Gary Siuzdak, Ph.D.

Mass Spectrometry, Sr Dir
Professor
Research Services
California Campus
Laboratory Website
siuzdak@scripps.edu
(858) 784-9415

Scripps Research Joint Appointments

Department of Chemistry
Department of Molecular Biology

Research Focus

Metabolomics and Mass Spectrometry

Our lab is developing mass spectrometry-based technology for unbiased comparative analysis as well as the structural and biological characterization of metabolites. These developments include nanostructure-based mass imaging, novel data analysis software, as well as a unique database to facilitate metabolite identification. Our XCMS software, a metabolomics LC/MS data analysis approach, has been widely applied (with over 20,000 downloads) for alignment and statistical data LC/MS analysis. XCMS is also coupled with Metlin, a database of metabolites and MS/MS data used to facilitate metabolite identification and classification. Our nanostructure-based mass spectrometry platform, a novel matrix-free surface analysis technology, is being developed for metabolite tissue imaging, activity screening and analyzing nano-arrays.

Education

Ph.D., Physical Chemistry, Dartmouth, 1990

Awards & Professional Activities

Rhode Island College Gehrenbeck lecturer Society of Analytical Chemists Distinguished Lecturer Environmental Protection Agency Distinguished Lecturer Ronald J. Boruch Award in Physical Sciences

Selected References

Patti G.J., Yanes O., Shriver L., Courade J-P., Tautenhahn R., Manchester M., Siuzdak G. Metabolomics Implicates Altered Sphingolipid Metabolites in Chronic Pain of Neuropathic Origin Nature Chemical Biology, 2012, 8, 232-234.

Yanes O., Hsu J., Wong D.M., Sanchez-Ruiz A., Benton H.P., Trauger S.A., Despont C., Ding S., Siuzdak G. Metabolic oxidation regulates embryonic stem cell differentiation Nature Chemical Biology, 2010, 6, 411-417.

Northen T.R., Yanes O., Northen M.T., Marrinucci D., Uritboonthai W., Apon J., Golledge S.L., Nordstrom A., Siuzdak G. Clathrate nanostructures for mass spectrometry Nature, 2007, 449(7165), 1033-1037.

Smith C.A., Want E.J., O'Maille G., Abagyan R., Siuzdak G. XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching and identification Analytical Chemistry, 2006, 78, 779-787

Wei J., Buriak J., Siuzdak G. Desorption-ionization mass spectrometry on porous silicon Nature, 1999, 399(6733), 243-246.

Links

Center for Metabolomics and Mass Spectrometry