.J., Rosenberg, J.B., De, B.P., Janda, K.D., Kaminsky, S.M., Crystal, R.G., "Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacquisition using a choice procedure in rhesus macaques"
Pharmacology, Biochemistry and Behavior, 150-151, 76 (2016)
516
Bremer, P.T., Xue, S., Janda, K.D., "Picolinic acids as beta-exosite inhibitors of Botulinum neurotoxin A light chain"
Chem. Commun., 52, 12521 (2016)
515
Zhou, B., Eubanks, L.M., Jacob, N.T., Ellis, B., Roberts, A.J., Janda, K.D., "Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose"
Bioorg. Med. Chem. Lett., 26, 5078 (2016)
514
Gooyit, M., Janda, K.D., "Reprofiled anthelmintics abate dormant and hypervirulent Clostridium difficile"
Nature Scientific Report, 6:33642, doi: 10.1038/srep33642 (2016)
513
Gooyit, M.D., Janda, K.D., "Modulation of the surface-layer protein of Clostridium difficile through Cwp84 inhibition"
ACS Infect. Dis., 2, 465 (2016)
512
Bremer, P.T., Kimishima, A., Schlosburg, J.E., Zhou, B., Collins, K.C., Janda, K.D., "Combatting synthetic designer opioids: A conjugate vaccine ablates lethal doses of fentanyl class drugs"
Angew. Chem. Int. Ed. Engl., 55, 3772 (2016)
511
Seki, H., Xue, S., Pellett, S., Silhar, P., Johnson, E.A., Janda, K.D., "Cellular protection of SNAP-25 against Botulinum Neurotoxin/A: Inhibition of thioredoxin reductase through a suicide substrate mechanism"
J. Am. Chem. Soc., 138, 5568 (2016)
510
Collins, K.C., Schlosburg, J.E., Bremer, P.T., Janda, K.D., "Methamphetamine vaccines: Improvement through hapten design"
J. Med. Chem., 59, 3878 (2016)
509
Tsuchikama, K., Gooyit, M., Harris, T.L., Zhu, J., Globisch, D., Kaufmann, G.F., Janda, K.D., "Glycation reactivity of a quorum-sensing signaling molecule"
Angew. Chem., 128, 4070 (2016)
508
Jacob, N.T., Lockner, J.W., Schlosburg, J.E., Ellis, B.A., Eubanks, L.M., Janda, K.D., "Investigations of enantiopure nicotine haptens using an adjuvanting carrier in anti-nicotine vaccine development"
J. Med. Chem., 59, 2523 (2016)
507
Harris, T.L., Wenthur, C.J., Diego-Taboada, A., MacKenzie, G., Corbitt, T.S., Janda, K.D., "Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-Diaminopyridine for treatment of Botulinum neurotoxin A intoxication"
Chem. Comm., 52, 4187 (2016)
506
Hart, J.R., Weinberg, M.S., Morris, K.V., Roberts, T.C., Janda, K.D., Garner, A.L., Vogt, P.K., "MINCR is not a MYC-induced IncRNA"
PNAS, 113(5), E496 (2016)
505
Collins, K.C., Janda, K.D., ""Hapten Design for Anti-addiction Vaccine Development""
in Biologics to treat Substance Abuse Disorders; Vaccines, Monoclonal Antibodies, and Enzymes, ed., Ivan D. Montoya, 327-365 (2015)
504
Globisch, D., Specht, S., Pfarr, K.M., Eubanks, L.M., Hoerauf, A., Janda, K.D., "Litomosoides sigmodontis: A jird urine metabolome study"
Bioorg. Med. Chem. Lett., 25, 5804 (2015)
503
Collins, K.C., Tsuchikama, K., Lowery, C.A., Zhu, J., Janda, K.D., "Dissecting AI-2-mediated quorum sensing through C5-analogue synthesis and biochemical analysis"
J. Am. Chem. Soc., 72, 3593 (2016)
502
Xue, S., Schlosburg, J.E., Janda, K.D., "A New Strategy for Smoking Cessation: Characterization of a Bacterial Enzyme for the Degradation of Nicotine"
J. Amer. Chem. Soc., 137, 10136 (2015)
501
Miller, M.L., Aarde, S.M., Moreno, A.Y., Creehan, K.M., Janda, K.D., Taffe, M.A., "Effects of active anti-methamphetamine vaccination on intravenous self-administration in rats"
Drug & Alcohol Dependence, 153, 29 (2015)
500
Cai, X., Globisch, D., Thompson, P., Lin, J., Toader, D., Dimasi, N., Gao, C., Janda, K.D., "A chemoenzymatic approach toward the preparation of site-specific antibody-drug conjugates"
Tetrahedron Lett., 56, 3172 (2015)
499
Zhu, J., Cai, X., Harris, T.L., Gooyit, M., Wood, M., Lardy, M., Janda, K.D., "Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model"
Chemistry & Biology, 22, 483 (2015)
498
Gooyit, M., Harris, T.L., Tricoche, N., Javor, S., Lustigman, S., Janda, K.D., "Onchocerca volvulus molting inhibitors identifeied through scaffold hopping"
ACS Infect. Dis., 1, 198 (2015)
497
Seki, H., Xue, S., Hixon, M.S., Pellett, S., Remes, M., Johnson, E.A., Janda, K.D., "Toward the discovery of dual inhibitors for botulinum nerotoxin A: concomitant targeting of endocytosis and light chain protease activity"
Chem. Commun., 51, 6226 (2015)
496
Gooyit, M., Tricoche, N., Javor, S., Lustigman, S., Janda, K.D., "Exploiting the polypharmacology of ß-carbolines to disrupt O. volvulus molting"
ACS Med. Chem. Lett., 6, 339 (2015)
495
Lockner, J.W., Eubanks, L.M., Choi, J.L., Lively, J.M., Schlosburg, J.E., Collins, K.C., Globisch, D., Rosenfeld-Gunn, R.J., Wilson, I.A., Janda, K.D., "Flagellin as carrier and adjuvant in cocaine vaccine development"
Mol. Pharmaceutics, 12, 653 (2015)
494
Lockner J.W., Lively, J.M., Collins, K.C., Vendruscolo, J.C.M., Azar, M.R., Janda, K.D., "A conjugate vaccine using enantiopure hapten imparts superior nicotine-binding capacity"
J. Med. Chem., 58, 1005 (2015)
493
Xue, S., Javor, S., Hixon, M.S., Janda, K.D., "Probing BoNT/A protease exosites: Implications for inhibitor design and light chain longevity"
Biochemistry, 53, 6820 (2014)
492
Hart, J.R., Garner, A.L., Yu, J., Ito, Y., Sun, M., Ueno, L., Rhee, J.-K., Baksh, M., Stefan, E., Hartl, M., Bister, K., Vogt, P.K., Janda, K.D., "Inhibitor of MYC identified in a Krohnke pyridine library"
PNAS, 111(34), 12556 (2014)
491
Raffeiner, P., Rock, R., Schraff, A., Hartl, M., Hart, J.R., Janda, K.D., Vogt, P.K., Stefan, E., Bister, K., "In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential"
Oncotarget, 5(19), 8869 (2014)
490
Eubanks, L.M., Ellis, B.A., Cai, X., Schlosburg, J.E., Janda, K.D., "A human recombinant monoclonal antibody to cocaine: Preparation, characterization and behavioral studies"
Bioorg. Med. Chem. Lett., 24, 4664 (2014)
489
Harris, T.L., Lowery, C.A., Hixon, M.S., Janda, K.D., "A Platform stratifying a sequestering agent and a pharacological antagonist as a means to negate Botulinum neurotoxicity"
ACS Chem. Neurosci., 5, 632 (2014)
488
Jacob, N.T., Lockner, J.W., Kravchenko, V.V., Janda, K.D., "Pharmacophore reassignment for induction of immunosurveillance cytokine TRAIL"
Angew. Chem. Int. Ed., 53, 6628 (2014)
487
Hicks, M.J., Kaminsky, S.M., De, B.P., Rosenberg, J.B., Evans, S.M., Foltin, R.W., Andrenyak, D.M., Moody, D.E., Koob, G.F., Janda, K.D., Ricart Arbona, R.J., Lepherd, M.L., Crystal, R.G., "Fate of systematically administered cocaine in nonhuman primates treated with the dAd5GNE anti-cocaine vaccine"
Hum. Gene Ther. Clin. Dev., 25(1), 40 (2014)
486
Collins, K.C., Schlosburg, J.E., Lockner, J.W., Bremer, P.T., Ellis, B.A., Janda, K.D., "Liquid tucaresol as an adjuvant for methamphetamine vaccine development"
Chem. Commun., 50, 4079 (2014)
485
Collins, K.C., Janda, K.D., "Investigating hapten clustering as a strategy to enhance vaccines against drugs of abuse"
Bioconjugate Chem., 25, 593 (2014)
484
Bremer, P.T., Hixon, M.S., Janda, K.D., "Benzoquinones as inhibitors of botulinum neurotoxin serotype A"
Bioorg. Med. Chem., 22, 3971 (2014)
483
Gooyit, M., Tricoche, N., Lustigman, S., Janda, K.D., "Dual protonophore - chitinase inhibitors dramatically affect O. volvulvus molting"
J. Med. Chem., 57, 5792 (2014)
482
Bremer P.T., Schlosburg, J.E., Lively, J.M., Janda, K.D., "Injection route and TLR9 agonist addition significantly impact heroin vaccine efficacy"
Mol. Pharmaceutics, 11, 1075 (2014)
481
Seki, H., Pellett, S., Silhar, P., Stowe, G.N., Blanco, B., Lardy, M.A., Johnson, E.A., Janda, K.D., "Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain"
Bioorg. Med. Chem., 22, 1208 (2014)
480
Silhar, P., Eubanks, L.M., Seki, H., Pellett, S., Javor, S., Tepp, W.H., Johnson, E.A., Janda, K.D., "Targeting Botulinum A cellular toxicity: A prodrug approach"
Bioorg. Med. Chem., 56, 7870 (2013)
479
Lowery, C.A., Adler, M., Borrell, A., Janda, K.D., "Scorpion toxins for the reversal of BoNT-induced paralysis"
Bioorg. Med. Chem. Lett., 23, 6743 (2013)
478
Cai, X., Whitfield, T.,Moreno, A.Y., Grant, Y., Hixon, M.S., Koob, G.F., Janda, K.D., "Probing the effects of hapten stability on cocaine vaccine immunogenicity"
Mol. Pharm. , 10, 4176 (2013)
477
Garner, A.L., Fullagar, J.L., Day, J.A., Cohen, S.M., Janda, K.D., "Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors"
J. Am. Chem. Soc., 135, 10014 (2013)
476
Lowery, C.A., Matamouros, S., Niessen, S., Zhu, J., Scolnick, J., Lively, J.M., Cravatt, B.F., Miller, S.I., Kaufmann, G.F., Janda, K.D., "A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level"
Chemistry & Biology, 20(7), 903 (2013)
475
Zhu, J., Hixon, M.S., Globisch, D., Kaufmann, G.F., Janda, K.D., "Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation"
J. Am. Chem. Soc., 135(21), 7827 (2013)
474
Maoz, A., Hicks, M.J., Vallabhjosula, S., Synan, M., Kothari, P.J., Dyke, J.P., Ballon, D.J., Kaminsky, S.M., De, B.P., Rosenburg, J.B., Martinez, D., Koob, G.F., Janda, K.D., Crystal, R.G., "Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter"
Neuropsychopharmacology, 38, 2170 (2013)
473
Schlosburg, J.E., Vendruscolo, L.F., Bremer, P.T., Lockner, J.W., Wade, C.L., Nunes, A.A., Stowe, G.N., Edwards, S., Janda, K.D., Koob, G.F., "Dynamic vaccine blocks relapse to compulsive intake of heroin"
PNAS, 110(22), 9036 (2013)
472
Matyas G.R., Mayorov, A.V., Rice, K.C., Jacobson, A.E., Cheng, K., Iyer, M.R., Li, F., Beck, Z., Janda, K.D., Alving, C.R., "Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs"
Vaccine, 31(26), 2804 (2013)
471
Cai, X., Whitfield, T., Hixon, M.S., Grant, Y., Koob, G.F., Janda, K.D., "Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design"
J. Med. Chem., 56(9), 3701 (2013)
470
Cai, X., Tsuchikama, K., Janda, K.D., "Modulating cocaine vaccine potency through hapten fluorination"
J. Am. Chem. Soc., 135, 2971 (2013)
469
Struss, A.K., Nunes, A., Waalen, J., Lowery, C.A., Pullanikat, P., Denery, J.R., Conrad, D.J., Kaufmann, G.F., Janda, K.D., "Toward implementation of quorum sensing autoinducers as biomarkers for infectious disease states"
Anal. Chem., 85, 3355 (2013)
468
De, B.P., Pagovich, O.E., Hicks, M.J., Rosenberg, J.B., Moreno, A.Y., Janda, K.D., Koob, G.F., Worgall, S., Kaminsky, S.M., Sondhi, D., Crystal, R.G., "Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity"
Human Gene Therapy, 24, 58 (2013)
467
Rosenberg, J.B., De, B.P., Hicks, M.J., Janda, K.D., Kaminsky, S.M., Worgall, S., Crystal, R.G., "Suppression of nicotine-induced pathophysiology by an adenovirus hexon-based anti-nicotine vaccine"
Human Gene Therapy, 24(6), 595 (2013)
466
Kravchenko V., Garner, A.L., Mathison, J., Seit-Nebi, A., Yu, J., Gileva, I.P., Ulevitch, R., Janda, K.D., "Facilitating cytokine-mediated cancer cell death by proteobacterial N-Acylhomoserine lactones"
ACS Chem. Biol., 8, 1117 (2013)
465
Globisch, D., Moreno, A.Y., Hixon, M.S., Nunes, A.A.K., Denery, J.R., Specht, S., Hoerauf, A., Janda, K.D., "Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness"
PNAS, 110(11), 4218 (2013)
464
Fullagar, J.L., Garner, A.L., Struss, A.K., Day, J.A., Martin, D.P., Yu, J., Cai, X., Janda, K.D., Cohen, S.M., "Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: Tropolones as inhibitors of P. aeruginosa elastase"
Chem. Commun., 49(31), 3197 (2013)
463
Silhar, P., Lardy, M.A., Hixon, M.S., Shoemaker, C.B., Barbieri, J.Y., Struss, A.K., Lively, J.M., Javor, S., Janda, K.D., "The C-Terminus of Botulinum A protease has profound and unanticipated kinetic consequences upon the catalytic cleft"
Med. Chem. Lett., 4(2), 283 (2013)
462
Silhar, P., Sivaggi, N.R., Pellett, S., Capkova, K., Johnson, E.A., Allen, K.N., Janda, K.D., "Evaluation of adamantane hydroxymates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies"
Bioorg. Med. Chem., 21, 1344 (2013)
461
Garner, A.L., Yu, J., Struss, A.K., Kaufmann, G.F., Kravchenko, V.V., Janda, K.D., "Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development"
Chem. Commun., 49, 1515 (2013)
460
Lockner, J.W., Ho, S.O., McCague, K.C., Chiang, S.M., Do, T.Q., Fujii, G., Janda, K.D., "Enhancing nicotine vaccine immunogenicity with liposomes"
Bioorg. Med. Chem. Lett., 23, 975 (2013)
459
Bremer, P.T., Janda, K.D., "Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance"
J. Med. Chem., 55, 10776 (2012)
458
Miller, M.L., Moreno, A.Y., Aarde, S.M., Creehan, K.M., Vanderwater, S.A., Vaillancourt, B.D., Wright, Jr., M.J., Janda, K.D., Taffe, M.A., "A methamphetamine vaccine attenuates methamphetamine-induced disruptions in thermoregulation and activity in rats"
Biol. Psychiatry, 73, 721 (2013)
457
von Hoven, G., Kloft, N., Neukirch, C., Ebinger, S., Bobkiewicz, W., Weis, S., Boller, K., Janda, K.D., Husman, M., "Modulation of translation and induction of autophagy by bacterial exoproducts"
Med. Microbiol. Immunol., 201(4), 409 (2012)
456
Moreno, A.Y., Azar, M.R., Koob, G.F., Janda, K.D., "Probing the protective effects of a conformationally constrained nicotine vaccine"
Vaccine, 30, 6665 (2012)
455
Hicks, M.J., Rosenberg, J.B., De, B.P., Pagovich, O.E., Young, C.N., Qiu, J., Kaminsky, S.M., Hackett, N.R., Worgall, S., Janda, K.D., Davisson, R.L., Crystal, R.G., "AAV-Directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation"
Science Translational Medicine, 4(140), 140ra87 (2012)
454
Garner, A.L., Struss, A.K., Fullagar, J.L., Agrawal, A., Moreno, A.Y., Cohen, S.M., Janda, K.D., "3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa virulence factor LasB"
Med. Chem. Lett., 3, 668 (2012)
453
Kirchdoerfer, R.F., Garner, A.L., Flack, C.E., Mee, J.M., Horswill, A.R., Janda, K.D., Kaufmann, G.F., "Structural basis for ligand recognition and discrimination of a quorum-quenching antibody"
J. Biol. Chem., 286(19), 17351 (2012)
452
Treweek, J.B., Janda, K.D., "An antidote for acute cocaine toxicity"
Mol. Pharmaceutics, 9(4), 969 (2012)
451
Zakhari, J.S., Zorrilla, E.P., Zhou, B., Mayorov, A.V., Janda, K.D., "Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice"
Pharmoceutics, 9, 281 (2012)
450
Globisch, D., Lowery, C.A., McCague, K.C., Janda, K.D., "Uncharacterized 4,5-Dihydroxy-2,3-pentanedione (DPD) molecules revealed through NMR spectroscopy: Implications for a greater signaling diversity in bacterial species"
Angew. Chem. Int. ed., 51, 4204 (2012)
449
Rosenberg, J.B., Hicks, M.J., De, B.P., Pagovich, O., Frenk, E., Janda, K.D., Wee, S., Koob, G.F., Hackett, N.R., Kaminsky, S.M., Worgall, S., Tignor, N., Mezey, J.G., Crystal, R.G., "AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that supresses cocaine-induced behavior"
Human Gene Therapy, 23, 451 (2012)
448
Kravchenko, V.V., Gloeckner, C., Stowe, G.N., Kang, Y.J., Tobias, .S., Mathison, J.C., Ulevitch, R.J., Kaufmann, G.F., Janda, K.D., "The use of small molecule probes to study spatially separated stimulus-induced signaling pathways"
Bioorg. Med. Chem. Lett., 22, 2043 (2012)
447
Romano, A.A., Hahn, T., Davis, N., Lowery, C.A., Struss, A.K., Janda, K.D., Bottger, L.H., Matznke, B.F., Carrano, C.J., "The Fe(III) and Ga(III) coordination chemistry of a 3-(1-hydroxymethylidene) and 3-(1-hydroxydecylidene)-5-(2-hydroxyethyl)pyrrolidine-2,4-dione: Novel tetramic acid degradation products of homoserine lactone bacterial quorum sensing molecules"
Journal of Inorganic Biochemistry, 107, 96 (2012)
446
Koob, G., Hicks, M.J., Wee, S., Rosenburg, J.B., De, B.P., Kaminsky, S.M., Moreno, A., Janda, K.D., Crystal, R.G., "Anti-cocaine analog to a disrupted adenovirus"
CNS Neurol. Disord. Drug targets, 10(8), 899 (2011)
445
Janda, K.D., Treweek, J.B., "Vaccines targeting drugs of abuse: is the glass half-empty or half-full?"
Nat. Rev. Immunol., 12(1), 67 (2011)
444
Stowe, G.N., Schlosburg, J.E., Vendruscolo, L.F., Edwards, S., Misra, K.K., Schulteis, G., Zakhari, J.S., Koob, G.F., Janda, K.D., "Developing a vaccine against multiple psycoactive targets: A case study of heroin"
CNS & Neurological Disorders - Drug Targets , 10, 865 (2011)
443
LI, Z., Garner, A.L., Gloeckner, C., Janda, K.D., Carlow, C.K., "Targeting the Wolbachia cell division protein FtsZ as a new approach for antifilarial therapy"
PLoS Neglected Tropical Diseaeses, 5(11), e1411 (2011)
442
Hoon, S., Zhou, B., Janda, K.D., Brenner, S., Scolnick, J., "Aptamer selection by high-throughput sequencing and informatics analysis"
Biotechniques, 51(6), 413 (2011)
441
Moreno, A.Y., Janda, K.D., "Current challenges for the creation of effective vaccines against drugs of abuse"
Expert Rev. Vaccines, 10(12), 1637 (2011)
440
Zakhari, J.S., Kinoyama, I., Hixon, M.S., Di Mola, A., Globisch, D., Janda, K.D., "Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization"
Bioorg. Med. Chem., 19, 6203 (2011)
439
Eubanks, L.E., Stowe, G.N., De Lamo Marin, S., Mayorov, A.V., Hixon, M.S., Janda, K.D., "Identification of alpha(2) macroglobulin as a major serum ghrelin esterase"
Angew. Chem. Int. Ed. Engl., 50, 10699 (2011)
438
Wee, S., Hicks, M.J., De, B.P., Rosenberg, J.B., Moreno, A.Y., Kaminsky, S.M., Janda, K.D., Crystal, R.G., Koob, G.F., "Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects"
Neuropsychopharmacology, 1 (2011)
437
Garner, A.L., Park, J., Zakhari, J.S., Lowery, C.A., Struss, A.K., Sawada, D., Kaufmann, G.F., Janda, K.D., "A multivalent probe for AI-2 quorum sensing receptors"
J. Am. Chem. Soc., 133, 15934 (2011)
436
Liu, Y., Jiang, P., Capkova, K., Xue, D., Ye, L., Sinha, S.C., Mackman, N., Janda, K.D., Liu, C., "Tissue factor activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy"
Cancer. Res., 71(20), 6492 (2011)
435
Tsuchikama, K., Lowery, C.A., Janda, K.D., "Probing autoinducer-2 based quorum sensing: the biological consequences of molecules unable to traverse equilibrium states"
J. Org. Chem., 76(17), 6981 (2011)
434
Stowe, G.N., Vendruscolo, L.F., Edwards, S., Schlosburg, J.E., Misra, K.K., Schulteis, G., Mayorov, A.V., Zakhari, J.S., Koob, G.F., Janda, K.D., "A vaccine strategy that induces protective immunity against heroin"
J. Med. Chem., 54(14), 5195 (2011)
433
Garner, A.L., Janda, K.D., "A small molecule antagonist of ghrelin O-acyltransferase (GOAT)"
Chem. Commun., 47, 7512 (2011)
432
Garner, A.L., Gloeckner, C., Trioche, N., Zakhari, J.S., Samje, M., Cho-Ngwa, F., Lustigman, S., Janda, K.D., "Design, synthesis, and biological activities of Closantel analogues: Structural promiscuity and its impact on Onchocerca vovulus"
J. Med. Chem., 54, 3963 (2011)
431
Moreno, A.Y., Mayorov, A.V., Janda, K.D., "Impact of distant chemical structures for the development of a methamphetamine vaccine"
J. Am. Chem. Soc., 133, 6587 (2011)
430
Uckun, F.M., Qazi, Z.O., Garner, A.L., Pitt, J., Ma, H., Janda, K.D., "Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signaling network"
British Journal of Haematology, 153, 741 (2011)
429
Janda, K.D., "Editor's Note"
Bioorg. Med. Chem., 19(1), 20 (2011)
428
Silhar, P., Alakurtti, S., Capkova, K., Xiaochuan, F., Shoemaker, C.B., Yli-Kauhaluoma, J., Janda, K.D., "Synthesis and evaluation of library of betulin derivitives against the botulinum neurotoxin A protease"
Bioorg. Med. Chem. Lett., 21, 2229 (2011)
427
Zakhari, J.S., Kinoyama, I., Struss, A.K., Pullanikat, P., Lowery, C.A., Lardy, M., Janda, K.D., "Synthesis and molecular modeling provide insight into a Pseudomonas aeruginosa quorum sensing conundrum"
J. Am. Chem. Soc., 133(11), 3840 (2011)
426
Treweek, J.B., Roberts, A.J., Janda, K.D., "Immunopharmacotherapeutic manifolds and modulation of cocaine overdose"
Pharmacol. Biochem. Behav., 98, 474 (2011)
425
Garner, A.L., Janda, K.D., "Shedding light on the Ghrelin/GOAT metabolism saga"
ChemBioChem, 12, 523 (2011)
424
Salzameda, N.T., Eubanks, L.M., Zakhari, J.S., Tsuchikama, K., DeNunzio, N.J., Allen, K.A., Hixon, M.S., Janda, K.D., "A cross-over inhibitor of the botulinum neurotoxin light chain B: A natural product implicating an exosite mechanism of action"
Chem. Commun., 47, 1713 (2011)
423
Hicks, M.J., Bishnu, P.D., Rosenberg, J.B., Davidson, J.T., Moreno, A.Y., Janda, K.D., Wee, S., Koob, G.F., Hackett, N.R., Kaminsky, S.M., Worgall, S., Toth, M., Mezey, J.G., Crystal, R.G., "Cocaine analog coupled to disrupted adenovirus: A vaccine strategy to evoke high-titer immunity against addictive drugs"
Molecular Therapy, 19(3), 612 (2011)
422
Garner, A.L., Yu, J., Struss, A.K., Lowery, C.A., Zhu, J., Kim, S.K., Park, J., Mayorov, A.V., Kaufmann, G.F., Kravchenko, V.V., Janda, K.D., "Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: Unanticipated effects on mammalian cell activation"
Bioorg. Med. Chem. Lett., 21, 2702 (2011)
421
Pier, C.L., Chen, C., Tepp, W.H., Lin, G., Janda, K.D., Barbieri, J.T., Pellett, S., Johnson, E.A., "Botulinum neurotoxin subtype A2 enters cells faster than subtype A1"
FEBS Letters, 585, 199 (2011)
420
Garner, A.L., Janda, K.D., "Protein-protein interactions and cancer: Targeting the central dogma"
Curr. Top. Med. Chem., 11, 258 (2011)
419
Kaufmann, G.F., Park, J., Mayorov,A.V., Kubitz, D.M., Janda, K.D., "Generation of quorum quenching antibodies"
Methods Mol. Biol., 692, 299-311 (2011)
418
Lowery, C.A., Kaufmann, G.F., Janda, K.D., "Determination of acyl homoserine lactone and tetramic acid concentrations in biological samples"
Methods Mol. Biol., 692, 101-111 (2011)
417
Stowe, G.N., Janda, K.D., "A Diels-Alder reaction conducted within the parameters of aqueous organocatalysis: Still just smoke and mirrors"
Tetrahedron Lett., 52, 2085 (2011)
416
Denery, J.R., Nunes, A.A., Hixon, M.S., Dickerson, T.J., Janda, K.D., "Metabolomics-based discovery of diagnostic biomarkers for onchocerciasis"
PLoS Negl. Trop. Dis., 4(10), e834 (2010)
415
Treweek, J.B., Roberts, A.J., Janda, K.D., "Superadditive effects of ethanol and flunitrazepam: Implications of using immunopharmacotherapy as a therapeutic"
Mol. Pharm., 7(6), 2056 (2010)
414
Garner, A.L., Janda, K.D., "cat-ELCCA: A robust method to monitor the fatty acid acyltransferase activity of Ghrelin O-Acyltransferase (GOAT)"
Angew. Chem. Int. Ed., 49(50), 9630 (2010)
413
Mayorov, A.V., Willis, B., Di Mola, A., Adler, D., Borgia, J., Jackson, O., Wang, J., Luo, Y., Tang, L., Knapp, R.J., Natarajan, C., Goodnough, M.C., Zilberberg, N., Simpson, L.L., Janda, K.D., "Symptomatic relief of Botulinum Neurotoxin/A intoxication with aminopyridines: A new twist on an old molecule"
ACS Chemical Biology, 5(12), 1183 (2010)
412
Eubanks, L.M., Silhar, P., Salzameda, N.T., Zakhari, J.S., Xiaochuan, F., Barbieri, J.T., Shoemaker, C.B., Hixon, M.S., Janda, K.D., "Identification of a natural product antagonist against the Botulinum neurotoxin light chain protease"
ACS Med. Chem. Lett., 1, 268 (2010)
411
Steiniger, S., Janda, K.D., "The good, the bad, and the very bad: A new platform strategy to identify drug targets in cancer stem cells"
Laboratory-Journal.com, (2010)
410
Lowery, C.A., Salzameda, N.T., Sawada, D., Kaufmann, G.F., Janda, K.D., "Medicinal chemistry as a conduit for the modulation of quorum sensing"
J. Med. Chem., 1, 268 (2010)
409
Thyagarajan, B., Potian, J.G., Garcia, C.C., Hognason, K., Capkova, K., Moe, S.T., Jacobson, A.R., Janda, K.D., McArdle, J.J., "Effects of hydroxamate mettalloprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions"
Neuropharmacology, 58, 1189 (2010)
408
Moreno, A.Y., Azar, M.R., Warren, N.A., Dickerson, T.J., Koob, G.F., Janda, K.D., "A critical evaluation of a nicotine vaccine within a self-administration behavioral model"
Molecular Pharmaceutics, 7(2), 431 (2010)
407
Staflin, K., Krueger, J.S., Hachman, J., Forsyth, J.S., Lorger, M., Steiniger, S.C.J., Mee, J., Pop, C., Salvesen, G.S., Janda, K.D., Felding-Habermann, B., "Targeting activated integrin alpha-v-beta-3 with patient-derived antibodies impacts late-stage multiorgan metastasis"
Clin. Exp. Metastasis, 27(4), 217 (2010)
406
Gloeckner, C., Garner, A., Mersha, F., Oksov, Y., Tricoche, N., Eubanks, L., Lustigman, S., Kaufmann, G., Janda, K.D., "Repositioning of an old drug for the neglected tropical disease Onchocerciasis"
PNAS, 107(8), 3424 (2010)
405
Silhar, P., Capkova, K., Salzameda, N.T., Barbieri, J.T., Hixon, M.S., Janda, K.D., "Botulinum neurotoxin A protease: Discovery of natural product exosite inhibitors"
J. Am. Chem. Soc., 132, 2868 (2010)
404
Stowe, G.N., Silhar, P., Hixon, M.S., Silvaggi, N.R., Allen, K.N., Moe, S.T., Jacobson, A.R., Barbieri, J.T., Janda, K.D., "Chirality holds the key for potent inhibition of the Botulinum Neurotoxin serotype A protease"
Org. Lett., 12(4), 756 (2010)
403
Nakai, Y., Tepp, W.H., Dickerson, T.J., Johnson, E.A., Janda, K.D., "Toosendanin: Synthesis of the AB-ring and investigations of its anti-Botulinum properties (part II)"
Bioorg. Med. Chem., 18, 1280 (2010)
402
Fukuchi, K., Steiniger, S.C.J., Deryungina, E., Liu, Y., Lowery, C.A., Gloeckner, C., Zhou, B., Kaufmann, G.F., Quigley, J.P., Janda, K.D., "Inhibition of tumor metastasis: Functional immune modulation of the CUB domain containing protein 1"
Molecular Pharmaceutics, 7(1), 245 (2010)
401
Capkova, K., Hixon, M.S., Pellet, ., Barbieri, J.T., Johnson, E.A., Janda, K.D., "Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase"
Bioorg. Med. Chem. Lett., 20, 206 (2010)
400
Lowery, C.A., Park, J., Gloeckner, C., Meijler, M.M., Mueller, R.S., Boshoff, H.I., Ulrich, R.L., Barry III, C.E., Bartlett, D.H., Kravchenko, V.V., Kaufmann, G.F., Janda, K.D., "Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals"
J. Am. Chem. Soc., 131, 14473 (2009)
399
Lowery, C.A., Abe, T., Park, J., Eubanks, L.M., Sawada, D., Kaufmann, G.F., Janda, K.D., "Revisiting AI-2 quorum sensing inhibitors: Direct comparison of alkyl-DPD analogues and a natural product Fimbrolide"
J. Am. Chem. Soc., 131, 15584 (2009)
398
Salzameda, N.T., Barbieri, J.T., Janda, K.D., "Synthetic substrate for application in both high and low throughput assays for botulinum neurotoxin B protease inhibitors"
Bioorg. Med. Chem. Lett., 19, 5848 (2009)
397
Steiniger, S., Janda, K.D., "The good, the bad, and the very bad: A new platform strategy to identify drug targets in cancer stem cells"
BIOforum Europe, 6, 25 (2009)
396
Capkova, K., Salzameda, N.T., Janda, K.D., "Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins"
Toxicon, 54, 575 (2009)
395
Pires-Alves, M., Ho, M., Aberle, K.K., Janda, K.D., Wilson, B.A., "Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity"
Toxicon, 53, 392 (2009)
394
Fischer, ., Nakai, Y., Eubanks, L.M., Clancy, C.M., Tepp, W.H., Pellett, S., Dickerson, T.J., Johnson, E.A., Janda, K.D., Montal, M., "Bimodal modulation of the botulinum neurotoxin protein-conducting channel"
PNAS, 106, 1330 (2009)
393
Treweek, J.B., Moreno, A.Y., Janda, K.D. , "SLEEPLESS-ness and insomnia in fruit flies"
Angew. Chem. Int. Ed., 48, 438 (2009)
392
Treweek, J.B., Dickerson, T.J., Janda, K.D., "Drugs of abuse that mediate advanced glycation end product formation: A chemical link to disease pathology"
Accounts of Chemical Research, 42(5), 659 (2009)
391
Frederick, M.O., De Lamo Marin, S., Janda, K.D., Nicolaou, K.C., Dickerson, T.J., "Monoclonal antibodies with orthoganal azaspiracid epitopes"
ChemBioChem, 10, 1625 (2009)
390
Moreno, A.Y., Janda, K.D., "Immunopharmacotherapy: Vaccination stratagies as a treatment for drug abuse and dependence"
Pharmacology, Biochemistry, and Behavior, 92, 199 (2009)
389
Nakai, Y., Tepp, W.H., Dickerson, T.J., Johnson, E.A., Janda, K.D., "Function-oriented synthesis applied to the anti-botulinum natural product toosendanin"
Bioorg. Med. Chem., 17, 1152 (2009)
388
Zhou, H., Zhou, B., Pellett, S., Johnson, E.A., Janda, K.D., "Selection and characterization of a human monoclonal neutralizing antibody for Clostridium Botulinum neurotoxin serotype B"
Bioorg. Med. Chem. Lett., 19, 662 (2009)
387
Sheng, J., Oyler, G., Zhou, B., Janda, K., Shoemaker, C.B., "Identification and characterization of a novel cell-penetrating peptide"
Biochemical and Biophysical Research Coomunications, 382, 236 (2009)
386
Brogan, A.P., Dickerson, T.J., Janda, K.D., "Catalytic Antibodies (Abzymes), Synthetic"
Wiley Encyclopedia of Chemical Biology, (2008)
385
Treweek, J.B., Sun, C., Mayorov, A.V., Qi, L., Levy, C.L., Roberts, A.J., Dickerson, T.J., Janda, K.D., "Prevention of drug-induced memory impairment by immunopharmacotherapy"
J. Med. Chem., 51, 6866 (2008)
384
Willis, B., Eubanks, L.M., Dickerson, T.J., Janda, K.D., "The strange case of the Botulinum neurotoxin: Using chemistry and biology to modulate the most deadly poison"
Angew. Chem. Int. Ed., 47, 8360 (2008)
383
Mayorov, A.V., Amara, N., Chang, J.Y., Moss, J.A., Hixon, M.S., Ruiz, D.I., Meijler, M.M., Zorilla, E.P., Janda, K.D., "Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice"
PNAS, 105(45), 17487 (2008)
382
Steiniger, S.C.J., Coppinger, J.A., Kruger, J.A., Yates III, J., Janda, K.D., "Quantitative mass spectrometry identifiies drug targets in cancer stem cell containing side population"
Stem Cells, 26(12), 3037 (2008)
381
Park, J., Dickerson, T.J., Janda, K.D., "Major sperm protein as a diagnostic antigen for onchocerciasis"
Bioorg. Med. Chem., 16, 7206 (2008)
380
Capkova, K., Hixon, M.S., McAllister,L.A., Janda, K.D., "Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations"
Chem. Commun., 3525 (2008)
379
Park, J., Kaufmann, G.F., Bowen, J.P., Arbiser, J.L., Janda, K.D., " Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aerginosa"
JID, 198, 1198 (2008)
378
Lowery, C.A., Park, J., Kaufmann, G.F., Janda, K.D., "An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-Dihydroxy-2,3-pentanedione analogues"
J. Am. Chem. Soc., 130(29), 9200 (2008)
377
Lowery, C.A., Dickerson, T.J., Janda, K.D., "Interspecies and interkingdom communication mediated by bacterial quorum sensing"
Chem. Soc. Rev., 37(7), 1337 (2008)
376
Kravchenko, V.V., Kaufmann, G.F., Mathison, J.C., Scott, D.A., Katz, A.Z., Grauer, D.C., Lehmann, M., Meijler, M.M., Janda, K.D., Ulevitch, R.J., "Modulation of gene expression via disruption of NF-kB signaling by a bacterial small molecule"
Science, 321, 259 (2008)
375
Debler, E.W., Kaufmann, G.F., Meijler, M.M., Heine, A., Mee, J.M., Pljevaljcic, G., Di Bilio, A.J., Schultz, P.G., Millar, D.P., Janda, K.D., Wilson, I.A., Gray, H.B., Lerner, R.A., "Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex"
Science, 319(5867), 1232 (2008)
374
Kaufmann, G.F., Park, J., Janda, K.D., "Bacterial quorum sensing: a new target for anti-infective immunotherapy"
Expert Opin. Biol. Ther., 8(6), 719 (2008)
373
Zhou, B., Pellett, S., Tepp, W.H., Zhou, H., Johnson, E.A., Janda, K.D., "Delineating the susceptibility of botulinum neurotoxins to denaturation through thermal effects"
FEBS Letters, 582, 1526 (2008)
372
Kaufmann, G.F., Park, J., Mee, J.M., Ulevitch, R.J., Janda, K.D., "The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone"
Molecular Immunology, 45, 2710 (2008)
371
Yoneda, Y., Steiniger, S.C.J., Capkova, K., Mee, J.M., Liu, Y., Kaufmann, G.F., Janda, K.D., "A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy"
Bioorg. Med. Chem. Lett., 18, 1632 (2008)
370
Zhou, B., Carney, C., Janda, K.D., "Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin"
Bioorg. Med. Chem., 16, 1903 (2008)
369
Willis, B., Eubanks, L.M., Wood, M.R., Janda, K.D., Dickerson, T.J., Lerner, R.A.L., "Biologically templated organic polymers with nanoscale order"
PNAS, 105(5), 1416 (2008)
368
Zarebski, L.M., Vaughan, K., Sidney, J., Peters, B., Grey, H., Janda, K.D., Casadevall, A., Sette, A., "Analysis of epitope information related to Bacillus anthracis and Clostridium botulinum"
Expert Rev. Vaccines, 7(1), 55 (2008)
367
Richardson, H.N., Zhao, Y., Fekete, E.M., Funk, C.K., Wirsching, P., Janda, K.D., Zorrilla, E.P., Koob, G.F., "MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist"
Pharmacology, Biochemistry and Behavior, 88, 497 (2008)
366
Brogan, A.P., Dickerson, T.J., Janda, K.D., "Nornicotine-organocatalyzed aqueous reduction of alpha, beta-unsaturated aldehydes"
Chem. Commun., 46, 4952 (2007)
365
Dickerson, T.J., McKenzie, K.M., Hoyt, A.S., Wood, M.R., Janda, K.D., Brenner, S.B., Lerner, R.A., "Phage escape libraries for checkmate analysis"
PNAS, 104(31), 12703 (2007)
364
Zhou, H., Zhou, B., Ma, H., Carney, C., Janda, K.D.,, "Selection and characterization of human monoclonal antibodies against Abrin by phage display"
Bioorg. Med. Chem. Lett., 17, 5690 (2007)
363
Park, J., Jagasia, R., Kaufmann, G.F., Mathison, J.C., Ruiz, D.I., Moss, J.A., Meijler, M.M., Ulevitch, R.J., Janda, K.D., "Infection control by antibody disruption of bacterial quorum sensing signaling"
Chemistry & Biology, 14, 1119 (2007)
362
Capkova, K., Yoneda, Y., Dickerson, T.J., Janda, K.D., "ynthesis and structure-activity relationships of second-generation hydroxymate botulinum neurotoxin A protease inhibitors"
Bioorg. Med. Chem. Lett., 17, 6463 (2007)
361
Xu, Y., Hixon, M.S., Dawson, P.E., Janda, K.D., "Development of a FRET assay for monitoring of HIV gp41 core disruption"
J. Org. Chem., 72(18), 6700 (2007)
360
Treweek, J., Wee, S., Koob, G.F., Dickerson, T.J., Janda, K.D., "Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease"
PNAS, 104(28), 11580 (2007)
359
Ino, A., Dickerson, T.J., Janda, K.D., "Positional linker effects in haptens for cocaine immunopharmacotherapy"
Bioorg. Med. Chem. Lett., 17, 4280 (2007)
358
Dickerson, T.J., Janda, K.D.,, "The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication"
Chem. Biol., 2(4), 359 (2007)
357
Debler, E.W., Kaufmann,G.F., Kirchdoerfer, R.N., Mee, J.M., Janda, K.D., Wilson, I.A., "Crystal structures of a quorum-quenching antibody"
J. Mol. Bio., 368(5), 1392 (2007)
356
Silvaggi, N.R., Boldt, G.E., Hixon, M.S., Kennedy, J.P., Tzipori, S., Janda, K.D., "Structures of Clostridium botulinum neurotoxin serotype A light chain complexed with small-molecule inhibitors highlight active-site flexibility"
Chemistry & Biology, 14, 533 (2007)
355
Eubanks, L.E., Dickerson, T.J., Janda, K.D., "Technological advancements for the detection of and protection against biological and chemical warfare agents"
Chem. Soc. Rev., 36(3), 441 (2007)
354
Liu, Y., Steiniger, S.C.J., Kim, Y., Kaufmann, G.F., Felding-Habermann, B., Janda, K.D., "Mechanistic studies of a peptidic GRP78 ligand for cancer celll-specific drug delivery"
Molecular Pharmaceutics, 4(3), 435 (2007)
353
Brogan, A.P., Eubanks, L.M., Koob, G.F., Dickerson, T.J., Janda, K.D., "Antibody-catalyzed oxidation of delta-9-tetrahydrocannabinol"
J. Am. Chem. Soc., 129, 3698 (2007)
352
De Lamo Marin, S., Xu, X., Meijler, M.M., Janda, K.D., , "Antibody catalyzed hydrolysis of a quorum sensing signal found in Gram-negative bacteria"
Bioorg. Med. Chem. Lett., 17, 1549 (2007)
351
McAllister, L.A., Hixon, M.S., Schwartz, R., Kubitz, D.S., Janda, K.D., "Synthesis and application of a novel ligand for affinity chromatography based removal of endotoxin from antibodies, "Synthesis and application of a novel ligand for affinity chromatography based removal of endotoxin from antibodies"
Bioconjugate Chem., 18, 559 (2007)
350
Xu, Y., Hixon, M.S., Yamamoto, N., McAllister, L.A., Wentworth, A.D., Wentworth, Jr., P., Janda, K.D., , "Antibody-catalyzed anaerobic destruction of methamphetamine"
PNAS, 104(10), 3681 (2007)
349
Steiniger, S.C.J., Altobell III, L., Zhou, B., Janda, K.D., "Selection of human antibodies against cell surface-associated oligomeric anthrax protective antigen"
Molecular Immunology, 44, 2749 (2007)
348
Eubanks, L.M., Hixon, M.S., Jin, W., Hong, S., Clancy, C.M., Tepp, W.H., Baldwin, M.R., Malizio, C.J., Goodnough, M.C., Barbieri, J.T., Johnson, E.A., Boger, D.L., Dickerson, T.J., Janda, K.D., "An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists"
PNAS, 104(8), 2602 (2007)
347
Rogers, C.J., Eubanks, L.M., Dickerson, T.J., Janda, K.D., "Unexpected acetylcholinesterase activity of cocaine esterases"
J. Am. Chem. Soc., 128, 15364 (2006)
346
McKenzie, K.M., Mee, J.M., Rogers, C.J., Hixon, M.S., Kaufmann, G.F., Janda, K.D., "Identification and characterization of single chain anti-cocaine catalytic antibodies"
J. Mol. Biol., 365, 722 (2006)
345
Kravchenko, V.V., Kaufmann, G.F., Mathison, J.C., Scott, D.A., Katz, A.Z., Woood, M.R., Brogan, A.P., Lehmann, M., Mee, J.M., Iwata, K., Pan, Q., Fearns, C., Knaus, U.G., Meijler, M.M., Janda, K.D., Ulevitch, R.J., "N-(3-Oxo-acyl)homoserine llactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways"
Journal of Biological Chemistry, 281(39), 28822 (2006)
344
Eubanks, L.M., Rojers, C.J., Beuscher IV, A.E., Koob, G.F., Olson, A.J., Dickerson, T.J., Janda, K.D., "A molecular link between the active component of marijuana and Alzheimer's disease pathology"
Molecular Pharmaceutics, 3(6), 773 (2006)
343
Brogan, A.P., Dickerson, T.J., Janda, K.D., "Enamine-based aldol organocatalysis in water: Are they really "all wet"?"
Angew. Chem. Int. Ed., 45, 8100 (2006)
342
Zorilla, E.P., Iwasaki, S., Moss, J.A., Chang, J., Otsuji, J., Inoue, K., Meijler, M.M., Janda, K.D., "Vaccination against weight gain"
PNAS, 103(35), 13226 (2006)
341
Kim, Y., Lillo, A.M., Steiniger, S.C.J., Liu, Y., Ballatore, C., Anichini, A., Mortarini, R., Kaufmann, G.F., Zhou, B., Felding-Habermann, B., Janda, K.D., "Targeting heat shock protiens on cancer cells: Selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand"
Biochemistry, 45, 9434 (2006)
340
Dickerson, T.J., Janda, K.D., "The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication"
ACS Chemical Biology, 1(6), 359 (2006)
339
Boldt, G.E., Eubanks, L.M., Janda, K.D., "Identification of a botulinum A protease inhibitor displaying efficacy in a cellular model, "Identification of a botulinum A protease inhibitor displaying efficacy in a cellular model"
Chem. Commun., 3063 (2006)
338
Ma, H., Zhou, B., Kim, Y., Janda, K.D., "A cyclic peptide-polymer probe for the detection of Clostridium botulinum neurotoxin serotype A"
Toxicon, 47, 901 (2006)
337
Fu, Z., Chen, S., Baldwin, M.R., Boldt, G.E., Crawford, A., Janda, K.D., Barbieri, J.T., Kim, J.-J.P., "Light chain of botulinum neurotoxin serotype A: Structural resolution of a catalytic intermediate"
Biochemistry, (ASAP), (2006)
336
Boldt, G.E., Kennedy, J.P., Hixon, M.S., Mcallister, L.A., Barbieri, J.T., Tzipori, S., Janda, K.D., "Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin A inhibitors"
J. Comb. Chem., 8, 513 (2006)
335
Xu, Y., Lu, H., Kennedy, J.P., Yan, X., McAllister, L.A., Yamamoto, N., Moss, J.A., Boldt, G.E., Jiang, S., Janda, K.D., "Evaluation of "credit-card" libraries for inhibition of HIV-1 gp41 fusogenic core formation"
J. Comb. Chem., 8, 531 (2006)
334
Boldt, G.E., Kennedy, J.P., Janda, K.D., "Identification of a potent botulinum neurotoxin A protease inhibitor using in situ lead identification chemistry"
Organic Lett., 8, 1729 (2006)
333
Xu, Y., Shi, J., Yamamoto, N., Moss, J.A., Vogt, P.K., Janda, K.D., "A credit-card library approach for disrupting protein-protein interactions"
Bioorg. Med. Chem., 14, 2660 (2006)
332
Kaufmann, G.F., Sartorio, R., Lee, S.-H., Mee, J.M., Altobell, III, L.J., Kujawa, D.P., Jeffries, E., Clapham, B., Meijler, M.M., Janda, K.D., "Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing"
J. Am. Chem. Soc., 128, 2802 (2006)
331
McAllister, L.A., Hixon, M.S., Kennedy, J.P., Dickerson, T.J., Janda, K.D., "Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: A new wrinkle in botulinum neurotoxin"
J. Am. Chem. Soc., 128, 4176 (2006)
330
Zhu, X., Dickerson, T.J., Rogers, C.J., Kaufmann, G.F., Mee, J.M., McKenzie, K.M., Janda, K.D., Wilson, I.A., "Complete reaction cycle of a cocaine catalytic antibody at atomic resolution"
Structure, 14, 205 (2006)
329
Shigenaga, S., Moss, J.A., Ashley, F.T., Kaufmann, G.F., Janda, K.D., "Solid-phase synthesis and cyclative cleavage of quorum sensing depsipeptide analogues by acylphenyldiazene activation"
SYNLETT, 4, 551 (2006)
328
Moss, J.A., Stokols, S., Hixon, M.S., Ashley, F.T., Chang, J.Y., Janda, K.D., "Solid-phase synthesis and kinetic characterization of fluorogenic enzyme-degradable hydrogel cross-linkers"
Biomacromolecules, 7, 1011 (2006)
327
Boldt, G.E., Dickerson, T.J., Janda, K.D., "Emerging chemical and biological approaches for the preparation of discovery libraries"
Drug Disc. Today, 11, 143 (2006)
326
Rogers, C.J., Dickerson, T.J., Janda, K.D., , "Kinetic isotope and thermodynamic analysis of the nornicotine-catalyzed aqueous aldol reaction"
Tetrahedron, 62, 352 (2006)
325
Zhang, L., Long, H., Boldt, G.E., Janda, K.D., Schatz, G.C., Lewis, F.D., "alpha- and beta-Stilbenosides as base-pair surrogates in DNA hairpins"
Org. Biomol. Chem., 4, 314 (2006)
324
Wu, W., Luo, Y., Sun, C., Liu, Y., Kuo, P., Varga, J., Xiang, R., Reisfeld, R., Janda, K.D., Edgington, T.S., Liu, C., "Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms"
Cancer Res., 66(2), 1 (2006)
323
Lillo, A.M., McKenzie, K.M., Janda, K.D., "Phage-Displayed Antibody Libraries"
In: Cell Biology: A Laboratory Handbook, ed. J.E. Celis, Elsevier Academic, USA, Chapter 59, pp. 491-496 (2006)
322
Dickerson, T.J., Janda, K.D., "Recent advances for the treatment of cocaine abuse: Central nervous system immunopharmacotherapy"
The AAPS Journal, 7(3), Article 59, E579 (2005)
321
Shimomura, O., Lee, B.S., Meth, S., Suzuki, H., Mahajan, S., Nomura, R., Janda, K.D., "Synthesis and application of polytetrahydrofuran-grafted polystyrene (PS-PTHF) resin supports for organic synthesis"
Tetrahedron, 61, 12160 (2005)
320
Rogers, C.J., Mee, J.M., Kaufmann, G.F., Dickerson, T.J., Janda, K.D., "A high-swelling reagent scaffold suitable for use in aqueous and organic solvents"
Tetrahedron, 61, 12140 (2005)
319
Kim, Y., Lillo, A., Moss, J.A., Janda, K.D., "A contiguous stretch of methionine residues mediates the energy-dependent internalization mechanism of a cell-penetrating peptide"
Molecular Pharmaceutics, 2(6), 528 (2005)
318
Meijler, M.M., Kaufmann, G.F., Qi, L., Mee, J.M., Coyle, A.R., Moss, J.A., Wirsching, P., Matsushita, M., Janda, K.D., "Fluorescent cocaine probes: A tool for the selection and engineering of therapeutic antibodies"
J. Am. Chem. Soc., 127, 2477 (2005)
317
Qi, L., Yamamoto, N., Meijler, M.M., Altobell, III, L.J., Koob, G.F., Wirsching, P., Janda, K.D., "Delta-9-tetrahydrocannabinol immunochemical studies: Haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta-9-tetrahydrocannabinol"
J. Med. Chem., 48, 7389 (2005)
316
Dickerson, T.J., Beuscher IV, A.E., Rogers, C.J., Hixon, M.S., Yamamoto, N., Xu, Y., Olson, A.J., Janda, K.D. , "Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library"
Biochemistry, 44, 14845 (2005)
315
Shute, T.S., Matsushita, M., Dickerson, T.J., La Clair, J.J., Janda, K.D., Burkart, M.D., "A site-specific bifunctional protein labeling system for affinity and fluorescent analysis"
Bioconjugate Chem., 16, 1352 (2005)
314
Matsushita, M., Meijler, M.M., Wirsching, P., Lerner, R.A., Janda, K.D., "A blue fluorescent antibody-cofactor sensor for mercury"
Org. Lett., 7, 4943 (2005)
313
Eubanks, L.M., Dickerson, T.J., Janda, K.D., "Vitamin B2-mediated cellular photoinhibition of botulinum neurotoxin A"
FEBS Letters, 579, 5361 (2005)
312
Carrera, M.R.A., Trigo, J.M., Wirsching,P., Roberts, A.J., Janda, K.D., "Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose"
Pharmacology, Biochemistry and Behavior, 81, 709 (2005)
311
McKenzie, K.M., Meijler, M.M., Lowery, C.A., Boldt, G.E., Janda, K.D., "A furanosyl-carbonate autoinducer in cell-to-cell communication of V. harveyi"
Chem. Commun., 4863 (2005)
310
Toker, J.D., Tremblay, M.R., Yli-Kauhaluoma, J., Wentworth, A.D., Zhou, B., Wentworth, Jr., P., Janda, K.D., "Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction"
J. Org. Chem., 70, 7810 (2005)
309
Xu, Y., Yamamoto, N., Ruiz, D.I., Kubitz, D.S., Janda, K.D., "Squaric monoamide monoester as a new class of reactive immunization hapten for catalytic antibodies"
Bioorg. Med. Chem. Lett., 15, 4304 (2005)
308
Yamashita, M., Lee, S.-H., Koch, G., Zimmermann, J., Clapham, B., Janda, K.D., "Solid-phase synthesis of oxazolones and other heterocycles via Wang resin-bound diazocarbonyls"
Tetrahedron Lett., 46, 5495 (2005)
307
Rogers, C.J., Mee, J.M., Kaufmann, G.F., Dickerson, T.J., Janda, K.D., "Toward cocaine esterase therapeutics"
J. Am. Chem. Soc., 127(28), 10016 (2005)
306
Brogan, A.P., Dickerson, T.J., Boldt, G.E., Janda, K.D., "Altered retinoid homeostasis catalyzed by a nicotine metabolite: Implications in macular degeneration and normal development"
Proc. Natl. Acad. Sci. U.S.A., 102(30), 10433 (2005)
305
Lee, B.S., Mahajan, S., Janda, K.D., "Molecular iodine-catalyzed imine activation for three-component nucleophilic addition reactions"
Synlett, 8, 1325 (2005)
304
Lee,B.S., Mahajan, S., Janda, K.D., "Asymmetric dihydroxylation catalyzed by ionic polymer-supported osmium tetroxide"
Tetrahedron Lett., 46, 4491 (2005)
303
Dickerson, T.J., Kaufmann, G.F., Janda, K.D., "Bacteriophage-mediated protein delivery into the central nervous system and its application in immunopharmacotherapy"
Expert Opin. Biol. Ther., 5(6), 773 (2005)
302
Lowery, C.A., McKenzie, K.M., Qi, L., Meijler, M.M., Janda, K.D., "Quorum sensing in Vibrio harveyi: probing the specificity of the LuxP binding site"
Bioorg. Med. Chem. Lett., 15, 2395 (2005)
301
Rogers, C.L., Dickerson, T.J., Brogan, A.P., Janda,K.D., "Hammett correlation of nornicotine analogues in the aqueous aldol reaction: Implications for green organocatalysis"
J. Org. Chem., 70(9), 3705 (2005)
300
Kaufmann, G.F., Meijler, M.M., Sun, C., Chen, D.-W., Kujawa, D.P., Mee, J.M., Hoffman, T.Z., Wirsching, P., Lerner, R.A., Janda, K.D., "Enzymatic incorporation of an antibody-activated blue fluorophore into DNA"
Angew. Chem. Int. Ed., 44, 2144 (2005)
299
Lee, B.S., Mahajan, S., Janda, K.D., "Cross-linked poly(4-vinylpyridine/styrene) copolymers as a support for immobilization of ytterbium triflate"
Tetrahedron, 61, 3081 (2005)
298
Reed, N.N., Dickerson, T.J., Boldt, G.E., Janda, K.D., "Enantioreversal in the Sharpless asymmetric epoxidation reaction controlled by the molecular weight of a covalently appended achiral polymer"
J. Org. Chem., 70, 1728 (2005)
297
Moss, J.A., Lillo, A., Kim, Y.S., Gao, C., Ditzel, H., Janda, K.D., "A dimerization 'switch' in the internalization mechanism of a cell-penetrating peptide"
J. Am. Chem. Soc., 127, 538 (2005)
296
Lee, B.S., Mahajan, S., Janda, K.D., "Novel method for catalyst immobilization using an ionic polymer: A case study using recyclable yttterbium triflate"
Tetrahedron Lett., 46, 807 (2005)
295
Kaufmann, G.F., Sartorio, R., Lee, S.-H., Rogers, C.J., Meijler, M.M., Moss, J.A., Clapham, B., Brogan, A.P., Dickerson, T.J., Janda, K.D., "Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones"
Proc. Natl. Acad. Sci. U.S.A., 102, 309 (2005)
294
Felding-Habermann, B., Lerner, R.A., Lillo, A., Zhuang, S., Weber, M.R., Arrues, S., Gao, C., Mao, S., Saven, A., Janda, K.D., "Combinatorial antibody libraries from cancer patients yield ligand mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis"
Proc. Natl. Acad. Sci. USA, 101, 17210 (2004)
293
Dickerson, T.J., Reed, N.N., La Clair, J.J., Janda, K.D., "A precipitator for the detection of thiophilic heavy metals in aqua"
J. Am. Chem. Soc., 126, 16582 (2004)
292
Lee, S.-H., Yoshida, K., Matsushita, H., Clapham, B., Koch, G., Zimmermann, J., Janda, K.D., "N-H insertion reactions of primary ureas: The synthesis of highly substituted imidazolones and imidazoles from diazocarbonyls"
J. Org. Chem., 69, 8829 (2004)
291
Matsushita, H., Lee, S.-H., Yoshida, K., Clapham, B., Koch, G., Zimmermann, J., Janda, K.D., "N-H insertion reactions of Boc-amino acid amides: Solution- and solid-phase synthesis of pyrazinones and pyrazines"
Organic Lett., 6, 4627 (2004)
290
Kim, Y.S., Moss, J.A., Janda, K.D., "Biological tuning of synthetic tactics in solid-phase synthesis: Application to Ab(1-42)"
J. Org. Chem., 69, 7776 (2004)
289
Qi, L., Meijler, M.M., Lee, S.-H., Sun, C., Janda, K.D., "Solid-phase synthesis of anandamide analogues"
Organic Lett., 6, 1673 (2004)
288
McDunn, J.E., Dickerson, T.J., Janda, K.D., "Antibody Catalysis of Disfavored Chemical Reactions"
Catalytic Antibodies, ed. Ehud Keinan, Wiley-VCH Verlag Gmbh & Co., Weinheim, Germany, pp. 184-216 (2004)
287
Xu, Y., Yamamoto, N., Janda, K.D., "Catalytic antibodies: Hapten design stratagies and screening methods"
Bioorg. Med. Chem., 12, 5247 (2004)
286
Dickerson, T.J., Yamamoto, N., Janda, K.D., "Antibody-catalyzed oxidative degradation of nicotine using riboflavin"
Bioorg. Med. Chem., 12, 4981 (2004)
285
Dickerson, T.J., Lovell, T., Meijler, M.M., Noodleman, L., Janda, K.D., "Nornicotine aqueous aldol reactions: Synthetic and theoretical investigations into origins of catalysis"
J. Org. Chem., 69, 6603 (2004)
284
Carrera, M.R.A., Meijler, M.M., Janda, K.D., "Cocaine pharmacology and current pharmacotherapies for its abuse"
Bioorg. Med. Chem., 12, 5019 (2004)
283
Dickerson, T.J., Yamamoto, N., Ruiz, D.I., Janda, K.D., "Immunological consequences of methamphetamine protein glycation"
J. Am. Chem. Soc., 126, 11446 (2004)
282
Lillo, A.M., Sun, C., Gao, C., Ditzel, H., Parrish, J., Gauss, C.-M., Moss, J., Felding-Habermann, B., Wirsching, P., Boger, D.L., Janda, K.D., "A human single-chain antibody specific for integrin alpha-3-beta-1 capable of cell internalization and delivery of antitumor agents"
Chemistry & Biology, 11, 897 (2004)
281
Carrera, M.R.A., Kaufmann, G.F., Mee, J.M., Meijler, M.M., Koob, G.F., Janda, K.D., "Treating cocaine addiction with viruses"
Proc. Natl. Acad. Sci. U.S.A., 101, 10416 (2004)
280
Lee, S.-H., Matsushita, H., Koch, G., Zimmermann, J., Clapham, B., Janda, K.D., "Smart cleavage reactions: the synthesis of an array of ureas from polymer-bound carbamates"
J. Comb. Chem., 6, 822 (2004)
279
Chen, D.-W., Janda, K.D., , "Catalytic Antibodies"
Encyclopedia of Supramolecular Chemistry, Marcel Dekker, New York, NY, P. 193 (2004)
278
Meijler, M.M., Hom, L.G., Kaufmann, G.F., McKenzie, K.M., Sun, C., Moss, J.A., Matsushita, M., Janda, K.D., "Synthesis and biological validation of a ubiquitous quorum-sensing molecule"
Angew. Chem. Int. Ed., 43, 2106 (2004)
277
Lee, B.-S., Mahajan, S., Clapham, B., Janda, K.D., "Suspension ring-opening metathesis polymerization: The preparation of norbornene-based resins for application in organic synthesis"
J. Org. Chem., 69, 3319 (2004)
276
Lee, S.-H., Matsushita, H., Clapham, B., Janda, K.D., "The direct conversion of carbamates to ureas using aluminum amides"
Tetrahedron, 60, 3439 (2004)
275
Meijler, M.M., Matsushita, M., Wirsching, P., Janda, K.D., "Development of immunopharmacotherapy against drugs of abuse"
Current Drug Discovery Technologies, 1, 77 (2004)
274
Ahn, J.-M., Wentworth, Jr., P., Janda, K.D., "Probing lipase/esterase libraries for lipid A hydrolysis - discovery of biocatalysts for the detoxification of bacterially-expressed recombinant protein"
Chem. Commun., 364 (2004)
273
Matsushita, H., Lee, S.-H., Joung, M., Clapham, B., Janda, K.D., "Smart cleavage reactions: the synthesis of benzimidazoles and benzothiazoles from polymer-bound esters"
Tetrahedron Lett., 45, 313 (2004)
272
Carrera, M.R.A., Ashley, J.A., Hoffman, T.Z., Isomura, S., Wirsching, P., Koob, G.F., Janda, K.D., "Investigations using immunization to attenuate the psychoactive effects of nicotine"
Bioorg. Med. Chem., 12, 563 (2004)
271
Zorilla, E., Fekete, E., Mason, B.J., Wirsching, P., Janda, K.D., Kooob, G.F., "CRF-1 antagonists for anxiety"
European Neuropsychopharmacology, 13(Suppl. 4), S130 (2003)
270
Matsushita, M., Yoshida, K., Yamamoto, N., Wirsching, P., Lerner, R.A., Janda, K.D., "High-throughput screening by using a blue-fluorescent antibody sensor"
Angew. Chemie, Int. Ed., 42, 5984 (2003)
269
Dickerson, T.J., Tremblay, M.R., Hoffman, T.Z., Ruiz, D.I., Janda, K.D., "Catalysis of the Photo-Fries reaction: Antibody-mediated stabilization of high energy states"
J. Amer. Chem. Soc., 125, 15395 (2003)
268
Moss, J.A., Coyle, A.R., Ahn, J.-A., Meijler, M.M., Offer, J., Janda, K.D., "Tandem IMAC-HPLC purification of a cocaine-binding scFv antibody"
Journal of Immunological Methods, 281, 143 (2003)
267
Wentworth, Jr., P., Nieva, J., Takeuchi, C., Galve, R., Wentworth, A.D., Dilley, R.B., DeLaria, G.A., Saven, A., Babior, B.M., Janda, K.D., Eschenmoser, A., Lerner, R.A., "Evidence for ozone formation in human atherosclerotic arteries"
Science, 302, 1053 (2003)
266
Chen, Y., Gambs, C., Abe, Y., Wentworth, P., Jr., Janda, K.D., " Total synthesis of the depsipeptide FR-901375"
J.Org. Chem., 68, 8902 (2003)
265
Lee, S.-H., Clapham, B., Koch, G., Zimmerman, J., Janda, K.D., "Solid-phase rhodium carbenoid N-H insertion reactions: the synthesis of a diverse array of indoles"
J. Comb. Chem., 5, 188 (2003)
264
Fujimori, T., Wirsching, P., Janda, K.D., "Preparation of a Krohnke pyridine combinatorial library suitable for solution-phase biological screening"
J. Comb. Chem., 5, 625 (2003)
263
Hasserodt, J., Janda, K.D., "Catalytic Antibodies"
In: Encyclopedia of Catalysis, ed. I.T. Horvath, Wiley, N.Y., pp. 440-476 (2003)
262
Dickerson, T.J., Reed, N.N., Janda, K.D., "Soluble polymers as catalyst and reagent platforms: Liquid-phase methodologies"
In: Polymeric Materials in Organic Synthesis and Catalysis ed. M.R. Buchmeiser, Wiley-VCH Verlag Gmbh, Weinheim, Germany, pp 241-276 (2003)
261
Dickerson, T.J., Janda, K.D., "Glycation of the amyloid beta-protein by a nicotine metabolite: A fortuitous chemical dynamic between smoking and Alzheimer's disease"
Proc. Natl. Acad. Sci. USA, 100(14), 8182 (2003)
260
Meijler, M.M., Matsushita, M., Altobell, III, L.J., Wirsching, P., Janda, K.D., "A new stategy for improved nicotine vaccines using conformationally constrained haptens"
J. Amer. Chem. Soc., 125(24), 7164 (2003)
259
Liu C., Sun, C., Huang, H., Janda, K., Edgington, T., "Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy"
Cancer Research, 63, 2957 (2003)
258
Gambs, C., Dickerson, T.J., Mahajan, S., Pasternack, L.B., Janda, K.D., "High-resolution diffusion-ordered spectroscopy to probe the microenvironment of JandaJel and Merrifield resins"
J. Org. Chem., 68(9), 3673 (2003)
257
Redwan, E-R.,M., Larsen, N.A., Zhou, B., Wirsching, P., Janda, K.D., Wilson, I.A., "Expression and characterization of a humanized cocaine-binding antibody"
Biotechnology and Bioengineering, 82(5), 612 (2003)
256
Zhu, X., Heine, A., Monnat, F., Houk, K.N., Janda, K.D., Wilson, I.A., "Structural basis for antibody catalysis of a cationic cyclization"
J. Mol. Bio., 329, 69 (2003)
255
Sun, C., Wirsching, P., Janda, K.D., "Enabling ScFvs as muti-drug carriers: A dendritic approach"
Bioorg. Med. Chem., 11, 1761 (2003)
254
Gao, C., Mao, S., Ronca, F., Zhuang, S., Quaranta, V., Wirsching, P., Janda, K.D., "De novo identification of tumor-specific internalizing human antibody-receptor pairs by phage-display methods"
Journal of Immunological Methods, 274, 185 (2003)
253
Wentworth, Jr., P., Wentworth, A.D., Zhu, X., Wilson, I.A., Janda, K.D., Eschenmoser, A., Lerner, R.A., "Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens"
Proc. Nat. Acad. Sci. USA, 100, 1490 (2003)
252
Ahn, J.-A., Wentworth, Jr., P., Janda, K.D., "Soluble polymer-supported convergent parallel library synthesis"
Chem. Commun., 480 (2003)
251
Cannizzaro, C.E., Ashley, J.A., Janda, K.D., Houk, K.N., "Experimental determination of the absolute enantioselectivity of an antibody-catalyzed Diels-Alder reaction and theoretical explorations of the origins of stereoselectivity"
J. Am. Chem. Soc., 125, 2489 (2003)
250
Lee, S.-H., Clapham, C., Koch, G., Zimmermann, J., Janda, K.D., "Rhodium carbenoid N-H insertion reactions of primary ureas: Solution and solid-phase synthesis of imidazolones"
Organic Lett., 5, 511 (2003)
249
Wang, Q., Krishnaswami, S.R., Janda, K.D., Lin, T., Finn, M.G., "Blue fluorescent antibodies as reporters of steric accessibility in virus conjugates"
Bioconjugate Chem., 14, 38 (2003)
248
Dickerson, T., Cordova, A., Chen, D.-W., Janda, K.D., "The Use of Enzymes and Catalytic Antibodies in the Asymmetric Aldol Reaction"
In: Encyclopedia of Catalysis, ed. I.T. Horvath, Wiley, N.Y., (2002)
247
Wentworth, Jr., P., McDunn, J.E., Wentworth, A.D., Takeuchi, C., Nieva, J., Jones, T., Bautista, C., Ruedi, J.M., Gutierrez, A., Janda, K.D., Babior, B.M., Eschenmoser, A., Lerner, R.A., "Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation"
Science, 298, 2195 (2002)
246
Gao, C., Mao, S., Ditzel, H.J., Farnaes, L., Wirsching, P., Lerner, R.A., Janda, K.D., "A cell-penetrating peptide from a novel pVII-pIX phage-displyed random peptide library"
Bioorg. Med. Chem., 10, 4057 (2002)
245
Dickerson, T.J., Janda, K.D., "A previously undescribed chemical link between smoking and metabolic disease"
Proc. Nat. Acad. Sci. USA, 99, 15084 (2002)
244
Lee, K.J., Mao, S., Sun C., Gao, C., Blixt, O., Arrues, S., Hom, L.G., Kaufmann, G.F., Hoffman, T.Z., Coyle, A.R., Paulson, J., Felding-Habermann, B., Janda, K.D., "Phage-display selection of a human single-chain Fv antibody highly specific for melanoma and breast cancer cells using a chemoenzymatically synthesized GM3-carbohydrate antigen"
J. Am. Chem. Soc., 124, 12439 (2002)
243
Jones, L.H., Altobell III, L.J., MacDonald, M.T., Boyle, N.A., Wentworth, Jr., P., Lerner, R.A., Janda, K.D., "Active immunization with a glycolipid transition state analogue protects against endotoxic shock"
Angew. Chem. Int. Ed., 41, 4241 (2002)
242
Dickerson, T.J., Reed, N.N., Janda, K.D., "Soluble polymers as scaffolds for recoverable catalysts and reagents"
Chem. Rev., 102, 3325 (2002)
241
Gao, C., Mao, S., Kaufmann, G., Wirsching, P., Lerner, R.A., Janda, K.D., "A method for the generation of combinatorial antibody libraries using pIX phage display"
Proc. Nat. Acad. Sci. USA, 99, 12612 (2002)
240
Shimomura, O., Clapham, B., Spanka, C., Mahajan, S., Janda, K.D., "Application of microgels as polymer supports for organic synthesis: Preparation of a small phthalide library, a scavenger, and a borohydride reagent"
J. Comb. Chem., 4, 436 (2002)
239
Clapham, B., Lee, S.-H., Koch, G., Zimmermann, J., Janda, K.D., "The preparation of polymer bound Beta-ketoesters and their conversion into an array of oxazoles"
Tetrahedron Lett., 43, 5407 (2002)
238
Ahn, J.-M., Boyle, N.A., MacDonald, M.T., Janda, K.D., "Peptidomimetics and peptide backbone modifications"
Mini Reviews in Medicinal Chemistry, 2, 463 (2002)
237
Sun, C., Wirsching, P., Janda, K.D., "Syntheses of dendritic linkers containing chlorambucil residues for the preparation of antibody-multidrug immunoconjugates"
Bioorg. Med. Chem. Lett., 12, 2213 (2002)
236
Delgado, M., Janda, K.D., "Polymeric supports for solid phase organic synthesis"
Current Organic Chemistry, 6, 1031 (2002)
235
Reed, N.N., Delgado, M., Hereford, K., Clapham, B., Janda, K.D., "Preparation of soluble and insoluble polymer supported IBX reagents"
bioorg. Med. Chem. Lett., 12, 2047 (2002)
234
Janda, K.D., "(Preface) Polymer supported catalysts and reagents in synthetic organic chemistry"
Bioorg. Med. Chem. Lett., 12, vii (2002)
233
Spanka, C. Wentworth, Jr., P., Janda, K.D., "Developing soluble polymers for high-throughput synthetic chemistry"
Combinatorial Chemistry and High Throughput Screening, 5, 233 (2002)
232
Delgado, M., Lee, K.J., Altobell, III, L., Spanka, C., Wentworth, Jr., P., Janda, K.D., "A parallel approach to the discovery of carrier delivery vehicles to enhance antigen immunogenicity"
J. Am. Chem. Soc., 124, 4946 (2002)
231
Spanka, C., Clapham, B., Janda, K.D., "reparation of new microgel polymers and their application as supports in organic synthesis"
J. Org. Chem., 67, 3045 (2002)
230
Boyle, N.A., Janda, K.D., "Formats for combinatorial synthesis: solid-phase, liquid-phase and surface"
Current opinion in Chemical Biology, 6, 339 (2002)
229
Zhou, B., Wirsching, P., Janda, K.D., "Human antibodies against spores of the genus Bacillus: A model study for the detection of and protection against anthrax and the bioterrorist threat"
Proc. Nat. Acad. Sci., 99, 5421 (2002)
228
Isomura, S., Ashley, J.A., Wirsching, P., Janda, K.D., "Antibody-catalyzed cleavage of the D-Ala-D-Lac depsipeptide: An immunological approach to the problem of vancomycin resistance"
Bioorg. Med. Chem. Lett., 12, 861 (2002)
227
Reger, T.S., Janda, K.D., "Parallel suspension polymerization for high-throughput resin synthesis"
Biorg. Med. Chem., 12, 837 (2002)
226
Kim, G.-T., Wenz, M., Park, J.-I., Hasserodt, J., Janda, K.D., "Polyene substrates with unusual methylation patterns to probe the active sites of three catalytic antibodies"
Bioorg. Med. Chem., 10, 1249 (2002)
225
Isomura, S., Hoffman, T.Z., Wirsching, P., Janda, K.D., "Synthesis, properties, and reactivity of cocaine benzoylthio ester possessing the cocaine absolute configuration"
J. Amer. Chem. Soc., 124, 3661 (2002)
224
Dickerson, T.J., Janda, K.D., "Aqueous aldol catalysis by a nicotine metabolite"
J. Am. Chem. Soc., 124, 3220 (2002)
223
Nicholas, K.M., Wentworth, Jr., P., Harwig, C.W., Wentworth, A.D., Shafton, A., Janda, K.D., "A cofactor approach to copper-dependent catalytic antibodies"
Biomacromolecules, 99, 2648 (2002)
222
Delgado, M., Spanka, C., Kerwin, L.D., Wentworth, Jr., P., Janda, K.D., "A tunable hydrogel for encapsulation and controlled release of bioactive proteins"
Biomacromolecules, 3, 262 (2002)
221
Matsushita, M., Janda, K.D., "Histidine kinases as targets for new antimicrobial agents"
Bioorg. Med. Chem. Lett., 10, 855 (2002)
220
Moss, J.A., Dickerson, T.J., Janda, K.D., "Solid phase peptide synthesis on JandaJel resin"
Tetrahedron Lett., 43, 37 (2002)
219
Larsen, N.A., Zhou, b., Heine, a., Wirsching, P., Janda, K.D., Wilson, I.A., "Crystal structure of a cocaine-binding antibody"
J.Mol. Bio., 9, 311 (2001)
218
Wentworth Jr., P., Jones, L.H., Wentworth, A.D., Zhu, X., Larsen, N.A., Wilson, I.A., Xu, X., Goddard III, W.A., Janda, K.D., Eschenmoser, A., Lerner, R.A., "Antibody catalysis of the oxidation of water"
Science, 293, 1806 (2001)
217
Kozlov, I.A., Mao, S., Xu, Y., Huang, X., Lee, L., Sears, P.S., Gao, C., Coyle, A.R., Janda, K.D., Wong, C.-H., "Synthesis of solid-supported mirror-image sugars: A novel method for selecting receptors for cellular-surface carbohydrates"
ChemBioChem, 2, 741 (2001)
216
Brummer, O., Hoffman, T.Z., Janda, K.D., "Metalloantibodies: Mercury(II)-dependent acyl transferases"
Bioorg. Med. Chem., 9, 2253 (2001)
215
Chen, D.-W., Kubiak, R.J., Ashley, J.A., Janda, K.D., "Reactive immunization elicits catalytic antibodies for polyester hydrolysis"
J. Chem. Soc., Perkin Trans., 1, 2796 (2001)
214
Tremblay, M.R., Dickerson, T.J., Janda, K.D., "Advances in antibody catalysis of cycloaddition reactions"
Adv. Synth. Catal., 343, 577 (2001)
213
Cordova, A., Tremblay, M.R., Clapham, B., Janda, K.D., "A sequential application of kinetic resolution and polymer-supported scavenging for the isolation of chiral secondary alcohols"
J. Org. Chem., 66, 5645 (2001)
212
Clapham, B., Spanka, C., Janda, K.D., "Solid-phase rhodium carbenoid reactions: An N-H insertion route to a diverse series of oxazoles"
Org. Lett., 3, 2173 (2001)
211
Cordova, A., Janda, K.D., "Synthesis and catalytic antibody functionalization of dendrimers"
J. Am. Chem. Soc., 123, 8248 (2001)
210
Lee, K.J., Janda, K.D., "Traceless solid-phase synthesis of 5-Benzoylbenzimidazoles"
Can. J. Chem., 79, 1556 (2001)
209
Dickerson, T., Reed, N.N., Janda, K.D., "Regio-reactive resin: A platform for orthogonal loading using the polymer backbone and cross-linker"
Bioorg. Med. Chem. Lett., 11, 1507 (2001)
208
Isomura, S., Wirsching, P., Janda, K.D., "An immunotherapeutic program for the treatment of nicotine addiction: Hapten design and synthesis"
J. Org. Chem., 66, 4115 (2001)
207
Wentworth, P. Jr., Janda, K.D., "Catalytic antibodies: Structure and function"
Cell Biochem. Biophys., 35, 63 (2001)
206
Brummer, O., La Clair, J.J., Janda, K.D., "Practical screening of mercury contamination in fish tissues"
Bioorg. Med. Chem. Lett., 9, 1067 (2001)
205
Clapham, B., Reger, T.S., Janda, K.D., "Polymer-supported catalysis in synthetic organic chemistry"
Tetrahedron, 57, 4637 (2001)
204
Brummer, O., Clapham, B., Janda, K.D., "Solid-phase synthesis of oligoesters using a JandaJel resin"
Tetrahedron Letters, 42, 2257 (2001)
203
Jones, L.H., Harwig, C.W., Wentworth, P. Jr., Simeonov, A., Wentworth, A.D., Py, S., Ashley, J.A., Lerner, R.A., Janda, K.D., "Conversion of enediynes into quinones by antibody catalysis and in aqueous buffers: Implications for an alternative enediyne therapeutic mechanism"
J. Am. Chem. Soc., 123, 3607 (2001)
202
Wen, K., Han, H., Hoffman, T.Z., Janda, K.D., Orgel, L.E., "The synthesis of beta-peptides containing guanidino groups"
Bioorg. Med. Chem. Lett., 11, 689 (2001)
201
Cordova, A., Janda, K.D., "A highly chemo- and stereoselective synthesis of beta-keto esters via a polymer-supported lipase catalyzed transesterification"
J. Org. Chem., 66, 1906 (2001)
200
Chen, D.-W., Beuscher IV, A.E., Stevens, R.C., Wirsching, P., Lerner, R.A., Janda,K.D., "Preparation of stilbene-tethered nonnatural nucleosides for use with blue-fluorescent antibodies"
J. Org. Chem., 66, 1725 (2001)
199
Matsushita, M., Hoffman, T.Z., Ashley, J.A., Zhou, B., Wirsching, P., Janda, K.D., "Cocaine catalytic antibodies: The primary importance of linker effects"
Bioorg. Med. Chem. Lett., 11, 87 (2001)
198
Carrera, M.R.A., Ashley, J.A., Wirsching, P., Koob, G.F., Janda,K.D., "A second-generation vaccine protects against the psychoactive effects of cocaine"
Proc. Natl. Acad. Sci. USA, 98, 1988 (2001)
197
Clapham, B., Cho, C.-W., Janda, K.D., "A polymer-supported proline-based diamine catalyst for the kinetic resolution of racemic secondary alcohols"
J. Org. Chem., 66, 868 (2001)
196
Toy, P.H., Reger, T.S., Garibay, P., Garno, J.C., Malikayil, J.A., Liu, G.-Y., Janda, K.D., "Polytetrahydrofuran cross-linked polystyrene resins for solid-phase organic synthesis"
J. Comb. Chem., 3, 117 (2001)
195
Brummer, O., Hoffman, T.Z., Chen, D.-W., Janda, K.D., "Antibody-catalyzed hydrolysis of oligomeric esters: A model for the degradation of polymeric materials"
Chem. Commun., 1, 19 (2001)
194
Toy, P.H., Reger, T.S., Janda, K.D., "Tailoring polystyrene solid-phase synthesis resins: Incorporation of flexible cross-linkers"
Aldrichimica Acta, 33, 87 (2000)
193
Manzotti, R., Reger, T.S., Janda, K.D., "Improved synthesis of (4-ethenylphenyl)diphenyl methanol and its application in the preparation of trityl functionalized polystyrene resin containing tetrahydrofuran derived cross-linker"
Tetrahedron Letters, 41, 8417 (2000)
192
Lopez-Pelegrin, J.A., Wentworth, P. Jr., Sieber, F., Metz, W.A., Janda, K.D., "Soluble polymer-supported chemoenzymatic synthesis of the C21-C27 fragment of the Bryostatins"
J. Org. Chem., 65, 8527 (2000)
191
Tremblay, M.R., Wentworth, P. Jr., Lee, G.E. Jr., Janda, K.D., "Parallel solid-phase synthesis and structural characterization of a library of highly substituted chiral 1,3-oxazolidines"
J. Comb. Chem., 2, 698 (2000)
190
Sieber, F., Wentworth, P. Jr., Janda, K.D., "Exploiting poly(ethylene glycol) as a matrix for liquid-phase organic synthesis"
Molecules, 5, 1018 (2000)
189
Simeonov, A., Matsushita, M., Juban, E.A., Thompson, E.H.Z., Hoffman, T.Z., Beuscher IV, A.E., Taylor, M.J., Wirsching, P., Rettig, W., McCusker, J.K., Stevens, R.C., Millar, D.P., Schultz, P.G., Lerner, R.A., Janda, K.D., "Blue-fluorescent antibodies"
Science, 290, 307 (2000)
188
Wentworth, A.D., Jones, L.H., Wentworth, P. Jr., Janda, K.D., Lerner, R.A., "Antibodies have the intrinsic capacity to destroy antigens"
Proc. Natl. Acad. Sci. USA, 97, 10930 (2000)
187
Manzotti, R., Tang, S.-Y., Janda, K.D., "Improved synthesis of prostanoids on a non-cross-linked polystyrene soluble support"
Tetrahedron, 56, 7885 (2000)
186
Vaino, A.R., Janda, K.D., "Solid phase organic synthesis: A critical understanding of the resin"
J. Comb. Chem., 2, 579 (2000)
185
Wentworth, P. Jr., Janda, K.D., "A tool-box of polymer matrices for the combinatorial chemist / biotechnologist"
International Convention on Agriculture, Biotechnology and Chemistry; Rome, Italy, p. 211 (2000)
184
Manzotti, R., Janda, K.D., "Solid and liquid phase chemistry: Development of new supports for solid phase organic synthesis and for liquid phase chemistry"
Chimica Oggi/Chemistry Today, 18, 14 (2000)
183
Reed, N.N., Janda, K.D., "A one step synthesis of monoprotected polyethylene glycol ethers"
J. Org. Chem., 65, 5843 (2000)
182
Hasserodt, J., Janda, K.D., Lerner, R.A., "A class of 4-aza-lithocholic acid-derived haptens for the generation of catalytic antibodies with steroid synthase capabilities"
Bioorg. Med. Chem., 8, 995 (2000)
181
Harwig, C.W., Hoffman, T.Z., Wentworth, A.D., Janda, K.D., "A one-pot multistep approach to alpha-azido-phospohonate and phosphonothioate diesters: Key intermediates in the synthesis of haptens for the generation of antibody ligases"
Bioorg. Med. Chem. Lett., 10, 915 (2000)
180
Vaino, A.R., Goodin, D.B., Janda, K.D., "Investigating resins for solid phase organic synthesis: The relationship between swelling and microenvironment as probed by EPR and fluorescence spectroscopy"
J. Comb. Chem., 2, 330 (2000)
179
Janda, K.D., "New Directions in Immunopharmacotherapy""
In: The Role of Natural Products in Drug Discovery (Ernest Schering Research Foundation Workshop S32) eds., J. Mulzer, R. Bohlmann, Springer-Verlag, Berlin, Heidelberg, New York, (2000)
178
Vaino, A.R., Janda, K.D., "Euclidean shape-encoded combinatorial chemical libraries"
Proc. Natl. Acad. Sci. USA, 97, 7692 (2000)
177
Toy, P.H., Reger, T.S., Janda, K.D., "Soluble polymer bound cleavage reagents: A multipolymer strategy for the cleavage of tertiary amines from REM resin"
Org. Lett., 2, 2205 (2000)
176
Brummer, O., Clapham, B., Janda, K.D., "Recent developments and applications of polymer-supported reagents in synthetic organic chemistry"
Current Opinion in Drug Discovery & Dev., 3, 462 (2000)
175
Toy, P.H., Janda, K.D., "Soluble polymer-supported organic synthesis"
Acc. Chem. Res., 33, 546 (2000)
174
Reger, T.S., Janda, K.D., "Polymer-supported (Salen)Mn catalysts for asymmetric epoxidation: A comparison between soluble and insoluble matrices"
J. Am. Chem. Soc., 122, 6929 (2000)
173
Carrera, M.R.A., Ashley, J.A., Zhou, B., Wirsching, P., Koob, G.F., Janda, K.D., "Cocaine vaccines: Antibody protection against relapse in a rat model"
Proc. Natl. Acad. Sci. USA, 97, 6202 (2000)
172
Lopez-Pelegrin, J.A., Janda, K.D., "Solution- and soluble-polymer supported asymmetric syntheses of six-membered ring prostanoids"
Chem. Eur. J., 6, 1917 (2000)
171
Reed, N.N., Janda, K.D., "Stealth star polymers: A new high-loading scaffold for liquid-phase organic synthesis"
Org. Lett., 2, 1311 (2000)
170
Toker, J.D., Wentworth, P. Jr., Hu, Y., Houk, K.N., Janda, K.D., "Antibody catalysis of a bimolecular asymmetric 1,3-Dipolar cycloaddition reaction"
J. Am. Chem. Soc., 122, 3244 (2000)
169
Wentworth, A.D., Wentworth, P. Jr., Mansoor, F.U., Janda, K.D., "A soluble polymer-supported triflating reagent: A high-throughput synthetic approach to aryl and enol triflates"
Org. Lett., 2, 477 (2000)
168
Hasserodt, J., Janda, K.D., Lerner, R.A., "Antibodies mimic natural oxidosqualene-cyclase action in steroid ring A formation"
J. Am. Chem. Soc., 122, 40 (2000)
167
Sieber, F., Wentworth, P. Jr., Janda, K.D., "Exploring the scope of poly(ethylene glycol) (PEG) as a soluble matrix for the Stille cross-coupling reaction"
J. Comb. Chem., 1, 540 (1999)
166
Datta, A., Wentworth, P. Jr., Shaw, J.P., Simeonov, A., Janda, K.D., "Catalytically distinct antibodies prepared by the reactive immunization versus transition state analogue hapten manifolds"
J. Am. Chem. Soc., 121, 10461 (1999)
165
Lee, K.J., Angulo, A., Ghazal, P., Janda, K.D., "Soluble-polymer supported synthesis of a prostanoid library: Identification of antiviral activity"
Org. Lett., 1, 1859 (1999)
164
Wentworth, P. Jr., Janda, K.D., "Liquid-phase chemistry: Recent advances in soluble polymer-supported catalysts, reagents and synthesis"
Chem. Commun., 1917 (1999)
163
Cordova, A., Reed, N.N., Ashley, J.A., Janda, K.D., "Convenient synthesis of L-proline benzyl ester"
Bioorg. Med. Chem. Lett., 9, 3119 (1999)
162
Brummer, O., Wentworth, P. Jr., Weiner, D.P., Janda, K.D., "Phosphorodithioates: Synthesis and evaluation of new haptens for the generation of antibody acyl transferases"
Tetrahedron Letters, 40, 7307 (1999)
161
Brummer, O., Gao, C., Mao, S., Weiner, D.P., Janda, K.D., "Design, synthesis and characterization of panning agents for the selection of metalloantibodies"
Letters in Peptide Science, 6, 295 (1999)
160
Gao, C., Brummer, O., Mao, S., Janda, K.D., "Selection of human metalloantibodies from a combinatorial phage single-chain antibody library"
J. Am. Chem. Soc., 121, 6517 (1999)
159
Garibay, P., Toy, P.H., Hoeg-Jensen, T., Janda, K.D., "Application of a new solid-phase resin: Benzamide ortho-lithiation and the synthesis of a phthalide library"
Synlett, 9, 1438 (1999)
158
Toy, P.H., Janda, K.D., "New supports for solid-phase organic synthesis: Development of polystyrene resins containing tetrahydrofuran derived cross-linkers"
Tetrahedron Letters, 40, 6329 (1999)
157
Janda, K.D., Wentworth, A.D., "A merging of chemistry and biology in terms of antibody catalysis"
Phosphorus, Sulfur and Silicon, 144-146, 117 (1999)
156
Wentworth, P., Janda, K.D., "Antibody catalysis of phosphodiester hydrolysis: A survey of hapten strategies"
Phosphorus, Sulfur and Silicon, 144-146, 247 (1999)
155
Mao, S., Gao, C., Lo, C.-H.L., Wirsching, P., Wong, C.-H., Janda, K.D., "Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewis-x and Lewis-x"
Proc. Natl. Acad. Sci. USA, 96, 6953 (1999)
154
Sieber, F., Wentworth, P. Jr., Toker, J.D., Wentworth, A.D., Metz, W.A., Reed, N.N., Janda, K.D., "Development and application of a poly(ethylene glycol)-supported triarylphosphine reagent: Expanding the sphere of liquid-phase organic synthesis"
J. Org. Chem., 64, 5188 (1999)
153
Taylor, M.J., Yli-Kauhaluoma, J.T., Ashley, J.A., Wirsching, P., Lerner, R.A., Janda, K.D., "The alpha-ketoamide group: A new motif for the elicitation of catalytic antibodies for acyl-transfer reactions"
J. Chem. Soc., Perkin Trans., 1, 1133 (1999)
152
Gao, C., Mao, S., Lo, C.-H.L., Wirsching, P., Lerner, R.A., Janda, K.D., "Making artificial antibodies: A format for phage display of combinatorial heterodimeric arrays"
Proc. Natl. Acad. Sci. USA, 96, 6025 (1999)
151
Ashley, J.A., Lin, C.-H., Wirsching, P., Janda, K.D., "Monitoring chemical warfare agents: A new method for the detection of methylphosphonic acid"
Angew. Chem. Int. Ed., 38, 1793 (1999)
150
Brummer, O., La Clair, J.J., Janda, K.D., "A colorimetric ligand for mercuric ion"
Org. Lett., 1, 415 (1999)
149
Paschall, C.M., Hasserodt, J., Jones, T., Lerner, R.A., Janda, K.D., Christianson, D.W., "Convergence of catalytic antibody and terpene cyclase mechanisms: Polyene cyclization directed by carbocation-pi interactions"
Angew. Chem. Int. Ed., 38, 1743 (1999)
148
Spivak, D.A., Hoffman, T.Z., Moore, A.H., Taylor, M.J., Janda, K.D., "A comparison of flexible and constrained haptens in eliciting antibody catalysts for paraoxon hydrolysis"
Bioorg. Med. Chem., 7, 1145 (1999)
147
Han, H., Cho, C.-W., Janda, K.D., "A substrate-based methodology that allows the regioselective control of the catalytic aminohydroxylation reaction"
Chem. Eur. J., 5, 1565 (1999)
146
Wentworth, P. Jr., Janda, K.D., "Catalytic Antibodies"
In: Comprehensive Asymmetric Catalysis, eds., E.N. Jacobsen, A. Pfaltz, H. Yamamoto, Springer-Verlag, N.Y., Vol. III, p. 1403 (1999)
145
Han, H., Yoon, J., Janda, K.D., "Azatides as Peptidomimetics / Solution and Liquid Phase Syntheses"
In: Peptidomimetics Protocols, (Methods in Molecular Medicine series), ed. W.M. Kazmierski, Humana Press, Totowa, N.J., Vol. 23, p. 87 (1999)
144
Yoon, J., Han, H., Janda, K.D., "Solution and Soluble Polymer Syntheses of Azatides and Azapeptides"
In: Advances in Amino Acid Mimetics and Peptidomimetics, ed., A. Abell , JAI Press, Inc., Stamford, CT., Vol. 2, p. 247 (1999)
143
Harwig, C.W., Gravert, D.J., Janda, K.D., "Soluble polymers: New options in both traditional and combinatorial synthesis"
Org. Chem. Chemtracts, 12, 1 (1999)
142
Berg, T., Simeonov, A., Janda, K.D., "A combined parallel synthesis and screening of macrocyclic lanthanide complexes for the cleavage of phospho di- and triesters and double-stranded DNA"
J. Comb. Chem., 1, 96 (1999)
141
Zhao, X.-Y., Janda, K.D., "Soluble polymer traceless linker investigations: Solvent effects on the desulfonylation of polyethylene glycol (PEG) substituted aryl alkyl sulfones with sodium amalgam"
Bioorg. Med. Chem. Lett., 8, 2439 (1998)
140
Yoon, J., Cho, C.-W., Han, H., Janda, K.D., "Solution and soluble polymer synthesis of 3-aminoimidazoline-2,4-diones"
Chem. Commun., 2703 (1998)
139
Taylor, M.J., Hoffman, T.Z., Yli-Kauhaluoma, J.T., Lerner, R.A., Janda, K.D., "A light-activated antibody catalyst"
J. Am. Chem. Soc., 120, 12783 (1998)
138
Zhao, X.-Y., Metz, W.A., Sieber, F., Janda, K.D., "Expanding on the purification methodology of polyethylene glycol (PEG) bound molecules: The synthesis of 3,5-Pyrazolidinediones"
Tetrahedron Letters, 39, 8433 (1998)
137
Hori, M., Gravert, D.J., Wentworth, P. Jr., Janda, K.D., "Investigating highly crosslinked macroporous resins for solid phase synthesis"
Bioorg. Med. Chem. Lett., 8, 2363 (1998)
136
Gravert, D.J., Datta, A., Wentworth, P. Jr., Janda, K.D., "Soluble supports tailored for organic synthesis: Parallel polymer synthesis via sequential normal/living free radical processes"
J. Am. Chem. Soc., 120, 9481 (1998)
135
Wentworth, P. Jr., Liu, Y., Wentworth, A.D., Fan, P., Foley, M.J., Janda, K.D., "A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis"
Proc. Natl. Acad. Sci. USA, 95, 5971 (1998)
134
Lin, C.-H., Hoffman, T.Z., Xie, Y., Wirsching, P., Janda, K.D., "An antibody transesterase derived from reactive immunization that utilizes a wide variety of alcohol substrates"
Chem. Commun., 1075 (1998)
133
Lerner, R.A., Barbas III, C.F., Janda, K.D., "Making Enzymes, The Harvey Lectures"
Series 92, Wiley-Liss, Inc., p. 1 (1998)
132
Chen, S., Janda, K.D., "Total synthesis of naturally occurring prostaglandin F2-alpha on a non-cross-linked polystyrene support"
Tetrahedron Letters, 39, 3943 (1998)
131
Berg, T., Vandersteen, A.M., Janda, K.D., "High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal complexes"
Bioorg. Med. Chem. Lett., 8, 1221 (1998)
130
Yli-Kauhaluoma, J.T., Harwig, C.W., Wentworth, P. Jr., Janda, K.D., "Unexpected 1,3-oxazolidine formation in the attempted oxidation of N-aryl-N-methyl substituted Beta-amino alcohols using pyridinium dichromate"
Tetrahedron Letters, 39, 2269 (1998)
129
Gao, C., Lavey, B.J., Lo, C.-H.L., Datta, A., Wentworth, P. Jr., Janda, K.D., "Direct selection for catalysis from combinatorial antibody libraries using a boronic acid probe: Primary amide bond hydrolysis"
J. Am. Chem. Soc., 120, 2211 (1998)
128
Han, H., Yoon, J., Janda, K.D., "An efficient asymmetric route to 2,3-diaminobutanoic acids"
J. Org. Chem., 63, 2045 (1998)
127
Gravert, D.J., Janda, K.D., "Bifunctional initiators for free radical polymerization of non-crosslinked block copolymers"
Tetrahedron Letters, 39, 1513 (1998)
126
Heine, A., Stura, E.A., Yli-Kauhaluoma, J.T., Gao, C. Deng, Q., Beno, B.R., Houk, K.N., Janda, K.D., Wilson, I.A., "An antibody exo-Diels-Alderase inhibitor complex at 1.95 Angstrom resolution"
Science, 279, 1934 (1998)
125
Hori, M., Janda, K.D., "A soluble polymer approach to the "Fishing Out" principle: Synthesis and purification of Beta-Amino alcohols"
J. Org. Chem., 63, 889 (1998)
124
Wentworth, P. Jr., Janda, K.D., "Catalytic antibodies"
Current Opinion in Chemical Biology, 2, 138 (1998)
123
Han, H., Yoon, J., Janda, K.D., "Investigations of azapeptides as mimetics of leu-enkephalin"
Bioorg. Med. Chem. Lett, 8, 117 (1998)
122
Wentworth, P. Jr., Janda, K.D., "Generating and analyzing combinatorial chemistry libraries"
Current Opinion in Biotechnology, 9, 109 (1998)
121
Gravert, D.J., Janda, K.D., "Synthesis on soluble polymers: New reactions and the construction of small molecules"
Current Opinion in Chemical Biology, 1, 107 (1997)
120
Han, H., Vandersteen, A., Janda, K.D., "Combinatorics, Peptide Mimetics and Combizymes"
In: Peptides: Frontiers of Peptide Science (Proceedings of the 15th American Peptide Symposium) eds., J.P. Tam , T. Pravin, P. Kaumaya, Kluwer/Escom, Nashville, TN., p.22 (1997)
119
Janda, K.D., Gravert, D.J., "Organic reactions on soluble polymer supports as an alternative methodology for combinatorial solid-phase synthesis"
Biotechnology Internl., 169 (1997)
118
Gravert, D.J., Janda, K.D., "Soluble polyethylene glycol supports for liquid-phase combinatorial synthesis"
Drugs of the Future, 22, 1147 (1997)
117
Lin, C.-H., Hoffman, T.Z., Wirsching, P., Barbas III, C.F., Janda, K.D., Lerner, R.A., "On roads not taken in the evolution of protein catalysts: Antibody steroid isomerases that use an enamine mechanism"
Proc. Natl. Acad. Sci. USA, 94, 11773 (1997)
116
Gao, C., Lin, C.-H., Lo, C.-H.L., Mao, S., Wirsching, P., Lerner, R.A., Janda, K.D., "Making chemistry selectable by linking it to infectivity"
Proc. Natl. Acad. Sci. USA, 94, 11777 (1997)
115
Lo, C.-H.L., Wentworth, P. Jr., Jung, K.W., Yoon, J., Ashley, J.A., Janda, K.D., "Reactive immunization strategy generates antibodies with high catalytic proficiencies"
J. Am. Chem. Soc., 119, 10251 (1997)
114
Chen, S., Janda, K.D., "Synthesis of prostaglandin E2 methyl ester on a soluble-polymer support for the construction of prostanoid libraries"
J. Am. Chem. Soc., 119, 8724 (1997)
113
Hasserodt, J., Janda, K.D., Lerner, R.A., "Formation of bridge-methylated decalins by antibody-catalyzed tandem cationic cyclization"
J. Am. Chem. Soc., 119, 5993 (1997)
112
Hasserodt, J., Janda, K.D., "Syntheses of octahydroquinoline-N-oxides: Haptens designed to elicit catalytic antibodies that control a terpenoid-like cascade cyclization"
Tetrahedron, 53, 11237 (1997)
111
Han, H., Janda, K.D., "Multipolymer-supported substrate and ligand approach to the Sharpless asymmetric dihydroxylation,"
Angew. Chem. Int. Ed., 36, 1731 (1997)
110
Zhao, X.-Y., Janda, K.D., "Syntheses of alkylated malonates on a traceless linker derived soluble polymer support"
Tetrahedron Letters, 38, 5437 (1997)
109
Wentworth, P. Jr., Janda, K.D., "Synthesis of oxorhenium (V) and oxotechnetium (V) complexes as inhibitors of ribonucleases and for the generation of catalytic antibodies"
Synlett, 5, 537 (1997)
108
Gravert, D.J., Janda, K.D., "Organic synthesis on soluble polymer supports: Liquid-phase methodologies"
Chemical Reviews, 97, 489 (1997)
107
Jung, K.W., Zhao, X.-Y., Janda, K.D., "Development of new linkers for the formation of aliphatic C-H bonds on polymeric supports"
Tetrahedron, 53, 6645 (1997)
106
Weiner, D.P., Wiemann, T., Wolfe, M.M., Wentworth, P. Jr., Janda, K.D., "A pentacoordinate oxorhenium (V) metallochelate elicits antibody catalysts for phosphodiester cleavage"
J. Am. Chem. Soc., 119, 4088 (1997)
105
Wentworth, P. Jr., Vandersteen, A.M., Janda, K.D., "Poly(ethylene glycol) (PEG) as a reagent support: The preparation and utility of PEG-triarylphosphine conjugate in liquid-phase organic synthesis (LPOS)"
Chem. Commun., 759 (1997)
104
Janda, K.D., A Book Review on, "Combinatorial Peptide and Nonpeptide Libraries : A Handbook by G. Jung, pub: VCH (1996)"
J. Amer. Chem. Soc., 119, 3848 (1997)
103
Han, H., Janda, K.D., "A soluble polymer-bound approach to the Sharpless catalytic asymmetric dihydroxylation (AD) reaction: Preparation and application of a [(DHQD)2 PHAL-PEG-OMe] ligand"
Tetrahedron Letters, 38, 1527 (1997)
102
Li, T., Lerner, R.A., Janda, K.D., "Antibody-catalyzed cationic reactions: The rerouting of chemical transformations via antibody catalysis"
Acc. Chem. Res., 30, 115 (1997)
101
Zhao, X.-Y., Jung, K.W., Janda, K.D., "Soluble polymer synthesis: An improved traceless linker methodology for aliphatic C-H bond formation"
Tetrahedron Letters, 38, 977 (1997)
100
Janda, K.D., Lo, L.-C., Lo, C.-H.L., Sim, M.-M., Wang, R., Wong, C.-H., Lerner, R.A., "Chemical selection for catalysis in combinatorial antibody libraries"
Science, 275, 945 (1997)
99
Gravert, D.J., Janda, K.D., "Organic Reactions on Soluble Polymer Supports as an Alternative Methodology for Combinatorial Solid-Phase Synthesis"
In: Biotechnology International , eds., T.H. Connor, and R.J. Hairi, (1997)
98
Wentworth, P. Jr., Wiemann, T., Janda, K.D., "A new class of pentacoordinate ribonuclease inhibitors: Synthesis, characterization and inhibition studies of ribonucleoside and anhydropentofuranose oxorhenium (V) complexes"
J. Am. Chem. Soc., 118, 12521 (1996)
97
Hasserodt, J., Janda, K.D., Lerner, R.A., "Antibody catalyzed terpenoid cyclization"
J. Am. Chem. Soc., 118, 11654 (1996)
96
Lo, C.-H.L., Gao, C., Mao, S., Matsui, K., Janda, K.D., "Chain shuffling: Investigations into the specificity and selectivity of antibody catalysis"
Israel Journal of Chemistry, 36, 195 (1996)
95
Vandersteen, A.M., Han, H., Janda, K.D., "Liquid phase combinatorial synthesis: In search of small-molecule enzyme mimics"
Molecular Diversity, 2, 89 (1996)
94
Vandersteen, A.M., Janda, K. D., "A re-examination of two linear pentapeptides claimed to be serine protease mimics"
J. Am. Chem. Soc., 118, 8787 (1996)
93
Lavey, B.J., Janda, K.D., "Catalytic antibody mediated hydrolysis of paraoxon"
J. Org. Chem., 61, 7633 (1996)
92
Wentworth, P. Jr., Janda, K.D., "A facile and efficient route to 3',5'-diamino-3',5'-dideoxynucleosides"
Chem. Commun., 2097 (1996)
91
Sakurai, M., Wirsching, P., Janda, K.D., "Design and synthesis of a cocaine-diamide hapten for vaccine development"
Tetrahedron Letters, 37, 5479 (1996)
90
Janda, K.D., Shevlin, C.G., Lo, C.-H.L., "Catalytic Antibodies: Chemical and Biological Approaches"
In: Comprehensive Supramolecular Chemistry, eds., J.M. Lehn, J.C. Atwood, J.E.D. Davies, D.D. MacNicol, F. Vogtle, Pergamon, UK, USA, Vol. 4, p. 43 (1996)
89
Han, H., Yoon, J., Janda, K.D., "Azatides: Solution and Liquid phase Syntheses"
In: Peptidomimetics, Methods in Molecular Biology series, Humana Press, Inc., eds. W.M. Kazmierski, (1996)
88
Jung, K.W., Sanfilippo, P.J., Wachter, M., Janda, K.D., "Syntheses and biological evaluation of two new naproxen analogs"
Bioorg. Med. Chem. Lett., 6, 2281 (1996)
87
Lo, L.-C., Lo, C.-H.L., Kassel, D.B., Raushel, F.M., Janda, K.D., "A versatile mechanism based reaction probe for the direct selection of biocatalysis"
Bioorg. & Med. Chem. Lett., 6, 2117 (1996)
86
Jung, K.W., Zhao, X.-Y., Janda, K.D., "A linker that allows efficient formation of aliphatic C-H bonds on polymeric supports"
Tetrahedron Letters, 37, 6491 (1996)
85
Yli-Kauhaluoma, J.T., Janda, K.D., "Catalytic antibodies: The rerouting of chemical reactions towards electrophilic aromatic substitution by carbon dioxide"
N.Y. Academy of Sciences, 799, 26 (1996)
84
Lavey, B.J., Janda, K.D., "Antibody catalyzed hydrolysis of a phosphotriester"
Bioorg. Med. Chem. Lett., 6, 1523 (1996)
83
Han, H., Janda, K.D., "Soluble polymer-bound ligand-accelerated catalysis: Asymmetric dihydroxylation"
J. Am. Chem. Soc., 118, 7632 (1996)
82
Janda, K.D., Han, H., "Combinatorial Chemistry: A Liquid-Phase Approach"
In: Methods in Enzymology, eds., J.N. Abelson, Academic Press, San Diego/London, Vol. 267, p. 234 (1996)
81
Gravert, D.J., Janda, K.D., "Liquid-Phase Combinatorial Synthesis"
In: Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery, eds., I.M. Chaiken and K.D. Janda, A.C.S. Conference Proceedings, Chapter 11, p. 118 (1996)
80
Yli-Kauhaluoma, J.T., Ashley, J.A., Lo, C.-H.L., Coakley, J., Wirsching, P., Janda, K.D., "Catalytic antibodies with peptidyl-prolyl cis-trans isomerase activity"
J. Am. Chem. Soc., 118, 5496 (1996)
79
Sakurai, M., Wirsching, P., Janda, K.D., "Synthesis of a nucleoside hapten with a [P(O)-O-N] linkage to elicit catalytic antibodies with phosphodiesterase activity"
Bioorg. Med. Chem. Lett., 6, 1055 (1996)
78
Gravert, D.J., Janda, K.D., "Developing small molecule libraries for drug discovery"
Trends in Biotechnology (TIBTECH), 14, 110 (1996)
77
Han, H., Janda, K.D., "Azatides: Solution and liquid phase syntheses of a new peptidomimetic"
J. Am. Chem. Soc., 118, 2539 (1996)
76
Li, T., Janda, K.D., Lerner, R.A., "Cationic cyclopropanation by antibody catalysis"
Nature, 379, 326 (1996)
75
Carrera, M.R.A., Ashley, J.A., Parsons, L.H., Wirsching, P., Koob, G.F., Janda, K.D., "Suppression of psychoactive effects of cocaine by active immunization"
Nature, 378, 727 (1995)
74
Wirsching, P., Ashley, J.A., Lo, C.-H.L., Janda, K.D., Lerner, R.A., "Reactive immunization"
Science, 270, 1775 (1995)
73
Lerner, R.A., Janda, K.D., "Catalytic Antibodies: Evolution of Protein Function in Real Time"
In: Interface Between Chemistry and Biology eds., P. Jolles and H. Jornvall, Verlag, Berlin, p.121 (1995)
72
Rosenblum, J.S., Lo, L.-C., Li, T., Janda, K.D., Lerner, R.A., "Antibody catalyzed phosphate triester hydrolysis"
Angew. Chem. Int. Ed. Engl., 34, 2275 (1995)
71
Li, T., Janda, K.D., "Synthesis of a bifunctional hapten designed to mimic both transition state and to induce "bait and switch" catalysis"
Bio. Med. Chem. Lett., 5, 2001 (1995)
70
Lavey, B.J., Janda, K.D., "Applying Antibody Catalysis to Organic Synthesis"
In: Antibody Expression and Engineering, ACS Symposium Series 604, eds., H.Y. Wang, T. Imanaka, Chapter 10, p.123 (1995)
69
Yli-Kauhaluoma, J.T., Ashley, J.A., Lo, C.-H., Tucker, L., Wolfe, M.M., Janda, K.D., "Anti-metallocene antibodies: A new approach to enantioselective catalysis of the Diels-Alder reaction"
J. Am. Chem. Soc., 117, 7041 (1995)
68
Han, H., Wolfe, M.M., Brenner, S., Janda, K.D., "Liquid-phase combinatorial synthesis"
Proc. Natl. Acad. Sci. USA, 92, 6419 (1995)
67
Janda, K.D., "Drug discovery and delivery: Exploiting biological diversity, libraries and mutations for research and drug development"
Molecular Medicine Today, 1, 4 (1995)
66
Li, T., Hilton, S., Janda, K.D., "Remarkable ability of different antibody catalysts to control and diversify the product outcome of cationic cyclization reactions"
J. Am. Chem. Soc., 117, 3308 (1995)
65
Janda, K.D., Shevlin, C.G., Lerner, R.A., "Oxepane synthesis along a disfavored pathway: The rerouting of a chemical reaction using a catalytic antibody"
J. Am. Chem. Soc., 117, 2659 (1995)
64
Li, T., Janda, K.D., Hilton, S., Lerner, R.A., "An antibody-catalyzed nucelophilic substitution reaction at a primary carbon that appears to proceed by an ionization mechanism"
J. Am. Chem. Soc., 117, 2367 (1995)
63
Fenniri, H., Janda, K.D., Lerner, R.A., "Encoded reaction cassette for the highly sensitive detection of the making and breaking of chemical bonds"
Proc. Natl. Acad. Sci. USA, 92, 2278 (1995)
62
Li, T., Hilton, S., Janda, K.D., "The potential application of catalytic antibodies to protecting group removal: Catalytic antibodies with broad substrate tolerance"
J. Am. Chem. Soc., 117, 2123 (1995)
61
Janda, K.D., "Tagged versus untagged libraries: Methods for the generation and screening of combinatorial libraries"
Proc. Natl. Acad. Sci. USA, 91, 10779 (1994)
60
Erb, E., Janda, K.D., Brenner, S., "Recursive deconvolution of combinatorial chemical libraries"
Proc. Natl. Acad. Sci. USA, 91, 11422 (1994)
59
Janda, K.D., "Catalytic antibodies and enzyme inhibitors"
Pure & Appl. Chem., 66, 703 (1994)
58
Cravatt, B.F., Ashley, J.A., Janda, K.D., Boger, D.L., Lerner, R.A., "Crossing extreme mechanistic barriers by antibody catalysis: Syn elimination to a cis olefin"
J. Am. Chem. Soc., 116, 6013 (1994)
57
Yli-Kauhaluoma, J., Janda, K.D., "An expedient synthesis of isopropyl anisoles and veratroles"
Tetrahedron Letters, 35, 4509 (1994)
56
Li, T., Janda, K.D., Ashley, J.A., Lerner, R.A., "Antibody catalyzed cationic cyclization"
Science, 264, 1289 (1994)
55
Yli-Kauhaluoma, J., Janda, K.D., "Twisted alpha-keto amides as transition-state analogues for acyl-transfer reactions: Synthesis of the immunoconjugates"
Bioorg. Med. Chem., 2, 521 (1994)
54
Nielsen, J., Janda, K.D., "Toward chemical implementation of encoded combinatorial libraries"
Methods, 6, 361 (1994)
53
Janda, K.D., Lo, C.-H.L., Li, T., Barbas III, C.F., Wirsching, P., Lerner, R.A., "Direct selection for a catalytic mechanism from combinatorial antibody libraries"
Proc. Natl. Acad. Sci. USA, 91, 2532 (1994)
52
Shevlin, C.G., Hilton, S., Janda, K.D., "Automation of antibody catalysis: A practical methodology for the use of catalytic antibodies in organic synthesis"
Bioorg. Med. Chem. Lett., 4, 297 (1994)
51
Janda, K.D., Chen, Y.-C.J., "Chemical and Biological Approaches to Catalytic Antibodies"
In: Handbook of Experimental Pharmacology : The Pharmacology of Monoclonal Antibodies, eds. M. Rosenberg and G. Moore, Vol. 113, pp. 209-241 (1994)
50
Gouverneur, V.E., Houk, K.N., de Pascual-Teresa, B., Beno, B., Janda, K.D., Lerner, R.A., "Control of the exo and endo pathways of the Diels-Alder reaction by antibody catalysis"
Science, 262, 204 (1993)
49
Janda, K.D., "Catalytic antibodies: The rerouting of chemical reactions"
Biochem. Soc. Trans., 21, 1090 (1993)
48
Nielsen, J., Brenner, S., Janda, K.D., "Synthetic methods for the implementation of encoded combinatorial chemistry"
J. Am. Chem. Soc., 115, 9812 (1993)
47
Na, J., Houk, K.N., Shevlin, C.G., Janda, K.D., Lerner, R.A., "The energetic advantage of 5-exo versus 6-endo epoxide openings: A preference overwhelmed by antibody catalysis"
J. Am. Chem. Soc., 115, 8453 (1993)
46
Wade, W.S., Ashley, J.A., Jahangiri, G.K., McElhaney, G., Janda, K.D., Lerner, R.A., "A highly specific metal-activated catalytic antibody"
J. Am. Chem. Soc., 115, 4906 (1993)
45
Ashley, J.A., Lo, C.-H.L., McElhaney, G., Wirsching, P., Janda, K.D., "A catalytic antibody model for PLP-dependent decarboxylases"
J. Am. Chem. Soc, 115, 2515 (1993)
44
Janda, K.D., Book Review on, "Studies in Organic Chemistry 46. Biocatalysts in Organic Synthesis by J. Halgas, pub: Elsevier (1992)"
J. Am. Chem. Soc., 115, 8888 (1993)
43
Ikeda, S., Janda, K.D., " Recent development on the research of catalytic antibodies and their applications"
J. Synth. Org. Chem., (Japan), 51, 284 (1993)
42
Chen, Y.-C.J., Danon, T., Sastry, L., Mubaraki, M., Janda, K.D., Lerner, R.A., "Catalytic antibodies from combinatorial libraries"
J. Am. Chem. Soc., 115, 357 (1993)
41
Janda, K.D., Shevlin, C.G., Lerner, R.A., "Antibody catalysis of a disfavored chemical transformation"
Science, 259, 490 (1993)
40
Weinhouse, M.I., Janda, K.D., "A new methodology for the preparation of vinyl esters"
Synthesis, 1, 81 (1993)
39
Gibbs, R.A., Benkovic, P.A., Janda, K.D., Lerner, R.A., Benkovic, S.J., "Substituent effects on an antibody-catalyzed hydrolysis of phenyl esters; further evidence for an acyl intermediate"
J. Am. Chem. Soc., 114, 3528 (1992)
38
Fernholz, E., Schloeder, D., Liu, K.-K.C., Bradshaw, C.W., Huang, H., Janda, K.D., Lerner, R.A., Wong, C.-H., "Specificity of antibody-catalyzed transesterifications using enol esters: A comparison with lipase reactions"
J. Org. Chem., 57, 4756 (1992)
37
Ashley, J.A., Janda, K.D., "Antibody catalysis in low water content media"
J. Org. Chem., 57, 6691 (1992)
36
Ikeda, S., Ashley, J.A., Wirsching, P., Janda, K.D., "Psi [PO2-CH2N+] A new amide bond replacement: Potent, slow-binding inhibition of the HIV-Protease"
J. Am. Chem. Soc., 114, 7604 (1992)
35
Reymond, J.-L., Janda, K.D., Lerner, R.A., "Highly enantioselective protonation catalyzed by an antibody"
J. Am. Chem. Soc., 114, 2257 (1992)
34
Chen, Y.-C.J., Janda, K.D., "A new approach toward the inhibition of ribonucleases: A water stable ribonucleoside-technetium chelate"
J. Am. Chem. Soc., 114, 1488 (1992)
33
Sastry, L., Mubaraki, M., Janda, K.D., Benkovic, S.J., Lerner, R.A., "Screening combinatorial antibody libraries for catalytic acyl transfer reactions"
Ciba Foundation Symposium, 159, 145 (1991)
32
Benkovic, S.J., Adams, J., Janda, K.D., Lerner, R.A., "A catalytic antibody uses a multistep kinetic sequence"
Ciba Foundation Symposium, 159, 9 (1991)
31
McLeod, D.A., Brinkworth, R.I., Ashley, J.A., Janda, K.D., Wirsching, P., "Phosphonamidates and phosphonamidate esters as HIV-1 protease inhibitors"
Bioorg. Med. Chem. Lett., 1, 653 (1991)
30
Hein, M.B., Tang, Y., McLeod, D.A., Janda, K.D., Hiatt, A., "Evaluation of immunoglobulins from plant cells"
Biotechnol. Prog., 7, 455 (1991)
29
Reymond, J.-L., Janda, K.D., Lerner, R.A., "Antibody catalysis of glycosidic bond hydrolysis"
Angew. Chem. Int. Ed. Engl., 30, 1711 (1991)
28
Harada, A., Janda, K.D., Lerner, R.A., "Abzymes to enzymes"
Kagaku to Kogyo (Japan), 44, 1108 (1991)
27
Fujii, I., Lerner, R.A., Janda, K.D., "Enantiofacial protonation by catalytic antibodies"
J. Am. Chem. Soc., 113, 8528 (1991)
26
Ikeda, S., Weinhouse, M.I., Janda, K.D., Lerner, R.A., Danishefsky, S.J., "Asymmetric induction via a catalytic antibody"
J. Am. Chem. Soc., 113, 7763 (1991)
25
Janda, K.D., Weinhouse, M.I., Danon, T., Pacelli, K.A., Schloeder, D.M., "Antibody bait and switch catalysis: A survey of antigens capable of inducing abzymes with acyl-transfer properties"
J. Am. Chem. Soc., 113, 5427 (1991)
24
Kang, A.S., Barbas, C.F., Janda, K.D., Benkovic, S.J., Lerner, R.A., "Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces"
Proc. Natl. Acad. Sci. USA, 88, 4363 (1991)
23
Chen, Y.-C.J., Hansske, F., Janda, K.D., Robbins, M.J., "Nucleic acid related compounds. 64. Synthesis of 2',3'-diazido-2',3'-dideoxyadenosine and 2',3'-diamino-2',3'-dideoxyadenosine from 9-(-Beta-D-Arabinofuranosyl) adenine"
J. Org. Chem., 56, 3410 (1991)
22
Wirsching, P., Ashley, J.A., Benkovic, S.J., Janda, K.D., Lerner, R.A., "An unexpectedly efficient catalytic antibody operating by ping-pong and induced fit mechanisms"
Science, 252, 680 (1991)
21
Janda, K., "Opportunities in organic synthesis for catalytic antibodies"
Proceedings of 15th ABC Symposium: Kyoto, Japan, 3, 63 (1991)
20
Janda, K.D., Benkovic, S.J., McLeod, D.A., Schloeder, D.M., Lerner, R.A., "Substrate attenuation: An approach to improve antibody catalysis"
Tetrahedron, 47, 2503 (1991)
19
Janda, K.D., Ashley, J.A., Jones, T.M., McLeod, D.A., Schloeder, D.M., Weinhouse, M.I., Lerner, R.A., Gibbs, R.A., Benkovic, P.A., Hilhorst, R., Benkovic, S.J., "Catalytic antibodies with acyl-transfer capabilities: Mechanistic and kinetic investigations"
J. Am. Chem. Soc., 113, 291 (1991)
18
Janda, K.D., Ashley, J.A., Jones, T.M., McLeod, D.A., Schloeder, D.M., Weinhouse, M.I., "Immobilized catalytic antibodies in aqueous and organic solvents"
J. Am. Chem. Soc., 112, 8886 (1990)
17
Benkovic, S.J., Adams, J.A., Borders, C.L. Jr., Janda, K.D., Lerner, R.A., "The enzymic nature of antibody catalysis: Development of multistep kinetic processing"
Science, 250, 1135 (1990)
16
Janda, K.D., "New strategies for the design of catalytic antibodies"
Biotechnol. Prog., 6, 178 (1990)
15
Janda, K.D., Ashley, J.A., "Syntheses of the saturated analogues of 4-nitrophenol and 4-nitroaniline"
Synth. Commun., 20, 1073 (1990)
14
Janda, K.D., Weinhouse, M.I., Schloeder, D.M., Lerner, R.A., "Bait and switch strategy for obtaining catalytic antibodies with acyl-transfer capabilities"
J. Am. Chem. Soc., 112, 1274 (1990)
13
Janda, K.D., Benkovic, S.J., Lerner, R.A., "Catalytic antibodies with lipase activity and R and S substrate selectivity"
Science, 244, 437 (1989)
12
Sastry, L., Alting-Mees, M., Huse, W.D., Short, J.M., Sorge, J.A., Hay, B.N., Janda, K.D., Benkovic, S.J., Lerner, R.A., "Cloning of the immunological repertoire in E. coli for generation of monoclonal catalytic antibodies: Construction of a heavy chain variable region-specific cDNA library"
Proc. Natl. Acad. Sci. USA, 86, 5728 (1989)
11
Janda, K.D., Schloeder, D., Benkovic, S.J., Lerner, R.A., "Induction of an antibody that catalyzes the hydrolysis of an amide bond"
Science, 241, 1188 (1988)
10
Janda, K.D., Lerner, R.A., Tramontano, A., "Antibody catalysis of bimolecular amide formation"
J. Am. Chem. Soc., 110, 4835 (1988)
9
Tramontano, A., Janda, K.D., Napper, A.D., Benkovic, S.J., Lerner, R.A., "Catalytic antibodies"
Cold Spring Harbor Symp., Quant. Biol., 52, 91 (1987)
8
Tramontano, A., Janda, K.D., Lerner, R.A., "Catalytic antibodies"
Science, 234, 1566 (1986)
7
Tramontano, A., Janda, K.D., Lerner, R.A., "Chemical reactivity at an antibody binding site elicited by mechanistic design of a synthetic antigen"
Proc. Natl. Acad. Sci. USA, 83, 6736 (1986)
6
Bates, R.B., Janda, K.D., Wright, M.E., "N-Isobutyrylbenzamide, C11H13NO2"
Acta. Cryst., C41, 263 (1985)
5
Bates, R.B., Janda, K.D., "A convenient synthesis of alpha-acyl amino alcohols from azlactones"
Synthesis, 4, 310 (1984)
4
Bates, R.B., Fletcher, F.A., Janda, K.D., Miller, W.A., "A convenient synthesis of unsymmetrical acyclic imides"
J. Org. Chem., 49, 3038 (1984)
3
Bates, R.B., Gin, S.L., Hassen, M.A., Hruby, V.J., Janda, K.D., Kriek, G.R., Michaud, J.-P., Vine, D.B., "Synthesis of Cyclo-N-Methyl-L-Tyr-N-Methyl-L-Tyr-D-Ala-L-Ala-O,N-Dimethyl-L-Tyr-L-Ala, a cyclic hexapeptide related to the anti-tumor agent deoxybouvardin"
Heterocycles, 22, 785 (1984)
2
Janda, K.D., McConnell, W.W., Nelson, G.O., Wright, M.E., "Preparation and reactivity of the new cyclopentadienyl-bridged complex (Me2SiCH2CH2SiMe2) (C5H4Fe(CO)2)2"
J. Organomet. Chem., 259, 139 (1983)
1
Bates, R.B., Janda, K.D., "High-yield benzyne synthesis of diaryl ethers"
J. Org. Chem., 47, 4374 (1982)