Lars Hangartner, Ph.D.

abouthangartner

Associate Professor of Immunology
Department of Immunology & Microbiology
The Scripps Research Institute

EDUCATION

B.A., Molecular Biology, University of Zurich, Switzerland, 1991

Ph.D., Immunology, Swiss Federal Institute of Technology, Zurich, Switzerland, 2002

POSITIONS

2015-present  Associate Professor of Immunology, Department of Immunology & Microbial Science, TSRI

2009-2015  Assistant Professor, Institute of Medical Virology, University of Zurich, Zurich, Switzerland

2009  Junior Group Leader, Institute of Medical Virology, University of Zurich, Zurich, Switzerland

2005-2008  Postdoctoral Fellow/Senior Research Associate, Department of Immunology & Microbial Science, TSRI

2002-2005  Postdoctoral Fellow, Institute of Immunology, University Hospital of Zurich, Switzerland

PUBLICATIONS

Hangartner L, Beauparlant D, Rakasz E, Nedellec R, Hozé N, McKenney K, Martins MA, Seabright GE, Allen JD, Weiler AM, Friedrich TC, Regoes RR, Crispin M, Burton DR. (2021) Effector function does not contribute to protection from virus challenge by a highly potent HIV broadly neutralizing antibody in nonhuman primates. Sci Transl Med. 13(585):eabe3349.

Turman JM, Cheplowitz AM, Tiwari C, Thomas T, Joshi D, Bhat M, Wu Q, Pong E, Chu SY, Szymkowski DE, Sharma A, Seveau S, Robinson JM, Kwiek JJ, Burton DR, Rajaram MVS, Kim J, Hangartner L, Ganesan LP. (2021) Accelerated Clearance and Degradation of Cell-Free HIV by Neutralizing Antibodies Occurs via FcγRIIb on Liver Sinusoidal Endothelial Cells by Endocytosis. J Immunol. 206(6):1284-1296.

Alter G, Yu WH, Chandrashekar A, Borducchi EN, Ghneim K, Sharma A, Nedellec R, McKenney KR, Linde C, Broge T, Suscovich TJ, Linnekin T, Abbink P, Mercado NB, Nkolola JP, McMahan K, Bondzie EA, Hamza V, Peter L, Kordana N, Mahrokhian S, Seaman MS, Li W, Lewis MG, Lauffenburger DA, Hangartner L, Sekaly RP, Barouch DH. Passive Transfer of Vaccine-Elicited Antibodies Protects against SIV in Rhesus Macaques. Cell. 2020 Oct 1;183(1):185-196.e14.

Pauthner MG, Hangartner L. Broadly Neutralizing Antibodies to Highly Antigenically Variable Viruses as Templates for Vaccine Design. Curr Top Microbiol Immunol. 2020;428:31-87.

Nogal B, Bianchi M, Cottrell CA, Kirchdoerfer RN, Sewall LM, Turner HL, Zhao F, Sok D, Burton DR, Hangartner L, Ward AB. Mapping Polyclonal Antibody Responses in Non-human Primates Vaccinated with HIV Env Trimer Subunit Vaccines. Cell Rep. 2020 Mar 17;30(11):3755-3765.e7.

Hangartner L. Public Endowment of B Cells. Immunity. 2019 Oct 15;51(4):601-603.

Voss JE, Gonzalez-Martin A, Andrabi R, Fuller RP, Murrell B, McCoy LE, Porter K, Huang D, Li W, Sok D, Le K, Briney B, Chateau M, Rogers G, Hangartner L, Feeney AJ, Nemazee D, Cannon P, Burton DR. Reprogramming the antigen specificity of B cells using genome-editing technologies. Elife. 2019 Jan 17;8:e42995.

Pauthner MG, Nkolola JP, Havenar-Daughton C, Murrell B, Reiss SM, Bastidas R, Prévost J, Nedellec R, von Bredow B, Abbink P, Cottrell CA, Kulp DW, Tokatlian T, Nogal B, Bianchi M, Li H, Lee JH, Butera ST, Evans DT, Hangartner L, Finzi A, Wilson IA, Wyatt RT, Irvine DJ, Schief WR, Ward AB, Sanders RW, Crotty S, Shaw GM, Barouch DH, Burton DR. Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers. Immunity. 2019 Jan 15;50(1):241-252.e6.

Bianchi, M., Turner, H. L., Nogal, B., Cottrell, C. A., Oyen, D., Pauthner, M., Bastidas, R., Nedellec, R., McCoy, L. E., Wilson, I. A., Burton, D. R. Electron-microscopy-based epitope mapping defines specificities of polyclonal antibodies elicited during HIV-1 BG505 envelope trimer immunization. Immunity. 2018 49:288-300.

Maurer, M. A., Meyer, L., Bianchi, M., Turner, H. L., Le, N. P. L., Steck, M., Wyrzucki, A., Orlowski, V., Ward, A. B., Crispin, M., Hangartner, L. Glycosylation of human IgA directly inhibits influenza A and other sialic-acid-binding viruses. Cell Reports. 2018 23:90-99

Burton, D. R., Hangartner, L. Broadly neutralizing antibodies to HIV and their role in vaccine design. Annual Review of Immunology. 2016 34:635-659

Wyrzucki, A., Bianchi, M., Kohler, I., Steck, M., Hangartner, L. Heterosubtypic antibodies to influenza A virus have limited activity against cell-bound virus but are not impaired by strain-specific serum antibodies. Journal of Virology. 2015 89:3136-3144

Kohler, I., Kouyos, R., Bianchi, M., Grube, C., Wyrzucki, A., Gunthard, H. F., Hangartner, L. The impact of vaccination on the breadth and magnitude of the antibody response to influenza A viruses in HIV-infected individuals. AIDS. 2015 29:1803-1810

Wyrzucki, A., Dreyfus, C., Kohler, I., Steck, M., Wilson, I. A., Hangartner, L. Alternative recognition of the conserved stem epitope in influenza A virus hemagglutinin by a VH3-30-encoded heterosubtypic antibody. Journal of Virology. 2014 88:7083-7092

Kohler, I., Scherrer, A. U., Zagordi, O., Bianchi, M., Wyrzucki, A., Steck, M., Ledergerber, B., Gunthard, H. F., Hangartner, L. Prevalence and predictors for homo- and heterosubtypic antibodies against influenza A virus. Clinical Infectious Diseases. 2014 59:1386-1393

Hoot, S., McGuire, A. T., Cohen, K. W., Strong, R. K., Hangartner, L., Klein, F., Diskin, R., Scheid, J. F., Sather, D. N., Burton, D. R., Stamatatos, L. Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs. PLoS Pathogens. 2013 9:e1003106

Ota, T., Doyle-Cooper, C., Cooper, A. B., Huber, M., Falkowska, E., Doores, K. J., Hangartner, L., Le, K., Sok, D., Jardine, J., Lifson, J., Wu, X. L., et al. Anti-HIV B Cell lines as candidate vaccine biosensors. Journal of Immunology. 2012 189:4816-4824

Hessell, A. J., Rakasz, E. G., Poignard, P., Hangartner, L., Landucci, G., Forthal, D. N., Koff, W. C., Watkins, D. I., Burton, D. R. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Pathogens. 2009 5:e1000433

Hessell, A. J., Poignard, P., Hunter, M., Tehrani, D. M., Bleeker, W. K., Parren, Pwhi, Marx, P. A., Burton, D. R., Hangartner, L. Effective, low-titer antibody protection against low-dose repeated mucosal shiv challenge in macaques. Nature Medicine. 2009 15:951-954

Geuking, M. B., Weber, J., Dewannieux, M., Gorelik, E., Heidmann, T., Hengartner, H., Zinkernagel, R. M., Hangartner, L. Recombination of retrotransposon and exogenous RNA virus results in nonretroviral cDNA integration. Science. 2009 323:393-396

Schildknecht, A., Welti, S., Geuking, M. B., Hangartner, L., van den Broek, M. Absence of CTL responses to early viral antigens facilitates viral persistence. Journal of Immunology. 2008 180:3113-3121

Law, M., Hangartner, L. Antibodies against viruses: passive and active immunization. Current Opinion in Immunology. 2008 20:486-492

Zuniga, A., Wang, Z., Liniger, M., Hangartner, L., Caballero, M., Pavlovic, J., Wild, P., Viret, J. F., Glueck, R., Billeter, M. A., Naim, H. Y. Attenuated measles virus as a vaccine vector. Vaccine. 2007 25:2974-2983

Recher, M., Lang, K. S., Navarini, A., Hunziker, L., Lang, P. A., Fink, K., Freigang, S., Georgiev, P., Hangartner, L., Zellweger, R., Bergthaler, A., Hegazy, A. N., et al. Extralymphatic virus sanctuaries as a consequence of potent T-cell activation. Nature Medicine. 2007 13:1316-1323

Hessell, A. J., Hangartner, L., Hunter, M., Havenith, C. E. G., Beurskens, F. J., Bakker, J. M., Lanigan, C. M. S., Landucci, G., Forthal, D. N., Parren, Pwhi, Marx, P. A., Burton, D. R. Fc receptor but not complement binding is important in antibody protection against HIV. Nature. 2007 449:101-104

Hangartner, L., Zinkernagel, R. M., Hengartner, H. Antiviral antibody responses: the two extremes of a wide spectrum. Nature Reviews Immunology. 2006 6:231-243

McCoy, K. D., Harris, N. L., Diener, P., Hatak, S., Odermatt, B., Hangartner, L., Senn, B. M., Marsland, B. J., Geuking, M. B., Hengartner, H., Macpherson, A. J. S., Zinkernagel, R. M. Natural IgE production in the absence of MHC class II cognate help. Immunity. 2006 24:329-339

Hangartner, L., Zellweger, R. M., Giobbi, M., Weber, J., Eschli, B., McCoy, K. D., Harris, N., Recher, M., Zinkernagel, R. M., Hengartner, H. Nonneutralizing antibodies binding to the surface glycoprotein of lymphocytic choriomeningitis virus reduce early virus spread. Journal of Experimental Medicine. 2006 203:2033-2042

Zellweger, R. M., Hangartner, L., Weber, J., Zinkernagel, R. M., Hengartner, H. Parameters governing exhaustion of rare T cell-independent neutralizing IgM-producing B cells after LCMV infection. European Journal of Immunology. 2006 36:3175-3185

Recher, M., Lang, K. S., Hunziker, L., Freigang, S., Eschli, B., Harris, N. L., Navarini, A., Senn, B. M., Fink, K., Lotscher, M., Hangartner, L., Zellweger, R., et al. Deliberate removal of T cell help improves virus-neutralizing antibody production. Nature Immunology. 2004 5:934-942

Hangartner, L., Senn, B. M., Ledermann, B., Kalinke, U., Seiler, P., Bucher, E., Zellweger, R. M., Fink, K., Odermatt, B., Burki, K., Zinkernagel, R. M., Hengartner, H. Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies. Proceedings of the National Academy of Sciences of the United States of America. 2003 100:12883-12888

Wang, Z., Hangartner, L., Cornu, T. I., Martin, L. R., Zuniga, A., Billeter, M. A., Naim, H. Y. Recombinant measles viruses expressing heterologous antigens of mumps and simian immunodeficiency viruses. Vaccine. 2001 19:2329-2336

Duprex, W. P., McQuaid, S., Hangartner, L., Billeter, M. A., Rima, B. K. Observation of measles virus cell-to-cell spread in astrocytoma cells by using a green fluorescent protein-expressing recombinant virus. Journal of Virology. 1999 73:9568-9575