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William Schief, Ph.D.

Department of Immunology and Microbiology
California Campus
Scripps VIVO Scientific Profile
(858) 784-7725

Scripps Research Joint Appointments

Faculty, Graduate Program

Other Joint Appointments

The Ragon Institute of MGH, MIT and Harvard (Associate Member)
IAVI Neutralizing Antibody Center, The Scripps Research Institute


Ph.D. (Physics), 1999
B.S. (Applied Mathematics), Yale University 1989

Professional Experience

2011-2014 Associate Professor of Immunology, Immunology and Microbial Science (IMS), The Scripps Research Institute

Selected References

All Publications

Abbott, R. K., Lee, J. H., Menis, S., Skog, P., Rossi, M., Ota, T., Kulp, D. W., Bhullar, D., Kalyuzhniy, O., Havenar-Daughton, C., Schief, W. R., Nemazee, D., et al. Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens. (2018). Immunity, 48(1), 133-+.

Crooks, E. T., Osawa, K., Tong, T., Grimley, S. L., Dai, Y. D., Whalen, R. G., Kulp, D. W., Menis, S., Schief, W. R. & Binley, J. M. Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction. (2017). Virology, 505, 193.

Pauthner, M., Havenar-Daughton, C., Sok, D., Nkolola, J. P., Bastidas, R., Boopathy, A. V., Carnathan, D. G., Chandrashekar, A., Cirelli, K. M., Cottrell, C. A., Eroshkin, A. M., Guenaga, J., et al. Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches. (2017). Immunity, 46(6), 1073-1088. PMCID: PMC5483234.

Virnik, K., Nesti, E., Dail, C., Hockenbury, M., Ni, Y. S., Felber, B. K., Schief, W. R. & Berkower, I. Expression of complete SIV p27 Gag and HIV gp120 engineered outer domains targeted by broadly neutralizing antibodies in live rubella vectors. (2017). Vaccine, 35(24), 3272-3278.

Cao, L., Diedrich, J. K., Kulp, D. W., Pauthner, M., He, L., Park, S. K. R., Sok, D., Su, C. Y., Delahunty, C. M., Menis, S., Andrabi, R., Guenaga, J., et al. Global site-specific N-glycosylation analysis of HIV envelope glycoprotein. (2017). Nature Communications, 8.

Irimia, A., Serra, A. M., Sarkar, A., Jacak, R., Kalyuzhniy, O., Sok, D., Saye-Francisco, K. L., Schiffner, T., Tingle, R., Kubitz, M., Adachi, Y., Stanfield, R. L., et al. Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design. (2017). PLoS Pathogens, 13. PMCID: PMC5338832.

Scally, S. W., McLeod, B., Bosch, A., Miura, K., Liang, Q., Carroll, S., Reponen, S., Nguyen, N., Giladi, E., Ramisch, S., Yusibov, V., Bradley, A., et al. Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25. (2017). Nature Communications, 8. PMCID: PMC5691035.

Labonte, J. W., Adolf-Bryfogle, J., Schief, W. R. & Gray, J. J. Residue-centric modeling and design of saccharide and glycoconjugate structures. (2017). Journal of Computational Chemistry, 38(5), 276-287. PMCID: PMC5182120.

Kulp, D. W., Steichen, J. M., Pauthner, M., Hu, X., Schiffner, T., Liguori, A., Cottrell, C. A., Havenar-Daughton, C., Ozorowski, G., Georgeson, E., Kalyuzhniy, O., Willis, J. R., et al. Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding. (2017). Nature Communications, 8. PMCID: PMC5698488.

Sok, D., Pauthner, M., Briney, B., Lee, J. H., Saye-Francisco, K. L., Hsueh, J., Ramos, A., Le, K. M., Jones, M., Jardine, J. G., Bastidas, R., Sarkar, A., et al. A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 binding and its camouflaging glycans. (2016). Immunity, 45(1), 31-45. PMCID: PMC4990068.