Lars Hangartner, Ph.D.


Associate Professor of Immunology
Department of Immunology & Microbiology
The Scripps Research Institute


B.A., Molecular Biology, University of Zurich, Switzerland, 1991

Ph.D., Immunology, Swiss Federal Institute of Technology, Zurich, Switzerland, 2002


2015-present  Associate Professor of Immunology, Department of Immunology & Microbial Science, TSRI

2009-2015  Assistant Professor, Institute of Medical Virology, University of Zurich, Zurich, Switzerland

2009  Junior Group Leader, Institute of Medical Virology, University of Zurich, Zurich, Switzerland

2005-2008  Postdoctoral Fellow/Senior Research Associate, Department of Immunology & Microbial Science, TSRI

2002-2005  Postdoctoral Fellow, Institute of Immunology, University Hospital of Zurich, Switzerland


Bianchi, M., Turner, H. L., Nogal, B., Cottrell, C. A., Oyen, D., Pauthner, M., Bastidas, R., Nedellec, R., McCoy, L. E., Wilson, I. A., Burton, D. R. Electron-microscopy-based epitope mapping defines specificities of polyclonal antibodies elicited during HIV-1 BG505 envelope trimer immunization. Immunity. 2018 49:288-300.

Maurer, M. A., Meyer, L., Bianchi, M., Turner, H. L., Le, N. P. L., Steck, M., Wyrzucki, A., Orlowski, V., Ward, A. B., Crispin, M., Hangartner, L. Glycosylation of human IgA directly inhibits influenza A and other sialic-acid-binding viruses. Cell Reports. 2018 23:90-99

Burton, D. R., Hangartner, L. Broadly neutralizing antibodies to HIV and their role in vaccine design. Annual Review of Immunology. 2016 34:635-659

Wyrzucki, A., Bianchi, M., Kohler, I., Steck, M., Hangartner, L. Heterosubtypic antibodies to influenza A virus have limited activity against cell-bound virus but are not impaired by strain-specific serum antibodies. Journal of Virology. 2015 89:3136-3144

Kohler, I., Kouyos, R., Bianchi, M., Grube, C., Wyrzucki, A., Gunthard, H. F., Hangartner, L. The impact of vaccination on the breadth and magnitude of the antibody response to influenza A viruses in HIV-infected individuals. AIDS. 2015 29:1803-1810

Wyrzucki, A., Dreyfus, C., Kohler, I., Steck, M., Wilson, I. A., Hangartner, L. Alternative recognition of the conserved stem epitope in influenza A virus hemagglutinin by a VH3-30-encoded heterosubtypic antibody. Journal of Virology. 2014 88:7083-7092

Kohler, I., Scherrer, A. U., Zagordi, O., Bianchi, M., Wyrzucki, A., Steck, M., Ledergerber, B., Gunthard, H. F., Hangartner, L. Prevalence and predictors for homo- and heterosubtypic antibodies against influenza A virus. Clinical Infectious Diseases. 2014 59:1386-1393

Hoot, S., McGuire, A. T., Cohen, K. W., Strong, R. K., Hangartner, L., Klein, F., Diskin, R., Scheid, J. F., Sather, D. N., Burton, D. R., Stamatatos, L. Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs. PLoS Pathogens. 2013 9:e1003106

Ota, T., Doyle-Cooper, C., Cooper, A. B., Huber, M., Falkowska, E., Doores, K. J., Hangartner, L., Le, K., Sok, D., Jardine, J., Lifson, J., Wu, X. L., et al. Anti-HIV B Cell lines as candidate vaccine biosensors. Journal of Immunology. 2012 189:4816-4824

Hessell, A. J., Rakasz, E. G., Poignard, P., Hangartner, L., Landucci, G., Forthal, D. N., Koff, W. C., Watkins, D. I., Burton, D. R. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Pathogens. 2009 5:e1000433

Hessell, A. J., Poignard, P., Hunter, M., Tehrani, D. M., Bleeker, W. K., Parren, Pwhi, Marx, P. A., Burton, D. R., Hangartner, L. Effective, low-titer antibody protection against low-dose repeated mucosal shiv challenge in macaques. Nature Medicine. 2009 15:951-954

Geuking, M. B., Weber, J., Dewannieux, M., Gorelik, E., Heidmann, T., Hengartner, H., Zinkernagel, R. M., Hangartner, L. Recombination of retrotransposon and exogenous RNA virus results in nonretroviral cDNA integration. Science. 2009 323:393-396

Schildknecht, A., Welti, S., Geuking, M. B., Hangartner, L., van den Broek, M. Absence of CTL responses to early viral antigens facilitates viral persistence. Journal of Immunology. 2008 180:3113-3121

Law, M., Hangartner, L. Antibodies against viruses: passive and active immunization. Current Opinion in Immunology. 2008 20:486-492

Zuniga, A., Wang, Z., Liniger, M., Hangartner, L., Caballero, M., Pavlovic, J., Wild, P., Viret, J. F., Glueck, R., Billeter, M. A., Naim, H. Y. Attenuated measles virus as a vaccine vector. Vaccine. 2007 25:2974-2983

Recher, M., Lang, K. S., Navarini, A., Hunziker, L., Lang, P. A., Fink, K., Freigang, S., Georgiev, P., Hangartner, L., Zellweger, R., Bergthaler, A., Hegazy, A. N., et al. Extralymphatic virus sanctuaries as a consequence of potent T-cell activation. Nature Medicine. 2007 13:1316-1323

Hessell, A. J., Hangartner, L., Hunter, M., Havenith, C. E. G., Beurskens, F. J., Bakker, J. M., Lanigan, C. M. S., Landucci, G., Forthal, D. N., Parren, Pwhi, Marx, P. A., Burton, D. R. Fc receptor but not complement binding is important in antibody protection against HIV. Nature. 2007 449:101-104

Hangartner, L., Zinkernagel, R. M., Hengartner, H. Antiviral antibody responses: the two extremes of a wide spectrum. Nature Reviews Immunology. 2006 6:231-243

McCoy, K. D., Harris, N. L., Diener, P., Hatak, S., Odermatt, B., Hangartner, L., Senn, B. M., Marsland, B. J., Geuking, M. B., Hengartner, H., Macpherson, A. J. S., Zinkernagel, R. M. Natural IgE production in the absence of MHC class II cognate help. Immunity. 2006 24:329-339

Hangartner, L., Zellweger, R. M., Giobbi, M., Weber, J., Eschli, B., McCoy, K. D., Harris, N., Recher, M., Zinkernagel, R. M., Hengartner, H. Nonneutralizing antibodies binding to the surface glycoprotein of lymphocytic choriomeningitis virus reduce early virus spread. Journal of Experimental Medicine. 2006 203:2033-2042

Zellweger, R. M., Hangartner, L., Weber, J., Zinkernagel, R. M., Hengartner, H. Parameters governing exhaustion of rare T cell-independent neutralizing IgM-producing B cells after LCMV infection. European Journal of Immunology. 2006 36:3175-3185

Recher, M., Lang, K. S., Hunziker, L., Freigang, S., Eschli, B., Harris, N. L., Navarini, A., Senn, B. M., Fink, K., Lotscher, M., Hangartner, L., Zellweger, R., et al. Deliberate removal of T cell help improves virus-neutralizing antibody production. Nature Immunology. 2004 5:934-942

Hangartner, L., Senn, B. M., Ledermann, B., Kalinke, U., Seiler, P., Bucher, E., Zellweger, R. M., Fink, K., Odermatt, B., Burki, K., Zinkernagel, R. M., Hengartner, H. Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies. Proceedings of the National Academy of Sciences of the United States of America. 2003 100:12883-12888

Wang, Z., Hangartner, L., Cornu, T. I., Martin, L. R., Zuniga, A., Billeter, M. A., Naim, H. Y. Recombinant measles viruses expressing heterologous antigens of mumps and simian immunodeficiency viruses. Vaccine. 2001 19:2329-2336

Duprex, W. P., McQuaid, S., Hangartner, L., Billeter, M. A., Rima, B. K. Observation of measles virus cell-to-cell spread in astrocytoma cells by using a green fluorescent protein-expressing recombinant virus. Journal of Virology. 1999 73:9568-9575