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Arthur Olson, Ph.D.

Anderson Research Chair
Professor
Department of Integrative Structural and Computational Biology
California Campus
Laboratory Website
olson@scripps.edu
(858) 784-9702

Scripps Research Joint Appointments

Faculty, Graduate Program

Research Focus

Biomolecular Interactions

The principal objectives of this laboratory are to develop and apply computational and computer graphic techniques in the study of biomolecular interactions. The growing data base of three-dimensional protein and nucleic acid structures highlights the need for new methods of analyzing and predicting molecular interaction. Our focus is on protein-protein recognition and binding in oligomer formation, antibody-antigen complexes, and on protein-substrate interactions in drug design. A new laboratory initiative is in developing methods to model "From Atoms to Cells."

We have developed a number of techniques for visualizing and analyzing protein structure and properties. We have also recently developed new representations of protein surfaces and properties using an expansion of spherical harmonic functions. This new characterization enables a flexible and continuous description of molecules over multiple length scales. We have used this approach to develop SurfDock-a program to predict protein-protein association.

We are continuing development of techniques to predict protein interactions. Our AutoDock code uses efficient global and local search procedures to dock flexible substrates into protein active sites. We are expanding these techniques to the design of new inhibitors, focusing on anti-HIV therapeutics, and the blood coagulation cascade.

Education

Ph.D., University of California, Berkeley, 1975

Awards & Professional Activities

Editorial Board, Computational Biology and Chemistry

Selected References

Perryman AL, Forli S, Morris GM, Burt C, Cheng Y, Palmer MJ, Whitby K, McCammon JA, Phillips C, Olson AJ. A dynamic model of HIV integrase inhibition and drug resistance. J Mol Biol. 2010 Mar 26;397(2):600-15.

Trott O, Olson AJ. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 2010 Jan 30;31(2):455-61.

Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, Olson AJ. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J Comput Chem. 2009 Dec;30(16):2785-91.

Jiang H, Bower KE, Beuscher AE 4th, Zhou B, Bobkov AA, Olson AJ, Vogt PK. Stabilizers of the Max homodimer identified in virtual ligand screening inhibit Myc function. Mol Pharmacol. 2009 Sep;76(3):491-502.

Gillet, A., Sanner, M., Stoffler, D., Olson, A.J. (2005) Tangible interfaces for structural molecular biology. Structure:13:483-491.