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Scripps Laboratories for tRNA Synthetase Research

Qian Zhang, Ph.D.

Contact: qianzh@scripps.edu

Photo of Qian Zhang

Education:
Ph.D. in Biochemistry and Molecular biology, School of Life Sciences, Xiamen University, Xiamen, China 2012
B.Sc. in Biotechnology, School of Life Sciences, Xiamen University, Xiamen, China 2007

Current Research Focus:
Aminoacyl-tRNA synthetases (aaRS) developed novel functions during evolution, which indicates the occurrence of binding partners involved in functions beyond protein translation. My current research is focused on:
1.  Elucidating the molecular mechanism of how Glycyl-tRNA synthetase interacts with the proteins involved in neddylation pathway from structural aspect;
2.  Elucidating the molecular mechanism of how Seryl-tRNA synthetase regulates the  angiogenesis by interacting with related binding partners from structural aspect.

Publications:
Shi, Y., Xu, X., Zhang, Q., Fu, G., Mo, Z., Wang, G. S., Kishi, S., and Yang, X.-L. (2014). tRNA synthetase counteracts c-Myc to develop functional vasculature. eLife 3: e02349.

Wang, J. W.*, Wang, Y.*, Chen, H. Z,*, Xing, Y. Z.*, Li, F. W.*, Zhang, Q., Zhou, B., Zhang, H. K., Huang, P. Q., Lin, T. W., and Wu, Q. (2014). Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat Chem Biol 10: 133-140.

Zhan, Y. Y.*, Chen, Y.*, Zhang, Q.*, Zhuang, J. J., Tian, M., Chen, H. Z., Zhang, L. R., Zhang, H. K., Huang, P. Q., Lin, T., and Wu, Q. (2012). The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat Chem Biol 8: 897-904. (*co-first authors).

Lin, T., Wang, G., Li, A., Zhang, Q., Wu, C., Zhang, R., Cai, Q., Song, W., and Yuen, K. Y. (2009). The hemagglutinin structure of an avian H1N1 influenza A virus. Virology 392: 73-81.

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