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Scripps Research Joint Appointments

Faculty, Kellogg School of Science and Technology

Research Focus

Synthetic Organic Chemistry

      Natural products, or secondary metabolites, constitute a vast molecular library that has proven useful for disease target identification, clinical study, and occasionally prescription. Natural products form the foundation of modern drug discovery and are projected to continue as central players in biomedical research. However, the complexity inherent to these molecules has often had a prohibitive effect on their inclusion in medicinal chemistry.
     Our lab seeks to address some of the issues at the heart of this problem by the invention of new chemical methods and new strategies for complex molecule synthesis. We use secondary metabolites as a springboard for discovery, both in synthetic organic chemistry and in biology. 

Education

B.S., Chemistry, The Pennsylvania State University, 2003
Ph.D., Chemistry, The Scripps Research Institute, 2008

Professional Experience

NIH Postdoctoral Fellow with E. J. Corey, Harvard University, 2008-2010

Awards & Professional Activities

Boehringer Ingelheim New Investigator Award, 2012
Eli Lilly New Faculty Award, 2011

Selected References

Jansen, D. J.; Shenvi, R. A. "Synthesis of (–)-Neothiobinupharidine" J. Am. Chem. Soc. 2013, ASAP page.

Pronin, S. V.; Shenvi, R. A. “Synthesis of a Potent Antimalarial Amphilectene” J. Am. Chem. Soc. 2012, 134, 19604–19606.

Pronin, S. V.; Shenvi, R. A. “Synthesis of Highly Strained Terpenes by Nonstop Tail-to-Head Polycyclization” Nature Chem. 2012, 4, 915–920.

Pronin, S. V.; Tabor, M. G.; Jansen, D. J.; Shenvi, R. A. “A Stereoselective Hydroamination Transform to Access Polysubstituted Indolizidines” J. Am. Chem. Soc. 2012, 134, 2012–2015.

Shenvi, R. A.; Corey, E. J. "A Short and Efficient Synthesis of (–)-7-Methylomuralide, a Potent Proteasome Inhibitor" J. Am. Chem. Soc. 2009, 131, 5746–5747.

Shenvi, R. A.; Guerrero, C. A.; Shi, J.; Li, C.-C.; Baran, P. S. "Synthesis of (+)-Cortistatin A" J. Am. Chem. Soc. 2008, 130, 7241–7243.

Baran, P. S.; Shenvi, R. A. "Total Synthesis of (±)-Chartelline C" J. Am. Chem. Soc. 2006, 128, 14028–14029.