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William Schief, Ph.D.

Professor
Department of Immunology and Microbial Science
California Campus
Scripps VIVO Scientific Profile
schief@scripps.edu
(858) 784-7725

Scripps Research Joint Appointments

Faculty, Graduate Program

Education

Ph.D. (Physics), University of Washington 1999
B.S. (Applied Mathematics), Yale University 1989

Selected References

All Publications

Sok, D., Pauthner, M., Briney, B., Lee, J. H., Saye-Francisco, K. L., Hsueh, J., Ramos, A., Le, K. M., Jones, M., Jardine, J. G., Bastidas, R., Sarkar, A., et al. A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 binding and its camouflaging glycans. (2016). Immunity, 45(1), 31-45. PMCID: PMC4990068.

Jardine, J. G., Kulp, D. W., Havenar-Daughton, C., Sarkar, A., Briney, B., Sok, D., Sesterhenn, F., Ereno-Orbea, J., Kalyuzhniy, O., Deresa, I., Hu, X., Spencer, S., et al. HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogene. (2016). Science, 351(6280), 1458-1463. PMCID: PMC4872700.

McCoy, L. E., van Gils, M. J., Ozorowski, G., Messmer, T., Briney, B., Voss, J. E., Kulp, D. W., Macauley, M. S., Sok, D., Pauthner, M., Menis, S., Cottrell, C. A., et al. Holes in the glycan shield of the native HIV Envelope are a target of trimer-elicited neutralizing antibodies. (2016). Cell Reports, 16(9), 2327-2338. PMCID: PMC5007210.

Tian, M., Cheng, C., Chen, X., Duan, H., Cheng, H. L., Dao, M., Sheng, Z., Kimble, M., Wang, L., Lin, S., Schmidt, S. D., Du, Z., et al. Induction of HIV neutralizing antibody lineages in mice with diverse precursor repertoires. (2016). Cell, 166(6), 1471-1484. PMCID: PMC5103708.

Jardine, J. G., Sok, D., Julien, J. P., Briney, B., Sarkar, A., Liang, C. H., Scherer, E. A., Henry Dunand, C. J., Adachi, Y., Diwanji, D., Hsueh, J., Jones, M., et al. Minimally mutated HIV-1 broadly neutralizing antibodies to guide reductionist vaccine design. (2016). PLoS Pathogens, 12. PMCID: PMC4999182.

Escolano, A., Steichen, J. M., Dosenovic, P., Kulp, D. W., Golijanin, J., Sok, D., Freund, N. T., Gitlin, A. D., Oliveira, T., Araki, T., Lowe, S., Chen, S. T., et al. Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knockin mice. (2016). Cell, 166(6), 1445-1458. PMCID: PMC5019122.

McGuire, A. T., Gray, M. D., Dosenovic, P., Gitlin, A. D., Freund, N. T., Petersen, J., Correnti, C., Johnsen, W., Kegel, R., Stuart, A. B., Glenn, J., Seaman, M. S., et al. Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice. (2016). Nature Communications, 7. PMCID: PMC4770077.

Mousa, J. J., Sauer, M. F., Sevy, A. M., Finn, J. A., Bates, J. T., Alvarado, G., King, H. G., Loerinc, L. B., Fong, R. H., Doranz, B. J., Correia, B. E., Kalyuzhniy, O., et al. Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein. (2016). Proceedings of the National Academy of Sciences of the United States of America, 113(44), E6849-E6858. PMCID: PMC5098655.

Briney, B., Sok, D., Jardine, J. G., Kulp, D. W., Skog, P., Menis, S., Jacak, R., Kalyuzhniy, O., de Val, N., Sesterhenn, F., Le, K. M., Ramos, A., et al. Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies. (2016). Cell, 166(6), 1459-1470. PMCID: PMC5018249.

Sanders, R. W., van Gils, M. J., Derking, R., Sok, D., Ketas, T. J., Burger, J. A., Ozorowski, G., Cupo, A., Simonich, C., Goo, L., Arendt, H., Kim, H. J., et al. HIV-1 neutralizing antibodies induced by native-like envelope trimers. (2015). Science, 349. PMCID: PMC4498988.