The Baoji Xu Laboratory at the Scripps Research Institute - Scripps Florida

Publications

PubMed

The following articles were published by Baoji Xu, his lab members and his collaborators. You may view the entire article by clicking on the abstract link at the end of the corresponding title. The link will redirect you to the PubMed.gov website.

--------------------------------------------------------------------------------------------------------------------------------

2017

Xu, H., An, J. J., and Xu, B. 2017. Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation. PLoS One, 12: e0177610. (PubMed link)

Chen, C. M., Orefice, L. L., Chiu, S. L., LeGates, T. A., Hattar, S., Huganir, R. L., Zhao, H., Xu, B., and Kuruvilla, R. 2017. Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc. Natl. Acad. Sci. USA 114: E619-E628. (PubMed link)

2016

Xie, K., Colgan, L. A., Dao, M., Ostrovskaya, O., Muntean, B. S., Orlandi, C., Boye, S. L., Boye, S. E., Sutton, L. P., Shih, C. –C, Li, Y., Xu, B., Smith, R., Yasuda, R., and Martemyanov, K. A. 2016. NF1 is a direct G protein effector essential for opioid signaling to Ras in the striatum and reward processing. Curr. Biol. 26: 2992-3003. (PubMed link)

Ghoshal, S., Zhu, Q., Asteian, A., Lin, H., Xu, H., Ernst, G., Barrow, J. C., Xu, B., Cameron, M. D., Kamenecka, T. M., and Chakraborty, A. 2016. TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl) purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway. Mol. Metab. 5: 903-917. (PubMed link)

Xu, B. and Xie, X. 2016. Neurotrophic factor control of satiety and body weight. Nat. Rev. Neurosci.17: 282-292. (PubMed link)

Yang, H., An, J. J., Sun, C., and Xu, B. 2016. Regulation of energy balance via BDNF expressed in non-paraventricular hypothalamic neurons. Mol. Endocrinol. 30: 494-503. (PubMed link)

Kamitakahara, A., Xu, B., and Simerly, R. 2016. Ventromedial hypothalamic expression of Bdnf is required to establish normal patterns of afferent GABAergic connectivity and responses to hypoglycemia. Mol. Metab. 5: 91-101. (PubMed link)

Orefice, L.L., Shih, C.C., Xu, H., Waterhouse, E G., and Xu, B. 2016. Control of spine maturation and pruning through proBDNF synthesized and released in dendrites. Mol. Cell Neurosci. 71: 66-79. (PubMed link)

Orefice, L.L., and Xu, B. 2016. Tools for analyzing the role of local protein synthesis in synaptic plasticity. Epigenetic Methods in Neuroscience Research, Nina N. Karpova (Ed.), ISBN: 978-1-4939-2753-1, pages 175-193.

2015

Xie, K., Masuho, I., Shih, C.C., Cao, Y., Sasaki, K., Lai, C.W., Han, P.L., Ueda, H., Dessauer, C.W., Ehrlich, M.E., Xu, B., Willardson, B. M., Martemyanov, K.A. 2015. Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling. eLife 4: e10451. (PubMed link)

An, J.J., Liao, G.Y., Kinney, C.E., Sahibzada, N., and Xu, B. 2015. Discrete BDNF neurons in the paraventricular hypothalamus control feeding and energy expenditure. Cell Metab. 22: 175-188. (PubMed link)

Liao, G.Y., Bouyer, K., Kamitakahara, A., Sahibzada, N., Wang, C.H., Rutlin, M., Simerly, R.B., and Xu, B. 2015. Brain-derived neurotrophic factor is required for axonal growth of selective groups of neurons in the arcuate nucleus. Mol. Metab. 4: 471-482. (PubMed link)

Vanevski, F. and Xu, B. 2015. HuD interacts with Bdnf mRNA and is essential for activity-induced BDNF synthesis in dendrites. PLoS One 10: e0117264. doi: 10.1371/journal.pone.0117264. (PubMed link)

2014

Baydyuk, M. and Xu, B. 2014. BDNF signaling and survival of striatal neurons. Front. Cell. Neurosci. 8: 254. doi: 10.3389/fncel.2014.00254. (PubMed link)

Unterwald, E.M., Page, M.E., Brown, T.B., Miller, J.S., Ruiz, M., Pescatore, K.A., Xu, B., Reichardt, L.F., Beverley, J., Tang, B., Steiner, H., Thomas, E.A., and Ehrlich, M.E. 2013. Behavioral and transcriptome alterations in male and female mice with postnatal deletion of TrkB in dorsal striatal medium spiny neurons. Mol. Neurodegener. 8: 47. (PubMed link)

Dorfman, M.D., Garcia-Rudaz, C., Alderman, Z., Kerr, B., Lomniczi, A., Dissen, G.A., Castellano, J.M., Garcia-Galiano, D., Gaytan, F., Xu, B., Tena-Sempere, M., and Ojeda, S. R. 2014. Loss of Ntrk2/Kiss1r signaling in oocytes causes premature ovarian failure. Endocrinology 155: 3098-3111. (PubMed link)

2013

Xu, B. 2013. BDNF (i)rising from exercise. Cell Metab. 18: 612-614. (PubMed link)

Liao, G.Y., Li, Y., and Xu, B. 2013. Ablation of TrkB expression in RGS9-2 cells leads to hyperphagic obesity. Mol. Metab. 2: 491-497. (PubMed link)

Waterhouse, E.G. and Xu, B. 2013. The skinny on brain-derived neurotrophic factor: evidence from animal models to GWAS. J. Mol. Med. 91: 1241-1247. (PubMed link)

Orefice, L.L., Waterhouse, E.G., Partridge, J.G., Lalchandani, R.R., Vicini, S., and Xu, B. 2013. Distinct roles for somatically and dendritically synthesized BDNF in morphogenesis of dendritic spines. J. Neurosci. 33: 11618-11632. (PubMed link)

Vanevski, F., and Xu, B. 2013. Molecular and neural bases underlying roles of BDNF in the control of body weight. Front. Neurosci. 7: 37. doi: 10.3389/fnins.2013.00037. (PubMed link)

Baydyuk, M., Xie, Y., Tessarollo, L., and Xu, B. 2013. Midbrain-derived neurotrophins support survival of immature striatal projection neurons. J. Neurosci. 33: 3363-3369. (PubMed link)

2012

Waterhouse, E.G., An, J. J., Orefice, L.L., Baydyuk, M., Liao, G.Y., Zheng, K., Lu, B., and Xu, B. 2012. BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission. J. Neurosci. 32: 14318-14330. (PubMed link)

Vigers, A.J., Amin, D.S., Talley-Farnham, T., Gorski, J.A., Xu, B., and Jones, K. R. 2012. Sustained expression of brain-derived neurotrophic factor is required for maintenance of dendritic spines and normal behavior. Neuroscience 212: 1-18. (PubMed link)

Kaneko, M., Xie, Y., An, J.J., Stryker, M.P., and Xu, B. 2012. Dendritic BDNF synthesis is required for late-phase spine maturation and recovery of cortical responses following sensory deprivation. J. Neurosci. 32: 4790-4802. (PubMed link)

Liao, G.Y., An, J.J., Gharami, K., Waterhouse, E.G., Vanevski, F., Jones, K.R., and Xu, B. 2012. Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin. Nat. Med. 18: 564-571. (PubMed link)

2011

Kang, Z., An, J.J., Yang, F., Xu, W., Xu, Z., Wu, J., Hökfelt, T., Fisahn, A., Xu, B., and Lu, B. 2011. TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus.  Proc. Natl. Acad. Sci. USA 108: 17201-17206. (PubMed link)

Baydyuk, M., Russell, T., Liao, G.Y., An, J.J., Reichardt, L.F., and Xu, B. 2011. TrkB receptor controls striatal formation by regulating the number of newborn striatal neurons. Proc. Natl. Acad. Sci. USA 108: 1669-1674. (PubMed link)

Baydyuk, M., Nguyen, M.T., and Xu, B. 2011. Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degeneration. Exp. Neurol. 228: 118-125. (PubMed link)

Baydyuk, M., and Xu, B. 2011. BDNF in Huntington’s disease: role in pathogenesis and treatment. Huntington’s Disease – Core Concepts and Current Advances, Nagehan Ersoy Tunali (Ed.), ISBN: 979-953-307-953-0, page: 495-506.

2010

Xie, Y., Hayden, M.R., and Xu. B. 2010. BDNF overexpression in the forebrain rescues Huntington’s disease phenotypes in YAC128 mice. J. Neurosci. 30: 14708-14718. (PubMed link)

Lau, A.G., Irier, H.A., Gu, J., Tian, D., Ku, L., Liu, G., Xiao, M., Fritsch, B., Zheng, J. Q., Dingledine, R., Xu, B., Lu, B., and Feng, Y. 2010. Distinct 3’UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF). Proc. Natl. Acad. Sci. U.S.A. 107: 15945-15950. (PubMed link)

Fu, X., Zang, K. Zhou, Z., Reichardt, L.F., and Xu, B. 2010. Retrograde neurotrophic signaling requires a protein interacting with receptor tyrosine kinases via C2H2 zinc fingers. Mol. Biol. Cell 21: 36-49. (PubMed link)

2009

Dumanis, S.B., Tesoriero, J., Babus, L.W., Nguyen, T.V., Trotter, J., Ladu, M., Weeber, E., Turner, R.S., Xu, B., Rebeck, G.W., and Hoe, H. S. 2009. ApoE4 decreases spine density and dendritic complexity in cortical neurons in vitro and in vivo. J. Neurosci. 29: 15317-15322. (PubMed link)

Greenberg, M.E., Xu, B., Lu, B., and Hempstead, B.L. 2009. New insights in the biology of BDNF synthesis and release: implications in CNS function. J. Neurosci. 29: 12764-12767. (PubMed link)

Waterhouse, E.G., and Xu, B. 2009. New insights into the role of brain-derived neurotrophic factor in synaptic plasticity. Mol. Cell. Neurosci. 42: 81-89. (PubMed link)

2008

An, J.J., Gharami, K., Liao, G.Y., Woo, N.H., Lau, A.G., Vanevski, F., Torre, E.R., Jones, K.R., Feng, Y., Lu, B., and Xu, B. 2008. Distinct role of long 3′ UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons. Cell 134: 175-187. (PubMed link)

Grishanin, R.N., Yang, H., Liu, X., Donohue-Rolfe, K., Nune, G.C., Zang, K., Xu, B., Duncan, J.L., LaVail, M.M., Copenhagen, D.R., and Reichardt, L.F. 2008. Retinal TrkB receptors regulate neural development in the inner, but not outer, retina. Mol. Cell. Neurosci. 38: 431-443. (PubMed link)

Gharami, K., Xie, Y., An, J.J., Tonegawa, S., and Xu, B. 2008. Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington’s disease phenotypes in mice. J. Neurochem. 105: 369-379. (PubMed link)

Liao, G.Y. and Xu, B. 2008. Cre recombinase-mediated gene deletion in layer 4 of murine sensory cortical areas. Genesis 46: 289-293. (PMCID: PMC2535924) (Pubmed link)

2007

Liu, X., Grishanin, R.N, Tolwani, R.J., Renteria, R.C., Xu, B., Reichardt, L.F., and Copenhagen, D.R. 2007. Brain-derived neurotrophic factor and TrkB modulate visual experience-dependent refinement of neuronal pathways in retina. J. Neurosci. 27: 7256-7267. (PubMed link)

2005

Hashimoto, T., Bergen, S.E., Nguyen, Q.L., Xu, B., Monteggia, L.M., Pierri, J.N., Sun, Z., Sampson, A.R., and Lewis, D.A. 2005. Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J. Neurosci. 25: 372-383. (PubMed link)

2004

Paredes, A., Romero, C., Dissen, G.A., DeChiara, T.M., Reichardt, L., Cornea, A., Ojeda, S.R., and Xu, B. 2004. TrkB receptors are required for follicular growth and oocyte survival in the mammalian ovary.  Dev. Biol. 267: 430-449.

2003

Xu, B., Goulding, E.H., Zang, K., Cepoi, D., Cone, R.D., Jones, K.R., Tecott, L.H., and Reichardt, L.F. 2003. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat. Neurosci. 6: 736-742. (PubMed link)

Tran, P.V., Lee, M.B., Marin, O., Xu, B., Jones, K.R., Reichardt, L.F., Rubenstein, J.R., and Ingraham, H.A. 2003. Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons. Mol. Cell. Neurosci. 22: 441-453. (PubMed link)

2002

Rico, B., Xu, B., and Reichardt, L.F. 2002. TrkB receptor signaling is required for establishment of GABAergic synapses in the cerebellum. Nat. Neurosci. 5: 225-233. (PubMed link)

2001

Sorensen, L., Ekstrand, M., Silva, J.P., Lindqvist, E., Xu, B., Rustin, P., Olson, L., and Larsson, N.G. 2001. Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice. J. Neurosci. 21: 8082-8090. (PubMed link)

2000

Xu, B., Zang, K., Ruff, N. L., Zhang, Y. A., McConnell, S.K., Stryker, M.P., and Reichardt, L.F. 2000. Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB. Neuron 26: 233-245. (PubMed link)

Xu, B., Gottschalk, W., Chow, A., Wilson, R.I., Schnell, E., Zang, K., Wang, D., Nicoll, R.A., Lu, B., and Reichardt, L.F. 2000. The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB. J. Neurosci. 20: 6888-6897. (PubMed link)

1999

Rohrer, B., Korenbrot, J.I., LaVail, M.M., Reichardt, L.F., and Xu, B. 1999. Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina. J. Neurosci. 19: 8919-8930. (PubMed link)

1996

Xu, B., and Clayton, D.A. 1996. RNA-DNA hybrid formation at the human mitochondrial heavy-strand origin ceases at replication start sites: an implication for RNA-DNA hybrids serving as primers. EMBO J. 15: 3135-3143. (PubMed Link)

1995

Xu, B., and Clayton, D.A. 1995. A persistent RNA-DNA hybrid is formed during transcription at a phylogenetically conserved mitochondrial DNA sequence. Mol. Cell. Biol. 15: 580-589. (PubMed link)

Eriksson, S., Xu, B., and Clayton, D.A. 1995. Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase. J. Biol. Chem. 270: 18929-18934. (PubMed Link)

1994

Eriksson, S., Xu, B., and Clayton, D.A. 1994. Properties of mitochondria DNA metabolizing enzymes: implications for chemotherapy. Adv. Exp. Med. Biol. 370: 465-469. (PubMed Link)

1993

Parisi, M.A., Xu, B., and Clayton, D.A. 1993. A human mitochondrial transcriptional activator can functionally replace a yeast mitochondrial HMG-box protein both in vivo and in vitro. Mol. Cell. Biol. 13: 1951-1961. (PubMed link)

1992

Xu, B., and Clayton, D.A. 1992. Assignment of a yeast protein necessary for mitochondrial transcription initiation. Nucleic Acids Res. 20: 1053-1059. (PubMed Link)

1990

Xu, D.–Q., Xu, B.–J., and Shen, Y.–G. 1990. Diurnal variation of photosynthetic efficiency in C3 plants. Acta Phytophysiologica Sinica 16: 1-5. (PubMed Link)

1989

Xu, B.–J., Li, D.–Y., and Shen, Y.–G. 1989. Enhancement of leaf oxygen evolution by low concentration of phenaxinemethosulfate. Acta Phytophysiologica Sinica 15: 307-312.

Xu, D.–Q., and Xu, B.–J. 1989. The role of stomatal limitation in photosynthetic induction of plant leaves. Acta Phytophysiologica Sinica 15: 275-280. (PubMed Link)

1988

Xu, D.–Q., Xu, B.–J., and Li, D.–Y. 1988. The effect of freezing injury on the photosynthetic efficiency in sweet viburnum (Viburnum odoratissimum) leaves. Acta Phytophysiologica Sinica 14: 199-202. Plant Mol Biol.  32:735-743. (PubMed Link)