Scripps Research Logo

Luke Lairson, Ph.D.

Assistant Professor
Department of Chemistry
California Campus
Scripps VIVO Scientific Profile
(858) 784-9335


Ph.D., Chemistry , University of British Columbia, 2007

Professional Experience

2011-2017 Assistant Professor of Chemistry, Chemistry, The Scripps Research Institute
2010-2011 Research Investigator, Genomics Institute of the Novartis Research Foundation
2007-2009 CIHR Fellow, The Scripps Research Institute

Selected References

All Publications

Vishal A. Deshmukh, Virginie Tardif, Costas A. Lyssiotis, Chelsea C. Green, Bilal Kerman, Hyung Joon Kim, Krishnan Padmanabhan, Jonathan G. Swoboda, Insha Ahmad, Toru Kondo, Fred H. Gage, Argyrios N. Theofilopoulos, Brian R. Lawson, Peter G. Schultz & Luke L. Lairson.  (2013) A regenerative approach to the treatment of multiple sclerosis.  Nature502:  327-332.

Luke L. Lairson, Costas A. Lyssiotis, Shoutian Zhu, and Peter G. Schultz.  (2013) Small Molecule Based Approaches to Adult Stem Cell Therapies.  Annual Review of Pharmacology and Toxicology53: 107-125.

Staerk J, Lyssiotis CA, Medeiro LA, Bollong M, Foreman RK, Zhu S, Garcia M, Gao Q, Bouchez LC, Lairson LL, Charette BD, Supekova L, Janes J, Brinker A, Cho CY, Jaenisch R, Schultz PG.  (2011)  Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells.  AngewandteChemie International Edition. 50: 5734-5736.

Wurdak H., Zhu S., Min K.H., Aimone L, Lairson L.L., Watson J., Chopiuk G., Demas J., Charette B., HalderR., Weerapana E., Cravatt B.F., Cline H.T., Peters E.C., Zhang J., Walker J.R., Wu C., Chang J., Tuntland T., Cho C.Y., Schultz P.G. (2010) A small molecule accelerates neuronal differentiation in the adult rat.Proceedings of the National Academy of Science USA.107: 16542-16547.

Wurdak, H., Zhu, S., Romero, A., Lorger, M., Watson, J., Chiang, C., Zhang, J., Natu, V.S., Lairson, L.L., Walker, J.R., Trussell, C.M., Harsh, G.R., Vogel. H., Felding-Habermann, B., Orth, A.P., Miraglia, L.J., Rines, D.R., Skirboll, S.L., and Schultz, P.G.  (2010) AnRNAi Screen Indentifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation.Cell Stem Cell6: 1-11.

Lyssiotis, C.A., Foreman, R.K., Staerk, J., Garcia, M., Mathur, D., Markoulaki, S., Hanna, J., Lairson, L.L., Charette, B.D., Bouchez, L.C., Bollong, M., Kunick, C., Brinker, A., Cho, C.Y., Schultz, P.G., and Jaenisch, R.  (2009)  Reprogramming murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.  Proceedings of the National Academy of Science USA.106: 8912-8917.

Lairson, L.L., Henrissat, B., Davies, G.J., and Withers, S.G.  (2008)  Glycosyltransferases: Structures, Functions, and Mechanisms.  Annual Review of Biochemistry. 77: 521-555.

Lairson, L.L., Watts, A.G., Wakarchuk, W.W., and Withers, S.G.  (2006)  Using Substrate Engineering to Harness Enzyme Promiscuity and Expand Biological Catalysis.  Nature Chemical Biology2: 724-728.   

Lairson, L.L., Chiu, C.P.C., Ly, H.D., He, S., Wakarchuk, W.W., Strynadka, N.C.J., Withers, S.G. (2004)  Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue.  Journal of Biological Chemistry.279: 28339-28344.

Chiu, C.P.C., Watts, A.G., Lairson, L.L., Gilbert, M., Lim, D., Wakarchuk, W.W., Withers, S.G., Strynadka, N.C.J.  (2004)  Structural analysis of the sialyltransferaseCstII from Campylobacter jejuni in complex with a substrate analog.  Nature Structural and Molecular Biology.11: 163-170.